{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:36:53Z","timestamp":1789371413182,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd001058.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000}}],"reference-count":118,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd001058.pub3","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T15:14:10Z","timestamp":1385997250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Antibiotics for preterm rupture of membranes"],"prefix":"10.1002","volume":"2013","author":[{"given":"Sara","family":"Kenyon","sequence":"first","affiliation":[{"name":"University of Birmingham; School of Health and Population Sciences; Public Health Building Edgbaston UK B15 2TT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boulvain","sequence":"additional","affiliation":[{"name":"Maternit\u00e9 H\u00f4pitaux Universitaires de Gen\u00e8ve; D\u00e9partement de Gyn\u00e9cologie et d'Obst\u00e9trique, Unit\u00e9 de D\u00e9veloppement en Obst\u00e9trique; Boulevard de la Cluse, 32 Gen\u00e8ve 14 Switzerland CH-1211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Neilson","sequence":"additional","affiliation":[{"name":"The University of Liverpool; Department of Women's and Children's Health; First Floor, Liverpool Women's NHS Foundation Trust Crown Street Liverpool UK L8 7SS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"10.1002\/14651858.CD001058.pub3-BIB0001|cit1","doi-asserted-by":"crossref","unstructured":"Amon E Lewis S Sibai BM Moretti M Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study Proceedings of 8th Annual Meeting of the Society of Perinatal Obstetricians; 1988 Feb 3-6; Las Vegas, Nevada, USA 1988 51","DOI":"10.1016\/S0002-9378(88)80002-4"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0002-9378(88)80002-4","article-title":"Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study","volume":"159","author":"Amon","year":"1988","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0003|cit3","first-page":"138","article-title":"Antibiotherapy in preterm premature rupture of membrane. Does it affect the latent period and infectious morbidity?","volume":"11","author":"Camli","year":"1997","journal-title":"Jinekoloji Ve Obstetrik Dergisi"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0004|cit4","first-page":"759","article-title":"Expectant management of preterm ruptured membranes: effects of antimicrobial therapy","volume":"80","author":"Christmas","year":"1992","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0005|cit5","unstructured":"Christmas JT Cox SM Gilstrap LC Leveno KJ Andrews W Dax J Expectant management of preterm ruptured membranes: effects of antimicrobial therapy on interval to delivery Proceedings of 10th Annual Meeting of Society of Perinatal Obstetricians; 1990 Jan 23-27; Houston, Texas, USA 1990 19"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0002-9378(95)91246-0","article-title":"Ruptured membranes at 24 to 29 weeks: a randomized double blind trial of antimicrobials versus placebo","volume":"172","author":"Cox","year":"1995","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD001058.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0002-9378(94)70220-9","article-title":"A prospective, randomized, placebo-controlled trial of penicillin in preterm premature rupture of membranes","volume":"170","author":"Ernest","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD001058.pub3-BIB0008|cit8","first-page":"203","article-title":"Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study","volume":"34","author":"Fuhr","year":"2006","journal-title":"Journal of Perinatal Medicine"},{"issue":"3","key":"10.1002\/14651858.CD001058.pub3-BIB0009|cit9","first-page":"96","article-title":"Erythromycin prophylaxis in preterm pregnancies with rupture of amniotic membranes","volume":"23","author":"Garcia-Burguillo","year":"1995","journal-title":"Clinica e Investigacion en Ginecologia y Obstetricia"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0002-9378(96)80049-4","article-title":"Group B streptococcus and preterm premature rupture of membranes: a randomized, double-blind clinical trial of antepartum ampicillin","volume":"175","author":"Grable","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD001058.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0002-9378(90)91060-P","article-title":"Antibiotic therapy in preterm premature rupture of membranes: a randomized, prospective, double-blind trial","volume":"163","author":"Johnston","year":"1990","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0012|cit12","unstructured":"Sanchez-Ramos L Johnston M Vaughn A Benrubi GI Todd M High dose antibiotic therapy in preterm premature rupture of the membranes: a double blind, randomized, prospective study Proceedings of 10th Annual Meeting of Society of Perinatal Obstetricians; 1990 Jan 23-27; Houston, Texas, USA 1990 18"},{"issue":"6","key":"10.1002\/14651858.CD001058.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1471-0528.2005.00558.x","article-title":"The effect of prepartum antibiotics on the type of neonatal bacteraemia: insights from the MRC ORACLE trials","volume":"112","author":"Gilbert","year":"2005","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD001058.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/adc.2010.184036","article-title":"Routine educational outcome measures in health studies: Key Stage 1 in the ORACLE Children Study follow-up of randomised trial cohorts","volume":"96","author":"Jones","year":"2011","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2393-8-14","article-title":"MRC ORACLE children study. Long term outcomes following prescription of antibiotics to pregnant women with either spontaneous preterm labour or preterm rupture of the membranes","volume":"8","author":"Kenyon","year":"2008","journal-title":"BMC Pregnancy & Childbirth"},{"issue":"9646","key":"10.1002\/14651858.CD001058.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(08)61202-7","article-title":"Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial","volume":"372","author":"Kenyon","year":"2008","journal-title":"Lancet"},{"issue":"437","key":"10.1002\/14651858.CD001058.pub3-BIB0017|cit17","first-page":"12","article-title":"ORACLE-antibiotics for preterm prelabour rupture of the membranes: short and long term outcomes","volume":"91","author":"Kenyon","year":"2002","journal-title":"Acta Paediatrica Supplement"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(00)04233-1","article-title":"Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE 1 randomised trial","volume":"357","author":"Kenyon","year":"2001","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-2007-994661","article-title":"Premature rupture of the membranes; effect of penicillin prophylaxis and long-term outcome of the children","volume":"9","author":"Kurki","year":"1992","journal-title":"American Journal of Perinatology"},{"issue":"6","key":"10.1002\/14651858.CD001058.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1067\/mob.2003.382","article-title":"Antibiotic therapy in preterm premature rupture of membranes: are seven days necessary? A preliminary randomized clinical trial","volume":"188","author":"Lewis","year":"2003","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0021|cit21","first-page":"378","article-title":"Double-blind, placebo-controlled trial of piperacillin sodium in preterm membrane rupture","volume":"168","author":"Lockwood","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/0002-9378(93)90037-J","article-title":"Double-blind, placebo-controlled trial of piperacillin prophylaxis in preterm membrane rupture","volume":"169","author":"Lockwood","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0020-7292(99)00036-3","article-title":"Prophylactic augmentin in prelabour preterm rupture of the membranes","volume":"65","author":"Magwali","year":"1999","journal-title":"International Journal of Gynecology & Obstetrics"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0025|cit24","unstructured":"McGregor JA French JI Double-blind, randomized, placebo controlled, prospective evaluation of the efficacy of short course erythromycin in prolonging gestation among women with preterm rupture of membranes Proceedings of 9th Annual Meeting of the Society of Perinatal Obstetricians; 1989 Feb 1-4; New Orleans, Louisiana, USA 1989"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0024|cit25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/0002-9378(91)90299-7","article-title":"Antimicrobial therapy in preterm premature rupture of membranes: results of a prospective, double-blind, placebo-controlled trial of erythromycin","volume":"165","author":"McGregor","year":"1991","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/0002-9378(92)91336-9","article-title":"Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients","volume":"166","author":"Mercer","year":"1992","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0027|cit27","first-page":"S15","article-title":"Impact of amnionitis and antepartum antibiotic treatment on neonatal outcome after PPROM","volume":"178","author":"Beazley","year":"1998","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S0002-9378(97)80224-4","article-title":"The NICHD-MFMU antibiotic treatment of PROM study: correlation with acute placental inflammation and prenatal morbidity","volume":"176","author":"Hauth","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ajog.2004.10.625","article-title":"Perinatal outcomes in women with preterm rupture of membranes between 24 and 32 weeks of gestation and a history of vaginal bleeding","volume":"193","author":"Hnat","year":"2005","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0031|cit30","first-page":"S8","article-title":"The NICHD-MFMU antibiotic treatment of PPROM study: evaluation of factors associated with successful outcome","volume":"176","author":"Mercer","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0030|cit31","first-page":"304","article-title":"A multicentre randomized controlled trial of antibiotic therapy versus placebo therapy after preterm premature rupture of the membranes","volume":"174","author":"Mercer","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD001058.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"145.e1","DOI":"10.1016\/j.ajog.2011.08.028","article-title":"The antibiotic treatment of PPROM study: systemic maternal and fetal markers and perinatal outcomes","volume":"206","author":"Mercer","year":"2012","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/jama.1997.03550120049032","article-title":"Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes","volume":"278","author":"Mercer","year":"1997","journal-title":"JAMA"},{"issue":"6 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0034|cit34","first-page":"S113","article-title":"Preterm premature rupture of membranes (PPROM): latency and neonatal outcome","volume":"187","author":"Ramsey","year":"2002","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S0002-9378(97)80225-6","article-title":"The NICHD-MFMU antibiotic treatment of PROM study: impact of initial amniotic fluid volume on pregnancy outcome","volume":"176","author":"Thurnau","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0036|cit36","first-page":"40","article-title":"Comparison of various parameters as predictors of chorioamnionitis in preterm patients with premature rupture of membranes","volume":"81","author":"Morales","year":"1988","journal-title":"Southern Medical Journal"},{"issue":"5","key":"10.1002\/14651858.CD001058.pub3-BIB0037|cit37","first-page":"721","article-title":"Use of ampicillin and corticosteroids in premature rupture of membranes: a randomized study","volume":"73","author":"Morales","year":"1989","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0038|cit38","first-page":"401","article-title":"Preterm premature rupture of membranes: a prospective randomized placebo controlled trial of antibiotic treatment","volume":"174(1 Pt 2)","author":"Ovalle","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0039|cit39","first-page":"S83","article-title":"Antibiotic administration in patients with preterm premature rupture of membranes reduces the rate of histological chorioamnionitis","volume":"180(1 Pt 2)","author":"Ovalle","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0040|cit40","first-page":"213","article-title":"Antibiotic therapy in patients with preterm premature rupture of membranes: a prospective, randomized, placebo-controlled study with microbiological assessment of the amniotic cavity and lower genital tract","volume":"2","author":"Ovalle-Salas","year":"1997","journal-title":"Prenatal and Neonatal Medicine"},{"issue":"4","key":"10.1002\/14651858.CD001058.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0002-9378(93)90038-K","article-title":"Randomised trial of prophylactic therapy after preterm amnion rupture","volume":"169","author":"Owen","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0042|cit42","first-page":"379","article-title":"Randomized trial of prophylactic antibiotic therapy after preterm amnion rupture","volume":"168","author":"Owen","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"6 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0043|cit43","first-page":"S72","article-title":"Optimal duration of antibiotic therapy after PPROM","volume":"187","author":"Segel","year":"2002","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1067\/S0002-9378(03)00765-8","article-title":"Duration of antibiotic therapy after preterm premature rupture of fetal membranes","volume":"189","author":"Segel","year":"2003","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0047|cit45","volume-title":"Preterm delivery and subclinical uro-genital infection [thesis]","author":"Svare","year":"1997"},{"issue":"Suppl 162","key":"10.1002\/14651858.CD001058.pub3-BIB0045|cit46","first-page":"36","article-title":"Antibiotic treatment in preterm labor or preterm premature rupture of the membranes - a randomized controlled double-blind trial","volume":"75","author":"Svare","year":"1996","journal-title":"Acta Obstetricia et Gynecologica Scandinavica Supplement"},{"issue":"167:1","key":"10.1002\/14651858.CD001058.pub3-BIB0046|cit47","first-page":"86","article-title":"Ampicillin-metronidazole treatment in threatening preterm delivery","volume":"76","author":"Svare","year":"1997","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000292046","article-title":"A randomised study on the impact of peroral amoxicillin in women with prelabour rupture of membranes preterm","volume":"41","author":"Almeida","year":"1996","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000293035","article-title":"A prospective study on the perinatal outcome in Mozambican pregnant women with preterm rupture of membranes using two different methods of clinical management","volume":"32","author":"Bergstrom","year":"1991","journal-title":"Gynecologic & Obstetric Investigation"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0002-9378(12)90700-0","article-title":"Multicenter double-blind prospective random trial of ceftizoxime vs placebo in women with preterm premature ruptured membranes (pPROM)","volume":"168","author":"Blanco","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0051|cit51","unstructured":"Cardamakis E Minaretzis D Papageorgiou J Karaiskakis P Kioses E Michalas S Premature rupture of the membranes. II. Chemioprophylaxis Proceedings of 12th European Congress of Perinatal Medicine; 1990 Sept 11-14; Lyon, France 1990 45"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0052|cit52","first-page":"S61","article-title":"A prospective randomized double blind trial of ampicillin with and without sulbactam in preterm premature rupture of the membranes [abstract]","volume":"182","author":"Carroll","year":"2000","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0053|cit53","first-page":"533","article-title":"Can one reduce the risk of neonatal infection after premature rupture of membranes?","volume":"19","author":"Debodinance","year":"1990","journal-title":"Journal de Gynecologie, Obstetrique et Biologie de la Reproduction"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/01443618609112279","article-title":"Preterm ruptured membranes, no contractions","volume":"7","author":"Dunlop","year":"1986","journal-title":"Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0055|cit55","first-page":"252","article-title":"Prolongation of the latency period in preterm premature rupture of the membranes using prophylactic antibiotics and tocolysis","volume":"3","author":"Fortunato","year":"1990","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0056|cit56","first-page":"42","article-title":"Treatment of patients with premature rupture of the fetal membranes: (a) prior to 32 weeks; (b) after 32 weeks. Premature rupture of the membranes - a rational approach to management","volume-title":"Controversy in Obstetrics & Gynecology II","author":"Gordon","year":"1974"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0057|cit57","unstructured":"Haas D Preterm premature rupture of membranes: erythromycin versus azithromycin a randomized trial comparing their efficacy to prolong latency (PEACE trial) http:\/\/clinicaltrials.gov\/show\/NCT01556334 (accessed 25 June 2012) 2010"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0058|cit58","unstructured":"Halis Ragosch Hundertmark Weitzel Hopp Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes - a randomized controlled trial 11th European Congress of Clinical Microbiology and Infectious Diseases; 2001 April 1-4; Istanbul, Turkey 2001"},{"issue":"7","key":"10.1002\/14651858.CD001058.pub3-BIB0059|cit59","first-page":"403","article-title":"[Comparison of maternal and perinatal outcomes in the conservative treatment preterm premature membrane rupture between the use of erythromycin and clindamycin]. [Spanish]","volume":"79","author":"Hernandez","year":"2011","journal-title":"Ginecologia y Obstetricia de Mexico"},{"issue":"6 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0060|cit60","first-page":"S66","article-title":"Randomised trial comparing long term versus short term antibiotic prophylaxis in preterm premature rupture of membranes (PPROM)","volume":"187","author":"Julien","year":"2002","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0061|cit61","unstructured":"Kim YH Song TB Kim CH Kim JW Cho MY Yang SY Changes of lipid peroxidation and protein carbonyls formation by antibiotic therapy in the maternal venous plasma of preterm premature rupture of membranes 55th Annual Meeting of the Society of Gynecologic Investigation; 2008 March 26-29; San Diego, USA 2008 Abstract no: 398"},{"issue":"4","key":"10.1002\/14651858.CD001058.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.placenta.2013.01.016","article-title":"The efficacy of cefazolin plus macrolide (erythromycin or clarithromycin) versus cefazolin alone in neonatal morbidity and placental inflammation for women with preterm premature rupture of membranes","volume":"34","author":"Kwak","year":"2013","journal-title":"Placenta"},{"issue":"2","key":"10.1002\/14651858.CD001058.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0002-9378(63)90502-7","article-title":"Double-blind study of premature rupture of the membranes","volume":"87","author":"Lebherz","year":"1963","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD001058.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0029-7844(95)00181-P","article-title":"Latency period after preterm premature rupture of membranes: a comparison of ampicillin with and without sulbactam","volume":"86","author":"Lewis","year":"1995","journal-title":"Obstetrics & Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD001058.pub3-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0029-7844(96)00319-5","article-title":"Preterm premature ruptured membranes: a randomized trial of steroids after treatment with antibiotics","volume":"88","author":"Lewis","year":"1996","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0066|cit66","first-page":"306","article-title":"A prospective randomized clinical trial of antibiotic therapy for preterm premature rupture of membranes","volume":"174","author":"Lovett","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"5","key":"10.1002\/14651858.CD001058.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0002-9378(97)70398-3","article-title":"A prospective, double-blind, randomized, controlled clinical trial of ampicillin-sulbactam for preterm premature rupture of membranes in women receiving antenatal corticosteroid therapy","volume":"176","author":"Lovett","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"10","key":"10.1002\/14651858.CD001058.pub3-BIB0068|cit68","first-page":"1109","article-title":"The efficacy of prophylactic antibiotic and tocolytic therapy for premature rupture of the membranes","volume":"45","author":"Matsuda","year":"1993","journal-title":"Acta Obstetricia et Gynecologica Japonica"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000292605","article-title":"Premature rupture of the membranes - aggressive versus conservative approach: effect of tocolytic and antibiotic therapy","volume":"36","author":"Matsuda","year":"1993","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0070|cit70","first-page":"26","article-title":"Premature rupture of membranes: maternal and fetal outcome in the absence of antibiotic prophylaxis","volume":"2","author":"Mbu","year":"1998","journal-title":"African Journal of Reproductive Health"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0020-7292(92)90724-W","article-title":"Adjunctive antibiotic treatment of women with preterm rupture of membranes or preterm labor","volume":"38","author":"McCaul","year":"1992","journal-title":"International Journal of Gynecology & Obstetrics"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0072|cit72","unstructured":"Norri L Yla-Outinen A Tuimala R Prophylactic antibiotics in premature rupture of membranes Proceedings of 13th World Congress of Gynaecology and Obstetrics (FIGO);1991 September; Singapore 1991 80"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0073|cit73","first-page":"401","article-title":"The efficacy of treating ureaplasma urealyticum in patients with preterm labor or preterm premature rupture of membranes","volume":"174","author":"Ogasawara","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"4","key":"10.1002\/14651858.CD001058.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-2007-994133","article-title":"The efficacy of prophylactic erythromycin in preventing vertical transmission of ureaplasma urealyticum","volume":"14","author":"Ogasawara","year":"1997","journal-title":"American Journal of Perinatology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0075|cit75","first-page":"12","article-title":"Efficacy of azithromycin in reducing lower genital ureaplasma urealyticum colonization in women at risk for preterm delivery","volume":"8","author":"Ogasawara","year":"1999","journal-title":"Journal of Maternal Fetal Medicine"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/jmf.12.1.35.41","article-title":"Antibiotic administration in patients with preterm premature rupture of the membranes reduces the rate of histological chorioamnionitis: a prospective, randomised, controlled study","volume":"12","author":"Ovalle","year":"2002","journal-title":"Journal of Maternal-Fetal & Neonatal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD001058.pub3-BIB0077|cit77","first-page":"35","article-title":"Antepartum antibiotic therapy and subsequent neonatal morbidity in patients with preterm premature rupture of the membranes","volume":"6","author":"Spitzer","year":"1993","journal-title":"International Journal of Experimental and Clinical Chemotherapy"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0078|cit78","unstructured":"Alderson P Green S Higgins JPT Cochrane Reviewers' Handbook 4.2.2 [updated March 2004] The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0079|cit79","doi-asserted-by":"crossref","unstructured":"Amon E Lewis S Sibai BM Moretti M Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study Proceedings of 8th Annual Meeting of the Society of Perinatal Obstetricians; 1988 Feb 3-6; Las Vegas, Nevada, USA 1988 51","DOI":"10.1016\/S0002-9378(88)80002-4"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0080|cit80","first-page":"S15","article-title":"Impact of amnionitis and antepartum antibiotic treatment on neonatal outcome after PPROM","volume":"178","author":"Beazley","year":"1998","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0081|cit81","first-page":"479","article-title":"Premature labour bacterial sources of phospholipase","volume":"57","author":"Bejar","year":"1981","journal-title":"Obstetrics & Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0082|cit82","unstructured":"Christmas JT Cox SM Gilstrap LC Leveno KJ Andrews W Dax J Expectant management of preterm ruptured membranes: effects of antimicrobial therapy on interval to delivery Proceedings of 10th Annual Meeting of Society of Perinatal Obstetricians; 1990 Jan 23-27; Houston, Texas, USA 1990 19"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"e7976","DOI":"10.1136\/bmj.e7976","article-title":"Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICURE studies)","volume":"345","author":"Costeloe","year":"2012","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0028-2243(89)90010-5","article-title":"Duration of the latency period in preterm premature rupture of the membranes. Maternal and neonatal consequences of expectant management","volume":"30","author":"Dale","year":"1989","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"issue":"1","key":"10.1002\/14651858.CD001058.pub3-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","article-title":"Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn","volume":"42","author":"Dammann","year":"1997","journal-title":"Pediatric Research"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD001058.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1471-0528.2005.00576.x","article-title":"Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection\/inflammation and long term outcome","volume":"112","author":"Dammann","year":"2005","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"6","key":"10.1002\/14651858.CD001058.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1471-0528.2005.00558.x","article-title":"The effect of prepartum antibiotics on the type of neonatal bacteraemia: insights from the MRC ORACLE trials","volume":"112","author":"Gilbert","year":"2005","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"9606","key":"10.1002\/14651858.CD001058.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S0002-9378(97)80224-4","article-title":"The NICHD-MFMU antibiotic treatment of PROM study: correlation with acute placental inflammation and prenatal morbidity","volume":"176","author":"Hauth","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0091|cit91","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ajog.2004.10.625","article-title":"Perinatal outcomes in women with preterm rupture of membranes between 24 and 32 weeks of gestation and a history of vaginal bleeding","volume":"193","author":"Hnat","year":"2005","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00013542-200107000-00001","article-title":"The role of infection in necrotising enterocolitis","volume":"12","author":"Hoy","year":"2001","journal-title":"Reviews in Medical Microbiology"},{"issue":"9646","key":"10.1002\/14651858.CD001058.pub3-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(08)61202-7","article-title":"Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial","volume":"372","author":"Kenyon","year":"2008","journal-title":"Lancet"},{"issue":"9646","key":"10.1002\/14651858.CD001058.pub3-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0140-6736(08)61203-9","article-title":"Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial","volume":"372","author":"Kenyon","year":"2008","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2393-8-14","article-title":"MRC ORACLE children study. Long term outcomes following prescription of antibiotics to pregnant women with either spontaneous preterm labour or preterm rupture of the membranes","volume":"8","author":"Kenyon","year":"2008","journal-title":"BMC Pregnancy & Childbirth"},{"issue":"4","key":"10.1002\/14651858.CD001058.pub3-BIB0097|cit97","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000246","article-title":"Prophylactic antibiotics for inhibiting preterm labour with intact membranes","author":"King","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1007\/BF01958074","article-title":"Cytokines in chronic lung disease of prematurity","volume":"155 Suppl 2","author":"Kotecha","year":"1996","journal-title":"European Journal of Pediatrics"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0099|cit99","first-page":"378","article-title":"Double-blind, placebo-controlled trial of piperacillin sodium in preterm membrane rupture","volume":"168","author":"Lockwood","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD001058.pub3-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa041367","article-title":"Neurologic and developmental disability at six years of age after extremely preterm birth","volume":"352","author":"Marlow","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0101|cit101","first-page":"835","article-title":"Evidence-based prevention of preterm birth and rupture of membranes: infection and inflammation","volume":"19","author":"McGregor","year":"1997","journal-title":"Journal of the Society of Obstetricians and Gynaecologists of Canada"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0102|cit102","first-page":"40","article-title":"Comparison of various parameters as predictors of chorioamnionitis in preterm patients with premature rupture of membranes","volume":"81","author":"Morales","year":"1988","journal-title":"Southern Medical Journal"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0103|cit103","first-page":"379","article-title":"Randomized trial of prophylactic antibiotic therapy after preterm amnion rupture","volume":"168","author":"Owen","year":"1993","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0104|cit104","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2011"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.1301\/nr.2007.dec.S194-S202","article-title":"Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury","volume":"65","author":"Romero","year":"2007","journal-title":"Nutrition Reviews"},{"issue":"9608","key":"10.1002\/14651858.CD001058.pub3-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0140-6736(08)60136-1","article-title":"An overview of mortality and sequelae of preterm birth from infancy to adulthood","volume":"371","author":"Saigal","year":"2008","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0107|cit107","unstructured":"Sanchez-Ramos L Johnston M Vaughn A Benrubi GI Todd M High dose antibiotic therapy in preterm premature rupture of the membranes: a double blind, randomized, prospective study Proceedings of 10th Annual Meeting of Society of Perinatal Obstetricians; 1990 Jan 23-27; Houston, Texas, USA 1990 18"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1084-2756(02)00190-2","article-title":"Inflammation and bronchopulmonary dysplasia","volume":"8 No. 1","author":"Speer","year":"2003","journal-title":"Seminars in Neonatology"},{"issue":"167:1","key":"10.1002\/14651858.CD001058.pub3-BIB0109|cit109","first-page":"86","article-title":"Ampicillin-metronidazole treatment in threatening preterm delivery","volume":"76","author":"Svare","year":"1997","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"2","key":"10.1002\/14651858.CD001058.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/archpedi.155.2.155","article-title":"Long-term family outcomes for children with very low birth weights","volume":"155","author":"Taylor","year":"2001","journal-title":"Archives of Pediatrics & Adolescent Medicine"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD001058.pub3-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S0002-9378(97)80225-6","article-title":"The NICHD-MFMU antibiotic treatment of PROM study: impact of initial amniotic fluid volume on pregnancy outcome","volume":"176","author":"Thurnau","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD001058.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/mrdd.10003","article-title":"Systematic review of chorioamnionitis and cerebral palsy","volume":"8","author":"Wu","year":"2002","journal-title":"Mental Retardation and Developmental Disabilities Research Reviews"},{"issue":"5","key":"10.1002\/14651858.CD001058.pub3-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1067\/mob.2000.109035","article-title":"The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis","volume":"183","author":"Yoon","year":"2000","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD001058.pub3-BIB0114|cit114","unstructured":"Crowley P Antibiotics for preterm prelabour rupture of membranes. [revised 05 May 1994] In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) Pregnancy and Childbirth Module. In: The Cochrane Pregnancy and Childbirth Database [database on disk and CDROM]. The Cochrane Collaboration; Issue 2, Oxford: Update Software; 1995"},{"issue":"3","key":"10.1002\/14651858.CD001058.pub3-BIB0115|cit115","article-title":"Antibiotics for preterm premature rupture of membranes","author":"Kenyon","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD001058.pub3-BIB0116|cit116","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001058","article-title":"Antibiotics for preterm rupture of membranes","author":"Kenyon","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD001058.pub3-BIB0117|cit117","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/14651858.CD001058","article-title":"Antibiotics for preterm rupture of the membranes: a systematic review","volume":"104","author":"Kenyon","year":"2004","journal-title":"Obstetrics & Gynecology"},{"issue":"8","key":"10.1002\/14651858.CD001058.pub3-BIB0118|cit118","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001058.pub2","article-title":"Antibiotics for preterm rupture of membranes","author":"Kenyon","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD001058.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T10:13:32Z","timestamp":1722680012000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD001058.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Pregnancy and Childbirth Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,2]]},"references-count":118,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd001058.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,2]]}}}