{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:16:53Z","timestamp":1793377013717,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd003285","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000}}],"reference-count":69,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd003285.pub2","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T09:52:15Z","timestamp":1374659535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Homocysteine lowering interventions for peripheral arterial disease and bypass grafts"],"prefix":"10.1002","volume":"2019","author":[{"given":"Alina","family":"Andras","sequence":"first","affiliation":[{"name":"Keele University; Keele Staffordshire UK ST5 5BG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Stansby","sequence":"additional","affiliation":[{"name":"Freeman Hospital; Northern Vascular Centre; Newcastle UK NE77DN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Hansrani","sequence":"additional","affiliation":[{"name":"James Cook Hospital; Department of Vascular Surgery; Middlesborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"issue":"9","key":"10.1002\/14651858.CD003285.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/bjs.6670","article-title":"Randomized clinical trial of folate supplementation in patients with peripheral arterial disease","volume":"96","author":"Khandanpour","year":"2009","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD003285.pub2-BIB0002|cit2","unstructured":"Khandanpour N Armon MP Jennings B Willis G Clark A Meyer FJ Folate supplementation improves arterial function in patients with peripheral arterial disease: a randomised double-blind, placebo-controlled clinical trial The Vascular Society of Great Britain & Ireland Yearbook 2008 2008 81"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0008-6363(02)00617-X","article-title":"ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins","volume":"57","author":"Sydow","year":"2003","journal-title":"Cardiovascular Research"},{"issue":"6","key":"10.1002\/14651858.CD003285.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/jn\/135.6.1393","article-title":"Daily supplementation with (n-3) PUFAs, oleic acid, folic acid, and vitamins B-6 and E increases pain-free walking distance and improves risk factors in men with peripheral vascular disease","volume":"135","author":"Carrero","year":"2005","journal-title":"The Journal of Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1046\/j.1365-2141.1999.01780.x","article-title":"Three months supplementation of hyperhomocysteinaemic patients with folic acid and vitamin B6 improves biological markers of endothelial dysfunction","volume":"107","author":"Constans","year":"1999","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2796.1999.00541.x","article-title":"Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature peripheral arterial occlusive disease. A prospective cohort study","volume":"246","author":"Jong","year":"1999","journal-title":"Journal of Internal Medicine"},{"issue":"6 Part 1","key":"10.1002\/14651858.CD003285.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0002-8703(99)70073-6","article-title":"Niacin treatment increases plasma homocyst(e)ine levels","volume":"138","author":"Garg","year":"1999","journal-title":"American Heart Journal"},{"issue":"15","key":"10.1002\/14651858.CD003285.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD003285.pub2-BIB0009|cit9","unstructured":"Anonymous Homocysteine and progression of atherosclerosis http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00005338 (accessed 1 May 2013)"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"772-80, discuss","DOI":"10.1016\/j.jvs.2005.12.051","article-title":"Prospective evaluation of the relationship of between C-reactive protein, D-dimer and progression of peripheral arterial disease","volume":"43","author":"Musicant","year":"2006","journal-title":"Journal of Vascular Surgery"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0011|cit11","first-page":"38-46, discussi","article-title":"Relationship between site of initial symptoms and subsequent progression of disease in a prospective study of atherosclerosis progression in patients receiving long-term treatment for symptomatic peripheral arterial disease","volume":"35","author":"Nicoloff","year":"2002","journal-title":"Journal of Vascular Surgery"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"8-19, discussio","DOI":"10.1016\/S0741-5214(99)70345-9","article-title":"Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease","volume":"29","author":"Taylor","year":"1999","journal-title":"Journal of Vascular Surgery"},{"issue":"9501","key":"10.1002\/14651858.CD003285.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(05)67704-5","article-title":"Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial.","volume":"366","author":"Adam","year":"2005","journal-title":"Lancet"},{"issue":"7135","key":"10.1002\/14651858.CD003285.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","article-title":"Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration","volume":"316","author":"Anonymous","year":"1998","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ahj.2005.04.025","article-title":"Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials","volume":"151","author":"B-Vitamin Treatment Trialists' Collaboration","year":"2006","journal-title":"American Heart Journal"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/hrt.72.2.128","article-title":"Peripheral vascular disease: consequence for survival and association with risk factors in the Speedwell prospective heart disease study","volume":"72","author":"Bainton","year":"1994","journal-title":"British Heart Journal"},{"issue":"13","key":"10.1002\/14651858.CD003285.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"issue":"6","key":"10.1002\/14651858.CD003285.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0741-5214(99)70053-4","article-title":"Folic acid inhibits homocysteine-induced proliferation of human arterial smooth muscle cells","volume":"30","author":"Carmody","year":"1999","journal-title":"Journal of Vascular Surgery"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0037-1614438","article-title":"Hyperhomocysteinemia, atherosclerosis and thrombosis","volume":"81","author":"Cattaneo","year":"1999","journal-title":"Thrombosis and Haemostasis"},{"issue":"11","key":"10.1002\/14651858.CD003285.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1359-61, A8","DOI":"10.1016\/S0002-9149(99)00575-5","article-title":"Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia","volume":"84","author":"Chao","year":"1999","journal-title":"American Journal of Cardiology"},{"issue":"17","key":"10.1002\/14651858.CD003285.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","article-title":"Hyperhomocysteinemia: an independent risk factor for vascular disease","volume":"324","author":"Clarke","year":"1991","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"10.1002\/14651858.CD003285.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Archives of Neurology"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/sim.4780060308","article-title":"Avoidance of large biases and large random errors in the assessment of moderate treatment effects: the need for systematic overviews","volume":"6","author":"Collins","year":"1987","journal-title":"Statistics in Medicine"},{"issue":"357","key":"10.1002\/14651858.CD003285.pub2-BIB0024|cit24","first-page":"149","article-title":"Prevalence of lower extremity arterial disease among elderly people in the community","volume":"42","author":"Coni","year":"1992","journal-title":"British Journal of General Practice"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1358863X9700200310","article-title":"The epidemiology of peripheral arterial disease: importance of identifying the population at risk","volume":"2","author":"Criqui","year":"1997","journal-title":"Vascular Medicine"},{"issue":"9","key":"10.1002\/14651858.CD003285.pub2-BIB0026|cit26","first-page":"1238","article-title":"Homocysteine:an independant risk factor for the failure of vascular intervention","volume":"83","author":"Currie","year":"1996","journal-title":"British Journal of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD003285.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1055\/s-0037-1615380","article-title":"Hyperhomocysteinemia and venous thrombosis: a meta-analysis","volume":"80","author":"Heijer","year":"1998","journal-title":"Thrombosis and Haemostasis"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0021-9150(03)00204-1","article-title":"High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study","volume":"172","author":"Diehm","year":"2004","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0950-821X(05)80676-0","article-title":"The fate of the claudicant -- a prospective study of 1969 claudicants","volume":"5","author":"Dormandy","year":"1991","journal-title":"European Journal of Vascular Surgery"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.ATV.14.3.465","article-title":"Treatment of mild hyperhomocysteinemia in vascular disease patients","volume":"14","author":"Franken","year":"1994","journal-title":"Arteriosclerosis and Thrombosis"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0735-1097(92)90171-I","article-title":"Therapeutic dissection after successful coronary balloon angioplasty: no influence on restenosis or clinical outcome in 693 patients. The MERCATOR Study Group (Multicenter European Research Trial with Cilazapril after Angioplasty to prevent Transluminal Coronary Obstruction and Restenosis)","volume":"20","author":"Hermans","year":"1992","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1002\/14651858.CD003285.pub2-BIB0032|cit32","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"7","key":"10.1002\/14651858.CD003285.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/aje\/153.7.666","article-title":"Incidence of and risk factors for asymptomatic peripheral arterial occlusive disease: a longitudinal study","volume":"153","author":"Hooi","year":"2001","journal-title":"American Journal of Epidemiology"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10741-012-9331-1","article-title":"Peripheral arterial disease and chronic heart failure: a dangerous mix","volume":"18","author":"Inglis","year":"2013","journal-title":"Heart Failure Reviews"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S1078-5884(96)80249-8","article-title":"Hyperhomocysteinaemia is a risk factor for vein graft stenosis","volume":"12","author":"Irvine","year":"1996","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"6","key":"10.1002\/14651858.CD003285.pub2-BIB0036|cit36","first-page":"357","article-title":"[Elevated levels of plasma homocysteine related to saphenous vein graft disease after coronary artery bypass graft surgery]","volume":"32","author":"Iwama","year":"1998 Dec","journal-title":"Journal of Cardiology"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jvs.2008.10.004","article-title":"Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis","volume":"49","author":"Khandanpour","year":"2009","journal-title":"Journal of Vascular Surgery"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejvs.2009.05.007","article-title":"Homocysteine and peripheral arterial disease: systematic review and meta-analysis","volume":"38","author":"Khandanpour","year":"2009","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"6","key":"10.1002\/14651858.CD003285.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/ije\/25.6.1172","article-title":"Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population","volume":"25","author":"Leng","year":"1996","journal-title":"International Journal of Epidemiology"},{"issue":"4 Suppl","key":"10.1002\/14651858.CD003285.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1238S","DOI":"10.1093\/jn\/126.suppl_4.1238S","article-title":"Plasma homocyst(e)ine: a risk factor for arterial occlusive diseases","volume":"126","author":"Malinow","year":"1996","journal-title":"Journal of Nutrition"},{"issue":"15","key":"10.1002\/14651858.CD003285.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJM199804093381501","article-title":"Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease","volume":"338","author":"Malinow","year":"1998","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0042|cit42","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0043|cit43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006612.pub3","article-title":"Homocysteine-lowering interventions for preventing cardiovascular events","author":"Marti-Carvajal","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0044|cit44","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully","year":"1969","journal-title":"American Journal of Pathology"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nm0496-386","article-title":"Homocysteine and vascular disease","volume":"2","author":"McCully","year":"1996","journal-title":"Nature Medicine"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1742-1241.2009.02207.x","article-title":"Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials","volume":"64","author":"Mei","year":"2010","journal-title":"International Journal of Clinincal Practice"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.ATV.18.2.185","article-title":"Peripheral arterial disease in the elderly: The Rotterdam Study","volume":"18","author":"Meijer","year":"1998","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"Supp 1","key":"10.1002\/14651858.CD003285.pub2-BIB0048|cit48","first-page":"27","article-title":"Plasma homocysteine is an independent risk factor for vein graft stenosis","volume":"85 Suppl","author":"Mireskandari","year":"1998","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD003285.pub2-BIB0049|cit49","unstructured":"National Institute for Health and Clinical Excellence Lower limb peripheral arterial disease: diagnosis and management http:\/\/guidance.nice.org.uk\/CG147\/NICEGuidance\/pdf\/English"},{"issue":"6","key":"10.1002\/14651858.CD003285.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/bjs.1800810613","article-title":"Trends in vascular surgery since the introduction of percutaneous transluminal angioplasty","volume":"81","author":"Pell","year":"1994","journal-title":"British Journal of Surgery"},{"key":"10.1002\/14651858.CD003285.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Annual Review of Medicine"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1023\/A:1005331902497","article-title":"Betaine dose and treatment intervals in therapy for homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency","volume":"21","author":"Sakura","year":"1998","journal-title":"Journal of Inherited Metabolic Disease"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2147\/vhrm.2007.3.2.229","article-title":"Epidemiology, classification, and modifiable risk factors of peripheral arterial disease","volume":"3","author":"Shammas","year":"2007","journal-title":"Vascular Health and Risk Management"},{"issue":"5","key":"10.1002\/14651858.CD003285.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0741-5214(98)70069-2","article-title":"Hyperhomocysteinemia increases intimal hyperplasia in a rat carotid endarterectomy model","volume":"28","author":"Southern","year":"1998","journal-title":"Journal of Vascular Surgery"},{"issue":"5","key":"10.1002\/14651858.CD003285.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1078-5884(03)00381-2","article-title":"The incidence of hyperhomocysteinaemia in vascular patients","volume":"26","author":"Spark","year":"2003","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"2","key":"10.1002\/14651858.CD003285.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/ije\/25.2.282","article-title":"The prevalence of asymptomatic and unrecognized peripheral arterial occlusive disease","volume":"25","author":"Stoffers","year":"1996","journal-title":"International Journal of Epidemiology"},{"issue":"11","key":"10.1002\/14651858.CD003285.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/01.RVI.0000137978.15352.C6","article-title":"Medical treatment of peripheral arterial disease: a comprehensive review","volume":"15","author":"Stoyioglou","year":"2004","journal-title":"Journal of Vascular and Interventional Radiology"},{"issue":"1","key":"10.1002\/14651858.CD003285.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"8-19, discussio","DOI":"10.1016\/S0741-5214(99)70345-9","article-title":"Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease","volume":"29","author":"Taylor","year":"1999","journal-title":"Journal of Vascular Surgery"},{"issue":"4","key":"10.1002\/14651858.CD003285.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0950-821X(05)80961-2","article-title":"The effect of transluminal endothelial seeding on myointimal hyperplasia following angioplasty","volume":"8","author":"Thompson","year":"1994","journal-title":"European Journal of Vascular Surgery"},{"issue":"7244","key":"10.1002\/14651858.CD003285.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1136\/bmj.320.7244.1262","article-title":"ABC of arterial and vascular disease. Secondary prevention of peripheral vascular disease","volume":"320","author":"Tierney","year":"2000","journal-title":"BMJ"},{"issue":"8","key":"10.1002\/14651858.CD003285.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1161\/01.CIR.92.8.2284","article-title":"Intra-arterial beta irradiation prevents neointimal hyperplasia in a hypercholesterolemic rabbit restenosis model","volume":"92","author":"Verin","year":"1995","journal-title":"Circulation"},{"issue":"9203","key":"10.1002\/14651858.CD003285.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0140-6736(99)07391-2","article-title":"Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial","volume":"355","author":"Vermeulen","year":"2000","journal-title":"Lancet"},{"issue":"37","key":"10.1002\/14651858.CD003285.pub2-BIB0063|cit63","first-page":"1870","article-title":"Peripheral arterial disease (PAD): secondary prevention","volume":"127","author":"Voller","year":"2002","journal-title":"Deutsche Medizinische Wochenschrift"},{"issue":"19","key":"10.1002\/14651858.CD003285.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1161\/CIRCULATIONAHA.106.621391","article-title":"Endovascular therapies for peripheral arterial disease: an evidence-based review","volume":"116","author":"White","year":"2007","journal-title":"Circulation"},{"issue":"8","key":"10.1002\/14651858.CD003285.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM198308253090802","article-title":"Homocystinuria - the effects of betaine in the treatment of patients not responsive to pyridoxine","volume":"309","author":"Wilcken","year":"1983","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD003285.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0026-0495(85)90156-8","article-title":"Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients","volume":"34","author":"Wilcken","year":"1985","journal-title":"Metabolism"},{"issue":"7","key":"10.1002\/14651858.CD003285.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0735-1097(99)00469-6","article-title":"Folic acid improves arterial endothelial function in adults with hyperhomocystinemia","volume":"34","author":"Woo","year":"1999","journal-title":"Journal of the American College of Cardiology"},{"issue":"9199","key":"10.1002\/14651858.CD003285.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(99)04180-X","article-title":"Cardiovascular gene therapy","volume":"355","author":"Yla-Herttuala","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD003285.pub2-BIB0069|cit69","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003285","article-title":"Homocysteine lowering interventions for peripheral arterial disease and bypass grafts","author":"Hansrani","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD003285.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:47:09Z","timestamp":1789966029000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD003285.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Vascular Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":69,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd003285.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}