{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:24:27Z","timestamp":1785583467535,"version":"3.56.0"},"update-to":[{"DOI":"10.1002\/14651858.cd003057","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2004,1,26]],"date-time":"2004-01-26T00:00:00Z","timestamp":1075075200000}}],"reference-count":40,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd003057.pub2","type":"journal-article","created":{"date-parts":[[2004,1,29]],"date-time":"2004-01-29T13:02:36Z","timestamp":1075381356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hyperbaric oxygen therapy for multiple sclerosis"],"prefix":"10.1002","volume":"2011","author":[{"given":"Michael H","family":"Bennett","sequence":"first","affiliation":[{"name":"Prince of Wales Hospital; Department of Anaesthesia; Barker Street Randwick NSW Australia 2031"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Heard","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital; Department of Diving and Hyperbaric Medicine; Barker Street Randwick Australia NSW 2031"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,26]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD003057.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0140-6736(85)91079-7","article-title":"Hyperbaric oxygen and multiple sclerosis: short term results of a placebo-controlled, double-blind trial","volume":"8424","author":"Barnes","year":"1985","journal-title":"The Lancet"},{"issue":"11","key":"10.1002\/14651858.CD003057.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/jnnp.50.11.1402","article-title":"Hyperbaric oxygen and multiple sclerosis: final results of a placebo-controlled, double blind trial","volume":"50","author":"Barnes","year":"1987","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"28","key":"10.1002\/14651858.CD003057.pub2-BIB0003|cit3","first-page":"1319","article-title":"Hyperbaric oxygen in multiple sclerosis","volume":"15","author":"Confavreux","year":"1986","journal-title":"La Presse M\u00e9dicale"},{"issue":"4","key":"10.1002\/14651858.CD003057.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1056\/NEJM198301273080402","article-title":"Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study","volume":"308","author":"Fischer","year":"1983","journal-title":"New England Journal of Medicine"},{"issue":"7","key":"10.1002\/14651858.CD003057.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1212\/WNL.36.7.988","article-title":"Hyperbaric oxygen therapy in chronic stable multiple sclerosis: double-blind study","volume":"36","author":"Harper","year":"1986","journal-title":"Neurology"},{"issue":"3","key":"10.1002\/14651858.CD003057.pub2-BIB0006|cit6","first-page":"201","article-title":"Hyperbaric oxygen treatment of chronic multiple sclerosis. Results of a placebo-controlled double-blind study in 49 patients","volume":"142","author":"L'Hermitte","year":"1986","journal-title":"Revue Neurologique (Paris)"},{"issue":"6","key":"10.1002\/14651858.CD003057.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/jnnp.48.6.497","article-title":"Hyperbaric oxygen in chronic progressive multiple sclerosis: visual evoked potentials and clinical effects","volume":"48","author":"Neiman","year":"1985","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0008|cit8","first-page":"237","article-title":"Long-term hyperbaric oxygen in multiple sclerosis: a placebo-controlled, double-blind trial with evoked potentials studies","volume":"5","author":"Oriani","year":"1990","journal-title":"Journal of Hyperbaric Medicine"},{"issue":"6517","key":"10.1002\/14651858.CD003057.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/bmj.292.6517.367","article-title":"Hyperbaric oxygen in multiple sclerosis: a double blind trial","volume":"292","author":"Wiles","year":"1986","journal-title":"British Medical Journal (Clinical Research Edition)"},{"issue":"6","key":"10.1002\/14651858.CD003057.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.5694\/j.1326-5377.1985.tb122957.x","article-title":"A double-blind trial of hyperbaric oxygen in the treatment of multiple sclerosis","volume":"143","author":"Wood","year":"1985","journal-title":"The Medical Journal of Australia"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD003057.pub2-BIB0011|cit11","first-page":"104","article-title":"Hyperbaric oxygen influences on the visual evoked potentials in multiple sclerosis patients","volume":"35","author":"Erwin","year":"1985","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0012|cit12","first-page":"143","article-title":"Multiple sclerosis: its etiology, pathogenesis and therapeutics with emphasis on the controversial use of HBO","volume":"3","author":"Gottlieb","year":"1988","journal-title":"Journal of Hyperbaric Medicine"},{"issue":"2","key":"10.1002\/14651858.CD003057.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/archneur.1991.00530140091021","article-title":"Treatment of multiple sclerosis with hyperbaric oxygen. Results of a national registry","volume":"48","author":"Kindwall","year":"1991","journal-title":"Archives of Neurology"},{"issue":"5","key":"10.1002\/14651858.CD003057.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1600-0404.1995.tb07017.x","article-title":"Hyperbaric oxygen for multiple sclerosis. Review of controlled trials","volume":"91","author":"Kleijnen","year":"1995","journal-title":"Acta Neurologica Scandinavica"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD003057.pub2-BIB0015|cit15","first-page":"104","article-title":"Hyperbaric oxygen in multiple sclerosis: a double-blind crossover study of 18 patients","volume":"35","author":"Massey","year":"1985","journal-title":"Neurology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD003057.pub2-BIB0016|cit16","first-page":"104","article-title":"Double-blind randomised study of hyperbaric oxygen (HBO) versus placebo in multiple sclerosis (MS)","volume":"35","author":"Murthy","year":"1985","journal-title":"Neurology"},{"issue":"42","key":"10.1002\/14651858.CD003057.pub2-BIB0017|cit17","first-page":"2947","article-title":"Hyperbaric therapy of multiple sclerosis","volume":"73","author":"Pallotta","year":"1982","journal-title":"Minerva-Medica"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD003057.pub2-BIB0018|cit18","first-page":"315","article-title":"Hyperbaric oxygen and multiple sclerosis: a double-blind, controlled study","volume":"35","author":"Slater","year":"1985","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0019|cit19","first-page":"229","article-title":"A double-blind controlled crossover trial investigating the efficacy of hyperbaric oxygen in patients with multiple sclerosis","volume-title":"Multiple Sclerosis. Immunological, Diagnostic and Therapeutic Aspects","author":"Worthington","year":"1987"},{"issue":"3","key":"10.1002\/14651858.CD003057.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1212\/WNL.28.3.251","article-title":"Cranial CT appearance of acute multiple sclerosis","volume":"28","author":"Aita","year":"1978","journal-title":"Neurology"},{"issue":"1-2","key":"10.1002\/14651858.CD003057.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0165-5728(99)00193-9","article-title":"Molecular pathogenesis of multiple sclerosis","volume":"100","author":"Bar-Or","year":"1999","journal-title":"Journal of Neuroimmunology"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0022|cit22","unstructured":"Bennett MH The Database of randomised controlled trials in hyperbaric medicine (DORCTIHM) www.hboevidence.com December 2001"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0023|cit23","unstructured":"Brickner RM The significance of localised vasoconstrictions in multiple sclerosis. Transient sudden miniature attacks of multiple sclerosis Association of Respiratory, Nervous and Mental Diseases Proceedings 1950 236 44"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0024|cit24","first-page":"45","article-title":"The genetic epidemiology of multiple sclerosis","volume-title":"McAlpine's Multiple Sclerosis","author":"Compston","year":"1998"},{"issue":"1","key":"10.1002\/14651858.CD003057.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomised clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"issue":"8268","key":"10.1002\/14651858.CD003057.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(82)91402-7","article-title":"Evidence for subacute fat embolism as the cause of multiple sclerosis","volume":"1","author":"James","year":"1982","journal-title":"Lancet"},{"issue":"8428","key":"10.1002\/14651858.CD003057.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(85)91223-1","article-title":"Hyperbaric oxygen and multiple sclerosis","volume":"1","author":"James","year":"1985","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1212\/WNL.15.7.654","article-title":"Further notes on disability evaluation in multiple sclerosis with scale modifications","volume":"15","author":"Kurtzke","year":"1965","journal-title":"Neurology (Minneapolis)"},{"issue":"11","key":"10.1002\/14651858.CD003057.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurological impairment in multiple sclerosis: an expanded disability staus scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0030|cit30","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 (updated September 2009). The Cochrane Collaboration, 2009 Available from www.cochrane-handbook.org"},{"issue":"1","key":"10.1002\/14651858.CD003057.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/oxfordjournals.bmb.a071393","article-title":"Diagnosis and classification of multiple sclerosis","volume":"33","author":"Donald","year":"1977","journal-title":"British Medical Bulletin"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0032|cit32","volume-title":"Hyperbaric oxygen therapy of multiple sclerosis. A multi-centre survey","author":"Neubauer","year":"1983"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0033|cit33","unstructured":"Perrins DJD Treatment of multiple sclerosis with prolonged courses of hyperbaric oxygen a twelve year update International Joint Meeting on Hyperbaric and Underwater Medicine Proceedings Bologna Graphica Victoria 1996 203 7"},{"issue":"3","key":"10.1002\/14651858.CD003057.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ana.410130302","article-title":"New diagnostic criteria for multiple sclerosis: guidelines for research protocols","volume":"13","author":"Poser","year":"1983","journal-title":"Annals of Neurology"},{"issue":"1","key":"10.1002\/14651858.CD003057.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ana.410050105","article-title":"Remyelination in multiple sclerosis","volume":"5","author":"Prineas","year":"1979","journal-title":"Annals of Neurology"},{"issue":"3","key":"10.1002\/14651858.CD003057.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/brain\/116.3.681","article-title":"Multiple Sclerosis. Pathology of recurrent lesions","volume":"116","author":"Prineas","year":"1993","journal-title":"Brain"},{"issue":"1","key":"10.1002\/14651858.CD003057.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1001\/archneurpsyc.1943.02290140038002","article-title":"Histogenesis of the early lesions of multiple sclerosis","volume":"49","author":"Sheinker","year":"1943","journal-title":"Archives of Neurology"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1749-6632.1965.tb20235.x","article-title":"Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials in multiple sclerosis","volume":"122","author":"Schumacher","year":"1965","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"3","key":"10.1002\/14651858.CD003057.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1212\/WNL.51.3.758","article-title":"Serial magnetisation transfer imaging to characterize the early evolution of new MS lesions","volume":"51","author":"Silver","year":"1998","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD003057.pub2-BIB0040|cit40","volume-title":"The hyperbaric oxygen therapy committee report 2001","author":"The Hyperbaric Oxygen Therapy Committee of the UHMS","year":"2001"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD003057.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:46:56Z","timestamp":1779335216000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD003057.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Multiple Sclerosis and Rare Diseases of the CNS Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2004,1,26]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd003057.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,26]]}}}