{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:34:29Z","timestamp":1791646469459,"version":"4.3.4"},"update-to":[{"DOI":"10.1002\/14651858.cd001289","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T00:00:00Z","timestamp":1398988800000}}],"reference-count":50,"publisher":"Wiley","issue":"7","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd001289.pub2","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T06:29:53Z","timestamp":1399012193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mucolytics for bronchiectasis"],"prefix":"10.1002","volume":"2018","author":[{"given":"Mark","family":"Wilkinson","sequence":"first","affiliation":[{"name":"University Hospitals of Morecambe Bay NHS Foundation Trust; Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karnam","family":"Sugumar","sequence":"additional","affiliation":[{"name":"Royal Preston Hospital, Lancashire Teaching Hospitals NHS Trust; Department of Paediatrics; Preston UK PR2 9HT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Milan","sequence":"additional","affiliation":[{"name":"Lancaster University; Medical School; Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hart","sequence":"additional","affiliation":[{"name":"Lancaster University; Lancaster Medical School, Clinical Research Hub; Lancaster Lancashire UK LA1 4TB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Crockett","sequence":"additional","affiliation":[{"name":"University of South Australia; School of Health Sciences; Adelaide South Australia Australia 5001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Crossingham","sequence":"additional","affiliation":[{"name":"East Lancashire Hospitals NHS Trust; Blackburn Lancashire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"issue":"9","key":"10.1002\/14651858.CD001289.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.clinthera.2007.09.003","article-title":"Effectiveness of erdosteine in elderly patients with bronchiectasis and hypersecretion: a 15-day, prospective, parallel, open-label, pilot study","volume":"29","author":"Crisafulli","year":"2007","journal-title":"Clinical Therapeutics"},{"issue":"5","key":"10.1002\/14651858.CD001289.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1378\/chest.113.5.1329","article-title":"Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I. rhDNase Study Group","volume":"113","author":"O'Donnell","year":"1998","journal-title":"Chest"},{"issue":"3-4","key":"10.1002\/14651858.CD001289.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000195910","article-title":"Role of bromhexine in exacerbations of bronchiectasis. Double-blind randomized multicenter study versus placebo","volume":"58","author":"Olivieri","year":"1991","journal-title":"Respiration"},{"issue":"2 Pt 1","key":"10.1002\/14651858.CD001289.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1164\/ajrccm.154.2.8756815","article-title":"Short-term recombinant human DNase in bronchiectasis. Effect on clinical state and in vitro sputum transportability","volume":"154","author":"Wills","year":"1996","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"53","key":"10.1002\/14651858.CD001289.pub2-BIB0005|cit5","first-page":"2995","article-title":"[Studies of the clinical and respiratory functional effects of a mucolytic-antibiotic preparation in chronic bronchopulmonary diseases. Controlled double-blind single code studies]","volume":"59","author":"Alberto","year":"1968","journal-title":"Minerva Medica"},{"issue":"37","key":"10.1002\/14651858.CD001289.pub2-BIB0006|cit6","first-page":"1995","article-title":"[D1-sobrerol in the treatment of acute and chronic bronchopulmonary phlogoses]. [Italian]","volume":"64","author":"Balzano","year":"1973","journal-title":"Minerva Medica"},{"issue":"18","key":"10.1002\/14651858.CD001289.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.5694\/j.1326-5377.1971.tb87967.x","article-title":"A new mucolytic, bromhexine ('bisolvon'). A double-blind study","volume":"1","author":"Bateman","year":"1971","journal-title":"Medical Journal of Australia"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0008|cit8","unstructured":"Benjamin C The use and efficacy of mucolytic agents South African Medical Journal 1971 948 52"},{"issue":"5","key":"10.1002\/14651858.CD001289.pub2-BIB0009|cit9","first-page":"341","article-title":"Influence of a fluidifying agent (bromhexine) on the penetration of antibiotics into respiratory secretions","volume":"5","author":"Bergogne Berezin","year":"1985","journal-title":"International Journal of Clinical Pharmacology Research"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD001289.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"A49 [S106]","DOI":"10.1136\/thoraxjnl-2011-201054b.106","article-title":"A randomised double blind 13 week crossover trial of hypertonic saline (HTS) (6%) vs isotonic saline (ITS) (0.9%) in patients with bronchiectasis [Abstract]","volume":"66","author":"Bradley","year":"2011","journal-title":"Thorax"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1445-5994.1971.tb02280.x","article-title":"The mucolytic agent bromhexine (Bisolvon) in chronic lung disease: a double-blind crossover trial","volume":"2","author":"Cobbin","year":"1971","journal-title":"Australian and New Zealand Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD001289.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/thx.43.6.480","article-title":"Efficacy of 'mucoregulatory' agents in Young's syndrome","volume":"43","author":"Currie","year":"1988","journal-title":"Thorax"},{"issue":"6","key":"10.1002\/14651858.CD001289.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1164\/ajrccm.159.6.9809074","article-title":"Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis","volume":"159","author":"Daviskas","year":"1999","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"4","key":"10.1002\/14651858.CD001289.pub2-BIB0014|cit14","first-page":"269","article-title":"Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol","volume":"92","author":"Fadda","year":"2001","journal-title":"Minerva Medica"},{"issue":"1-2","key":"10.1002\/14651858.CD001289.pub2-BIB0015|cit15","first-page":"33","article-title":"Clinical trial of ambroxol in 2 different dosage programs in 120 patients with bronchiectasis. [Portuguese]","volume":"17","author":"Germouty","year":"1988","journal-title":"Revista Brasileira de Clinica E Terapeutica"},{"issue":"2","key":"10.1002\/14651858.CD001289.pub2-BIB0016|cit16","first-page":"157","article-title":"Feprazone plus bromhexine in treatment of flare-ups of chronic bronchopathies. [Italian]","volume":"33","author":"Ghiringhelli","year":"1981","journal-title":"Archivio Di Medicina Interna"},{"issue":"5","key":"10.1002\/14651858.CD001289.pub2-BIB0017|cit17","first-page":"1420","article-title":"Regional mucus transport following unproductive cough and forced expiration technique in patients with airways obstruction","volume":"105","author":"Hasani","year":"1994","journal-title":"European Respiratory Journal"},{"issue":"6","key":"10.1002\/14651858.CD001289.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/thx.49.6.557","article-title":"Regional lung clearance during cough and forced expiration technique (FET): effects of flow and viscoelasticity","volume":"49","author":"Hasani","year":"1994","journal-title":"Thorax"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0019|cit19","first-page":"32","article-title":"Clinical effects of proteinase, sfericase (AI-794), on chronic bronchitis and similar diseases","volume":"22","author":"Itoh","year":"1984","journal-title":"International Journal of Clinical Pharmacology, Therapy, and Toxicology"},{"issue":"6","key":"10.1002\/14651858.CD001289.pub2-BIB0020|cit20","first-page":"1268","article-title":"Clinical role of Branhamella catarrhalis infection in pulmonary disorders. [Japanese]","volume":"44","author":"Kawashima","year":"1989","journal-title":"Saishin Igaku [Modern Medicine]"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.rmed.2004.05.006","article-title":"Evaluation of nebulised hypertonic saline (7%) as an adjunct to physiotherapy in patients with stable bronchiectasis","volume":"99","author":"Kellett","year":"2005","journal-title":"Respiratory Medicine"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0022|cit22","first-page":"125","article-title":"Ultrasonic aerosol apparatus hire system - Therapy of chronic obstructive bronchitis and bronchiectasia. [German]","volume":"155","author":"Kossmagk","year":"1980","journal-title":"Zeitschrift Fur Erkrankungen der Atmungsorgane"},{"issue":"9125","key":"10.1002\/14651858.CD001289.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(05)60471-0","article-title":"Effect of arginine on mucociliary function in primary ciliary dyskinesia","volume":"352","author":"Loukides","year":"1998","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD001289.pub2-BIB0024|cit24","first-page":"305","article-title":"A long term tolerance trial of bromhexine","volume":"9","author":"Mareels","year":"1983","journal-title":"Acta Therapeutica"},{"issue":"3","key":"10.1002\/14651858.CD001289.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1378\/chest.06-2951","article-title":"Pulmonary radioaerosol mucociliary clearance in diagnosis of primary ciliary dyskinesia","volume":"132","author":"Marthin","year":"2007","journal-title":"Chest"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1164\/ajrccm.160.1.9806146","article-title":"Effect of aerosolized uridine-5'-triphosphate on airway clearance with cough in patients with primary ciliary dyskinesia","volume":"160","author":"Noone","year":"1999","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"2","key":"10.1002\/14651858.CD001289.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/1479972306075483","article-title":"Acapella versus 'usual airway clearance' during acute exacerbation in bronchiectasis: a randomized crossover trial","volume":"4","author":"Patterson","year":"2007","journal-title":"Chronic Respiratory Disease"},{"issue":"3","key":"10.1002\/14651858.CD001289.pub2-BIB0028|cit28","first-page":"137","article-title":"The effect of methyl cysteine (Visclair) in respiratory diseases. A pilot study","volume":"19","author":"Sahay","year":"1982","journal-title":"Clinical Trials Journal"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0029|cit29","doi-asserted-by":"crossref","unstructured":"Serisier DJ Martin ML McGuckin MA Lourie R Chen AC Brain B Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial JAMA 2013 1260 7","DOI":"10.1001\/jama.2013.2290"},{"issue":"2","key":"10.1002\/14651858.CD001289.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1183\/09031936.93.01020161","article-title":"The clinical effect and the effect on the ciliary motility of oral N-acetylcysteine in patients with cystic fibrosis and primary ciliary dyskinesia","volume":"1","author":"Stafanger","year":"1988","journal-title":"The European Respiratory Journal"},{"issue":"9","key":"10.1002\/14651858.CD001289.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.rmed.2011.04.017","article-title":"The influence of Flutter VRP1 components of mucus transport of patients with bronchiectasis","volume":"105","author":"Tambascio","year":"2011","journal-title":"Respiratory Medicine"},{"issue":"2","key":"10.1002\/14651858.CD001289.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0954-6111(06)80233-7","article-title":"Effect of bromhexine on sputum amoxycillin levels in lower respiratory infections","volume":"86","author":"Taskar","year":"1992","journal-title":"Respiratory Medicine"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1013-7025(09)70037-5","article-title":"Postural drainage or flutter device in conjunction with breathing and coughing compared to breathing and coughing alone in improving secretion removal and lung function in patients with acute exacerbation of bronchiectasis. A pilot study","volume":"21","author":"Tsang","year":"2003","journal-title":"Hong Kong Physiotherapy Journal"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0034|cit34","first-page":"71","article-title":"Mucolytic treatment in chronic obstructive lung disease: double-blind comparative clinical trial with N-acetylcysteine, bromhexine and placebo","volume":"70","author":"Verstraeten","year":"1979","journal-title":"Acta Tuberculosea et Pneumologica Belgica"},{"issue":"9842","key":"10.1002\/14651858.CD001289.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic","volume":"380","author":"Wong","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2710.2006.00708.x","article-title":"Effects of clarithromycin on inflammatory parameters and clinical conditions in children with bronchiectasis","volume":"31","author":"Yal\u00e7in","year":"2006","journal-title":"Journal of Clinical Pharmacy and Therapeutics"},{"issue":"116","key":"10.1002\/14651858.CD001289.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"127-33","DOI":"10.1183\/09059180.00003510","article-title":"Mucoactive drugs","volume":"19","author":"Balsamo","year":"2010","journal-title":"European Respiratory Review"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0038|cit38","unstructured":"Pasteur MC Bilton D Hill AT BTS guideline for non-CF bronchiectasis www.brit-thoracic.org.uk\/LinkClick.aspx?link=496&tabid=69"},{"issue":"2","key":"10.1002\/14651858.CD001289.pub2-BIB0039|cit39","first-page":"73","article-title":"No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid","volume":"70","author":"Cotgreave","year":"1987","journal-title":"European Journal of Respiratory Diseases"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/pgmj.2009.091041","article-title":"Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century","volume":"86","author":"Goeminne","year":"2010","journal-title":"Postgraduate Medical Journal"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"24-9","DOI":"10.1016\/j.prrv.2007.02.009","article-title":"Mucolytics in cystic fibrosis","volume":"8","author":"Henke","year":"2007","journal-title":"Paediatric Respiratory Reviews"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0042|cit42","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011 www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0043|cit43","unstructured":"Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan). 5.2 2012"},{"issue":"9","key":"10.1002\/14651858.CD001289.pub2-BIB0044|cit44","first-page":"1176-97","article-title":"Mucoactive agents for airway mucus hypersecretory diseases","volume":"52","author":"Rogers","year":"2007","journal-title":"Respiratory Care"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/adc.2007.130054","article-title":"Non cystic fibrosis bronchiectasis: its diagnosis and management","volume":"95","author":"Stafler","year":"2010","journal-title":"Archives of Diseases in Childhood. Education and Practice Edition"},{"issue":"6","key":"10.1002\/14651858.CD001289.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"8S-13S","DOI":"10.1016\/S0002-9343(99)80304-0","article-title":"Role of inflammation in respiratory tract infections","volume":"99","author":"Stockley","year":"1995","journal-title":"American Journal of Medicine"},{"issue":"6","key":"10.1002\/14651858.CD001289.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"259-65","DOI":"10.1006\/pulp.1995.1035","article-title":"A comparison of a new mucolytic N-acetylcysteine l-lysinate with N-acetylcysteine: airway epithelial function and mucus changes in dog","volume":"8","author":"Tomkiewicz","year":"1995","journal-title":"Pulmonary Pharmacology"},{"key":"10.1002\/14651858.CD001289.pub2-BIB0048|cit48","unstructured":"TSANZ and the Lung Foundation Chronic suppurative lung disease and bronchiectasis in children and adults 2010 http:\/\/www.lungfoundation.com.au\/professional-resources\/guidelines\/"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"Zafarullah","year":"2003","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"1","key":"10.1002\/14651858.CD001289.pub2-BIB0050|cit50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001289","article-title":"Mucolytics for bronchiectasis","author":"Crockett","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD001289.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T04:03:29Z","timestamp":1669349009000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD001289.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Airways Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,2]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd001289.pub2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718379468.793530596","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,2]]}}}