{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:46:54Z","timestamp":1776754014300,"version":"3.51.2"},"publisher-location":"Chichester, UK","reference-count":195,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd000551.pub2","type":"reference-entry","created":{"date-parts":[[2008,8,11]],"date-time":"2008-08-11T11:49:16Z","timestamp":1218455356000},"source":"Crossref","is-referenced-by-count":46,"title":["Ursodeoxycholic acid for primary biliary cirrhosis"],"prefix":"10.1002","author":[{"given":"Yan","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Bi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"10.1002\/14651858.CD000551.pub2-BIB1|cit1","first-page":"1421","article-title":"A randomised controlled trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC) (AASLD Abstract)","volume":"8","author":"Hadziyannis","year":"1988","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB4|cit2","series-title":"XI International Bile Acid Meeting. Bile Acids as Therapeutic Agents - From Basic Science to Clinical Practice. Freiburg","first-page":"57","article-title":"Long-term treatment of primary biliary cirrhosis with ursodeoxycholic acid: the third year of a controlled trial","author":"Hadziyannis","year":"1990"},{"key":"10.1002\/14651858.CD000551.pub2-BIB2|cit3","series-title":"Bile Acids as Therapeutic Agents. From Basic Science to Clinical Practice. Falk Symposium 58","first-page":"287","article-title":"Long-term treatment of primary biliary cirrhosis with ursodeoxycholic acid: the third year of a controlled trial","author":"Hadziyannis","year":"1990"},{"key":"10.1002\/14651858.CD000551.pub2-BIB3|cit4","first-page":"580","article-title":"A randomized controlled trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC) [abstract]","volume":"10","author":"Hadziyannis","year":"1989","journal-title":"Hepatology"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD000551.pub2-BIB5|cit5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0168-8278(00)80485-7","article-title":"Ursodeoxycholic-acid for primary biliary cirrhosis: final results of a 12-year prospective, randomised, controlled trial","volume":"32","author":"Papatheodoridis","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1572-0241.2002.05923.x","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis: final results of a 12-year, prospective, randomized, controlled trial","volume":"97","author":"Papatheodoridis","year":"2002","journal-title":"The American Journal of Gastroenterology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000551.pub2-BIB9|cit7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0168-8278(01)81572-5","article-title":"Factors influencing histological progression of early primary biliary cirrhosis. Effect of ursodeoxycholic acid","volume":"34","author":"Pares","year":"2001","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000551.pub2-BIB10|cit8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0168-8278(01)81564-6","article-title":"Long-term ursodeoxycholic acid treatment delays progression of mild primary biliary cirrhosis","volume":"34","author":"Pares","year":"2001","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB8|cit9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0168-8278(00)80216-0","article-title":"Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: results of a double-blind controlled multicentric trial","volume":"32","author":"Par\u00e9s","year":"2000","journal-title":"Journal of Hepatology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000551.pub2-BIB7|cit10","first-page":"166","article-title":"Long-term treatment of primary biliary cirrhosis with ursodeoxycholic acid: results of a randomized, double-blind, placebo-controlled trial (abstract)","volume":"26","year":"1997","journal-title":"J Hepatol"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB11|cit11","first-page":"A1163","article-title":"Extended follow-up of patients in the U.S. multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis (Abstract)","volume":"110","author":"Carithers","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB14|cit12","doi-asserted-by":"crossref","first-page":"175A","DOI":"10.1016\/0270-9139(93)92227-Q","article-title":"A randomized, double-blind, placebo-controlled trial of ursodeoxcholic acid (UDCA) in primary biliary cirrhosis (AASLD Abstract)","volume":"18","author":"Combes","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB15|cit13","series-title":"Falk Symposium No. 68. XII International Bile Acid Meeting. Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Basel","first-page":"43","article-title":"A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC)","author":"Combes","year":"1992"},{"key":"10.1002\/14651858.CD000551.pub2-BIB16|cit14","series-title":"Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Falk Symposium 68","first-page":"289","article-title":"A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis","author":"Combes","year":"1993"},{"key":"10.1002\/14651858.CD000551.pub2-BIB17|cit15","series-title":"Falk Symposium No. 80. XIII International Bile Acid Meeting. Bile Acids in Gastroenterology: Basic and Clinical Aspects. San Diego","first-page":"67","article-title":"The American multicenter primary biliary cirrhosis, Ursodiol versus placebo study group (PUPS) trial","author":"Combes","year":"1994"},{"key":"10.1002\/14651858.CD000551.pub2-BIB12|cit16","first-page":"759","article-title":"A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis","volume":"22","author":"Combes","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB13|cit17","first-page":"91A","article-title":"Ursodeoxycholic acid therapy in patients with primary biliary cirrhosis [AASLD abstract]","volume":"14","author":"Combes","year":"1991","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB18|cit18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/hep.510300315","article-title":"The effect of ursodeoxycholic acid on the florid duct lesion of primary biliary cirrhosis","volume":"30","author":"Combes","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB19|cit19","first-page":"168A","article-title":"Does ursodeoxycholic acid improve survival in patients with primary biliary cirrhosis? Comparison of outcome in the US multicenter trial to expected survival using the Mayo Clinic prognostic model [AASLD abstract]","volume":"24","author":"Emond","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB20|cit20","first-page":"49","article-title":"Treatment of chronic active hepatitis and primary biliary cirrhosis with ursodeoxycholic acid","volume":"30 Suppl 1","author":"G\u00fcld\u00fctuna","year":"1992","journal-title":"Z-Gastroenterol"},{"key":"10.1002\/14651858.CD000551.pub2-BIB21|cit21","series-title":"Bile acids and the hepatobiliary system. From Basic Science to Clinical Practice. Falk Symposium 68","first-page":"299","article-title":"Ursodeoxycholic acid therapy in primary biliary cirrhosis","author":"Leuschner","year":"1993"},{"key":"10.1002\/14651858.CD000551.pub2-BIB22|cit22","first-page":"A621","article-title":"Does ursodeoxycholic acid (UDCA) influence cell membrane architecture in patients with primary biliary cirrhosis (PBC)?","volume":"96","author":"Leuschner","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB23|cit23","first-page":"133","article-title":"UDCA in der Behandlung der prim\u00e4ren bili\u00e4ren Zirrhose: Ergebnisse einer kontrollierten Studie","volume":"24","author":"Leuschner","year":"1989","journal-title":"Ergebnisse der Gastroenterologie"},{"key":"10.1002\/14651858.CD000551.pub2-BIB24|cit24","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/0016-5085(89)91698-3","article-title":"Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind trial","volume":"97","author":"Leuschner","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB25|cit25","series-title":"Trends in Bile Acid Research. Falk Symposium 52","first-page":"355","article-title":"Ursodeoxycholic acid (UDCA) treatment of primary biliary cirrhosis: clinical and histological results of a controlled study","author":"Leuschner","year":"1989"},{"key":"10.1002\/14651858.CD000551.pub2-BIB26|cit26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/00365529709000190","article-title":"Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. A Swedish multicentre, double-blind, randomized controlled study","volume":"32","author":"Eriksson","year":"1997","journal-title":"Scand-J-Gastroenterol"},{"key":"10.1002\/14651858.CD000551.pub2-BIB27|cit27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00196579","article-title":"Ursodeoxycholic acid treatment lowers the serum levels of antibodies against pyrovate dehydrogenase and influences their inhibitory capacity for the enzyme complex in patients with primary biliary cirrhosis","volume":"74","author":"Kisand","year":"1996","journal-title":"Journal of Molecular Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB29|cit28","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/0270-9139(95)90046-2","article-title":"Serum cholestanol, cholesterol precursors, and plant sterols during placebo-controlled treatment of primary biliary cirrhosis with ursodeoxycholic acid or colchicine","volume":"21","author":"Miettinen","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB28|cit29","first-page":"A954","article-title":"Improvement of serum noncholesterol sterols may indicate retarded progression of primary biliary cirrhosis (PBC) in a randomized placebo controlled two-year trial with colchicine and ursodeoxycholic acid (AASLD abstract)","volume":"104","author":"Miettinen","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB30|cit30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0168-8278(97)80293-0","article-title":"Expression and therapeutic response related to apolipoprotein E polymorphism in primary biliary cirrhosis","volume":"27","author":"Vuoristo","year":"1997","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/0016-5085(95)90696-7","article-title":"A placebo-controlled trial of primary biliary cirrhosis treatment with colchicine and ursodeoxycholic acid [see comments]","volume":"108","author":"Vuoristo","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB32|cit32","first-page":"151A","article-title":"A trial of ursodeoxycholic acid (UDCA) and colchicine in primary biliary cirrhosis (PBC) (AASLD abstract)","volume":"20","author":"Goddard","year":"1994","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000551.pub2-BIB33|cit33","first-page":"A30","article-title":"Surrogate markers of response in a trial of ursodeoxycholic acid (UDCA) and colchicine in primary biliary cirrhosis (PBC)","volume":"36","author":"Goddard","year":"1995","journal-title":"Gut"},{"issue":"2","key":"10.1002\/14651858.CD000551.pub2-BIB34|cit34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1478-3231.1999.tb00020.x","article-title":"Utilization of the Mayo risk score in patients with primary biliary cirrhosis receiving ursodeoxycholic acid","volume":"19","author":"Angulo","year":"1999","journal-title":"Liver"},{"key":"10.1002\/14651858.CD000551.pub2-BIB35|cit35","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0025-6196(12)61815-1","article-title":"Effect of ursodeoxycholic acid on serum lipids of patients with primary biliary cirrhosis [see comments]","volume":"69","author":"Balan","year":"1994","journal-title":"Mayo-Clin-Proc"},{"key":"10.1002\/14651858.CD000551.pub2-BIB36|cit36","doi-asserted-by":"crossref","first-page":"175A","DOI":"10.1016\/0270-9139(93)92228-R","article-title":"The effects of ursodeoxycholic acid on hepatic inflammation and histological stage in patients with primary biliary cirhosis (AASLD Abstract)","volume":"18","author":"Batts","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB37|cit37","first-page":"2314","article-title":"Effects of ursodeoxycholic acid on hepatic inflammation and histological stage in patients with primary biliary cirrhosis","volume":"91","author":"Batts","year":"1996","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB38|cit38","first-page":"A732","article-title":"The effect of ursodeoxycholic acid compared to placebo on lumbar spine bone mineral density in patients with primary biliary cirrhosis","volume":"100","author":"Crippin","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB41|cit39","series-title":"Bile acids as therapeutic agents. From Basic Science to Clinical Practice. Falk Symposium 58","first-page":"271","article-title":"Beneficial effects of ursodeoxycholic acid in an open trial of patients with primary biliary cirrhosis","author":"Dickson","year":"1991"},{"key":"10.1002\/14651858.CD000551.pub2-BIB39|cit40","series-title":"Falk Symposium No. 68. XII International Bile Acid Meeting. Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Basel","first-page":"44","article-title":"Ursodiol (URSO) is effective therapy for patients with primary biliary cirrhosis (PBC)","author":"Dickson","year":"1992"},{"key":"10.1002\/14651858.CD000551.pub2-BIB40|cit41","series-title":"Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Falk Symposium 68","first-page":"292","article-title":"Ursodiol is effective therapy for patients with primary biliary cirrhosis","author":"Dickson","year":"1993"},{"issue":"10","key":"10.1002\/14651858.CD000551.pub2-BIB42|cit42","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1111\/j.1572-0241.2002.06043.x","article-title":"Results of long-term ursodiol treatment for patients with primary biliary cirrhosis","volume":"97","author":"Jorgensen","year":"2002","journal-title":"The American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB43|cit43","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/gut.36.6.935","article-title":"Characterisation of patients with a complete biochemical response to ursodeoxycholic acid","volume":"36","author":"Jorgensen","year":"1995","journal-title":"Gut"},{"issue":"4 (Part 2)","key":"10.1002\/14651858.CD000551.pub2-BIB44|cit44","doi-asserted-by":"crossref","first-page":"174 A","DOI":"10.1016\/0270-9139(93)92221-K","article-title":"Dissimilar patterns of serum and biliary bile acids in primary biliary cirrhosis (PBC) patients treated with ursodeoxycholic acid (UDCA)","volume":"18","author":"Lacerda","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB45|cit45","first-page":"1840","article-title":"The natural history of abdominal pain associated with primary biliary cirrhosis","volume":"89","author":"Laurin","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB46|cit46","first-page":"91A","article-title":"Ursodeoxycholic acid (UDCA) is beneficial therapy for patients with primary biliary cirrhosis (PBC) [AASLD abstract]","volume":"16","author":"Lindor","year":"1992","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB47|cit47","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/0016-5085(94)90021-3","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis [see comments]","volume":"106","author":"Lindor","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB48|cit48","first-page":"389","article-title":"Bone disease in primary biliary cirrhosis: does ursodeoxycholic acid make a difference?","volume":"21","author":"Lindor","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB49|cit49","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4065\/72.12.1137","article-title":"Ursodeoxycholic acid delays the onset of esophageal varices in primary biliary cirrhosis","volume":"72","author":"Lindor","year":"1997","journal-title":"Mayo Clinic Proceedings. Mayo Clinic"},{"key":"10.1002\/14651858.CD000551.pub2-BIB50|cit50","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1572-0241.1998.00470.x","article-title":"Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis","volume":"93","author":"Lindor","year":"1998","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB51|cit51","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1053\/gast.1996.v110.pm8613058","article-title":"Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis","volume":"110","author":"Lindor","year":"1996","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB52|cit52","doi-asserted-by":"crossref","first-page":"A1111","DOI":"10.1016\/0016-5085(95)28744-2","article-title":"Effects of ursodeoxycholic acid (UDCA) on survival in patients with primary biliary cirrhosis (PBC) [AASLD abstract]","volume":"108","author":"Lindor","year":"1995","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1002\/14651858.CD000551.pub2-BIB53|cit53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00004836-200308000-00018","article-title":"Treatment with ursodeoxycholic acid is associated with weight gain in patients with primary biliary cirrhosis","volume":"37","author":"Siegel","year":"2003","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB54|cit54","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1572-0241.1998.00287.x","article-title":"Autoimmune conditions associated with primary biliary cirrhosis: response to ursodeoxycholic acid therapy","volume":"93","author":"Zukowski","year":"1998","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB55|cit55","doi-asserted-by":"crossref","first-page":"57I","DOI":"10.1016\/0270-9139(94)90396-4","article-title":"Does treatment with ursodeoxycholic acid (UDCA) really diminish cholesterol serum levels in primary biliary cirrhosis (PBC)? [IASL abstract]","volume":"19","author":"Mora","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB56|cit56","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0168-8278(05)80214-4","article-title":"Ursodeoxycholic acid for symptomatic primary biliary cirrhosis. Preliminary analysis of a double-blind multicenter trial. Italian Multicenter Group for the Study of UDCA in PBC","volume":"17","author":"Battezzati","year":"1993","journal-title":"J-Hepatol"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000551.pub2-BIB57|cit57","first-page":"87","article-title":"Ursodeoxycholic acid (UDCA) for symptomatic primary biliary cirrhosis (PBC): a double-blind multicenter trial (EASL abstract)","volume":"9","year":"1989","journal-title":"J Hepatol"},{"key":"10.1002\/14651858.CD000551.pub2-BIB58|cit58","series-title":"Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Falk Symposium 68","first-page":"310","article-title":"Long-term effect of the administration of ursodeocycholic acid alone or with colchicine in patients with primary biliary cirrhosis: a double-blind multicentre study","author":"Podda","year":"1993"},{"key":"10.1002\/14651858.CD000551.pub2-BIB59|cit59","first-page":"639","article-title":"Urodeoxycholic acid (UDCA) for symptomatic primary biliary cirrhosis (PBC): a double-blind multicenter trial [AASLD abstract]","volume":"10","author":"Podda","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB60|cit60","first-page":"222","article-title":"Effect of ursodiol on biliary bile acid composition and conjugation in patients with primary biliary cirrhosis","volume":"98","author":"Batta","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB61|cit61","first-page":"A617","article-title":"Ursodiol treatment of primary biliary cirrhosis","volume":"98","author":"O'Brian","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB62|cit62","series-title":"Second International Meeting on Pathochemistry, Pathophysiology and Pathomechanisms of the Biliary System and New Strategies for the Treatment of Hepato-Biliary Diseases. Bologna","first-page":"208","article-title":"Caution: not all patients with primary biliary cirrhosis may successfully be treated by ursodiol","author":"O'Brian","year":"1990"},{"key":"10.1002\/14651858.CD000551.pub2-BIB63|cit63","first-page":"438","article-title":"Effect of oral ursodiol treatment on the predicted probability of mortality in primary biliary cirrhosis","volume":"12","author":"Senior","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB64|cit64","series-title":"Bile Acids as Therapeutic Agents. From Basic Science to Clinical Practice. Falk Symposium 58","first-page":"273","article-title":"Mortality risk indices as outcome measures of the effectiveness of ursodeoxycholic acid treatment of cholestatic liver diseases","author":"Senior","year":"1991"},{"key":"10.1002\/14651858.CD000551.pub2-BIB65|cit65","first-page":"415","article-title":"No symptomatic or histological benefit from ursodeoxycholic acid treatment in PBC after 1 year. Controlled pilot study [IASL abstract]","volume":"12","author":"Myszor","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB66|cit66","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1440-1746.1994.tb01237.x","article-title":"A two year controlled trial examining the effectiveness of ursodeoxycholic acid in primary biliary cirrhosis","volume":"9","author":"Turner","year":"1994","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1002\/14651858.CD000551.pub2-BIB67|cit67","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1440-1746.1993.tb01189.x","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a short-term, randomized, double-blind controlled, cross-over study with long-term follow up","volume":"8","author":"Hwang","year":"1993","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB68|cit68","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/BF02779195","article-title":"A multi-center double-blind controlled trial of ursodeoxycholic acid for primary biliary cirhosis","volume":"25","author":"Oka","year":"1990","journal-title":"Gastroenterologia Japonica"},{"key":"10.1002\/14651858.CD000551.pub2-BIB69|cit69","series-title":"XI International Bile Acid Meeting. Bile Acids as Therapeutic Agents - From Basic Science to Clinical Practice. Freiburg","first-page":"76","article-title":"A multi-center double-blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis in Japan","author":"Toda","year":"1990"},{"key":"10.1002\/14651858.CD000551.pub2-BIB70|cit70","first-page":"438 A","article-title":"Ursodeoxycholic acid therapy effects on pruritus and fatigue in primary biliary cirrhosis","volume":"26","author":"Ghent","year":"1997","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB71|cit71","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/hep.1840190512","article-title":"The Canadian Multicenter Double-blind Randomized Controlled Trial of ursodeoxycholic acid in primary biliary cirrhosis","volume":"19","author":"Heathcote","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB72|cit72","series-title":"XII International Bile Acid Meeting. Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Basel. Falk Symposium No. 68","first-page":"45","article-title":"A double blind randomized controlled multi-centre trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC): results from a blinded interim analysis","author":"Heathcote","year":"1992"},{"key":"10.1002\/14651858.CD000551.pub2-BIB73|cit73","first-page":"91A","article-title":"The Canadian multi-centre double blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis [AASLD abstract]","volume":"16","author":"Heathcote","year":"1992","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB74|cit74","first-page":"A914","article-title":"A four-year follow-up study of ursodeoxycholic acid therapy for primary biliary cirrhosis","volume":"104","author":"Heathcote","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB75|cit75","series-title":"Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Falk Symposium 68","first-page":"294","article-title":"A double-blind randomized controlled multicentre trial of ursodeoxycholic acid in primary biliary cirrhosis: results from a 1991 interim analysis","author":"Heathcote","year":"1993"},{"key":"10.1002\/14651858.CD000551.pub2-BIB76|cit76","first-page":"1148","article-title":"Is the Mayo model for predicting survival useful after the introduction of ursodeoxycholic acid treatment for primary biliary cirrhosis?","volume":"23","author":"Kilmurry","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB77|cit77","series-title":"XV International Bile Acid Meeting. Bile Acids and Cholestasis. Titisee, Germany. Falk Symposium No 108","first-page":"59","article-title":"Ursodeoxycholic acid reduces fibrosis in primary biliary cirrhosis (Abstract)","author":"Neuman","year":"1998"},{"key":"10.1002\/14651858.CD000551.pub2-BIB78|cit78","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/0300-9084(91)90098-L","article-title":"Ursodeoxycholic acid (UDCA) in the treatment of chronic cholestatic diseases","volume":"73","author":"Calmus","year":"1991","journal-title":"Biochimie"},{"key":"10.1002\/14651858.CD000551.pub2-BIB79|cit79","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1053\/jhep.2000.20240","article-title":"The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis","volume":"32","author":"Corpechot","year":"2000","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB80|cit80","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/hep.510290444","article-title":"Histopathologic study of primary biliary cirrhosis and the effect of ursodeoyxhcolic acid treatment on histological progression","volume":"29","author":"Degott","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB81|cit81","first-page":"202A","article-title":"Long term effect of ursodeoxycholic acid (UDCA) on hepatic function and portal hypertension in primary biliary cirrhosis (PBC) [AASLD abstract]","volume":"20","author":"Huet","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB83|cit82","series-title":"XII International Bile Acid Meeting. Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. Basel. Falk Symposium No. 68","first-page":"118","article-title":"Effects of ursodeoxycholic acid (UDCA) on hepatic function and portal hypertension in primary biliary cirrhosis (PBC)","author":"Huet","year":"1992"},{"key":"10.1002\/14651858.CD000551.pub2-BIB82|cit83","first-page":"907","article-title":"Effects of ursodeoxycholic acid (UDCA) on hepatic function and portal hypertension in primary biliary cirrhosis (PBC) [AASLD abstract]","volume":"12","author":"Huet","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB85|cit84","series-title":"International Lugano Symposium on Biliary Physiology and Diseases: Strategies for the Treatment of Hepatobiliary Diseases. Lugano. Falk Symposium No. 53","first-page":"22","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis","author":"Poupon","year":"1989"},{"key":"10.1002\/14651858.CD000551.pub2-BIB84|cit85","series-title":"Strategies for the Treatment of Hepatobiliary Diseases. Falk Symposium 53","first-page":"79","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis","author":"Poupon","year":"1990"},{"key":"10.1002\/14651858.CD000551.pub2-BIB86|cit86","series-title":"First International Symposium. Trends and Discovery in Bile Acid Research. Bora-Bora (French Polynesia)","first-page":"123","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis","author":"Poupon","year":"1990"},{"issue":"6 Suppl 2","key":"10.1002\/14651858.CD000551.pub2-BIB87|cit87","first-page":"48","article-title":"A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis","volume":"115","author":"Poupon","year":"1991","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB88|cit88","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJM199105303242204","article-title":"A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis","volume":"324","author":"Poupon","year":"1991","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB89|cit89","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/hep.1840190314","article-title":"Predictive factors in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: role of serum markers of connective tissue","volume":"19","author":"Poupon","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB90|cit90","first-page":"872","article-title":"Beneficial effect of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC). Final results of the French Canadian trial [AASLD abstract]","volume":"12","author":"Poupon","year":"1990","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB91|cit91","first-page":"91A","article-title":"Ursodeoxycholic therapy for primary biliary cirrhosis: a four year controlled study","volume":"16","author":"Poupon","year":"1992","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB92|cit92","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.1840170412","article-title":"Serum bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid therapy","volume":"17","author":"Poupon","year":"1993","journal-title":"Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB93|cit93","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0168-8278(90)90265-S","article-title":"Ursodeoxycholic acid for the treatment of primary biliary cirrhosis. Interim analysis of a double-blind multicentre randomized trial. The UDCA-PBC Study Group","volume":"11","author":"Poupon","year":"1990","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB94|cit94","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hep.1840170408","article-title":"Cholesterol-lowering effect of ursodeoxycholic acid in patients with primary biliary cirrhosis","volume":"17","author":"Poupon","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB95|cit95","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM199405123301903","article-title":"Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group [see comments]","volume":"330","author":"Poupon","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB96|cit96","first-page":"639","article-title":"Ursodeoxycholic acid (UDCA) for treatment of primary biliary cirrhosis (PBC). Interim analysis of a double-blind multicenter randomized trial","volume":"10","author":"Poupon","year":"1989","journal-title":"Hepatology"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB97|cit97","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/hep.510290301","article-title":"Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis","volume":"29","author":"Angulo","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB98|cit98","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0168-8278(99)80136-6","article-title":"Comparison of three doses of ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a randomized trial","volume":"30","author":"Angulo","year":"1999","journal-title":"J Hepatol"},{"issue":"874","key":"10.1002\/14651858.CD000551.pub2-BIB99|cit99","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/pgmj.74.874.482","article-title":"Ursodeoxycholic acid therapy for primary biliary cirrhosis. A 10-year British single-centre population-based audit of efficacy and survival","volume":"74","author":"Bateson","year":"1998","journal-title":"Postgraduate Medical Journal"},{"issue":"7","key":"10.1002\/14651858.CD000551.pub2-BIB100|cit100","first-page":"215","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis","volume":"136","author":"Brodanova","year":"1997","journal-title":"Casopis Lekaru Ceskych"},{"issue":"5","key":"10.1002\/14651858.CD000551.pub2-BIB101|cit101","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gut.43.5.705","article-title":"Fatigue in primary biliary cirrhosis","volume":"43","author":"Cauch-Dudek","year":"1998","journal-title":"Gut"},{"key":"10.1002\/14651858.CD000551.pub2-BIB102|cit102","first-page":"367","article-title":"Prolonged treatment with ursodeoxycholic acid for primary biliary cirrhosis","volume":"146","author":"Crippa","year":"1995","journal-title":"Clinical Therapeutics"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB103|cit103","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF02213140","article-title":"Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study","volume":"41","author":"Crosignani","year":"1996","journal-title":"Digestive Diseases and Sciences"},{"issue":"34","key":"10.1002\/14651858.CD000551.pub2-BIB104|cit104","first-page":"695","article-title":"Treatment of primary biliary cirrhosis with ursodeoxycholic acid. Part 2: Prospective long-term trial in 21 patients","volume":"106","author":"Eisenburg","year":"1988","journal-title":"Fortschritte der Medizin"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB105|cit105","first-page":"321","article-title":"Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A controlled comparison with ursodeoxycholic acid","volume":"143","author":"Ferri","year":"1993","journal-title":"Clinica Terapeutica"},{"issue":"5","key":"10.1002\/14651858.CD000551.pub2-BIB106|cit106","first-page":"367","article-title":"Prolonged treatment with ursodeoxycholic acid for primary biliary cirrhosis","volume":"146","author":"Crippa","year":"1995","journal-title":"Clinica Terapeutica"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB107|cit107","first-page":"62","article-title":"Efficacy of ursodeoxycholic acid in lowering alanine aminotransferase and gamma-glutamyl transpeptidase serum levels in patients with chronic active hepatitis and primary biliary cirrhosis","volume":"47","author":"Id\u00e9o","year":"1990","journal-title":"Current Therapeutic Research Clinical and Experimental"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB108|cit108","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-8278(96)80191-7","article-title":"Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: A prospective randomized study","volume":"24","author":"Ikeda","year":"1996","journal-title":"Journal of Hepatology"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD000551.pub2-BIB109|cit109","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/0168-8278(91)91511-E","article-title":"Effect of UDCA on the natural course of PBC","volume":"13","author":"Kehagioglou","year":"1991","journal-title":"Journal of Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB110|cit110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/hep.510260103","article-title":"Does antimitochondrial antibody status affect response to treatment in patients with primary biliary cirrhosis? Outcomes of ursodeoxycholic acid therapy and liver transplantation","volume":"26","author":"Kim","year":"1997","journal-title":"Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB111|cit111","first-page":"11","article-title":"Ursodeoxycholic acid treatment in primary biliary cirrhosis with the emphasis on late stage disease","volume":"41","author":"Kneppelhout","year":"1992","journal-title":"Netherlands Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB112|cit112","first-page":"231","article-title":"Effects of ursodeoycholic acid treatment on bilirubin concentration and survival of patients with primary biliary cirrhosis","volume":"6","author":"Krzeski","year":"1999","journal-title":"Gastroenterol Pol (Gastroenterologia-Polska)"},{"issue":"2","key":"10.1002\/14651858.CD000551.pub2-BIB113|cit113","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-2036.1997.124295000.x","article-title":"Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: A pilot crossover study","volume":"11","author":"Larghi","year":"1997","journal-title":"Alimentary Pharmacology and Therapeutics"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB114|cit114","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0168-8278(96)80327-8","article-title":"Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis","volume":"25","author":"Leuschner","year":"1996","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB115|cit115","series-title":"XV International Bile Acid Meeting. Bile Acids and Cholestasis. Falk Symposium No 108. Titisee, Germany","first-page":"62","article-title":"Determining the most efficacious dose of ursodeoxycholic acid in primary biliary cirrhosis (Abstract)","author":"Verma","year":"1998"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB116|cit116","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0168-8278(90)90134-D","article-title":"Ursodeoxycholic acid in primary biliary cirrhosis: No evidence for toxicity in the stages I to III","volume":"10","author":"Lotterer","year":"1990","journal-title":"Journal of Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB117|cit117","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00004836-199401000-00010","article-title":"Biochemical and histological changes after more than four years of treatment of ursodeoxycholic acid in primary biliary cirrhosis","volume":"18","author":"Matsuzaki","year":"1994","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"1","key":"10.1002\/14651858.CD000551.pub2-BIB118|cit118","first-page":"15","article-title":"Improvement of biliary enzyme levels and itching as a result of long-term administration of ursodeoxycholic acid in primary biliary cirrhosis","volume":"85","author":"Matsuzaki","year":"1990","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB119|cit119","first-page":"438 A","article-title":"Comparison of three different doses of ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a randomized trial","volume":"26","author":"Lindor","year":"1997","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB120|cit120","first-page":"1221 (A)","article-title":"Ursodeoxycholic acid improves liver function and reduces serum and urinary endogenous bile acids in primary biliary cirrhosis","volume":"8","author":"Batta","year":"1988","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB121|cit121","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0022-2275(20)38207-9","article-title":"Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment","volume":"30","author":"Batta","year":"1989","journal-title":"Journal of Lipid Research"},{"key":"10.1002\/14651858.CD000551.pub2-BIB122|cit122","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.1840100404","article-title":"Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis","volume":"10","author":"Batta","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB123|cit123","first-page":"1065 (A)","article-title":"Ursodeoxycholic acid treatment of primary biliary cirrhosis","volume":"83","author":"Eskreis","year":"1988","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB124|cit124","first-page":"691","article-title":"Effect of long-term treatment with ursodiol on clinical and biochemical features and biliary bile acid metabolism in patients with primary biliary cirrhosis","volume":"88","author":"Batta","year":"1993","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB125|cit125","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2957\/kanzo.34.306","article-title":"Effect of urosodeoxycholic acid therapy on lymphocyte function of patients with primary biliary cirrhosis","volume":"34","author":"Ogino","year":"1993","journal-title":"Acta Hepatologica Japonica"},{"issue":"6","key":"10.1002\/14651858.CD000551.pub2-BIB126|cit126","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2957\/kanzo.29.799","article-title":"A case of primary biliary cirrhosis - 4 years' treatment with 300 mg\/day ursodeoxycholic acid","volume":"29","author":"Okuyama","year":"1988","journal-title":"Acta Hepatologica Japonica"},{"issue":"12 SUPPL.","key":"10.1002\/14651858.CD000551.pub2-BIB127|cit127","doi-asserted-by":"crossref","first-page":"49S","DOI":"10.1007\/BF01536663","article-title":"Effect of ursodeoxycholic acid in chronic hepatitis and primary biliary cirrhosis","volume":"34","author":"Osuga","year":"1989","journal-title":"Digestive Diseases and Sciences"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB128|cit128","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/0016-5085(92)90781-S","article-title":"Progression of primary biliary cirrhosis with ursodeoxycholic acid therapy","volume":"102","author":"Perdigoto","year":"1992","journal-title":"Gastroenterology"},{"issue":"(SUPPL. 2)","key":"10.1002\/14651858.CD000551.pub2-BIB129|cit129","first-page":"S25","article-title":"Ursodeoxycholic acid for chronic liver diseases","volume":"10","author":"Podda","year":"1988","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"12 SUPPL.","key":"10.1002\/14651858.CD000551.pub2-BIB130|cit130","doi-asserted-by":"crossref","first-page":"59S","DOI":"10.1007\/BF01536665","article-title":"Effect of different doses of ursodeoxycholic acid in chronic liver disease","volume":"34","author":"Podda","year":"1989","journal-title":"Digestive Diseases and Sciences"},{"issue":"8537","key":"10.1002\/14651858.CD000551.pub2-BIB131|cit131","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0140-6736(87)91610-2","article-title":"Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?","volume":"1","author":"Poupon","year":"1987","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000551.pub2-BIB132|cit132","first-page":"637","article-title":"Ursodeoxycholic acid improves histologic features and progression of primary biliary cirrhosis","author":"Poupon","year":"1989","journal-title":"Hepatology"},{"issue":"5","key":"10.1002\/14651858.CD000551.pub2-BIB133|cit133","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/hep.510240520","article-title":"A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis","volume":"24","author":"Poupon","year":"1996","journal-title":"Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB134|cit134","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1159\/000201472","article-title":"Serial quantitative liver function tests in patients with primary biliary cirrhosis: A prospective long-term study","volume":"58","author":"Schonfeld","year":"1997","journal-title":"Digestion"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB135|cit135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1440-1746.1992.tb00980.x","article-title":"Combination therapy with ursodeoxycholic acid and colchicine for primary biliary cirrhosis","volume":"7","author":"Shibata","year":"1992","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"3 I","key":"10.1002\/14651858.CD000551.pub2-BIB136|cit136","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/hep.1840120308","article-title":"Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis","volume":"12","author":"Stiehl","year":"1990","journal-title":"Hepatology"},{"issue":"6","key":"10.1002\/14651858.CD000551.pub2-BIB137|cit137","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00042737-199406000-00015","article-title":"Does cholestyramine reduce the efficacy of ursodeoxycholic acid in primary biliary cirrhosis?","volume":"6","author":"Taha","year":"1994","journal-title":"European Journal of Gastroenterology and Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB138|cit138","first-page":"376","article-title":"A case of primary biliary cirrhosis with a histological improvement after long-term therapy with ursodeoxycholic acid","volume":"45","author":"Takezaki","year":"1991","journal-title":"IRYO Japanese Journal of National Medical Services"},{"key":"10.1002\/14651858.CD000551.pub2-BIB139|cit139","first-page":"443","article-title":"Dose-dependency of effect of ursodeoxycholic acid on primary biliary cirrhosis: a randomised, double-blind controlled study","volume":"37","author":"Toda","year":"1998","journal-title":"KAN-TAN-SUI (Japan)"},{"key":"10.1002\/14651858.CD000551.pub2-BIB140|cit140","series-title":"XI International Bile Acid Meeting. Bile Acids as Therapeutic Agents - From Basic Science to Clinical Practice. Freiburg","first-page":"Abstract No. 77","article-title":"Effects of ursodeoxycholic acid on lymphocyte functions in primary biliary cirrhosis","author":"Unoura","year":"1990"},{"key":"10.1002\/14651858.CD000551.pub2-BIB141|cit141","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0168-8278(96)80293-5","article-title":"Single or multiple dose ursodeoxycholic acid for cholestatic liver disease: biliary enrichment and biochemical response","volume":"25","author":"Meeberg","year":"1996","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB142|cit142","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.1365-2036.1998.00395.x","article-title":"A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg\/kg or 20 mg\/kg. Dutch Multicentre PBC Study Group","volume":"12","author":"Hoogstraten","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"issue":"10","key":"10.1002\/14651858.CD000551.pub2-BIB143|cit143","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/00042737-199910000-00001","article-title":"Optimum dose of ursodeoxycholic acid in primary biliary cirrhosis","volume":"11","author":"Verma","year":"1999","journal-title":"European Journal of Gastroenterology and Hepatology"},{"issue":"19","key":"10.1002\/14651858.CD000551.pub2-BIB144|cit144","first-page":"810","article-title":"Eosinophilia in primary biliary cirrhosis: Regression under therapy with ursodeoxycholic acid","volume":"124","author":"Wirth","year":"1994","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"15","key":"10.1002\/14651858.CD000551.pub2-BIB145|cit145","first-page":"750","article-title":"Subtype pattern of antimitochondrial antibodies in primary biliary cirrhosis and response to ursodeoxycholic acid","volume":"125","author":"Wirth","year":"1995","journal-title":"Schweizerische Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD000551.pub2-BIB146|cit146","first-page":"84","article-title":"Combined treatment with ursodeoxycholic acid and prednisone in primary biliary cirrhosis","volume":"44","author":"Wolfhagen","year":"1994","journal-title":"The Netherlands Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB147|cit147","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2957\/kanzo.33.348","article-title":"A patient with asymptomatic primary biliary cirrhosis associated with eosinophilic infiltration and peripheral eosinophilia improved by the administration of ursodeoxycholic acid","volume":"33","author":"Yamazaki","year":"1992","journal-title":"Acta Hepatologica Japonica"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB148|cit148","first-page":"516","article-title":"Eosinophilia in primary biliary cirrhosis","volume":"91","author":"Yamazaki","year":"1996","journal-title":"American Journal of Gastroenterology"},{"issue":"2","key":"10.1002\/14651858.CD000551.pub2-BIB149|cit149","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2957\/kanzo.37.102","article-title":"Rapid improvement of intractable pruritus in a case with primary biliary cirrhosis by a combined therapy of ursoderoxycholate (UDCA) and cholestyramine (CS) - Serum bile acid analysis","volume":"37","author":"Yokomori","year":"1996","journal-title":"Acta Hepatologica Japonica"},{"issue":"5","key":"10.1002\/14651858.CD000551.pub2-BIB150|cit150","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00005792-199409000-00005","article-title":"Primary biliary cirrhosis (classical article)","volume":"73","author":"Ahrens","year":"1994","journal-title":"Medicine-Baltimore"},{"key":"10.1002\/14651858.CD000551.pub2-BIB151|cit151","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S0140-6736(00)02039-0","article-title":"Subgroup analysis and other (mis)uses of baseline data in clinical trials","volume":"355","author":"Assmann","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000551.pub2-BIB152|cit152","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2288-3-16","article-title":"A perfect correlate dose not a surrogate make","volume":"3","author":"Baker","year":"2003","journal-title":"BMC Medical Research Methodology"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB153|cit153","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1002\/14651858.CD000551.pub2-BIB154|cit154","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0016-5085(92)90855-S","article-title":"Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse","volume":"103","author":"Calmus","year":"1992","journal-title":"Gastroenterogy"},{"key":"10.1002\/14651858.CD000551.pub2-BIB155|cit155","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/sim.4780060325","article-title":"Methods of combining randomized clinical trials: strengths and limitations","volume":"6","author":"DeMets","year":"1987","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB156|cit156","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clin Trials"},{"key":"10.1002\/14651858.CD000551.pub2-BIB157|cit157","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD000551.pub2-BIB158|cit158","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jclinepi.2004.09.013","article-title":"Uncertainty method improved on best\/worst case analysis in a binary meta-analysis","volume":"58","author":"Gamble","year":"2005","journal-title":"Journal of Clinical Epidemiology"},{"issue":"5","key":"10.1002\/14651858.CD000551.pub2-BIB159|cit159","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0168-8278(01)00061-7","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis - lessons for the future","volume":"34","author":"Gluud","year":"2001","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB160|cit160","unstructured":"Gluud C Als-Nielsen B D'Amico G Gluud LL Khan S Klingenberg SL Hepato-Biliary Group About The Cochrane Collaboration (Collaborative Review Groups (CRGs))"},{"key":"10.1002\/14651858.CD000551.pub2-BIB161|cit161","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jhep.2007.01.003","article-title":"Hepatology may have problems with putative surrogate outcome measures","volume":"46","author":"Gluud","year":"2007","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB162|cit162","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0140-6736(98)11293-X","article-title":"Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis","volume":"354","author":"Goulis","year":"1999","journal-title":"The Lancet"},{"key":"10.1002\/14651858.CD000551.pub2-BIB163|cit163","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB164|cit164","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006] In: The Cochrane Library, Issue 4, 2006. Chichester, UK: John Wiley & Sons, Ltd"},{"key":"10.1002\/14651858.CD000551.pub2-BIB165|cit165","volume-title":"Code of Federal Regulation & ICH Guidelines","year":"1997"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB166|cit166","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1073\/pnas.98.3.831","article-title":"Evolution of treatment effects over time: empirical insight from recursive cumulative metaanalyses","volume":"98","author":"Ioannidis","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1002\/14651858.CD000551.pub2-BIB167|cit167","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0016-5085(94)94899-2","article-title":"Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid","volume":"106","author":"Jazrawi","year":"1994","journal-title":"Gastroenterogy"},{"issue":"21","key":"10.1002\/14651858.CD000551.pub2-BIB168|cit168","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJM199611213352107","article-title":"Primary biliary cirrhosis","volume":"335","author":"Kaplan","year":"1996","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB169|cit169","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Kaplan","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB170|cit170","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1053\/gast.2000.20197","article-title":"Epidemiology and natural history of primary biliary cirrhosis in a U.S. community","volume":"119","author":"Kim","year":"2000","journal-title":"Gatroenterology"},{"issue":"11","key":"10.1002\/14651858.CD000551.pub2-BIB171|cit171","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodological quality and discrepancies between large and small randomized trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB172|cit172","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jhep.2005.06.017","article-title":"Agreement between reported use of interventions for liver diseases and research evidence in Cochrane systematic reviews","volume":"43","author":"K\u00fcrstein","year":"2005","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB173|cit173","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7326\/0003-4819-30-1-121","article-title":"Xanthomatous biliary cirrhosis (a clinical syndrome)","volume":"30","author":"MacMahon","year":"1949","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB174|cit174","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ncpgasthep0360","article-title":"Patients and patience: the pitfalls of primary biliary cirrhosis trials","volume":"2","author":"Mayo","year":"2005","journal-title":"Nature Clinical Practise Gastroenterology & Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB175|cit175","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD000551.pub2-BIB176|cit176","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7326\/0003-4819-116-1-78","article-title":"A consumer's guide to subgroup analyses","volume":"116","author":"Oxman","year":"1992","journal-title":"Annals of Internal Medicine"},{"issue":"3","key":"10.1002\/14651858.CD000551.pub2-BIB177|cit177","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB178|cit178","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1055\/s-2007-1007193","article-title":"Survival algorithms and outcome analysis in primary biliary cirrhosis","volume":"17","author":"Pasha","year":"1997","journal-title":"Seminars in Liver Disease"},{"key":"10.1002\/14651858.CD000551.pub2-BIB179|cit179","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/hep.510290116","article-title":"Cost-effectiveness of ursodeoxycholic acid therapy in primary biliary cirrhosis","volume":"29","author":"Pasha","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB180|cit180","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0016-5085(97)70183-5","article-title":"Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis","volume":"113","author":"Poupon","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB181|cit181","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0168-8278(00)80232-9","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis: lessons from the past - issues for the future","volume":"32","author":"Poupon","year":"2000","journal-title":"J Hepatol"},{"key":"10.1002\/14651858.CD000551.pub2-BIB182|cit182","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1053\/gast.2002.36027","article-title":"Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years","volume":"123","author":"Prince","year":"2002","journal-title":"Gatroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB183|cit183","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1089-3261(03)00102-8","article-title":"The epidemiology of primary biliary cirrhosis","volume":"7","author":"Prince","year":"2003","journal-title":"Clinics in Liver Disease"},{"issue":"2","key":"10.1002\/14651858.CD000551.pub2-BIB184|cit184","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1385\/CRIAI:28:2:135","article-title":"Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis","volume":"28","author":"Rust","year":"2005","journal-title":"Clinical Review in Allergy & Immunology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB185|cit185","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methdological quality associated with estimates of treatment in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD000551.pub2-BIB186|cit186","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1002\/1097-0258(20001215)19:23<3251::AID-SIM625>3.0.CO;2-2","article-title":"Analying the relationship between treatment effect and underlying risk in meta-analysis: comparison and development of approaches","volume":"19","author":"Sharp","year":"2000","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB187|cit187","first-page":"392","article-title":"Ursodeoxycholic therapy in chronic liver disease: a meta-analysis in primary biliary cirrhosis and in chronic hepatitis","volume":"89","author":"Simko","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD000551.pub2-BIB188|cit188","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(03)13808-1","article-title":"Primary biliary cirrhosis","volume":"362","author":"Talwalkar","year":"2003","journal-title":"The Lancet"},{"issue":"11","key":"10.1002\/14651858.CD000551.pub2-BIB189|cit189","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/sim.1187","article-title":"How should meta-regression analyses be undertaken and interpreted?","volume":"21","author":"Thompson","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD000551.pub2-BIB190|cit190","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/0470854200.ch11","article-title":"A Bayesian approach to meta-analysis","volume-title":"Meta-analysis of controlled clinical trials","author":"Whitehead","year":"2002"},{"key":"10.1002\/14651858.CD000551.pub2-BIB191|cit191","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jama.1991.03470010097038","article-title":"Analysis and interpretation of treatment effects in subgroups of patients in randomised clinical trials","volume":"266","author":"Yusuf","year":"1991","journal-title":"JAMA"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB192|cit192","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis (Protocol)","author":"Christensen","year":"1997","journal-title":"The Cochrane Library"},{"issue":"2","key":"10.1002\/14651858.CD000551.pub2-BIB193|cit193","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis (Updated protocol)","author":"Gluud","year":"1999","journal-title":"The Cochrane Library"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD000551.pub2-BIB194|cit194","first-page":"83 (Abstract)","article-title":"Ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC) - a Cochrane Hepato-Biliary systematic review","volume":"30","author":"Gluud","year":"1999","journal-title":"Journal of Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD000551.pub2-BIB195|cit195","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000551","article-title":"Ursodeoxycholic acid for primary biliary cirrhosis","author":"Gluud","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd000551.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD000551.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T16:12:18Z","timestamp":1631635938000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD000551.pub2"}},"subtitle":[],"editor":[{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2008,7,16]]},"references-count":195,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd000551.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD000551.pub3","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2008,7,16]]}}}