{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:02:39Z","timestamp":1774616559284,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd002233","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T00:00:00Z","timestamp":1268784000000}}],"reference-count":86,"publisher":"Wiley","issue":"3","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd002233.pub2","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T07:26:02Z","timestamp":1268724362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Emergency sclerotherapy versus vasoactive drugs for bleeding oesophageal varices in cirrhotic patients"],"prefix":"10.1002","volume":"2010","author":[{"given":"Gennaro","family":"D'Amico","sequence":"first","affiliation":[{"name":"Ospedale V Cervello; Gastroenterology Unit; Via Trabucco 180 Palermo Italy 90146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"Viale Croce Rossa 115 Palermo Italy 90144"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Pietrosi","sequence":"additional","affiliation":[{"name":"University of Palermo; Clininica Medica; Ospedale V Cervello Via Trabucco 180 Palermo Italy 90146"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Ospedale V Cervello; Clininica Medica; Via Trabucco 180 Palermo Italy 90146"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,17]]},"reference":[{"key":"10.1002\/14651858.CD002233.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/003655200750024001","article-title":"Efficacy of octreotide and sclerotherapy in the treatment of acute variceal bleeding in cirrhotic patients. A prospective, multicenter, and randomized clinical trial","volume":"35","author":"Bildozola","year":"2000","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0002|cit2","first-page":"A583","article-title":"Somatostatin and urgent sclerotherapy in active esophageal variceal bleeding","volume":"98","author":"Febo","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0168-8278(98)80259-6","article-title":"Randomized controlled trial of sclerotherapy versus somatostatin infusion in the prevention of early rebleeding following acute variceal hemorrhage in patients with cirrhosis","volume":"29","author":"Escorsell","year":"1998","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1053\/jhep.2000.16601","article-title":"Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: the TEST study","volume":"32","author":"Escorsell","year":"2000","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0005|cit5","first-page":"1310","article-title":"Octreotide in acute bleeding esophageal varices: a prospective randomized study","volume":"47","author":"Freitas","year":"2000","journal-title":"Hepato-gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.41.4.526","article-title":"A multicentre randomised trial comparing octreotide and injection sclerotherapy in the management and outcome of acute variceal hemorrhage","volume":"41","author":"Jenkins","year":"1997","journal-title":"Gut"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0007|cit7","first-page":"574A","article-title":"Octreotide vs sclerotherapy in the treatment of acute variceal bleeding","volume":"30","author":"Lopez","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/hep.1840200216","article-title":"A prospective randomized trial comparing somatostatin and sclerotherapy in the treatment of acute variceal bleeding","volume":"20","author":"Planas","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0009|cit9","first-page":"A1297","article-title":"Octreotide versus emergency sclerotherapy in acute variceal hemorrhage in liver cirrhosis. A randomized multicenter study","volume":"110","author":"Poo","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1590\/S0004-28032000000300002","article-title":"Sclerotherapy versus somatostatin in the treatment of upper digestive hemorrhage caused by rupture of esophageal varices","volume":"37","author":"Ramires","year":"2000","journal-title":"Arquivos de Gastroenterologia"},{"issue":"11","key":"10.1002\/14651858.CD002233.pub2-BIB0011|cit11","first-page":"677","article-title":"A comparative study of efficacy of octreotide and sclerotherapy in variceal bleeding","volume":"12","author":"Shaikh","year":"2002","journal-title":"Journal of the College of Physicians and Surgeons - Pakistan"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0168-8278(05)80105-9","article-title":"A prospective randomised controlled trial comparing the efficacy of somatostatin with injection sclerotherapy in the control of oesophageal varices","volume":"16","author":"Shields","year":"1992","journal-title":"Journal of Hepatology"},{"issue":"3","key":"10.1002\/14651858.CD002233.pub2-BIB0013|cit13","first-page":"285","article-title":"Octreotide administration and\/or endoscopic treatment in cirrhotic patients with acute variceal bleeding: a multicentric study","volume":"132","author":"Silva","year":"2004","journal-title":"Revista Medica de Chile"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0014|cit14","first-page":"166","article-title":"A prospective randomized trial from Turkey comparing octreotide versus injection sclerotherapy in acute variceal bleeding","volume":"47","author":"Sivri","year":"2000","journal-title":"Hepato-Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0140-6736(93)91758-E","article-title":"Octreotide infusion or emergency sclerotherapy for variceal hemorrhage","volume":"342","author":"Sung","year":"1993","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/hep.1840090219","article-title":"Controlled clinical trial of injection sclerotherapy for active variceal bleeding","volume":"9","author":"Westaby","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0017|cit17","first-page":"95","article-title":"Initial management of acute variceal haemorrhage. Comparison of octreotide and sclerotherapy","volume":"10","author":"Yousuf","year":"2000","journal-title":"Journal of the College of Physicians and Surgeons - Pakistan"},{"issue":"Suppl","key":"10.1002\/14651858.CD002233.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/0168-8278(90)91337-V","article-title":"Is sclerotherapy the first choice treatment for active oesophageal variceal bleeding in cirrhotic patients? Final report of a randomized clinical trial","volume":"11","author":"Alexandrino","year":"1990","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0011-393X(05)80451-5","article-title":"Randomized controlled trial with terlipressin in cirrhotic patients with bleeding esophageal varices: effects on precocious rebleeding and mortality rate","volume":"52","author":"Arcidiacono","year":"1992","journal-title":"Current Therapeutic Research, Clinical and Experimental"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0140-6736(97)05099-X","article-title":"Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: the European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial","volume":"350","author":"Avguerinos","year":"1997","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJM199508313330904","article-title":"Sclerotherapy with or without octreotide for acute variceal bleeding","volume":"333","author":"Besson","year":"1995","journal-title":"New England Journal of Medicine"},{"issue":"4 Pt 2","key":"10.1002\/14651858.CD002233.pub2-BIB0022|cit22","first-page":"207A","article-title":"Sclerotherapy alone vs sclerotherapy plus terlipressin vs sclerotherapy plus octreotide in the treatment of acute variceal hemorrhage","volume":"24","author":"Brunati","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM200101043440104","article-title":"Early administration of vapreotide for variceal bleeding in patients with cirrhosis","volume":"344","author":"Cales","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"4 Suppl1","key":"10.1002\/14651858.CD002233.pub2-BIB0024|cit24","first-page":"553","article-title":"Octreotide vs sclerotherapy in the control of acute variceal bleeding in schistosomal portal hypertension: A randomized trial","volume":"28","author":"El-Jackie","year":"1998","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0016-5107(88)71363-2","article-title":"Endoscopic sclerotherapy versus medical treatment for bleeding esophageal varices in patients with schistosomal liver disease","volume":"34","author":"El-Zayadi","year":"1988","journal-title":"Gastrointestinal Endoscopy"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0016-5107(97)70201-3","article-title":"Sclerotherapy for actively bleeding esophageal varices in male alcoholics with cirrhosis","volume":"46","author":"Hartigan","year":"1997","journal-title":"Gastrointestinal Endoscopy"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/jama.1986.03370040071026","article-title":"Acute esophageal variceal sclerotherapy","volume":"255","author":"Larson","year":"1986","journal-title":"JAMA"},{"issue":"73","key":"10.1002\/14651858.CD002233.pub2-BIB0028|cit28","first-page":"195","article-title":"Octreotide for esophageal variceal bleeding treated with endoscopic sclerotherapy: a randomized, placebo-controlled trial","volume":"54","author":"Morales","year":"2007","journal-title":"Hepato-Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0029|cit29","first-page":"207A","article-title":"Octreotide vs sclerotherapy and octreotide for acute variceal bleeding. A pilot study","volume":"24","author":"Novella","year":"1996","journal-title":"Hepatology"},{"issue":"5","key":"10.1002\/14651858.CD002233.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/0270-9139(95)90054-3","article-title":"Sclerotherapy plus octreotide versus sclerotherapy alone in the prevention of early rebleeding from esophageal varices: a randomized, double-blind, placebo-controlled, multicenter trial","volume":"21","author":"Primignani","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0031|cit31","first-page":"E66","article-title":"Octreotide and endoscopic variceal sclerotherapy in the management of acute variceal haemorrhage","volume":"31","author":"Signorelli","year":"1999","journal-title":"Endoscopy"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0032|cit32","first-page":"449","article-title":"Endoscopic sclerotherapy v. conservative management of bleeding esophageal varices","volume":"151","author":"S\u00f6derlund","year":"1985","journal-title":"Acta Chirurgica Scandinavica"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/hep.510300222","article-title":"Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute variceal bleeding: a prospective randomized trial","volume":"30","author":"Villanueva","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1572-0241.2000.01858.x","article-title":"Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis","volume":"95","author":"Zuberi","year":"2000","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0140-6736(97)05099-X","article-title":"Early administration of somatostatin and efficacy of sclerotherapyin acute oesophageal variceal bleeds: the European Acute BleedingOesophageal Variceal Episodes (ABOVE) randomised trial","volume":"350","author":"Avgerinos","year":"1997","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/hep.20236","article-title":"Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis","volume":"39","author":"Avgerinos","year":"2004","journal-title":"Hepatology"},{"issue":"3","key":"10.1002\/14651858.CD002233.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1053\/jhep.2002.31354","article-title":"Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis","volume":"35","author":"Banares","year":"2002","journal-title":"Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD002233.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1053\/j.gastro.2004.07.015","article-title":"Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial","volume":"127","author":"Bosch","year":"2004","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1002\/14651858.CD002233.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/hep.22216","article-title":"Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: a randomized controlled trial","volume":"47","author":"Bosch","year":"2008","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0040|cit40","unstructured":"Burroughs AK ed Methodology and review of clinical trials in portal hypertension Excerpta Medica Amsterdam 1987"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/hep.1840090602","article-title":"Cirrhotics with variceal hemorrhage: The importance of the time interval between admission and the start of analysis for survival and rebleeding rates","volume":"9","author":"Burroughs","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/0016-5085(90)91166-4","article-title":"Randomized, double-blind, placebo-controlled trial of somatostatin for variceal bleeding. Emergency control and prevention of early variceal rebleeding","volume":"99","author":"Burroughs","year":"1990","journal-title":"Gastroenterology"},{"issue":"suppl","key":"10.1002\/14651858.CD002233.pub2-BIB0043|cit43","first-page":"352A","article-title":"Double blind randomised trial of 5 day octreotide versus placebo, associated with sclerotherapy for trial failures. [Abstract]","volume":"24","author":"Burroughs","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/hep.20339","article-title":"Improved survival after variceal bleeding in patients with cirrhosis over the past two decades","volume":"40","author":"Carbonell","year":"2004","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1572-0241.2003.07294.x","article-title":"Improved patient survival after acute variceal bleeding: a multicenter, cohort study","volume":"98","author":"Chalasani","year":"2003","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/hep.1840220145","article-title":"The treatment of portal hypertension. A meta-analytic review","volume":"22","author":"D'Amico","year":"1995","journal-title":"Hepatology"},{"issue":"2","key":"10.1002\/14651858.CD002233.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0950-3528(97)90038-5","article-title":"Portal hypertension. Natural history. Clinical-hemodynamic correlations. Prediction of the risk of bleeding","volume":"11","author":"D'Amico","year":"1997","journal-title":"Baillieres Clinical Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-2007-1007133","article-title":"Pharmacological treatment of portal hypertension: an evidence based approach","volume":"19","author":"D'Amico","year":"1999","journal-title":"Seminars in Liver Disease"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/jhep.2003.50385","article-title":"Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators","volume":"38","author":"D'Amico","year":"2003","journal-title":"Hepatology"},{"issue":"4 IS THIS REFER","key":"10.1002\/14651858.CD002233.pub2-BIB0050|cit50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD00223","article-title":"Emergency sclerotherapy versus vasoactive drugs for bleeding oesophageal varices in cirrhotic patients","author":"D'Amico","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0051|cit51","doi-asserted-by":"crossref","unstructured":"D'Amico G Criscuoli V Fil\u00ec D Mocciaro F Pagliaro L Meta-analysis of trials for variceal bleeding Hepatology 2002 1023 4","DOI":"10.1053\/jhep.2002.34737"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0052|cit52","first-page":"256","article-title":"Definitions, methodology and therapeutic strategies in portal hypertension. A consensus development workshop, Baveno, Lake Maggiore, Italy, April 5 and 6, 1990","volume":"15","author":"Franchis","year":"1992","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0053|cit53","volume-title":"Portal hypertension II. Proceedings of the second Baveno International Consensus Workshop on definitions, methodology, and therapeutic strategies","author":"Franchis","year":"1996"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0168-8278(00)80320-7","article-title":"Updating consensus in portal hypertension: report of the Baveno III Consensus Workshop on definitions, methodology and therapeutic strategies in portal hypertension","volume":"33","author":"Franchis","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2005.05.009","article-title":"Evolving consensus in portal hypertension report of the Baveno IV Consensus Workshop on methodology of diagnosis and therapy in portal hypertension","volume":"43","author":"Franchis","year":"2005","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"Simonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-2007-1007130","article-title":"Influence of pharmacological agents on portal hemodynamics: basis for its use in the treatment of portal hypertension","volume":"19","author":"Garcia-Pagan","year":"1999","journal-title":"Seminars in Liver Disease"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0058|cit58","doi-asserted-by":"publisher","first-page":"[Epub ahead of","DOI":"10.1136\/gut.2008.171207","article-title":"Nadolol plus isosorbide mononitrate alone or associated with band ligation in the prevention of recurrent bleeding: A multicenter randomized controlled trial","volume":"12 Feb 2009","author":"Garcia-Pagan","year":"2009","journal-title":"Gut"},{"issue":"3","key":"10.1002\/14651858.CD002233.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/hep.21907","article-title":"Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis","volume":"46","author":"Garcia-Tsao","year":"2007","journal-title":"Hepatology"},{"issue":"5","key":"10.1002\/14651858.CD002233.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1002\/hep.22273","article-title":"Portal hypertension and variceal bleeding - unresolved issues. Summary of an American Association for the Study of Liver Diseases and European Association for the Study of the Liver - single topic conference","volume":"47","author":"Garcia Tsao","year":"2008","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/aje\/kwj069","article-title":"Bias in clinical intervention research","volume":"163","author":"Gluud","year":"2006","journal-title":"Americal Journal of Epidemiology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0062|cit62","unstructured":"Gluud C Nikolova D Klingenberg SL Alexakis N Als-Nielsen B Colli A Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)) 2009, Issue 4. Art. No.: LIVER"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0063|cit63","first-page":"389","article-title":"Portal hypertensive bleeding: prevention and treatment","volume-title":"Evidence based Gastroenterology and Hepatology","author":"Goulis","year":"1999"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0064|cit64","first-page":"1081","article-title":"Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension","volume":"92","author":"Grace","year":"1997","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/hep.510280339","article-title":"Portal hypertension and variceal bleeding: an AASLD single topic symposium","volume":"28","author":"Grace","year":"1998","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0016-5085(81)90144-X","article-title":"The course of patients after variceal hemorrhage","volume":"80","author":"Graham","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0067|cit67","first-page":"1495","article-title":"Somatostatin v placebo in bleeding oesophageal varices: randomized trials and meta-analysis","volume":"310","author":"G\u00f8tzsche","year":"1995","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"2","key":"10.1002\/14651858.CD002233.pub2-BIB0068|cit68","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000193","article-title":"Somatostatin analogues for acute bleeding oesophageal varices","author":"G\u00f8tzsche","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0069|cit69","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008] The Cochrane Colloboration, 2008. Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0070|cit70","volume-title":"International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice\/\/1997 CFR & ICH Guidelines","volume":"1","author":"International conference on harmonisation expert working group","year":"1997"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/0016-5085(95)90590-1","article-title":"A meta-analysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage","volume":"109","author":"Imperiale","year":"1995","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1002\/14651858.CD002233.pub2-BIB0072|cit72","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002147","article-title":"Terlipressin for acute esophageal variceal hemorrhage","author":"Ioannou","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"Suppl iii","key":"10.1002\/14651858.CD002233.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"iii1","DOI":"10.1136\/gut.46.suppl_3.iii1","article-title":"UK guidelines on the management of variceal haemorrhage in cirrhotic patients","volume":"46","author":"Jalan","year":"2000","journal-title":"Gut"},{"issue":"11","key":"10.1002\/14651858.CD002233.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodological quality and discrepancies between large and small randomised trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJM198806303182605","article-title":"An assessment of clinically useful measures of the consequences of treatment","volume":"318","author":"Laupacis","year":"1988","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/hep.510250509","article-title":"Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices","volume":"25","author":"Lo","year":"1997","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/lt.21083","article-title":"A randomized study comparing ligation with propranolol for primary prophylaxis of variceal bleeding in candidates for liver transplantation","volume":"13","author":"Norberto","year":"2007","journal-title":"Liver Transplantation"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0078|cit78","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan). Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration. 2008"},{"issue":"4","key":"10.1002\/14651858.CD002233.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0266462303000552","article-title":"Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches","volume":"19","author":"Royle","year":"2003","journal-title":"International Journal of Technology Assessment in Health Care"},{"issue":"11","key":"10.1002\/14651858.CD002233.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1111\/j.1572-0241.2003.t01-1-07705.x","article-title":"Acute bleeding varices: a multicenter prospective member-based study","volume":"98","author":"Sorbi","year":"2003","journal-title":"American Journal of Gastroenterology"},{"issue":"8","key":"10.1002\/14651858.CD002233.pub2-BIB0081|cit81","first-page":"797","article-title":"An evaluation of emergency sclerotherapy of varices in randomized trials: Looking the needle in the eye","volume":"38","author":"Triantos-CK","year":"2006","journal-title":"Endoscopy"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/hep.510300222","article-title":"Somatostatin alone or combined with emergency sclerotherapyin the treatment of acute esophageal variceal bleeding: A prospective randomized trial","volume":"30","author":"Villanueva","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jhep.2006.05.016","article-title":"A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding","volume":"45","author":"Villanueva","year":"2006","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD002233.pub2-BIB0084|cit84","first-page":"114","article-title":"Recent advances in the endoscopic management of variceal bleeding","volume-title":"Portal hypertension II. Proceedings of the second Baveno International Consensus Workshop on definitions, methodology, and therapeutic strategies","author":"Williams","year":"1996"},{"issue":"7644","key":"10.1002\/14651858.CD002233.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.39465.451748.AD","article-title":"Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study","volume":"336","author":"Wood","year":"2008","journal-title":"BMJ (Clinical Research Ed)"},{"issue":"1","key":"10.1002\/14651858.CD002233.pub2-BIB0086|cit86","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002233","article-title":"Emergency sclerotherapy versus medical interventions for bleeding oesophageal varices in cirrhotic patients","author":"D'Amico","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD002233.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:05:30Z","timestamp":1769385930000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD002233.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Hepato-Biliary Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,3,17]]},"references-count":86,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd002233.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,17]]}}}