{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:31:02Z","timestamp":1753860662664,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":1012,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["15390191","17390179","20249039","23249033","16K09107","19H03906"],"award-info":[{"award-number":["15390191","17390179","20249039","23249033","16K09107","19H03906"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To clarify whether indium in serum (In-S) is an appropriate parameter for assessing accumulated indium concentration in the lungs (In-L).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>During our approximately 15-year Japanese cohort follow-up, five male indium-tin oxide (ITO) or\/and indium trioxide-exposed workers underwent lung surgical procedures to treat lung diseases or to confirm a diagnosis of lung impairments. We measured In-L of these Cases 1-5 and were able to assess the relationship between In-L and the most recent In-S. Another 1 Japanese case (Case 6) exposed to indium trioxide and indium hydroxide was referred from an article.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cases 1 and 3 had lung cancer, Case 2 suffered from recurrent pneumothorax, and Case 4 had interstitial pneumonia with mild emphysema. Case 5 had severe emphysema with pulmonary hypertension and underwent bilateral lung transplantation. In Cases 1-5, In-L and In-S ranged from 3.4 to 161.2 \u00b5g\/g wet weight and 0.7 to 60.4 ng\/mL, respectively, and In-L\/In-S ratios ranged from 2484 to 4857. The slope of the single regression equation with zero intercept was 2767 and the correlation coefficient was 0.995. In contrast, Case 6 was extraordinarily outlying, but the reason is unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In-S is an excellent predictor for assessing indium load in the lungs in ITO or\/and indium trioxide-exposed workers. However, number of cases was only five and not enough to authorize definite conclusion. It is desirable to add more cases to confirm our conclusion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/1348-9585.12207","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T17:42:41Z","timestamp":1614188561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Indium concentration in serum is an excellent predictor for assessing accumulated indium concentration in the lungs"],"prefix":"10.1093","volume":"63","author":[{"given":"Miyuki","family":"Hirata","sequence":"first","affiliation":[{"name":"Environmental Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-1315","authenticated-orcid":false,"given":"Makiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Environmental Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Omae","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"issue":"3","key":"2024071808122018700_joh212207-bib-0001","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1539\/joh.45.137","article-title":"Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide","volume":"45","author":"Homma","year":"2003","journal-title":"J Occup 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workers","volume":"70","author":"Amata","year":"2015","journal-title":"Thorax"},{"key":"2024071808122018700_joh212207-bib-0008","first-page":"526","volume-title":"Clinical Aspects of Diffuse Pulmonary Diseases","author":"Amejima","year":"2011"},{"issue":"5","key":"2024071808122018700_joh212207-bib-0009","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1539\/joh.16-0076-CS","article-title":"An advanced case of indium lung disease with progressive emphysema","volume":"58","author":"Nakano","year":"2016","journal-title":"J Occup Health"},{"issue":"1","key":"2024071808122018700_joh212207-bib-0010","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12165","article-title":"Indium kinetics in an indium exposed worker before and after bilateral lung transplantation","volume":"62","author":"Nakano","year":"2020","journal-title":"J Occup Health"}],"container-title":["Journal of Occupational 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