{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:23:48Z","timestamp":1774617828188,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd000103","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000}}],"reference-count":113,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd000103.pub2","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T06:34:18Z","timestamp":1409121258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Haemodilution for acute ischaemic stroke"],"prefix":"10.1002","volume":"2014","author":[{"given":"Timothy S","family":"Chang","sequence":"first","affiliation":[{"name":"University of Wisconsin; Institute for Clinical and Translational Research; FCB Room 7273 1685 Highland Ave Madison WI USA 53705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B","family":"Jensen","sequence":"additional","affiliation":[{"name":"University of Wisconsin; Department of Neurology; 1685 Highland Ave, room 7273 Madison WI USA 53705"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD000103.pub2-BIB0001|cit1","first-page":"e228","article-title":"The Albumin in Acute Stroke (ALIAS) Trial: part 1 safety analysis","volume":"41","author":"Ginsberg","year":"2010","journal-title":"Stroke"},{"issue":"1","key":"10.1002\/14651858.CD000103.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/STROKEAHA.110.596072","article-title":"The Albumin in Acute Stroke (ALIAS) multicenter clinical trial: safety analysis of part 1 and rationale and design of part 2","volume":"42","author":"Ginsberg","year":"2011","journal-title":"Stroke"},{"issue":"6","key":"10.1002\/14651858.CD000103.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/STROKEAHA.110.610980","article-title":"The Albumin in Acute Stroke Part 1 Trial: an exploratory efficacy analysis","volume":"42","author":"Hill","year":"2011","journal-title":"Stroke"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1747-4949.2007.00143.x","article-title":"The ALbumin In Acute Stroke trial (ALIAS); design and methodology","volume":"2","author":"Hill","year":"2007","journal-title":"International Journal of Stroke"},{"issue":"11","key":"10.1002\/14651858.CD000103.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S1474-4422(13)70223-0","article-title":"High-dose albumin treatment for acute ischaemic stroke (ALIAS) Part 2: a randomised, double-blind, phase 3, placebo-controlled trial","volume":"12","author":"Ginsberg","year":"2013","journal-title":"Lancet Neurology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0006|cit6","first-page":"154","article-title":"Isovolaemic haemodilution with plasma in acute ischaemic stroke","volume":"16","author":"Balcarce","year":"1991","journal-title":"Revista Neurologica Argentina"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0007|cit7","first-page":"455","article-title":"Dextran-40 in nonhemorrhagic cerebrovascular accidents","volume":"100","author":"Bornstein","year":"1981","journal-title":"Harefuah"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/01.STR.18.2.373","article-title":"Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis","volume":"18","author":"Frei","year":"1987","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.1969.03160280033005","article-title":"Treatment of acute stroke with Dextran 40","volume":"210","author":"Gilroy","year":"1969","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0010|cit10","first-page":"2422","article-title":"Haemodilution in acute cerebral infarction; administration of albumin solution and crystalline infusion fluid guided by the haematocrit","volume":"136","author":"Goslinga","year":"1992","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/01.STR.23.2.181","article-title":"Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke","volume":"23","author":"Goslinga","year":"1992","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0012|cit12","first-page":"41","article-title":"Hemodilution and rehydration in acute ischemic stroke. A preliminary report on the Amsterdam Stroke Study","volume":"18 Suppl 1","author":"Goslinga","year":"1991","journal-title":"Acta Medica Austriaca"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0013|cit13","unstructured":"Haass A Decker I Hamann G Stoll M Schimrigk K Kasser U Hemodilution therapy of acute stroke Proceedings of the Satellite Symposium on Haemodilution at the First European Stroke Conference; 1990 10-12 May; Dusseldorf, Germany"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0014|cit14","first-page":"137","article-title":"Hemodynamic effect of hemodilution with hydroxyethyl starch","volume":"20","author":"Krack","year":"1989","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0016|cit15","first-page":"206","article-title":"Regional cerebral blood flow in acute cerebral infarction during hypervolemic hemodilution","volume-title":"Cerebral Vascular Disease 5","author":"Hartmann","year":"1985"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0015|cit16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/978-3-642-71787-1_50","article-title":"Effect of hemodilution on regional cerebral blood flow in patients with acute cerebral infarction","volume-title":"Cerebral Ischemia and Hemorheology","author":"Hartmann","year":"1987"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.STR.20.3.317","article-title":"Hypervolemic hemodilution treatment of acute stroke. Results of a randomized multicenter trial using pentastarch","volume":"20","author":"The Hemodilution in Stroke Study Group","year":"1989","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0018|cit18","first-page":"318","article-title":"Haemodilution in acute stroke: results from the Italian Haemodilution Trial","volume":"i","author":"Italian Acute Stroke Study Group","year":"1988","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.STR.18.3.670","article-title":"The Italian hemodilution trial in acute stroke. Italian Acute Stroke Study Group","volume":"18","author":"Italian Acute Stroke Study Group","year":"1987","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1136\/bmj.2.6049.1409","article-title":"Combined dexamethasone and low-molecular-weight dextran in acute brain infarction: double-blind study","volume":"2","author":"Kaste","year":"1976","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.STR.21.10.1429","article-title":"Adjusted hypervolemic hemodilution in acute ischemic stroke","volume":"21","author":"Koller","year":"1990","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/S0022-510X(97)85201-X","article-title":"Hypervolemic hemodilution and rehydration in the early phase of ischemic stroke: results of the Multicenter Austrian Hemodilution Stroke Trial (MAHST)","volume":"150 Suppl","author":"Aichner","year":"1997","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.STR.29.4.743","article-title":"Hypervolemic hemodilution in acute ischemic stroke: the Multicenter Austrian Hemodilution Stroke Trial (MAHST)","volume":"29","author":"Aichner","year":"1998","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.STR.22.5.680","article-title":"Neurological deterioration under isovolemic hemodilution with hydroxyethyl starch in acute cerebral ischemia","volume":"22","author":"Mast","year":"1991","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/str.22.7.955a","article-title":"Hemodilution in ischemic stroke","volume":"22","author":"Mast","year":"1991","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/brain\/99.2.193","article-title":"A blind controlled trial of dextran 40 in the treatment of ischemic stroke","volume":"99","author":"Matthews","year":"1976","journal-title":"Brain"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0027|cit27","first-page":"79","article-title":"Haemodilution therapy in acute ischaemic stroke","volume":"27","author":"Popa","year":"1989","journal-title":"Revue Roumaine de Neurologie et de Psychiatrie"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0028|cit28","first-page":"270","article-title":"Hypervolemic hemodilution by hydroxyethyl starch in acute ischemic stroke","volume":"30","author":"Heiss W-D for the HES Study Group","year":"1999","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0029|cit29","first-page":"121","article-title":"Evaluation of safety of hydroxyethyl starch (HES) in hypervolemic hemodilution in patients with acute ischemic stroke - an explanatory pilot study","volume":"11 Suppl 4","author":"Rudolf","year":"2001","journal-title":"Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000063721","article-title":"Hydroxyethyl starch for hypervolemic hemodilution in patients with acute ischemic stroke: a randomized, placebo-controlled phase II safety study","volume":"14","author":"Rudolf","year":"2002","journal-title":"Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/01.STR.4.6.895","article-title":"Management of completed stroke with dextran 40. A community hospital failure","volume":"4","author":"Spudis","year":"1973","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0032|cit32","first-page":"143","article-title":"Hemodilution in acute ischemic stroke - a randomized multicenter trial","volume":"17","author":"Scandinavian Stroke Study Group","year":"1986","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/01.STR.18.4.691","article-title":"Multicenter trial of hemodilution in acute ischemic stroke: I. Results in the total patient population","volume":"18","author":"Scandinavian Stroke Study Group","year":"1987","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/01.STR.16.5.885","article-title":"Multicenter trial of hemodilution in acute ischemic stroke: background and study protocol","volume":"16","author":"Scandinavian Stroke Study Group","year":"1985","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/01.STR.19.4.464","article-title":"Multicenter trial of hemodilution in acute ischemic stroke: results of subgroup analyses","volume":"19","author":"Scandinavian Stroke Study Group","year":"1988","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0036|cit36","first-page":"148","article-title":"Ischemic stroke treated by haemodilution: an interim report of a randomized trial","volume-title":"Cerebral Vascular Disease 4. I.C.S. No. 616","author":"Asplund","year":"1982"},{"issue":"5","key":"10.1002\/14651858.CD000103.pub2-BIB0039|cit37","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.STR.23.5.657","article-title":"Evaluation of long-term outcome and safety after hemodilution therapy in acute ischemic stroke","volume":"23","author":"Strand","year":"1992","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0037|cit38","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/01.STR.15.6.980","article-title":"A randomized controlled trial of hemodilution therapy in acute ischemic stroke","volume":"15","author":"Strand","year":"1984","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0038|cit39","first-page":"122","article-title":"Hemodilution treatment of ischemic stroke","volume":"14","author":"Strand","year":"1983","journal-title":"Stroke"},{"issue":"2","key":"10.1002\/14651858.CD000103.pub2-BIB0040|cit40","first-page":"184","article-title":"Evaluation of modified hemodilution combined therapy in the treatment of acute ischemic stroke in the elderly","volume":"1","author":"Chen","year":"2006","journal-title":"Neural Regeneration Research"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0041|cit41","first-page":"146","article-title":"A prospective trial of hemodilution therapy in acute cerebral infarction","volume":"25","author":"Ding","year":"1992","journal-title":"Chung Hua Shen Ching Ching Shen Ko Tsa Chih"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0042|cit42","first-page":"S87","article-title":"Therapeutic safety of a high-dose volume therapy with hydroxyethyl starch in patients with acute stroke under intensive care monitoring","volume":"34","author":"Grauer","year":"1999","journal-title":"Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0043|cit43","first-page":"S136","article-title":"Hypervolemic hemodilution for the elderly patients with atherothrombotic and hemodynamic ischemic stroke","volume":"2 Suppl 1","author":"Hamamoto","year":"1992","journal-title":"Journal of Stroke and Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0044|cit44","unstructured":"Hartmann A Unpublished data"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/ejvs.1999.0948","article-title":"Transcranial Doppler-directed dextran-40 therapy is a cost-effective method of preventing carotid thrombosis after carotid endarterectomy","volume":"19","author":"Hayes","year":"2000","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0046|cit46","first-page":"41","article-title":"Hemodilution therapy with neuron metabolism specific therapy in ischemic stroke - encouraging results of a comparative study","volume":"146","author":"Koppi","year":"1996","journal-title":"Wiener Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0047|cit47","first-page":"30","article-title":"Use of cerebrolysin in the treatment of ischemic stroke","volume":"98","author":"Koppi","year":"1998","journal-title":"Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0048|cit48","first-page":"137","article-title":"Hemodynamic effect of hemodilution with hydroxyethyl starch","volume":"20","author":"Krack","year":"1989","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0049|cit49","first-page":"244","article-title":"Hemodilution in the treatment of acute cerebral ischemia","volume":"24","author":"Luo","year":"1991","journal-title":"Chung Hua Shen Ching Ching Shen Ko Tsa Chih"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0050|cit50","first-page":"235","article-title":"Is there new safety information to be gained out of the use of thrombelastography in stroke patients receiving hydroxyethyl starches for treatment?","volume":"29 Suppl 2","author":"Morgenthaler","year":"2010","journal-title":"Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0051|cit51","first-page":"669","article-title":"Hemorheology in acute ischemic stroke: influence of isovolemic hemodilution","volume":"5","author":"Porro","year":"1985","journal-title":"Clinical Hemorheology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/01.STR.29.8.1550","article-title":"Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke","volume":"29","author":"Schwarz","year":"1998","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s00415-006-0456-9","article-title":"Albumin therapy in acute stroke patients","volume":"254","author":"Shin","year":"2007","journal-title":"Journal of Neurology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0054|cit54","first-page":"2944","article-title":"The treatment of acute cerebral infarcts. Comparative study of hemodilution therapy with 10% HES 200\/0.5 and 10% dex 40","volume":"37","author":"Staedt","year":"1987","journal-title":"Therapiewoche"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0055|cit55","first-page":"113","article-title":"Effect of HAES 200\/0,5-, dextran 40 and isotonic solution on haemorheology and microcirculation in patients with brain infarction","volume":"78 Suppl 1","author":"Staedt","year":"1989","journal-title":"Zeitschrift fur Kardiologie"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0056|cit56","first-page":"163","article-title":"Is there a relation between the improvement of blood fluidity and neurological symptoms in brain infarction?","volume":"20 Suppl 33","author":"Staedt","year":"1991","journal-title":"VASA. Supplementum"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/01616412.1998.11740511","article-title":"Hemodynamics of stroke patients under therapy with low molecular weight hydroxyethyl starch","volume":"20","author":"Stoll","year":"1998","journal-title":"Neurological Research"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0058|cit58","first-page":"8","article-title":"Update hemodilution therapy: dextran improves the clinical course in patients with cerebral infarction and leukocytosis","volume":"13 Suppl 3","author":"Strand","year":"2002","journal-title":"Cerebrovascular Diseases"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0059|cit59","first-page":"350","article-title":"Hydroxyethyl starch in the treatment of ischemic stroke","volume":"6","author":"Tessitore","year":"1990","journal-title":"Quaderni di Medicina e Chirurgia"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0060|cit60","first-page":"78","article-title":"The effects of isovolemic hemodilution in acute ischemic stroke: a randomized controlled clinical trial","volume":"2","author":"Torun","year":"1995","journal-title":"European Journal of Neurology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0022-510X(94)90090-6","article-title":"Extracorporeal fibrinogen and platelet precipitation as a new haemorheological treatment for acute stroke","volume":"126","author":"Walzl","year":"1994","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0062|cit62","first-page":"269","article-title":"Treatment of ischemic cerebral stroke by isovolemic hemodilution","volume":"8","author":"Wang","year":"1988","journal-title":"Clinical Hemorheology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0063|cit63","first-page":"81","article-title":"Treatment of ischemic cerebral apoplexy by equivalent volume hemodilution","volume":"23","author":"Wang","year":"1990","journal-title":"Chung Hua Shen Ching Ching Shen Ko Tsa Chih"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0064|cit64","first-page":"6","article-title":"Comparison of papaverine and decadron to decadron and dextran to decadrone therapy alone in acute ischemic infarction","volume":"7","author":"Wise","year":"1976","journal-title":"Stroke"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000077819","article-title":"Influence of a long-term, high-dose volume therapy with 6% hydroxyethyl starch 130\/0.4 or crystalloid solution on hemodynamics, rheology and hemostasis in patients with acute ischemic stroke. Results of a randomized, placebo-controlled, double-blind study","volume":"33","author":"Woessner","year":"2003","journal-title":"Pathophysiology of Haemostasis and Thrombosis"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0066|cit66","first-page":"49","article-title":"Dynamic state of haematocrit and blood dilution treatment of ischemic cerebrovascular diseases","volume":"7","author":"Zhang","year":"1990","journal-title":"Journal of Apoplexy and Nervous Diseases"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0067|cit67","first-page":"98","article-title":"A comparative study of the efficacy of normovolemic hemodilution and traditional therapy in treating ischemic stroke","volume":"96","author":"Zhang","year":"1996","journal-title":"Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/01.STR.27.9.1571","article-title":"Combined neuroprotection and reperfusion therapy for stroke. Effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia","volume":"27","author":"Aronowski","year":"1996","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000108908","article-title":"Hemodilution in acute stroke","volume":"1 Suppl 1","author":"Asplund","year":"1991","journal-title":"Cerebrovascular Diseases"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/01.STR.32.2.553","article-title":"Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window","volume":"32","author":"Belayev","year":"2001","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0071|cit71","first-page":"419","article-title":"Haemorheology in disease: pathophysiological significance and therapeutic implications","volume":"1","author":"Chien","year":"1981","journal-title":"Clinical Hemorheology"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/bja\/79.3.346","article-title":"Effect of hemoglobin concentration on brain oxygenation in focal stroke: a mathematical modelling study","volume":"79","author":"Dexter","year":"1997","journal-title":"British Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0074|cit74","first-page":"33","article-title":"Haemorheological changes associated with acute and chronic cerebrovascular disease","volume":"100","author":"Perri","year":"1986","journal-title":"Royal Society of Medicine International Congress and Symposium Series"},{"issue":"5","key":"10.1002\/14651858.CD000103.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1159\/000131083","article-title":"Guidelines for management of ischaemic stroke and transient ischaemic attack 2008","volume":"25","author":"European Stroke Organisation (ESO) Executive Committee","year":"2008","journal-title":"Cerebrovascular Diseases"},{"issue":"1","key":"10.1002\/14651858.CD000103.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(03)00266-7","article-title":"Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century","volume":"2","author":"Feigin","year":"2003","journal-title":"Lancet Neurology"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuropharm.2007.12.007","article-title":"Neuroprotection for ischemic stroke: past, present and future","volume":"55","author":"Ginsberg","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1055\/s-0028-1104065","article-title":"Treatment of acute cerebral ischemia with low-molecular dextran. Results of a retrospective study","volume":"101","author":"Gottstein","year":"1976","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0079|cit79","first-page":"127","article-title":"Normovolemic and hypervolemic hemodilution in cerebrovascular ischemia","volume":"47","author":"Gottstein","year":"1981","journal-title":"Bibliotheca Haematologica"},{"issue":"44","key":"10.1002\/14651858.CD000103.pub2-BIB0080|cit80","first-page":"1681","article-title":"Dextran 40 or HES 200\/0.5? Hemorheology of the long-term treatment of ischemic cerebral attacks","volume":"111","author":"Haass","year":"1986","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0140-6736(81)90298-1","article-title":"Effect of hematocrit on carotid stenosis and cerebral infarction","volume":"ii","author":"Harrison","year":"1981","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0082|cit82","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Jauch","year":"2013","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.STR.3.4.409","article-title":"Hemoglobin and the risk of cerebral infarction. The Framingham Study","volume":"3","author":"Kannel","year":"1972","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/01.STR.17.4.687","article-title":"Hematocrit as a risk factor of cerebral infarction: long-term prospective population survey in a Japanese rural community","volume":"17","author":"Kiyohara","year":"1986","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0002-9610(91)90168-D","article-title":"Beneficial effects of isovolemic hemodilution using a perfluorocarbon emulsion in a stroke model","volume":"162","author":"Kline","year":"1991","journal-title":"American Journal of Surgery"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1227\/00006123-198808000-00003","article-title":"Clinical, hemodynamic, and hemorheological effects of isovolemic hemodilution in acute cerebral infarction","volume":"23","author":"Korosue","year":"1988","journal-title":"Neurosurgery"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0088|cit88","first-page":"597","article-title":"Behandlung des akuten Hirninfarktes durch hypervolamische hamodilutionstherapie","volume":"13","author":"Krepp","year":"1984","journal-title":"Klinikarzt"},{"issue":"5","key":"10.1002\/14651858.CD000103.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1016\/S2214-109X(13)70089-5","article-title":"Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010","volume":"1","author":"Krishnamurthi","year":"2013","journal-title":"The Lancet Global Health"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF00541299","article-title":"Haemodilution therapy in ischemic stroke: plasma concentrations and plasma viscosity during long-term infusion of dextran 40 or hydroxyethyl starch 200\/0.5","volume":"31","author":"Kroemer","year":"1987","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/jcbfm.1981.45","article-title":"Effects of hematocrit variations on cerebral blood flow and oxygen transport in ischemic cerebrovascular disease","volume":"1","author":"Kusunoki","year":"1981","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0092|cit92","first-page":"15","article-title":"Clinical characteristics in diabetic stroke patients","volume":"14","author":"Lithner","year":"1988","journal-title":"Diabetes and Metabolism"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-2999(01)01255-9","article-title":"Neuroprotective effect of treatment with human albumin in permanent focal cerebral ischemia: histopathology and cortical perfusion studies","volume":"428","author":"Liu","year":"2001","journal-title":"European Journal of Pharmacology"},{"issue":"9859","key":"10.1002\/14651858.CD000103.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0095|cit95","article-title":"Stroke: National Clinical Guideline for Diagnosis and Initial Management of Acute Stroke and Transient Ischaemic Attack (TIA)","volume-title":"National Institute for Health and Clinical Excellence: Guidance","author":"National Collaborating Centre for Chronic Conditions (UK)","year":"2008"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0096|cit96","first-page":"25","article-title":"The clinical importance of haemorheological alteration in cerebrovascular disease","volume":"100","author":"Ott","year":"1986","journal-title":"Royal Society of Medicine International Congress and Symposium Series"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.STR.2.4.327","article-title":"Cerebral apoplexy (stroke). Pathogenesis, pathophysiology and therapy as illustrated by regional blood flow measurements","volume":"2","author":"Paulson","year":"1971","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0140-6736(78)92098-6","article-title":"Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia","volume":"2","author":"Pearson","year":"1978","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0099|cit99","first-page":"44","article-title":"Basic intensive care of ischemic cerebral stroke. Method of therapeutic hemodilution","volume":"Jul-Aug","author":"Popov","year":"2000","journal-title":"Anesteziologiia i Reanimatologiia"},{"issue":"3","key":"10.1002\/14651858.CD000103.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1515\/rns.2011.028","article-title":"Current perspectives on potential role of albumin in neuroprotection","volume":"22","author":"Prajapati","year":"2011","journal-title":"Reviews of Neurosciences"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0101|cit101","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2012"},{"issue":"2","key":"10.1002\/14651858.CD000103.pub2-BIB0102|cit102","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000096.pub2","article-title":"Glycerol for acute stroke","author":"Righetti","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"9","key":"10.1002\/14651858.CD000103.pub2-BIB0103|cit103","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000064.pub2","article-title":"Corticosteroids for acute ischaemic stroke","author":"Sandercock","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0104|cit104","first-page":"1031","article-title":"Haemodilution in acute ischemic insults. Comparative study on the clinical and haemorheological effectiveness of 10% HES 200\/0,5 and Dextran 40","volume":"103","author":"Schneider","year":"1985","journal-title":"Fortschritte der Medizin"},{"issue":"23","key":"10.1002\/14651858.CD000103.pub2-BIB0105|cit105","first-page":"2485","article-title":"Hemodilution in patients with cerebrovascular ischemia, using low-molecular dextran (Dex 40) and middle-molecular weight hydroxyethyl starch (HES 200)","volume":"36","author":"Staedt","year":"1986","journal-title":"Therapiewoche"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1517\/14712598.1.5.831","article-title":"Haemoglobin-based erythrocyte transfusion substitutes","volume":"1","author":"Standl","year":"2001","journal-title":"Expert Opinion on Biological Therapy"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0107|cit107","first-page":"H2026","article-title":"Cerebral blood flow oxygen delivery during hypoxemia and hemodilution: role of arterial oxygen content","volume":"267","author":"Todd","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.STR.9.4.369","article-title":"Importance of the hematocrit as a risk factor in cerebral infarction","volume":"9","author":"Tohgi","year":"1978","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/978-3-642-71787-1_47","article-title":"Effect of hydroxyethyl starch and low molecular weight dextran on cerebral blood flow and hemorheology in normal baboons","volume-title":"Cerebral Ischemia and Hemorheology","author":"Tsuda","year":"1987"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.7.884","article-title":"Hemodilution increases cerebral blood flow in acute ischemic stroke","volume":"20","author":"Vorstrup","year":"1989","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1001\/jama.1982.03330220043034","article-title":"Observations during hypervolemic hemodilution of patients with acute focal cerebral ischemia","volume":"248","author":"Wood","year":"1982","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0112|cit112","first-page":"588","article-title":"Improvement in cerebral blood flow and power spectral EEG after isovolemic hemodilution in stroke patients","volume":"3","author":"Wood","year":"1983","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1002\/14651858.CD000103.pub2-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.STR.16.5.765","article-title":"Hemorheology of the cerebral circulation in stroke","volume":"16","author":"Wood","year":"1985","journal-title":"Stroke"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD000103.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:22:52Z","timestamp":1709040172000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD000103.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Stroke Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,27]]},"references-count":113,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd000103.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,27]]}}}