{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:39:55Z","timestamp":1784129995622,"version":"3.55.0"},"publisher-location":"Chichester, UK","reference-count":61,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd000456.pub2","type":"reference-entry","created":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T07:10:33Z","timestamp":1097737833000},"source":"Crossref","is-referenced-by-count":31,"title":["Synchronized mechanical ventilation for respiratory support in newborn infants"],"prefix":"10.1002","author":[{"given":"A","family":"Greenough","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AD","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Dimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,19]]},"reference":[{"key":"10.1002\/14651858.CD000456.pub2-BIB1|cit1","doi-asserted-by":"crossref","first-page":"F5","DOI":"10.1136\/fn.82.1.F5","article-title":"International randomised controlled trial of patient triggered ventilation in neonatal respiratory distress syndrome","volume":"82","author":"Baumer","year":"2000","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB2|cit2","doi-asserted-by":"crossref","first-page":"F14","DOI":"10.1136\/fn.82.1.F14","article-title":"Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome","volume":"82","author":"Beresford","year":"2000","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB3|cit3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0022-3476(96)70354-2","article-title":"Randomized multicenter trial comparing synchronized and conventional intermittent mandatory ventilation in neonates","volume":"128","author":"Bernstein","year":"1996","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB4|cit4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF02072516","article-title":"Randomised controlled trial of weaning by patient triggered ventilation or conventional ventilation","volume":"152","author":"Chan","year":"1993","journal-title":"European Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB5|cit5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1651-2227.1994.tb18108.x","article-title":"Comparison of weaning by patient triggered ventilation or synchronous mandatory intermittent ventilation","volume":"83","author":"Chan","year":"1994","journal-title":"Acta Paediatrica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB6|cit6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1442-200X.1997.tb03644.x","article-title":"Comparison of synchronized and conventional intermittent mandatory ventilation in neonates","volume":"39","author":"Chen","year":"1997","journal-title":"Acta Paediatrica Japonica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB7|cit7","doi-asserted-by":"crossref","first-page":"F188","DOI":"10.1136\/fn.72.3.F188","article-title":"Synchronous intermittent mandatory ventilation modes versus patient triggered ventilation during weaning","volume":"72","author":"Dimitriou","year":"1995","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB8|cit8","doi-asserted-by":"crossref","first-page":"F188","DOI":"10.1136\/fn.72.3.F188","article-title":"Synchronous intermittent mandatory ventilation modes versus patient triggered ventilation during weaning","volume":"72","author":"Dimitriou","year":"1995","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB9|cit9","first-page":"90","article-title":"Flow-synchronized ventilation of preterm infants with respiratory distress syndrome","volume":"14","author":"Donn","year":"1994","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB10|cit10","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0022-3476(81)80604-X","article-title":"Prospective clinical comparison of two methods for mechanical ventilation of neonates: rapid rate and short inspiratory time versus slow rate and long inspiratory time","volume":"98","author":"Heicher","year":"1981","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB11|cit11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/adc.66.7_Spec_No.770","article-title":"Multicentre randomised controlled trial of high against low frequency positive pressure ventilation","volume":"66","year":"1991","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB12|cit12","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/BF01954127","article-title":"Decreased incidence of extra-alveolar air leakage or death prior to air leakage in high versus low rate positive pressure ventilation: results of a randomised seven-centre trial in preterm infants","volume":"151","author":"Pohlandt","year":"1992","journal-title":"European Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB13|cit13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00003246-199301000-00022","article-title":"Synchronous mechanical ventilation of the neonate with respiratory disease","volume":"21","author":"Amitay","year":"1993","journal-title":"Critical Care Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB14|cit14","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1164\/ajrccm\/148.2.358","article-title":"Response time and reliability of three neonatal patient triggered ventilators","volume":"148","author":"Bernstein","year":"1993","journal-title":"American Review of Respiratory Disease"},{"key":"10.1002\/14651858.CD000456.pub2-BIB15|cit15","first-page":"216","article-title":"Neonatal patient triggered ventilators. Performance in acute and chronic lung disease","volume":"3","author":"Chan","year":"1993","journal-title":"Br J Int Care"},{"key":"10.1002\/14651858.CD000456.pub2-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1542\/peds.107.6.1323","article-title":"Feasibility of tidal volume-guided ventilation in newborn infants: a randomized, crossover trial using the volume guarantee modality","volume":"107","author":"Cheema","year":"2001","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB17|cit17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0022-3476(95)70460-4","article-title":"Improved oxygenation during synchronized intermittent mandatory ventilation in neonates with respiratory distress syndrome: a randomized, crossover study","volume":"126","author":"Cleary","year":"1995","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB18|cit18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1056\/NEJMoa012750","article-title":"High-Frequency Oscillatory ventilation versus convetional mechanical ventilation for very-low birth-weight infants","volume":"347","author":"Courtney","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB19|cit19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.jp.7210849","article-title":"The sy-fi study: a randomized prospective trial of synchronized intermittent mandatory ventilation versus a high-frequency flow interrupter in infants less than 1000 g","volume":"23","author":"Craft","year":"2003","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB20|cit20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/adc.68.3_Spec_No.308","article-title":"Long term trigger ventilation in neonatal respiratory distress syndrome","volume":"68","author":"Boer","year":"1993","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1651-2227.1998.tb00948.x","article-title":"Comparison of airway pressure triggered and airflow triggered ventilation in immature infants","volume":"87","author":"Dimitriou","year":"1998","journal-title":"Acta Paediatrica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB22|cit22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.jp.7210527","article-title":"Early high-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in very low birth weight infants: a pilot study of two ventilation protocols","volume":"21","author":"Durand","year":"2001","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB23|cit23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/sj.jp.7200205","article-title":"A randomized trial of nasopharyngeal synchronized interittent mandatory ventilation versus nasopharyngeal continuous positive airway pressure in very low birthweight infants after extubation","volume":"19","author":"Friedlich","year":"1999","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB24|cit24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-3782(86)90007-1","article-title":"Fighting the ventilator - are fast rates an effective alternative to paralysis?","volume":"13","author":"Greenough","year":"1986","journal-title":"Early Human Development"},{"key":"10.1002\/14651858.CD000456.pub2-BIB25|cit25","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1651-2227.1987.tb10553.x","article-title":"Comparison of different rates of artificial ventilation in preterm neonates with the respiratory distress syndrome","volume":"76","author":"Greenough","year":"1987","journal-title":"Acta Paediatrica Scandinavica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB26|cit26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1651-2227.1987.tb10554.x","article-title":"Synchronous respiration - which ventilator rate is best?","volume":"76","author":"Greenough","year":"1987","journal-title":"Acta Paediatrica Scandinavica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB27|cit27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/adc.63.1.77","article-title":"Patient triggered ventilation in premature neonates","volume":"63","author":"Greenough","year":"1988","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB28|cit28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/adc.63.4.394","article-title":"Neonatal patient triggered ventilation","volume":"63","author":"Greenough","year":"1988","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB29|cit29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/jpme.1991.19.6.471","article-title":"Airway pressure triggered ventilation for preterm neonates","volume":"19","author":"Greenough","year":"1991","journal-title":"Journal of Perinatal Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB30|cit30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1542\/peds.110.3.529","article-title":"Effects of volume-guaranteed synchronized intermittent mandatory ventilation in preterm infants recovering from respiratory failure","volume":"110","author":"Herrera","year":"2002","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB31|cit31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0378-3782(90)90133-4","article-title":"Causes of failure of neonatal patient triggered ventilation","volume":"23","author":"Hird","year":"1990","journal-title":"Early Human Development"},{"key":"10.1002\/14651858.CD000456.pub2-BIB32|cit32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1088\/0143-0815\/11\/4\/003","article-title":"Gestational age: an important influence on the success of patient triggered ventilation","volume":"11","author":"Hird","year":"1990","journal-title":"Clinical Physics and Physiological Measurement"},{"key":"10.1002\/14651858.CD000456.pub2-BIB33|cit33","doi-asserted-by":"crossref","first-page":"379-84 (listed","DOI":"10.1515\/jpme.1991.19.5.379","article-title":"Randomised trial of patient triggered ventilation versus high frequency positive pressure ventilation in acute respiratory distress","volume":"19","author":"Hird","year":"1991","journal-title":"Journal of Perinatal Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB34|cit34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/BF01958767","article-title":"Patient triggered ventilation in chronically ventilator-dependent infants","volume":"150","author":"Hird","year":"1991","journal-title":"European Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1136\/adc.66.10_Spec_No.1140","article-title":"Patient triggered ventilation using a flow triggered system","volume":"66","author":"Hird","year":"1991","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB36|cit36","first-page":"426-8 (abstract","article-title":"Comparison of triggering systems for neonatal patient triggered ventilation","volume":"66","author":"Hird","year":"1991","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB37|cit37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1099-0496(199611)22:5<305::AID-PPUL3>3.0.CO;2-J","article-title":"Influence of different methods of synchronized mechanical ventilation on ventilation, gas exchange, patient effort and blood pressure fluctuations in premature neonates","volume":"22","author":"Hummler","year":"1996","journal-title":"Pediatric Pulmonology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB38|cit38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/(SICI)1099-0496(199709)24:3<195::AID-PPUL5>3.0.CO;2-M","article-title":"Increased incidence of sighs (augmented inspiratory eforts) during synchronized intermittent mandatory ventilation (SIMV) in preterm neonates","volume":"24","author":"Hummler","year":"1997","journal-title":"Pediatric Pulmonology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1164\/ajrccm.153.3.8630564","article-title":"Patient-triggered ventilation decreases the work of breathing in neonates","volume":"153","author":"Jarreau","year":"1996","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB40|cit40","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1651-2227.1994.tb13168.x","article-title":"Airway and body surface sensors for triggering in neonatal ventilation","volume":"83","author":"John","year":"1994","journal-title":"Acta Paediatrica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB41|cit41","doi-asserted-by":"crossref","first-page":"306A","DOI":"10.1203\/00006450-199904020-01821","article-title":"Effort and work of breathing in neonates during assisted patient triggered ventilation","volume":"45","author":"Kapasi","year":"1999","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD000456.pub2-BIB42|cit42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1651-2227.1997.tb08841.x","article-title":"Comparison of body surface and airway triggered ventilation in extremely premature infants","volume":"86","author":"Laubscher","year":"1997","journal-title":"Acta Paediatrica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB43|cit43","doi-asserted-by":"crossref","first-page":"F14","DOI":"10.1136\/fn.84.1.F14","article-title":"Randomised study comparing extent of hypocarbia in preterm infants during conventional and patient triggered ventilation","volume":"84","author":"Luyt","year":"2001","journal-title":"Archives of Disease in Childhood. Fetal and Neonatal edition"},{"key":"10.1002\/14651858.CD000456.pub2-BIB44|cit44","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/ppul.10273","article-title":"Effect on respiratory function of pressure support ventilation versus synchronised intermittent mandatory ventilation in preterm infants","volume":"35","author":"Migliori","year":"2003","journal-title":"Pediatric Pulmonology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB45|cit45","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/adc.64.7_Spec_No.924","article-title":"Limitations of neonatal patient triggered ventilation","volume":"64","author":"Mitchell","year":"1989","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD000456.pub2-BIB46|cit46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1442-200X.1994.tb03154.x","article-title":"Efficacy of synchronized IMV on weaning neonates from the ventilator","volume":"36","author":"Mizuno","year":"1994","journal-title":"Acta Paediatrica Japonica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB47|cit47","first-page":"278","article-title":"Efficacy of abdominal expansion triggered synchronized IMV in newborns","volume":"30","author":"Mizuno","year":"1994","journal-title":"J Jap Neonat Assoc"},{"key":"10.1002\/14651858.CD000456.pub2-BIB48|cit48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-3782(99)00046-8","article-title":"Comparing the effects of nasal synchronized intermittent positive pressure ventilation (nSIPPV) and nasal continuous positive airway pressure (nCPAP) after extubation in very low birth weight infants","volume":"56","author":"Moretti","year":"1999","journal-title":"Early Human Development"},{"key":"10.1002\/14651858.CD000456.pub2-BIB49|cit49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1099-0496(200001)29:1<11::AID-PPUL3>3.0.CO;2-5","article-title":"Randomized controlled trial of volume-targeted synchronized ventilation and conventional intermittent mandatory ventilation following initial exogenous surfactant therapy","volume":"29","author":"Mrozek","year":"2000","journal-title":"Pediatric Pulmonology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB50|cit50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF03012913","article-title":"Triggering delay time and work of breathing in three paediatric patient triggered ventilators","volume":"45","author":"Nakae","year":"1998","journal-title":"Canadian Journal of Anaesthesia"},{"key":"10.1002\/14651858.CD000456.pub2-BIB51|cit51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1099-0496(199607)22:1<28::AID-PPUL5>3.0.CO;2-G","article-title":"Patient triggered ventilation: a comparison of tidal volume and chest wall and abdominal motion as trigger signals","volume":"22","author":"Nikischin","year":"1996","journal-title":"Pediatric Pulmonology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB52|cit52","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1164\/ajrccm.152.6.8520753","article-title":"The response of flow-triggered infant ventilators","volume":"152","author":"Nishimura","year":"1995","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB53|cit53","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/sj.jp.7210772","article-title":"Crossover trial comparing pressure support with synchronized intermittent mandatory ventilation","volume":"22","author":"Olsen","year":"2002","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD000456.pub2-BIB54|cit54","first-page":"249","article-title":"Feasibility of applying flow-synchronized ventilation to very low birthweight infants","volume":"37","author":"Servant","year":"1992","journal-title":"Respiratory Care"},{"key":"10.1002\/14651858.CD000456.pub2-BIB55|cit55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s001340050359","article-title":"Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation","volume":"23","author":"Smith","year":"1997","journal-title":"Intensive Care Medicine"},{"key":"10.1002\/14651858.CD000456.pub2-BIB56|cit56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1442-200X.1994.tb03154.x","article-title":"Efficacy of synchronized IMV on weaning neonates from the ventilator","volume":"36","author":"Takeuchi","year":"1994","journal-title":"Acta Paediatrica Japonica"},{"key":"10.1002\/14651858.CD000456.pub2-BIB57|cit57","first-page":"333","article-title":"The energy expenditure of the newborn infants during SIMV","volume":"31","author":"Tanaka","year":"1995","journal-title":"J Jap Neonat Assoc"},{"key":"10.1002\/14651858.CD000456.pub2-BIB58|cit58","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF02034755","article-title":"The effect of changes in inspiratory time on neonatal triggered ventilation","volume":"149","author":"Upton","year":"1990","journal-title":"European Journal of Pediatrics"},{"key":"10.1002\/14651858.CD000456.pub2-BIB59|cit59","first-page":"347","article-title":"Patient triggered synchronized assisted ventilation of newborns: report of a preliminary study and three years' experience","volume":"11","author":"Vishveshwara","year":"1991","journal-title":"Journal of Perinatology"},{"issue":"1","key":"10.1002\/14651858.CD000456.pub2-BIB60|cit60","article-title":"Synchronized mechanical ventilation for respiratory support in newborn infants (Cochrane Review)","author":"Greenough","year":"1998","journal-title":"The Cochrane Library"},{"issue":"1","key":"10.1002\/14651858.CD000456.pub2-BIB61|cit61","article-title":"Synchronized mechanical ventilation for respiratory support in newborn infants (Cochrane Review)","author":"Greenough","year":"2001","journal-title":"The Cochrane Library"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD000456.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T20:57:27Z","timestamp":1628542647000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD000456.pub2"}},"subtitle":[],"editor":[{"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2004,7,19]]},"references-count":61,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd000456.pub2","relation":{},"subject":[],"published":{"date-parts":[[2004,7,19]]}}}