{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:49:08Z","timestamp":1793144948466,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd000126.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000}}],"reference-count":75,"publisher":"Wiley","issue":"10","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd000126.pub5","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T17:32:29Z","timestamp":1634319149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Local versus general anaesthesia for carotid endarterectomy"],"prefix":"10.1002","volume":"2021","author":[{"given":"Amaraporn","family":"Rerkasem","sequence":"additional","affiliation":[{"name":"Environmental - Occupational Health Sciences and Non Communicable Diseases Center of Excellence, Research Institute for Health Sciences; Chiang Mai University; Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saritphat","family":"Orrapin","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Faculty of Medicine; Thammasat University (Rangsit Campus); Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic PJ","family":"Howard","sequence":"additional","affiliation":[{"name":"Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences; University of Oxford; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sothida","family":"Nantakool","sequence":"additional","affiliation":[{"name":"Environmental - Occupational Health Sciences and Non Communicable Diseases Center of Excellence, Research Institute for Health Sciences; Chiang Mai University; Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittipan","family":"Rerkasem","sequence":"additional","affiliation":[{"name":"Environmental - Occupational Health Sciences and Non Communicable Diseases Center of Excellence, Research Institute for Health Sciences; Chiang Mai University; Chiang Mai Thailand"},{"name":"Department of Surgery, Faculty of Medicine; Chiang Mai University; Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"10.1002\/14651858.CD000126.pub5-BIB0001|cit1","first-page":"19","article-title":"Carotid endarterectomy surgery in cervical block: an economic alternative to general anaesthesia?","volume":"4","author":"Binder","year":"1999","journal-title":"Gesundheits\u00f6konomie und Qualit\u00e4tsmanagement"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0950-821X(89)80124-0","article-title":"Local versus general anaesthesia in carotid surgery. A prospective, randomised study","volume":"3","author":"Forssell","year":"1989","journal-title":"European Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0003|cit3","volume-title":"Studies on Risks and Results in Carotid Artery Surgery [Dissertation]","author":"Forssell","year":"1991"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0950-821X(05)80205-1","article-title":"Carotid artery surgery. Local versus general anaesthetic as related to sympathetic activity and cardiovascular effects","volume":"4","author":"Takolander","year":"1990","journal-title":"European Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1016\/S0140-6736(08)61699-2","article-title":"General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial","volume":"372","author":"GALA Trial Collaborative Group","year":"2008","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ejvs.2008.06.008","article-title":"Carotid endarterectomy: technical practices of surgeons participating in the GALA trial","volume":"36","author":"Girn","year":"2008","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/bjs.7110","article-title":"Cost-effectiveness analysis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial)","volume":"97","author":"Gomes","year":"2010","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"doi: 10.1186\/17","DOI":"10.1186\/1745-6215-9-28","article-title":"GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery","volume":"9","author":"Gough","year":"2008","journal-title":"Trials"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ejvs.2008.09.001","article-title":"The GALA trial - a summary of the findings","volume":"36","author":"Gough","year":"2008","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/s00268-009-0047-x","article-title":"Impact of general versus local anesthesia on early postoperative cognitive dysfunction following carotid endarterectomy: GALA study subgroup analysis","volume":"33","author":"Weber","year":"2009","journal-title":"World Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejvs.2009.05.011","article-title":"Jugular venous neurone specific enolase (NSE) increases following carotid endarterectomy under general, but not local, anaesthesia","volume":"38","author":"Wijeyaratne","year":"2009","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD000126.pub5-BIB0012|cit12","first-page":"97","article-title":"A comparison of general anaesthesia and loco-regional anaesthesia in surgery of the internal carotid artery and its repercussion on haemodynamic control","volume":"11","author":"Gimenez","year":"2003","journal-title":"Cardiovascular Surgery"},{"issue":"5","key":"10.1002\/14651858.CD000126.pub5-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4103\/ija.IJA_545_16","article-title":"Lactate\/pyruvate monitoring during carotid endarterectomy under general anaesthesia versus cervical plexus block: a randomised controlled study","volume":"61","author":"Hussien","year":"2017","journal-title":"Indian Journal of Anaesthesia"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000126.pub5-BIB0014|cit14","first-page":"16","article-title":"Local versus general anaesthesia in carotid surgery - results of a prospective randomised study","volume":"7","author":"Kasprzak","year":"1999","journal-title":"Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1024\/0301-1526.35.4.232","article-title":"General versus locoregional anesthesia in carotid surgery: a prospective randomised trial","volume":"35","author":"Kasprzak","year":"2006","journal-title":"VASA"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1136\/rapm-00115550-200807000-00009","article-title":"Comparison of regional anesthesia versus combined regional and general anesthesia for elective carotid endarterectomy: a small exploratory study","volume":"33","author":"Luchetti","year":"2008","journal-title":"Regional Anesthesia and Pain Medicine"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/ANA.0b013e3181d5e421","article-title":"Subclinical neurocognitive dysfunction after carotid endarterectomy - the impact of shunting","volume":"22","author":"Mazul-Sunko","year":"2010","journal-title":"Journal of Neurosurgical Anesthesiology"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/ejvs.2002.1715","article-title":"Physiological advantages of cerebral blood flow during carotid endarterectomy under local anaesthesia","volume":"24","author":"McCarthy","year":"2002","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ejvs.2004.03.010","article-title":"Patient satisfaction for carotid endarterectomy performed under local anaesthesia","volume":"27","author":"McCarthy","year":"2004","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/ANA.0b013e3181e16e14","article-title":"Neuromonitoring in carotid surgery: are the results obtained in awake patients transferable to patients under sevoflurane\/fentanyl anesthesia?","volume":"22","author":"Moritz","year":"2010","journal-title":"Journal of Neurosurgical Anesthesiology"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0021|cit21","first-page":"202","article-title":"Anesthesia options in carotid endarterectomy","volume":"18","author":"Mrozek","year":"2007","journal-title":"Anesteziologie a Intenzivni Medicina"},{"issue":"1","key":"10.1002\/14651858.CD000126.pub5-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jvs.2018.10.066","article-title":"Anesthesia type determines risk of cerebral infarction after carotid endarterectomy","volume":"70","author":"Orlick\u00fd","year":"2019","journal-title":"Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0750-7658(89)80138-8","article-title":"Blood pressure profiles during carotid endarterectomy. Comparing flunitrazepam\/fentanyl\/nitrous oxide with epidural anaesthesia (author's translation)","volume":"8","author":"Pluskwa","year":"1989","journal-title":"Annales Fran\u00e7aises d'Anesth\u00e8sie et de R\u00e8animation"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00008506-198903000-00007","article-title":"Hemodynamic status following regional and general anesthesia for carotid endarterectomy","volume":"1","author":"Prough","year":"1989","journal-title":"Journal of Neurosurgical Anesthesiology"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0741-5214(99)70185-0","article-title":"Locoregional versus general anesthesia in carotid surgery: is there an impact on perioperative myocardial ischemia? Results of a prospective monocentric randomized trial","volume":"30","author":"Sbarigia","year":"1999","journal-title":"Journal of Vascular Surgery"},{"issue":"12","key":"10.1002\/14651858.CD000126.pub5-BIB0026|cit26","first-page":"626","article-title":"Perioperative myocardial ischemia in patients treated with carotid surgery. Impact of the type of anesthesia (locoregional vs general)","volume":"47","author":"Vizza","year":"1999","journal-title":"Minerva Cardioangiologica"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2298\/ACI0403037S","article-title":"Comparison of the influence of general and regional anesthesia on basic haemodynamic parameters during carotid endarterectomy","volume":"51","author":"Sindelic","year":"2004","journal-title":"Acta Chirurgica Iugoslavica"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0028|cit28","first-page":"20","article-title":"General anesthesia vs combined anesthesia during internal carotid artery surgery","volume":"6","author":"Krajnic","year":"2011","journal-title":"Anesteziologiya i Reanimatologiya"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000126.pub5-BIB0029|cit29","first-page":"e125","article-title":"Comparison between combined (deep and superficial) cervical plexus block with low-concentrated levobupivacaine and ropivacaine for carotid endarterecomy","volume":"43","author":"Martynov","year":"2018","journal-title":"Regional Anesthesia and Pain Medicine"},{"issue":"2","key":"10.1002\/14651858.CD000126.pub5-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1053\/j.jvca.2017.06.034","article-title":"A randomized controlled trial examining the effect of the addition of the mandibular block to cervical plexus block for carotid endarterectomy","volume":"32","author":"Kavrut Ozturk","year":"2018","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"2","key":"10.1002\/14651858.CD000126.pub5-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/bja\/aer118","article-title":"Comparison of intermediate vs subcutaneous cervical plexus block for carotid endarterectomy","volume":"107","author":"Ramachandran","year":"2011","journal-title":"British Journal of Anaesthesia"},{"issue":"1","key":"10.1002\/14651858.CD000126.pub5-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1213\/ANE.0b013e3181e1e9ab","article-title":"The addition of fentanyl to local anesthetics affects the quality and duration of cervical plexus block: a randomized, controlled trial","volume":"111","author":"Sindjelic","year":"2010","journal-title":"Anesthesia and Analgesia"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","article-title":"Collaborative overview of trials of antiplatelet therapy - I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients","volume":"308","author":"Antiplatelet Trialists Collaboration","year":"1994","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0741-5214(89)90137-7","article-title":"Intraoperative transcranial doppler: limitations of the method","volume":"10","author":"Bass","year":"1989","journal-title":"Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0035|cit35","first-page":"592","article-title":"Carotid surgery. Is regional anesthesia always appropriate?","volume":"32","author":"Becquemin","year":"1991","journal-title":"Journal of Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0036|cit36","first-page":"673","article-title":"Awake patient monitoring to determine the need for shunting during carotid endarterectomy","volume":"114","author":"Benjamin","year":"1993","journal-title":"Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0037|cit37","first-page":"428","article-title":"Comparative results after endarterectomy of internal carotid artery performed with or without a shunt","volume":"29","author":"Buche","year":"1988","journal-title":"Journal of Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0140-6736(00)03651-5","article-title":"Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials","volume":"357","author":"Collins","year":"2001","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archsurg.1987.01400190073014","article-title":"The influence of anesthetic choice on carotid endarterectomy outcome","volume":"122","author":"Corson","year":"1987","journal-title":"Archives of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0140-6736(91)92916-P","article-title":"MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis","volume":"337","author":"European Carotid Surgery Trialists Collaborative Group","year":"1991","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF03187416","article-title":"Carotid artery stump pressure: how reliable is it in predicting the need for a shunt?","volume":"3","author":"Gnanadev","year":"1989","journal-title":"Annals of Vascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0042|cit42","first-page":"656","article-title":"Cost effectiveness of regional anesthesia in carotid endarterectomy","volume":"55","author":"Godin","year":"1989","journal-title":"American Surgeon"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/bjs.7110","article-title":"Cost-effectiveness analysis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial)","volume":"97","author":"Gomes","year":"2010","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1161\/01.STR.19.12.1485","article-title":"Carotid endarterectomy: to shunt or not to shunt","volume":"19","author":"Gumerlock","year":"1988","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/153857440303700303","article-title":"Local versus general anaesthesia for carotid endarterectomy: report of 329 cases","volume":"37","author":"Gurer","year":"2003","journal-title":"Vascular and Endovascular Surgery"},{"issue":"10","key":"10.1002\/14651858.CD000126.pub5-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/anae.14320","article-title":"Meta-analysis and trial sequential analysis of local vs. general anaesthesia for carotid endarterectomy","volume":"73","author":"Hajibandeh","year":"2018","journal-title":"Anaesthesia"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0048|cit48","unstructured":"Higgins JP Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.handbook.cochrane.org"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF01561267","article-title":"Seventeen-year experience with routine shunting in carotid surgery","volume":"3","author":"Javid","year":"1979","journal-title":"World Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/01.STR.23.4.498","article-title":"Somatosensory evoked potential sensitivity relative to electroencephalography for cerebral ischemia during carotid endarterectomy","volume":"23","author":"Kearse","year":"1992","journal-title":"Stroke"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1067\/mva.1991.26500","article-title":"Limitations of electroencephalographic monitoring in the detection of cerebral ischemia accompanying carotid endarterectomy","volume":"13","author":"Kresowik","year":"1991","journal-title":"Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0002-9610(84)90225-3","article-title":"Barbiturate therapy in the postoperative endarterectomy patient with a neurologic deficit","volume":"148","author":"Markowitz","year":"1984","journal-title":"American Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/ejvs.2001.1381","article-title":"Patient and hospital benefits of local anaesthesia for carotid endarterectomy","volume":"22","author":"McCarthy","year":"2001","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0300-9572(75)90027-1","article-title":"Cerebral protection by anesthetics during ischemia (a review)","volume":"4","author":"Michenfelder","year":"1975","journal-title":"Resuscitation"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM199108153250701","article-title":"Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis","volume":"325","author":"North American Symptomatic Carotid Endarterectomy Trial Collaborators","year":"1991","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/00000658-198006000-00008","article-title":"Carotid endarterectomy without temporary intraluminal shunt. Study of 309 consecutive operations","volume":"191","author":"Ott","year":"1980","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0057|cit57","unstructured":"Page MJ Higgins JP Sterne JA Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021 Available from www.training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/00000658-197706000-00010","article-title":"Carotid endarterectomy: neurologic complications as related to surgical techniques","volume":"185","author":"Prioleau","year":"1977","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S031716710002624X","article-title":"Carotid endarterectomy without indwelling shunts and intraoperative electrophysiologic monitoring","volume":"14","author":"Reddy","year":"1987","journal-title":"Canadian Journal of Neurological Sciences"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1161\/STROKEAHA.109.569236","article-title":"Routine or selective carotid artery shunting for carotid endarterectomy and different methods of monitoring in selective shunting","volume":"41","author":"Rerkasem","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"10.1002\/14651858.CD000126.pub5-BIB0061|cit61","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001081.pub2","article-title":"Carotid endarterectomy for symptomatic carotid stenosis","author":"Rerkasem","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0062|cit62","unstructured":"Review Manager 5 (RevMan 5) Nordic Cochrane Centre, The Cochrane Collaboration 2020"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/00000658-198311000-00014","article-title":"Determining criteria for shunt placement during carotid endarterectomy. EEG versus back pressure","volume":"198","author":"Ricotta","year":"1983","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0140-6736(03)12228-3","article-title":"Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis","volume":"361","author":"Rothwell","year":"2003","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0065|cit65","first-page":"353","volume-title":"Angiology: Strategy for Diagnosis and Therapeutics","author":"Schweiger","year":"1988"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01405270","article-title":"Results of microsurgical carotid endarterectomy. A prospective study with transcranial Doppler and EEG monitoring, and elective shunting","volume":"100","author":"Steiger","year":"1989","journal-title":"Acta Neurochirurgica"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00000658-198602000-00014","article-title":"The risk-benefit ratio of intraoperative shunting during carotid endarterectomy. Relevancy to operative and postoperative results and complications","volume":"203","author":"Ebersold","year":"1986","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/sim.1761","article-title":"What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data","volume":"23","author":"Sweeting","year":"2004","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01561265","article-title":"Complications of carotid endarterectomy and their prevention","volume":"3","author":"Thompson","year":"1979","journal-title":"World Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/s00268-009-0047-x","article-title":"Impact of general versus local anesthesia on early postoperative cognitive dysfunction following carotid endarterectomy: GALA study subgroup analysis","volume":"33","author":"Weber","year":"2009","journal-title":"World Journal of Surgery"},{"key":"10.1002\/14651858.CD000126.pub5-BIB0071|cit71","first-page":"216","article-title":"Increased tolerance to cerebral ischemia produced by general anesthesia during temporary carotid occlusion","volume":"54","author":"Wells","year":"1963","journal-title":"Surgery"},{"issue":"2","key":"10.1002\/14651858.CD000126.pub5-BIB0072|cit72","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000126","article-title":"Local versus general anaesthesia for carotid endarterectomy","author":"Rerkasem","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD000126.pub5-BIB0073|cit73","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000126","article-title":"Local versus general anaesthesia for carotid endarterectomy","author":"Rerkasem","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD000126.pub5-BIB0074|cit74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000126","article-title":"Carotid endarterectomy performed under local anaesthetic compared to general anaesthetic: a systematic review of the evidence","author":"Tangkanakul","year":"1996","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD000126.pub5-BIB0075|cit75","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000126.pub4","article-title":"Local versus general anaesthesia for carotid endarterectomy","author":"Vaniyapong","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:35:01Z","timestamp":1768905301000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD000126.pub5"}},"subtitle":[],"editor":[{"name":"Cochrane Stroke Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":75,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd000126.pub5","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]}}}