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The pH values and viscosity of sterilized CNF dispersions were compared with those of control and autoclaved CNF dispersions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Phosphorylated CNF dispersions at a concentration of 2.0 mg\/mL or lower and the addition of 10 \u00b5g\/mL benzalkonium chloride alone or 250 \u00b5g\/mL methyl parahydroxybenzoate and 250 \u00b5g\/mL propyl parahydroxybenzoate in combination can sterilize CNF dispersions without changing the physical and chemical properties of CNFs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We developed sterilization method for CNF dispersions that uses multiple preservatives with different hydrophilicities without affecting the physical and chemical properties of CNFs. This sterilization method for CNFs dispersions can be applied to the safety assessment of CNF with different physicochemical properties in the future.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/1348-9585.12176","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T11:15:12Z","timestamp":1604747712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Screening of preservatives and evaluation of sterilized cellulose nanofibers for toxicity studies"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-5210","authenticated-orcid":false,"given":"Takafumi","family":"Sai","sequence":"first","affiliation":[{"name":"Innovation Promotion Division, Oji Holdings Corporation , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Maru","sequence":"additional","affiliation":[{"name":"Research Institute of 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