{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:15:59Z","timestamp":1781842559329,"version":"3.54.5"},"update-to":[{"DOI":"10.1002\/14651858.cd002996.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000}}],"reference-count":66,"publisher":"Wiley","issue":"5","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd002996.pub3","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T12:05:05Z","timestamp":1399896305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Inhaled hyperosmolar agents for bronchiectasis"],"prefix":"10.1002","volume":"2014","author":[{"given":"Anna","family":"Hart","sequence":"first","affiliation":[{"name":"Lancaster University; Lancaster Medical School, Clinical Research Hub; Lancaster Lancashire UK LA1 4TB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karnam","family":"Sugumar","sequence":"additional","affiliation":[{"name":"Royal Preston Hospital, Lancashire Teaching Hospitals NHS Trust; Department of Paediatrics; Preston UK PR2 9HT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Milan","sequence":"additional","affiliation":[{"name":"St George's, University of London; Population Health Sciences and Education; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Fowler","sequence":"additional","affiliation":[{"name":"University Hospital of South Manchester; University of Manchester, NIHR Respiratory and Allergy Clinical Research Facility; Manchester UK"},{"name":"Lancashire Teaching Hospitals NHS Foundation Trust; Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Crossingham","sequence":"additional","affiliation":[{"name":"Royal Blackburn Hospital; Blackburn Lancashire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"issue":"Suppl 2","key":"10.1002\/14651858.CD002996.pub3-BIB0001|cit1","first-page":"49 [423]","article-title":"Inhaled mannitol in patients with bronchiectasis: effect on lung function and health status [Abstract]","volume":"17","author":"Bennoor","year":"2012","journal-title":"Respirology"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0007|cit2","unstructured":"Safety and efficacy of bronchitol in bronchiectasis http:\/\/ClinicalTrials.gov\/show\/NCT00277537"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0002|cit3","doi-asserted-by":"crossref","first-page":"215\u201325","DOI":"10.1378\/chest.12-1763","article-title":"Phase 3 randomized study of the efficacy and safety of inhaled dry powder mannitol for the symptomatic treatment of non-cystic fibrosis bronchiectasis","volume":"144","author":"Bilton","year":"2013","journal-title":"Chest"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0003|cit4","doi-asserted-by":"crossref","unstructured":"Bilton D Daviskas E Jaques A Anderson S Charlton B A randomised placebo-controlled trial of inhaled mannitol in patients with bronchiectasis [Abstract] European Respiratory Society Annual Congress, Berlin, Germany, October 4-8 2008 [P602]","DOI":"10.1164\/ajrccm-conference.2009.179.1_MeetingAbstracts.A3221"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0004|cit5","doi-asserted-by":"crossref","unstructured":"Bilton D Daviskas E Jaques A Anderson SD Charlton B A randomised, placebo-controlled trial of inhaled mannitol in patients with bronchiectasis [Abstract] American Thoracic Society International Conference, May 15-20, 2009, San Diego 2009 A3221 [Poster #E21]","DOI":"10.1164\/ajrccm-conference.2009.179.1_MeetingAbstracts.A3221"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD002996.pub3-BIB0006|cit6","first-page":"A99","article-title":"A new approach to treatment of difficult bronchiectasis [Abstract]","volume":"12","author":"Daviskas","year":"2007","journal-title":"Respirology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD002996.pub3-BIB0005|cit7","first-page":"A29","article-title":"A randomised, placebo -controlled trial of inhaled mannitol in patients with bronchiectasis [Abstract]","volume":"14","author":"Daviskas","year":"2009","journal-title":"Respirology (Carlton, Vic.)"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD002996.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"A49 [S106]","DOI":"10.1136\/thoraxjnl-2011-201054b.106","article-title":"A randomised double blind 13 week crossover trial of hypertonic saline (HTS) (6%) vs isotonic saline (ITS) (0.9%) in patients with bronchiectasis [Abstract]","volume":"66","author":"Bradley","year":"2011","journal-title":"Thorax"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0009|cit9","unstructured":"NCT01112410 Hypertonic saline (6%) versus isotonic saline (0.9%) in bronchiectasis http:\/\/ClinicalTrials.gov\/show\/NCT01112410"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0010|cit10","unstructured":"Chandra AR Jones AS King GG Effects of inhaled mannitol treatment on airway wall dimensions measured by HRCT in patients with bronchiectasis [Abstract] American Thoracic Society International Conference, May 16-21, 2008, Toronto 2008 Poster #121"},{"issue":"6","key":"10.1002\/14651858.CD002996.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1164\/ajrccm.159.6.9809074","article-title":"Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis","volume":"159","author":"Daviskas","year":"1999","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"Suppl 48","key":"10.1002\/14651858.CD002996.pub3-BIB0012|cit12","first-page":"707s","article-title":"A placebo controlled trial with inhaled mannitol improves health related quality of life in patients with bronchiectasis","volume":"24","author":"Daviskas","year":"2004","journal-title":"European Respiratory Journal"},{"issue":"Suppl 48","key":"10.1002\/14651858.CD002996.pub3-BIB0013|cit13","first-page":"470s","article-title":"Inhaled mannitol improves lung function assessed by forced oscillation in a placebo controlled trial in patients with bronchiectasis","volume":"24","author":"Goldman","year":"2004","journal-title":"European Respiratory Journal"},{"issue":"4","key":"10.1002\/14651858.CD002996.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1183\/09031936.00119707","article-title":"Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis","volume":"31","author":"Daviskas","year":"2008","journal-title":"European Respiratory Journal"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0015|cit15","unstructured":"Kellett F Niven R Nebulised 7 % hypertonic sodium chloride improves lung function and airway clearance in non cystic fibrosis bronchiectasis [Abstract] European Respiratory Society Annual Congress, Barcelona, Spain, September 18-22 2010 [P4587]"},{"issue":"12","key":"10.1002\/14651858.CD002996.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.rmed.2011.07.019","article-title":"Nebulised 7% hypertonic saline improves lung function and quality of life in bronchiectasis","volume":"105","author":"Kellett","year":"2011","journal-title":"Respiratory Medicine"},{"issue":"Suppl 33","key":"10.1002\/14651858.CD002996.pub3-BIB0017|cit17","first-page":"484s","article-title":"Double blind trial of hyperosmolar saline as an adjunct to physiotherapy in patients with bronchiectasis","volume":"18","author":"Kellett","year":"2001","journal-title":"European Respiratory Journal"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.rmed.2004.05.006","article-title":"Evaluation of nebulised hypertonic saline (7%) as an adjunct to physiotherapy in patients with stable bronchiectasis","volume":"99","author":"Kellett","year":"2005","journal-title":"Respiratory Medicine"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0019|cit19","unstructured":"Bilton D Tino G Barker A Chambers D DeSoyza A Dupont L Inhaled mannitol for non-cystic fibrosis bronchiectasis:Results of a 12 month, multi-centre, double-blind, controlled study ERS Annual Conference September 7-11 2013, Barcelona 2013"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0020|cit20","unstructured":"NCT00669331 Inhaled mannitol as a mucoactive therapy for bronchiectasis http:\/\/ClinicalTrials.gov\/show\/NCT00669331"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0021|cit21","unstructured":"NCT00484263 The long term effect of inhaled hypertonic saline (6%) in patients with non cystic fibrosis bronchiectasis http:\/\/ClinicalTrials.gov\/show\/NCT00484263"},{"issue":"5","key":"10.1002\/14651858.CD002996.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.rmed.2011.12.021","article-title":"The long term effect of inhaled hypertonic saline 6% in non-cystic fibrosis bronchiectasis","volume":"106","author":"Nicolson","year":"2012","journal-title":"Respiratory Medicine"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD002996.pub3-BIB0023|cit23","first-page":"A1","article-title":"Prevention of airway narrowing following mannitol inhalation in subjects with bronchiectasis [Abstract]","volume":"14","author":"Briffa","year":"2009","journal-title":"Respirology"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1440-1843.2010.01894.x","article-title":"Sodium cromoglycate and eformoterol attenuate sensitivity and reactivity to inhaled mannitol in subjects with bronchiectasis","volume":"16","author":"Briffa","year":"2011","journal-title":"Respirology"},{"issue":"2","key":"10.1002\/14651858.CD002996.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1378\/chest.119.2.414","article-title":"The 24-h effect of Mannitol on the clearance of mucus in patients with bronchiectasis","volume":"119","author":"Daviskas","year":"2001","journal-title":"Chest"},{"issue":"Suppl 45","key":"10.1002\/14651858.CD002996.pub3-BIB0026|cit26","first-page":"430s","article-title":"Increase in health status after 12 days treatment with inhaled mannitol in patients with bronchiectasis","volume":"22","author":"Daviskas","year":"2003","journal-title":"European Respiratory Journal"},{"issue":"11","key":"10.1002\/14651858.CD002996.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.rmed.2010.05.019","article-title":"Beneficial effect of inhaled mannitol and cough in asthmatics with mucociliary dysfunction","volume":"104","author":"Daviskas","year":"2010","journal-title":"Respiratory Medicine"},{"issue":"5","key":"10.1002\/14651858.CD002996.pub3-BIB0028|cit28","first-page":"544","article-title":"Bronchial hyper-reactivity in bronchiectasis","volume":"13","author":"Harrison","year":"1983","journal-title":"Australian and New Zealand Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD002996.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1164\/rccm.201005-0756OC","article-title":"A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis","volume":"183","author":"Murray","year":"2011","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0030|cit30","unstructured":"NCT00105183 EZ-2053 in the prophylaxis of acute pulmonary allograft rejection http:\/\/ClinicalTrials.gov\/show\/NCT00105183"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0031|cit31","unstructured":"NCT00730977 A pilot study to investigate administration of mannitol via a novel dry powder inhaler device http:\/\/ClinicalTrials.gov\/show\/NCT00730977"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0032|cit32","unstructured":"NCT00749866 Long term nebulised gentamicin in patients with bronchiectasis http:\/\/ClinicalTrials.gov\/show\/NCT00749866"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0033|cit33","unstructured":"NCT01076491 High dose inhaled mannitol study http:\/\/ClinicalTrials.gov\/show\/NCT01076491"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0034|cit34","unstructured":"NCT01313624 A study to see if AZLI (an inhaled antibiotic) is effective in treating adults with non-CF bronchiectasis - AIR-BX1 http:\/\/ClinicalTrials.gov\/show\/NCT01313624"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0035|cit35","unstructured":"NCT01314716 A study to see if AZLI (an inhaled antibiotic) is effective in treating adults with non-CF bronchiectasis - AIR-BX2 http:\/\/ClinicalTrials.gov\/show\/NCT01314716"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0036|cit36","unstructured":"NCT01677403 A study to access safety and efficacy of nebulized tobramycin in patients with bronchiectasis http:\/\/clinicaltrials.gov\/show\/NCT01677403"},{"issue":"12","key":"10.1002\/14651858.CD002996.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/jama.2013.2290","article-title":"Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: The BLESS randomized controlled trial","volume":"309","author":"Serisier","year":"2013","journal-title":"JAMA"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/thx.43.1.57","article-title":"Use of nebulised saline and nebulised terbutaline as an adjunct to chest physiotherapy","volume":"43","author":"Sutton","year":"1988","journal-title":"Thorax"},{"issue":"7","key":"10.1002\/14651858.CD002996.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1001\u20137","DOI":"10.1016\/j.rmed.2013.04.013","article-title":"Phenotyping adults with non-cystic fibrosis bronchiectasis: A prospective observational cohort study","volume":"107","author":"Anwar","year":"2013","journal-title":"Respiratory Medicine"},{"issue":"2","key":"10.1002\/14651858.CD002996.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"233\u201348","DOI":"10.1016\/j.ccm.2012.02.007","article-title":"Imaging of bronchiectasis","volume":"33","author":"Bonavita","year":"2012","journal-title":"Clinics in Chest Medicine"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0041|cit41","unstructured":"Pasteur MC Bilton D Hill AT (on behalf of the British Thoracic Society Bronchiectasis (non-CF) Guideline Group:a sub-group of the British Thoracic Society Standards of Care Committee) BTS Guideline for non-CF Bronchiectasis http:\/\/www.brit-thoracic.org.uk\/Guidelines\/Bronchiectasis-Guideline-non-CF.aspx"},{"issue":"4","key":"10.1002\/14651858.CD002996.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1183\/09031936.96.09040725","article-title":"Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects","volume":"9","author":"Daviskas","year":"1996","journal-title":"European Respiratory Journal"},{"issue":"6","key":"10.1002\/14651858.CD002996.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"445\u201352","DOI":"10.1097\/01.mcp.0000245714.89632.b2","article-title":"Inhaled hypertonic saline as a therapy for cystic fibrosis","volume":"12","author":"Elkins","year":"2006","journal-title":"Current Opinion in Pulmonary Medicine"},{"issue":"3","key":"10.1002\/14651858.CD002996.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJMoa043900","article-title":"A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis","volume":"354","author":"Elkins","year":"2006","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD002996.pub3-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/adc.2006.094979","article-title":"Hypertonic saline inhalation in cystic fibrosis - salt in the wound, or sweet success?","volume":"92","author":"Enderby","year":"2007","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1183\/09031936.96.09081601","article-title":"Lung function in bronchiectasis: the influence of Pseudomonas aeruginosa","volume":"9","author":"Evans","year":"1996","journal-title":"European Respiratory Journal"},{"issue":"99","key":"10.1002\/14651858.CD002996.pub3-BIB0047|cit47","first-page":"477-8, 480-3","article-title":"Bronchiectasis: a reemerging disease","volume":"3","author":"Frey","year":"2007","journal-title":"Revue M\u00e9dicale Suisse"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0048|cit48","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1","author":"Higgins","year":"updated March 2011"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1081\/COPD-200050513","article-title":"St Georges Respiratory Questionnaire:MCID","volume":"2","author":"Jones","year":"2005","journal-title":"COPD"},{"issue":"7446","key":"10.1002\/14651858.CD002996.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature11868","article-title":"Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells","volume":"496","author":"Kleinewietfeld","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1002\/14651858.CD002996.pub3-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1378\/chest.07-0490","article-title":"Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis","volume":"132","author":"Martinez-Garc\u00eda","year":"2007","journal-title":"Chest"},{"issue":"8","key":"10.1002\/14651858.CD002996.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"823\u201331","DOI":"10.1164\/rccm.201208-1518OC","article-title":"Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease","volume":"187","author":"Mart\u00ednez-Garc\u00eda","year":"2013","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"Suppl 1:i1-58","DOI":"10.1136\/thx.2010.142778","article-title":"British Thoracic Society guideline for non-CF bronchiectasis","volume":"65","author":"Pasteur","year":"2010","journal-title":"Thorax"},{"issue":"2","key":"10.1002\/14651858.CD002996.pub3-BIB0054|cit54","first-page":"199","article-title":"Enhanced clearance of secretions from the human lung after the administration of hypertonic saline aerosol","volume":"117","author":"Pavia","year":"1978","journal-title":"American Review of Respiratory Disease"},{"issue":"11","key":"10.1002\/14651858.CD002996.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1164\/rccm.201101-0072OC","article-title":"Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis","volume":"183","author":"Reeves","year":"2011","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0056|cit56","unstructured":"Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan). 5.2 2012"},{"issue":"10","key":"10.1002\/14651858.CD002996.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/thx.52.10.900","article-title":"Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis","volume":"52","author":"Robinson","year":"1997","journal-title":"Thorax"},{"issue":"2","key":"10.1002\/14651858.CD002996.pub3-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1440-1843.2003.00454.x","article-title":"Effect of osmolality on mucociliary transportability and rheology of cystic fibrosis and bronchiectasis sputum","volume":"8","author":"Shibuya","year":"2003","journal-title":"Respirology"},{"issue":"6","key":"10.1002\/14651858.CD002996.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"1163\u201370","DOI":"10.1016\/j.rmed.2006.11.008","article-title":"Aetiology in adult patients with bronchiectasis","volume":"101","author":"Shoemark","year":"2007","journal-title":"Respiratory Medicine"},{"issue":"21","key":"10.1002\/14651858.CD002996.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"1963\u201370","DOI":"10.1056\/NEJMoa1301725","article-title":"Risk factors for bronchiectasis in children with cystic fibrosis","volume":"368","author":"Sly","year":"2013","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD002996.pub3-BIB0061|cit61","unstructured":"Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand http:\/\/www.lungfoundation.com.au\/wp-content\/uploads\/2012\/06\/bronchiectasis.pdf"},{"issue":"4","key":"10.1002\/14651858.CD002996.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.cpm.0000171422.98696.ed","article-title":"Prevalence and economic burden of bronchiectasis","volume":"12","author":"Weycker","year":"2005","journal-title":"Clinical Pulmonary Medicine"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1172\/JCI119138","article-title":"Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea","volume":"99","author":"Wills","year":"1997","journal-title":"Journal of Clinical Investigation"},{"issue":"7446","key":"10.1002\/14651858.CD002996.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature11984","article-title":"Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1","volume":"496","author":"Wu","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1002\/14651858.CD002996.pub3-BIB0065|cit65","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002996","article-title":"Inhaled hyperosmolar agents for bronchiectasis","author":"Wills","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD002996.pub3-BIB0066|cit66","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002996.pub2","article-title":"Inhaled hyperosmolar agents for bronchiectasis","author":"Wills","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD002996.pub3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T10:20:38Z","timestamp":1706005238000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD002996.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Airways Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd002996.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}