{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:47:19Z","timestamp":1787687239723,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd000953","type":"journal-article","created":{"date-parts":[[2003,11,20]],"date-time":"2003-11-20T21:47:03Z","timestamp":1069364823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Iloprost and cisaprost for Raynaud's phenomenon in progressive systemic sclerosis"],"prefix":"10.1002","author":[{"given":"Janet","family":"Pope","sequence":"first","affiliation":[{"name":"University of Western Ontario; Dept of Medicine and Epidemiology and Biostatistics; St. Joseph's Health Care 268 Grosvenor St London Ontario Canada N6A 4V2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Fenlon","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, University of Western Ontario; Department of Surgery; 375 South Street, Suite N345 London Ontario Canada N6A 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Thompson","sequence":"additional","affiliation":[{"name":"St Joseph's Health Care; Department of Rheumatology; 268 Grosvenor Street London Ontario Canada N6A 4V2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"Shea","sequence":"additional","affiliation":[{"name":"University of Ottawa; Institute of Population Health; 1 Stewart St. Room 312 Ottawa Ontario Canada K1N 6N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Furst","sequence":"additional","affiliation":[{"name":"Virginia Mason Research Center; 10000 Seneca Street Seattle WA 98101 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A","family":"Wells","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute; Cardiovascular Research Reference Centre; Room H1-1 40 Ruskin Street Ottawa Ontario Canada K1Y 4W7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Silman","sequence":"additional","affiliation":[{"name":"University of Manchester; ARC Epidemiology Research Unit; Stopford Building, Oxford Road Manchester UK M13 9PT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,4,27]]},"reference":[{"issue":"3","key":"10.1002\/14651858.CD000953-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/ard.54.3.197","article-title":"Cooke ED.Kirby JD.Lau CS.Madhok R.Murphy E. Oral iloprost as a treatment for Raynaud's syndrome: a double blind multicentre placebo controlled study","volume":"54","author":"Belch","year":"1995","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1002\/14651858.CD000953-BIB0002|cit2","first-page":"1403","article-title":"Placebo Controlled Study Showing Therapeutic Benefit of Iloprost in the Treatment of Raynaud's Phenomenon","volume":"19","author":"Kyle","year":"1992","journal-title":"Journal of Rheumatology"},{"issue":"1","key":"10.1002\/14651858.CD000953-BIB0003|cit3","first-page":"35","article-title":"Madhok R.Cappell H.Herrick A.Jayson M.Thompson JM. A randomised, double-blind study of cicaprost, an oral prostacyclin analogue, in the treatment of Raynaud's phenomenon secondary to systemic sclerosis","volume":"11","author":"Lau","year":"1993","journal-title":"Clinical & Experimental Rheuma tology"},{"issue":"1","key":"10.1002\/14651858.CD000953-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/ard.47.1.43","article-title":"Watson H.Belcher G.Amadi A.Ring EF.Black CM. Infusion of iloprost, a prostacyclin analogue, for treatment of Raynaud's phenomenon in systemic sclerosis","volume":"47","author":"McHugh","year":"1988","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"9","key":"10.1002\/14651858.CD000953-BIB0005|cit5","first-page":"1407","article-title":"Intravenous iloprost treatment of Raynaud's phenomenon and ischemic ulcers secondary to systemic sclerosis","volume":"19","author":"Wigley","year":"1992","journal-title":"Journal of Rheumatology"},{"issue":"3","key":"10.1002\/14651858.CD000953-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-120-3-199402010-00004","article-title":"Intravenous iloprost infusion in patients with Raynaud phenomenon secondary to systemic sclerosis. A multicenter, placebo-controlled, double-blind study","volume":"120","author":"Wigley","year":"1994","journal-title":"Annals of Internal Medicine"},{"issue":"3","key":"10.1002\/14651858.CD000953-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/rheumatology\/27.3.220","article-title":"Rustin M.Belcher G.Snaith ML.Dowd PM.Machin SJ. Successful treatment of Raynaud's syndrome with Iloprost, a chemically stable prostacyclin analogue","volume":"27","author":"Yardumian","year":"1988","journal-title":"British Journal of Rheumatology"},{"issue":"8320","key":"10.1002\/14651858.CD000953-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0140-6736(83)91624-0","article-title":"Intermittent epoprostenol (prostacyclin) infusion in patients with Raynaud's syndrome. A double-blind controlled trial","volume":"1","author":"Belch","year":"1983","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD000953-BIB0009|cit9","first-page":"271","article-title":"Saniabadi A.Scott N.Belch JJ. The pharmacological effects of cicaprost, an oral prostacyclin analogue, in patients with Raynaud's syndrome secondary to systemic sclerosis--a preliminary study","volume":"9","author":"Lau","year":"1991","journal-title":"Clinical & Experimental Rheumatology"},{"issue":"4","key":"10.1002\/14651858.CD000953-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/jca.2920010404","article-title":"Osmundson PJ.Pineda AA. Plasma exchange: a controlled study of the effect in patients with Raynaud's phenomenon and scleroderma","volume":"1","author":"McCune","year":"1983","journal-title":"Journal of Clinical Apheresis"},{"issue":"11","key":"10.1002\/14651858.CD000953-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/ard.44.11.754","article-title":"Smith EA.Belch J.Simms MH. A multiclinic, placebo-controlled, double-blind study of prostaglandin E1 in Raynaud's syndrome","volume":"44","author":"Mohrland","year":"1985","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"11","key":"10.1002\/14651858.CD000953-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/ard.50.11.800","article-title":"A double blind, randomised, multicentre comparison of two doses of intravenous iloprost in the treatment of Raynaud's phenomenon secondary to connective tissue diseases","volume":"50","author":"Torley","year":"1991","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1002\/14651858.CD000953-BIB0013|cit13","doi-asserted-by":"crossref","unstructured":"van den Hoogen F H.J., van de Putte,L.B.A. Treatment of systemic sclerosis 637 641","DOI":"10.1097\/00002281-199411000-00015"},{"key":"10.1002\/14651858.CD000953-BIB0014|cit14","first-page":"1917","article-title":"Controlled Multicenter Double Blind Trial of an Oral Analog of Prostacyclin in the Treatment of Primary Raynaud's Phenomenon","volume":"23","author":"Vayssairat","year":"1996","journal-title":"Journal of Rheumatology"},{"issue":"1","key":"10.1002\/14651858.CD000953-BIB0015|cit15","first-page":"80","article-title":"Acute effects of misoprostol on digital circulation in patients with Raynaud's phenomenon","volume":"21","author":"Wise","year":"1994","journal-title":"Journal of Rheumatology"},{"key":"10.1002\/14651858.CD000953-BIB0016|cit16","first-page":"739","article-title":"Effetti della terapia a lungo termine con iloprost sul fenomeno di Raynaud nella sclerosi sistemica progressiva","volume":"83","author":"Cordioli","year":"1992","journal-title":"Minerva Medica"},{"key":"10.1002\/14651858.CD000953-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780230510","article-title":"ARA Preliminary criteria for the classification of systemic sclerosis (scleroderma): Special article","volume":"23","year":"1980","journal-title":"Arthritis and Rheumatism"},{"key":"10.1002\/14651858.CD000953-BIB0018|cit18","unstructured":"Cohen J Statistical Power Analysis for the Behavioural Sciences. Hillside, New Jersey: Lawrence Erlbaum Associates, Inc 1988 21 34"},{"key":"10.1002\/14651858.CD000953-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/bmj.309.6964.1286","article-title":", Scherer R., Lefebvre C. Identifying relevant studies for systematic reviews","volume":"309","author":"Dickersin","year":"1994","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD000953-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":", Moore A., Carrol D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD000953-BIB0021|cit21","first-page":"994","article-title":"Systemic sclerosis (scleroderma), eosinophilic fasciitis, and calcinosis","volume-title":"Arthritis and Allied Conditions","author":"Medsger","year":"1985"},{"key":"10.1002\/14651858.CD000953-BIB0022|cit22","first-page":"90","volume-title":"Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine","author":"Petitti","year":"1994"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD000953\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T20:58:34Z","timestamp":1628542714000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD000953"}},"subtitle":[],"editor":[{"name":"Cochrane Musculoskeletal Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[1998,4,27]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd000953","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4,27]]}}}