{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:41:45Z","timestamp":1793227305160,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd000254.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,30]],"date-time":"2017-07-30T00:00:00Z","timestamp":1501372800000}}],"reference-count":152,"publisher":"Wiley","issue":"9","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd000254.pub4","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T15:30:46Z","timestamp":1506439846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration"],"prefix":"10.1002","volume":"2017","author":[{"given":"Jennifer R","family":"Evans","sequence":"first","affiliation":[{"name":"London School of Hygiene & Tropical Medicine; Cochrane Eyes and Vision, ICEH; Keppel Street London UK WC1E 7HT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Lawrenson","sequence":"additional","affiliation":[{"name":"City University of London; Centre for Applied Vision Research, School of Health Sciences; Northampton Square London UK EC1V 0HB"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,30]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0001|cit1","first-page":"12","article-title":"Multicenter ophthalmic and nutritional age-related macular degeneration study-part 1: design, subjects and procedures","volume":"67","author":"Richer","year":"1996","journal-title":"Journal of the American Optometric Association"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0002|cit2","first-page":"30","article-title":"Multicenter ophthalmic and nutritional age-related macular degeneration study-part 2: antioxidant intervention and conclusions","volume":"67","author":"Richer","year":"1996","journal-title":"Journal of the American Optometry Association"},{"issue":"10","key":"10.1002\/14651858.CD000254.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8","volume":"119","author":"Age-Related Eye Disease Study Research Group","year":"2001","journal-title":"Archives of Ophthalmology"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0002-9394(01)01218-1","article-title":"The age-related eye disease study (AREDS) system for classifying age-related macular degeneration from stereoscopic color fundus photographs: The age-related eye disease study report no. 6","volume":"132","author":"Age-Related Eye Disease Study Research Group","year":"2001","journal-title":"American Journal of Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/jamaophthalmol.2013.6636","article-title":"Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36","volume":"132","author":"Chew","year":"2014","journal-title":"JAMA Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.ophtha.2013.01.021","article-title":"Long-term effects of vitamins C and E, beta-carotene, and zinc on age-related macular degeneration: AREDS report no. 35","volume":"120","author":"Chew","year":"2013","journal-title":"Ophthalmology"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.ophtha.2014.05.008","article-title":"No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38","volume":"121","author":"Chew","year":"2014","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/archopht.122.5.716","article-title":"Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the age-related eye disease study: AREDS report no. 13","volume":"122","author":"Clemons","year":"2004","journal-title":"Archives of Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.juro.2006.09.047","article-title":"High dose zinc increases hospital admissions due to genitourinary complications","volume":"177","author":"Johnson","year":"2007","journal-title":"Journal of Urology"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajo.2006.09.056","article-title":"Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration","volume":"143","author":"Moriarty-Craige","year":"2007","journal-title":"American Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD000254.pub4-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-2456(99)00031-8","article-title":"The age-related eye disease study (AREDS): design implications AREDS report no. 1","volume":"20","author":"The Age-Related Eye Disease Study Research Group","year":"1999","journal-title":"Controlled Clinical Trials"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaophthalmol.2013.7376","article-title":"Secondary analyses of the effects of lutein\/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3","volume":"132","author":"Chew","year":"2014","journal-title":"JAMA Ophthalmology"},{"issue":"19","key":"10.1002\/14651858.CD000254.pub4-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1001\/jama.2013.4997","article-title":"Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the age-related eye disease study 2 (AREDS2) randomized clinical trial","volume":"309","author":"Age-Related Eye Disease Study 2 Research Group","year":"2013","journal-title":"JAMA"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.ophtha.2012.05.027","article-title":"The age-related eye disease study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)","volume":"119","author":"Chew","year":"2012","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1167\/iovs.07-1267","article-title":"Brightness, contrast, and color balance of digital versus film retinal images in the age-related eye disease study 2","volume":"49","author":"Hubbard","year":"2008","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0016|cit16","unstructured":"McBee WL Clemons TE Chew EY SanGiovanni JP An examination of site visit data audit results compiled during the initial four years of a long-term clinical trial Clinical Trials Conference: 32nd Meeting of the Society of Clinical Trials. 2011 May 15-18; Vancouver (BC) 2011"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/jamainternmed.2014.328","article-title":"Effect of long-chain omega-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the age-related eye disease study 2 (AREDS2) randomized clinical trial","volume":"174","author":"Bonds","year":"2014","journal-title":"JAMA Internal Medicine"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1475-2891-2-12","article-title":"A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology","volume":"2","author":"Bartlett","year":"2003","journal-title":"Nutrition Journal"},{"issue":"9","key":"10.1002\/14651858.CD000254.pub4-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.ejcn.1602626","article-title":"Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial","volume":"61","author":"Bartlett","year":"2007","journal-title":"European Journal of Clinical Nutrition"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1017\/S0007114512004187","article-title":"The effects of a lutein-based supplement on objective and subjective measures of retinal and visual function in eyes with age-related maculopathy - a randomised controlled trial","volume":"109","author":"Berrow","year":"2013","journal-title":"British Journal of Nutrition"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ophtha.2012.08.040","article-title":"Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration","volume":"120","author":"Beatty","year":"2013","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ophtha.2012.09.013","article-title":"Visual outcome after antioxidant supplementation","volume":"120","author":"Beatty","year":"2013","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1097\/IAE.0b013e31820d3ed1","article-title":"Functional and morphologic benefits in early detection of neovascular age-related macular degeneration using the preferential hyperacuity perimeter","volume":"31","author":"Lai","year":"2011","journal-title":"Retina"},{"issue":"6","key":"10.1002\/14651858.CD000254.pub4-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/09286580802154275","article-title":"Carotenoids and co-antioxidants in age-related maculopathy: design and methods","volume":"15","author":"Neelam","year":"2008","journal-title":"Ophthalmic Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0025|cit25","first-page":"216","article-title":"Carotenoids in age-related maculopathy Italian study (CARMIS): two-year results of a randomized study","volume":"22","author":"Piermarocchi","year":"2011","journal-title":"European Journal of Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1167\/iovs.12-10715","article-title":"Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study","volume":"54","author":"Murray","year":"2013","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"e73387","DOI":"10.1371\/journal.pone.0073387","article-title":"The effect of lutein supplementation on blood plasma levels of complement factor D, C5a and C3d","volume":"8","author":"Tian","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0028|cit28","unstructured":"Professor Soubrane Zinc supplementation Universitaire de Creteil, France"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0029|cit29","first-page":"391","article-title":"Oral zinc-therapy in age-related macular degeneration: a double-blind study","volume":"2","author":"Holz","year":"1993","journal-title":"German Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD000254.pub4-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000310646","article-title":"Visaline in the treatment of age-related macular degeneration: a pilot study","volume":"209","author":"Kaiser","year":"1995","journal-title":"Ophthalmologica"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0031|cit31","first-page":"605","article-title":"Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration.","volume":"23","author":"Schmetterer","year":"2013","journal-title":"European Journal of Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0032|cit32","doi-asserted-by":"crossref","unstructured":"Schmidl D Weigert G Kaya S Pemp B Sacu S Lasta M How lutein supplementation affects macular pigment optical density and visual acuity in patients with age related macular degeneration Joint Annual Meeting of the German, Swiss, and Austrian Societies for Clinical Pharmacology and Toxicology; 2011 Oct 20-22; Zurich British Journal of Clinical Pharmacology 2011","DOI":"10.1167\/iovs.11-7522"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1167\/iovs.11-7522","article-title":"Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration","volume":"52","author":"Weigert","year":"2011","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0034|cit34","first-page":"564738","article-title":"Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degeneration","volume":"2015","author":"Huang","year":"2015","journal-title":"Biomed Research International"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/bjophthalmol-2014-305503","article-title":"Changes following supplementation with lutein and zeaxanthin in retinal function in eyes with early age-related macular degeneration: a randomised, double-blind, placebo-controlled trial","volume":"99","author":"Huang","year":"2015","journal-title":"British Journal of Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.nut.2012.06.009","article-title":"Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration","volume":"29","author":"Huang","year":"2013","journal-title":"Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ajo.2012.04.014","article-title":"Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial","volume":"154","author":"Ma","year":"2012","journal-title":"American Journal of Ophthalmology"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.ophtha.2012.06.014","article-title":"Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration","volume":"119","author":"Ma","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0039|cit39","unstructured":"NCT01048476 Effects of lutein and zeaxanthin supplementation on age-related macular degeneration clinicaltrials.gov\/ct2\/show\/NCT01048476"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/archopht.1988.01060130202026","article-title":"Oral zinc in macular degeneration","volume":"106","author":"Newsome","year":"1988","journal-title":"Archives of Ophthalmology"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/02713680802178437","article-title":"A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration","volume":"33","author":"Newsome","year":"2008","journal-title":"Current Eye Research"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0042|cit42","first-page":"1225","article-title":"Oral zinc and the second eye in age-related macular degeneration","volume":"37","author":"Stur","year":"1996","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1076\/opep.6.3.195.1500","article-title":"Methodology of the VECAT study: vitamin E intervention in cataract and age-related maculopathy","volume":"6","author":"Garrett","year":"1999","journal-title":"Ophthalmic Epidemiology"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0895-4356(99)00153-5","article-title":"Community-based recruitment strategies for a longitudinal interventional study: the VECAT experience","volume":"53","author":"Garrett","year":"2000","journal-title":"Journal of Clinical Epidemiology"},{"issue":"6","key":"10.1002\/14651858.CD000254.pub4-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1046\/j.1440-1606.1999.00240.x","article-title":"Baseline ophthalmic findings in the vitamin E, cataract and age-related maculopathy (VECAT) study","volume":"27","author":"Robman","year":"1999","journal-title":"Australian and New Zealand Journal of Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0046|cit46","first-page":"S311","article-title":"Vitamin E supplementation and age-related maculopathy","volume":"42","author":"Taylor","year":"2001","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1076\/opep.6.3.181.1502","article-title":"The VECAT study: methodology and statistical power for measurement of age-related macular features. Vitamin E, cataract, and age-related maculopathy study","volume":"6","author":"Tikellis","year":"1999","journal-title":"Ophthalmic Epidemiology"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.optm.2006.10.019","article-title":"LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls","volume":"78","author":"Richer","year":"2007","journal-title":"Optometry"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S1529-1839(04)70049-4","article-title":"Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (lutein antioxidant supplementation trial)","volume":"75","author":"Richer","year":"2004","journal-title":"Optometry"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0050|cit50","first-page":"1290","article-title":"Effects of zinc and antioxidant on visual function of patients with age-related macular degeneration","volume":"8","author":"Wang","year":"2004","journal-title":"Zhongguo Linchuant Kangfu"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/eye.2015.64","article-title":"Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration","volume":"29","author":"Akuffo","year":"2015","journal-title":"Eye"},{"issue":"1139","key":"10.1002\/14651858.CD000254.pub4-BIB0052|cit52","first-page":"60","article-title":"Eye health: The role of nutritional supplements in reducing the risk and progression of age-related macular degeneration","volume":"96","author":"Anonymous","year":"2015","journal-title":"Australian Journal of Pharmacy"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2415-6-23","article-title":"Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial","volume":"6","author":"Bahrami","year":"2006","journal-title":"BMC Ophthalmology"},{"issue":"7-8","key":"10.1002\/14651858.CD000254.pub4-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/02713680600760501","article-title":"Effect of niacin on retinal vascular diameter in patients with age-related macular degeneration","volume":"31","author":"Barakat","year":"2006","journal-title":"Current Eye Research"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1079\/BJN20061796","article-title":"Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L)","volume":"96","author":"Benzie","year":"2006","journal-title":"British Journal of Nutrition"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1743-7075-4-12","article-title":"Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin","volume":"4","author":"Bone","year":"2007","journal-title":"Nutrition and Metabolism"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2415-7-3","article-title":"TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD","volume":"7","author":"Cangemi","year":"2007","journal-title":"BMC Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/archopht.125.3.333","article-title":"Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians","volume":"125","author":"Christen","year":"2007","journal-title":"Archives of Ophthalmology"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1167\/iovs.11-8025","article-title":"Supplementation with all three macular carotenoids: response, stability, and safety","volume":"52","author":"Connolly","year":"2011","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/09286586.2014.888085","article-title":"Central retinal enrichment supplementation trials (CREST): design and methodology of the CREST randomized controlled trials","volume":"21","author":"Akuffo","year":"2014","journal-title":"Ophthalmic Epidemiology"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5414\/TEP23103","article-title":"Serum zinc and copper level in age-related macular degeneration","volume":"23","author":"Cumurcu","year":"2006","journal-title":"Trace Elements and Electrolytes"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1167\/iovs.09-4995","article-title":"Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration","volume":"51","author":"Falsini","year":"2010","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0063|cit63","first-page":"69","article-title":"Serum and macular responses to antioxidant supplementation versus a carotenoid-rich dietary intervention in the elderly","volume":"4","author":"Franciose","year":"2006","journal-title":"Current Topics in Nutraceuticals Research"},{"issue":"10","key":"10.1002\/14651858.CD000254.pub4-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/jn\/136.10.2519","article-title":"Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations","volume":"136","author":"Goodrow","year":"2006","journal-title":"Journal of Nutrition"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0065|cit65","unstructured":"ISRCTN35481392 Macular pigment and its contribution to visual performance and comfort www.controlled-trials.com\/ISRCTN35481392"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0066|cit66","unstructured":"ISRCTN57556290 A multi-site trial of a novel nutritional supplement (taurine, omega-3 fatty acids, zinc, antioxidants, and lutein) and micro-current stimulation in the treatment of atrophic (dry) age-related macular degeneration www.controlled-trials.com\/ISRCTN57556290"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0067|cit67","unstructured":"ISRCTN81595685 Comparison of macular and serum responses after supplementation with two different macular carotenoid formulations www.controlled-trials.com\/ISRCTN81595685"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00417-005-0108-2","article-title":"Plasma homocysteine, vitamin B12 and folate levels in age-related macular degeneration","volume":"244","author":"Kamburoglu","year":"2006","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1167\/iovs.06-0504","article-title":"The effect of lutein and zeaxanthin supplementation on metabolites of these carotenoids in the serum of persons aged 60 or older","volume":"47","author":"Khachik","year":"2006","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0070|cit70","first-page":"503","article-title":"Vitamins for age-related macular degeneration demonstrate minimal differences","volume":"59","author":"Kolber","year":"2013","journal-title":"Canadian Family Physician"},{"issue":"21","key":"10.1002\/14651858.CD000254.pub4-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1021\/jf0614802","article-title":"Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention","volume":"54","author":"Kopsell","year":"2006","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"167","DOI":"10.18388\/abp.2012_2198","article-title":"Comparison of dietary supplementation with lutein diacetate and lutein: a pilot study of the effects on serum and macular pigment","volume":"59","author":"Landrum","year":"2012","journal-title":"Acta Biochimica Polonica"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00006982-200603000-00010","article-title":"One-year results of a pilot study using oral 13-cis retinoic acid as a treatment for subfoveal predominantly occult choroidal neovascularization in patients with age-related macular degeneration","volume":"26","author":"Lim","year":"2006","journal-title":"Retina"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.exer.2006.12.010","article-title":"Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study","volume":"84","author":"Trieschmann","year":"2007","journal-title":"Experimental Eye Research"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1167\/iovs.12-9713","article-title":"Profiles of macular pigment optical density and their changes following supplemental lutein and zeaxanthin: new results from the LUNA study","volume":"53","author":"Zeimer","year":"2012","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/jamaophthalmol.2013.2851","article-title":"Macular xanthophylls and omega-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial","volume":"131","author":"Arnold","year":"2013","journal-title":"JAMA Ophthalmology"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1007\/s00417-013-2376-6","article-title":"Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study","volume":"251","author":"Dawczynski","year":"2013","journal-title":"Graefes Archive for Clinical and Experimental Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-0031-1273339","article-title":"[Changes of macular pigment and drusen morphology in patients with lutein supplementation]","volume":"229","author":"Dawczynski","year":"2012","journal-title":"Klinische Monatsblatter fur Augenheilkunde"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1475-1313.2006.00387.x","article-title":"Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance","volume":"26","author":"Kvansakul","year":"2006","journal-title":"Ophthalmic and Physiological Optics"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1475-1313.2006.00386.x","article-title":"The effects of supplementation with lutein and\/or zeaxanthin on human macular pigment density and colour vision","volume":"26","author":"Rodriguez-Carmona","year":"2006","journal-title":"Ophthalmic and Physiological Optics"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.abb.2006.09.032","article-title":"Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (lutein xanthophyll eye accumulation) study","volume":"458","author":"Schalch","year":"2007","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0082|cit82","first-page":"23","article-title":"Macular response to supplementation with differing carotenoid formulations in subjects with and without age-related macular degeneration","volume":"612","author":"Meagher","year":"2013","journal-title":"European Journal of Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/archopht.124.8.1151","article-title":"Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the carotenoids in age-related eye disease study (CAREDS): ancillary study of the women's health initiative","volume":"124","author":"Moeller","year":"2006","journal-title":"Archives of Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0084|cit84","unstructured":"NCT00006202 Lutein for age-related macular degeneration clinicaltrials.gov\/ct2\/show\/NCT00006202"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0085|cit85","unstructured":"NCT00121589 Lutein\/zeaxanthin and omega-3 supplementation in persons over age 60 clinicaltrials.gov\/ct2\/show\/NCT00121589"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0086|cit86","unstructured":"NCT00563979 Enhancement of macular pigment density by oral lutein supplementation (EMPOLS) clinicaltrials.gov\/ct2\/show\/NCT00563979"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0087|cit87","unstructured":"NCT00564902 The zeaxanthin and visual function study (ZVF) clinicaltrials.gov\/ct2\/show\/NCT00564902"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0088|cit88","unstructured":"NCT00718653 Effects of antioxidants on human macular pigments clinicaltrials.gov\/ct2\/show\/NCT00718653"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0089|cit89","unstructured":"NCT00800995 Superoxide Dismutase (SOD) as antioxidant treatment of age related macular degeneration (ARMD) clinicaltrials.gov\/ct2\/show\/NCT00800995"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0090|cit90","unstructured":"NCT00893724 Supplemental adjuvants for intracellular nutrition and treatment (SAINTS) clinicaltrials.gov\/ct2\/show\/NCT00893724"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0091|cit91","unstructured":"NCT02264938 Drusen morphology changes in nonexudative age-related degeneration after oral antioxidants supplementation clinicaltrials.gov\/ct2\/show\/NCT02264938"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/02713680500514677","article-title":"Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin","volume":"31","author":"Nolan","year":"2006","journal-title":"Current Eye Research"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exer.2006.08.016","article-title":"Risk factors for age-related maculopathy are associated with a relative lack of macular pigment","volume":"84","author":"Nolan","year":"2007","journal-title":"Experimental Eye Research"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exer.2012.05.006","article-title":"Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment","volume":"101","author":"Nolan","year":"2012","journal-title":"Experimental Eye Research"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajo.2005.07.036","article-title":"Vitamin E in the treatment of uveitis-associated macular edema","volume":"141","author":"Nussenblatt","year":"2006","journal-title":"American Journal of Ophthalmology"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1167\/iovs.05-1292","article-title":"Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy","volume":"47","author":"Owsley","year":"2006","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ophtha.2013.09.038","article-title":"Effects of multivitamin supplement on cataract and age-related macular degeneration in a randomized trial of male physicians","volume":"121","author":"Christen","year":"2014","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.ophtha.2012.01.053","article-title":"Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians","volume":"119","author":"Christen","year":"2012","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1167\/iovs.05-1513","article-title":"Dose-ranging study of lutein supplementation in persons aged 60 years or older","volume":"47","author":"Rosenthal","year":"2006","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"9","key":"10.1002\/14651858.CD000254.pub4-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1097\/IAE.0000000000000174","article-title":"Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration","volume":"34","author":"Sabour-Pickett","year":"2014","journal-title":"Retina"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s00417-011-1780-z","article-title":"Effect of 1-year lutein supplementation on macular pigment optical density and visual function","volume":"249","author":"Sasamoto","year":"2011","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0102|cit102","first-page":"399","article-title":"Dynamic phototherapy of age-related macular degeneration with or without antioxidant therapy","volume":"37","author":"Scalinci","year":"2002","journal-title":"Canadian Journal of Ophthalmology"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0008-4182(02)80042-4","article-title":"Photodynamic therapy for age related macular degeneration with and without antioxidants","volume":"37","author":"Scorolli","year":"2002","journal-title":"Canadian Journal of Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.ophtha.2013.01.005","article-title":"Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the nutritional AMD treatment 2 study","volume":"120","author":"Souied","year":"2013","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1167\/iovs.13-13784","article-title":"Retinal hemodynamic effects of antioxidant supplementation in an endotoxin-induced model of oxidative stress in humans","volume":"55","author":"Told","year":"2014","journal-title":"Investigative Ophthalmology and Vision Science"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1167\/iovs.14-15581","article-title":"Antioxidative capacity of a dietary supplement on retinal hemodynamic function in a human lipopolysaccharide (LPS) model","volume":"56","author":"Told","year":"2015","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1755-3768.1958.tb00843.x","article-title":"On the treatment of arteriosclerotic chorioretinopathy","volume":"36","author":"Vannas","year":"1958","journal-title":"Acta Ophthalmologica"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0108|cit108","doi-asserted-by":"crossref","unstructured":"Vidal K Bucheli P Gao QT Moulin J Shen LS Blum S Effect of a milk-based wolfberry preparation on immune function and physical status of elderly Clinical Nutrition Gothenurg Sweden ESPEN 2011","DOI":"10.1016\/S1744-1161(11)70341-6"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ajcn\/85.3.762","article-title":"Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration","volume":"85","author":"Wang","year":"2007","journal-title":"American Journal of Clinical Nutrition"},{"issue":"10","key":"10.1002\/14651858.CD000254.pub4-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1093\/jn\/136.10.2568","article-title":"A 12-wk egg intervention increases serum zeaxanthin and macular pigment optical density in women","volume":"136","author":"Wenzel","year":"2006","journal-title":"Journal of Nutrition"},{"issue":"13","key":"10.1002\/14651858.CD000254.pub4-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"8069","DOI":"10.1167\/iovs.15-17586","article-title":"Oral lutein supplementation enhances macular pigment density and contrast sensitivity but not in combination with polyunsaturated fatty acids","volume":"56","author":"Wolf-Schnurrbusch","year":"2015","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"12","key":"10.1002\/14651858.CD000254.pub4-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.1167\/iovs.10-5637","article-title":"Treatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trial","volume":"51","author":"Wong","year":"2010","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0113|cit113","first-page":"53","article-title":"Carotenoids and ocular health","volume":"4","author":"Zhao","year":"2006","journal-title":"Current Topics in Nutraceuticals Research"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0114|cit114","unstructured":"NCT01694680 Intervention trial in early age-related macular degeneration (I-TEAM) clinicaltrials.gov\/ct2\/show\/NCT01694680"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0115|cit115","unstructured":"NCT02625376 Resveratrol for exudative age-related macular degeneration (AGED) clinicaltrials.gov\/ct2\/show\/NCT02625376"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000357528","article-title":"Evidence-based nutritional advice for patients affected by age-related macular degeneration","volume":"231","author":"Andreatta","year":"2014","journal-title":"Ophthalmologica"},{"issue":"14","key":"10.1002\/14651858.CD000254.pub4-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1080\/10408398.2014.912199","article-title":"Efficacy of multivitamin\/mineral spplementation to reduce chronic disease risk: a critical review of the evidence from observational studies and randomized controlled trials","volume":"55","author":"Angelo","year":"2015","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaophthalmol.2013.7376","article-title":"Secondary analyses of the effects of lutein\/zeaxanthinon age-related macular degeneration progression AREDS2 Report No. 3","volume":"132","author":"The Age-Related Eye Disease Study 2 (AREDS2) Research Group","year":"2014","journal-title":"JAMA Ophthalmology"},{"issue":"15","key":"10.1002\/14651858.CD000254.pub4-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199404143301501","article-title":"The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers","volume":"330","author":"The","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0120|cit120","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007176.pub2","article-title":"Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases","author":"Bjelakovic","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/nutrit\/nuv005","article-title":"Dietary modification and supplementation for the treatment of age-related macular degeneration","volume":"73","author":"Broadhead","year":"2015","journal-title":"Nutrition Reviews"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/eye.2010.122","article-title":"Causes of blind and partial sight certifications in England and Wales: April 2007-March 2008","volume":"24","author":"Bunce","year":"2010","journal-title":"Eye"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2147\/OPTH.S59724","article-title":"Recent developments in the management of dry age-related macular degeneration","volume":"9","author":"Buschini","year":"2015","journal-title":"Clinical Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0124|cit124","doi-asserted-by":"publisher","first-page":"Article ID 6469","DOI":"10.1155\/2017\/6469138","article-title":"Nutritional and lifestyle interventions for age-related macular degeneration: a review","volume":"2017","author":"Carneiro","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"6","key":"10.1002\/14651858.CD000254.pub4-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jamaophthalmol.2014.643","article-title":"Vitamins and minerals, for eyes only?","volume":"132","author":"Chew","year":"2014","journal-title":"JAMA Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/1047-2797(95)00094-1","article-title":"Antioxidants and age-related eye disease. Current and future perspectives","volume":"6","author":"Christen","year":"1996","journal-title":"Annals of Epidemiology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0127|cit127","unstructured":"Veritas Health Innovation Covidence systematic review software 2016"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0128|cit128","unstructured":"Deeks JJ Higgins JP Altman DG editor(s) Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JP, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration 2011 Available from handbook.cochrane.org"},{"issue":"8","key":"10.1002\/14651858.CD000254.pub4-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/OPX.0000000000000285","article-title":"Nutrition and age-related macular degeneration: research evidence in practice","volume":"91","author":"Downie","year":"2014","journal-title":"Optometry and Vision Science"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0130|cit130","volume-title":"Early Treatment Diabetic Retinopathy Study Manual of Operations","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1980"},{"issue":"7","key":"10.1002\/14651858.CD000254.pub4-BIB0131|cit131","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000253.pub4","article-title":"Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration","author":"Evans","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0132|cit132","first-page":"130","article-title":"How to identify randomized controlled trials in MEDLINE: ten years on","volume":"94","author":"Glanville","year":"2006","journal-title":"Journal of the Medical Library Association"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0133|cit133","unstructured":"GRADE Working Group, McMaster University GRADEpro 2014"},{"issue":"1-2","key":"10.1002\/14651858.CD000254.pub4-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11010-013-1908-z","article-title":"Antioxidants and vision health: facts and fiction","volume":"388","author":"Grover","year":"2014","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1136\/bjophthalmol-2015-306972","article-title":"Current therapeutic developments in atrophic age-related macular degeneration","volume":"100","author":"Hanus","year":"2016","journal-title":"British Journal of Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0136|cit136","unstructured":"Higgins JP Altman DG Sterne JAC editor(s) Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"5","key":"10.1002\/14651858.CD000254.pub4-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"372","DOI":"10.7326\/0003-4819-145-5-200609050-00135","article-title":"The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference","volume":"145","author":"Huang","year":"2006","journal-title":"Annals of Internal Medicine"},{"issue":"6","key":"10.1002\/14651858.CD000254.pub4-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0161-6420(92)31871-8","article-title":"Prevalence of age-related maculopathy. The beaver dam eye study","volume":"99","author":"Klein","year":"1992","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD000254.pub4-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1167\/iovs.14-15553","article-title":"Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration","volume":"56","author":"Liu","year":"2016","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jama.293.11.1338","article-title":"Effects of long term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial","volume":"293","author":"Lonn","year":"2005","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0141|cit141","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fitote.2015.12.009","article-title":"Zeaxanthin and ocular health, from bench to bedside","volume":"109","author":"Manikandan","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0142|cit142","unstructured":"NICE Macular degeneration - NICE guidelines www.nice.org.uk\/guidance\/indevelopment\/gid-cgwave0658\/"},{"issue":"18","key":"10.1002\/14651858.CD000254.pub4-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM199605023341802","article-title":"Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease","volume":"334","author":"Omenn","year":"1996","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD000254.pub4-BIB0144|cit144","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jtemb.2014.07.019","article-title":"Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging","volume":"28","author":"Prasad","year":"2014","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0145|cit145","unstructured":"Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 5 (RevMan 5) 2014"},{"issue":"3","key":"10.1002\/14651858.CD000254.pub4-BIB0146|cit146","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ophtha.2011.09.027","article-title":"Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis","volume":"119","author":"Rudnicka","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0147|cit147","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-017-0086-6","article-title":"A review of current and future management of geographic atrophy","author":"Sacconi","journal-title":"Ophthalmology and Therapy"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0148|cit148","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/aos.12650","article-title":"Nutritional supplements in age-related macular degeneration","volume":"93","author":"Schmidl","year":"2015","journal-title":"Acta Ophthalmologica"},{"key":"10.1002\/14651858.CD000254.pub4-BIB0149|cit149","unstructured":"Sch\u00fcnemann HJ Oxman AD Vist GE Higgins JP Deeks JJ Glasziou P Chapter 12: Interpreting results and drawing conclusions. In: Higgins JP, Green S editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nutres.2013.10.011","article-title":"Review of nutrient actions on age-related macular degeneration","volume":"34","author":"Zampatti","year":"2014","journal-title":"Nutrition Research"},{"issue":"2","key":"10.1002\/14651858.CD000254.pub4-BIB0151|cit151","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000254.pub2","article-title":"Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration","author":"Evans","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD000254.pub4-BIB0152|cit152","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000254.pub3","article-title":"Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration","author":"Evans","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd000254.pub5","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD000254.pub4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T09:12:01Z","timestamp":1678698721000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD000254.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Eyes and Vision Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,30]]},"references-count":152,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd000254.pub4","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD000254.pub5","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,30]]}}}