{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:46:45Z","timestamp":1779162405950,"version":"3.51.4"},"publisher-location":"Chichester, UK","reference-count":18,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd002064","type":"reference-entry","created":{"date-parts":[[2003,11,20]],"date-time":"2003-11-20T22:33:39Z","timestamp":1069367619000},"source":"Crossref","is-referenced-by-count":18,"title":["Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis\/motor neuron disease"],"prefix":"10.1002","author":[{"given":"JD","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JHJ","family":"Wokke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GD","family":"Borasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,22]]},"reference":[{"key":"10.1002\/14651858.CD002064-BIB1|cit1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1212\/WNL.51.2.583","article-title":"A placebo controlled trial of insulin-like nerve growth factor-1 in amyotrophic lateral sclerosis","volume":"51","author":"Borasio","year":"1998","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD002064-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.49.6.1621","article-title":"Effect of recombinant human insulin-like growth factor-1 on progression of ALS. A placebo-controlled study","volume":"49","author":"Lai","year":"1997","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD002064-BIB3|cit3","unstructured":"Sorenson E IGF-1\/ALS Trial http:\/\/www.clinicaltrials.gov"},{"key":"10.1002\/14651858.CD002064-BIB4|cit4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF01277964","article-title":"Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis","volume":"97","author":"Adem","year":"1994","journal-title":"Journal of Neural Transmission. General Section"},{"key":"10.1002\/14651858.CD002064-BIB5|cit5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ana.410220308","article-title":"A rating scale for amyotrophic lateral sclerosis: description and preliminary experience","volume":"22","author":"Appel","year":"1987","journal-title":"Annals of Neurology"},{"key":"10.1002\/14651858.CD002064-BIB6|cit6","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1212\/WNL.33.7.911","article-title":"Geographic distribution of motor neuron disease and correlation with possible etiologic factors","volume":"33","author":"Bharucha","year":"1983","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD002064-BIB7|cit7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1212\/WNL.51.2.583","article-title":"A placebo-controlled trial of insulin-like growth factor-1 in amyotrophic lateral sclerosis","volume":"51","author":"Borasio","year":"1998","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD002064-BIB8|cit8","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1083\/jcb.110.4.1307","article-title":"Nerve sprouting in innervated adult skeletal muscle induced by elevated levels of insulin-like nerve growth factors","volume":"110","author":"Caroni","year":"1990","journal-title":"Journal of Cell Biology"},{"key":"10.1002\/14651858.CD002064-BIB9|cit9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1749-6632.1993.tb26219.x","article-title":"Activity-sensitive signals by muscle-derived IGFs in the developing and regenerating neuromuscular system","volume":"692","author":"Caroni","year":"1993","journal-title":"Annals of the New York Academy of Science"},{"key":"10.1002\/14651858.CD002064-BIB10|cit10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0169-328X(96)00081-2","article-title":"Distribution and levels of insulin like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients","volume":"41","author":"Dore","year":"1996","journal-title":"Brain Research. Molecular Brain Research"},{"key":"10.1002\/14651858.CD002064-BIB11|cit11","first-page":"122","article-title":"Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease","volume":"Suppl","author":"Hantai","year":"129","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1002\/14651858.CD002064-BIB12|cit12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/brain\/118.3.707","article-title":"Natural history of amyotrophic lateral sclerosis in a database population - validation of a scoring system and a model for survival prediction","volume":"118","author":"Haverkamp","year":"1995","journal-title":"Brain"},{"key":"10.1002\/14651858.CD002064-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.49.6.1621","article-title":"Effect of recombinant human insulin-like growth factor-1 on progression of ALS. A placebo-controlled study","volume":"49","author":"Lai","year":"1997","journal-title":"Neurology"},{"issue":"1","key":"10.1002\/14651858.CD002064-BIB14|cit14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/exnr.1993.1177","article-title":"Insulin-like growth factor-1: potential for treatment of motor neuronal disorder","volume":"124","author":"Lewis","year":"1993","journal-title":"Experimental Neurology"},{"key":"10.1002\/14651858.CD002064-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1212\/WNL.46.5.1442","article-title":"Relationship of the Tufts Quantitative Neuromuscular Exam (TQNE) and the Sickness Impact Profile (SIP) in measuring progression of ALS","volume":"46","author":"McGuire","year":"1996","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD002064-BIB16|cit16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0022-510X(99)00209-9","article-title":"Consensus guidelines for the design and implementation of clinical trials in ALS","volume":"169","author":"Miller","year":"1999","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1002\/14651858.CD002064-BIB17|cit17","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/jnnp.65.6.842","article-title":"Geographical epidemiology of residence of patients with motor neuron disease in Lancashire and South Cumbria","volume":"65","author":"Mitchell","year":"1998","journal-title":"Journal of Neurology Neurosurgery and Psychiatry"},{"key":"10.1002\/14651858.CD002064-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/neu.480241203","article-title":"Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival","volume":"24","author":"Neff","year":"1993","journal-title":"Journal of Neurobiology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD002064\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T17:08:57Z","timestamp":1628528937000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD002064"}},"subtitle":[],"editor":[{"given":"J Douglas","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2002,7,22]]},"references-count":18,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd002064","relation":{},"subject":[],"published":{"date-parts":[[2002,7,22]]}}}