{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:07:35Z","timestamp":1790057255033,"version":"4.0.1"},"publisher-location":"Chichester, UK","reference-count":61,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd003311.pub2","type":"reference-entry","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T16:19:30Z","timestamp":1192033170000},"source":"Crossref","is-referenced-by-count":203,"title":["Cooling for newborns with hypoxic ischaemic encephalopathy"],"prefix":"10.1002","author":[{"given":"Susan E","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William O","family":"Tarnow-Mordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie E","family":"Inder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,17]]},"reference":[{"key":"10.1002\/14651858.CD003311.pub2-BIB1|cit1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0952-3278(03)00055-3","article-title":"Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia","volume":"69","author":"Akisu","year":"2003","journal-title":"Prostaglandins, Leokotrienes and Essential Fatty Acids"},{"key":"10.1002\/14651858.CD003311.pub2-BIB2|cit2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2004.06.014","article-title":"Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes","volume":"32","author":"Eicher","year":"2005","journal-title":"Pediatric Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB3|cit3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pediatrneurol.2004.06.015","article-title":"Moderate hypothermia in neonatal encephalopathy: safety outcomes","volume":"32","author":"Eicher","year":"2005","journal-title":"Pediatric Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB4|cit4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD003311.pub2-BIB5|cit5","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1542\/peds.2006-2839","article-title":"Determinants of outcomes after head cooling for neonatal encephalopathy","volume":"119","author":"Wyatt","year":"2007","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB6|cit6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.107.3.480","article-title":"Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia","volume":"107","author":"Battin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB7|cit7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1542\/peds.111.2.244","article-title":"Treatment of term infants with head cooling and mild systemic hypothermia (35C and 34.5C) after perinatal asphyxia","volume":"111","author":"Battin","year":"2003","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB8|cit8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: A safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB9|cit9","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jpeds.2004.07.034","article-title":"Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy","volume":"145","author":"Inder","year":"2004","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB10|cit10","series-title":"Hot Topics in Neonatology","article-title":"Feasibility of a pragmatic randomised controlled trial of whole body cooling for term newborns with hypoxic-ischaemic encephalopathy","author":"Jacobs","year":"2002"},{"key":"10.1002\/14651858.CD003311.pub2-BIB11|cit11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/sj.jp.7211412","article-title":"Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit","volume":"26","author":"Lin","year":"2006","journal-title":"Journal of Perinatology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB12|cit12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.110.2.377","article-title":"Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants","volume":"110","author":"Shankaran","year":"2002","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD003311.pub2-BIB14|cit14","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.106.4.684","article-title":"Pilot study of treatment with whole body hypothermia for neonatal encephalopathy","volume":"106","author":"Azzopardi","year":"2000","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB15|cit15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000065890","article-title":"Hypothermia reduces neurological damage in asphyxiated newborn infants","volume":"82","author":"Compagnoni","year":"2002","journal-title":"Biology of the Neonate"},{"key":"10.1002\/14651858.CD003311.pub2-BIB16|cit16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1469-8749.2003.tb00854.x","article-title":"Whole-body cooling after perinatal asphyxia: a pilot study in term neonates","volume":"45","author":"Debillon","year":"2003","journal-title":"Developmental Medicine and Child Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB17|cit17","first-page":"976","article-title":"Selective cerebral hypothermia for post-hypoxic neuroprotection in neonates using a solid ice cap","volume":"96","author":"Horn","year":"2006","journal-title":"South African Medical Journal"},{"key":"10.1002\/14651858.CD003311.pub2-BIB18|cit18","first-page":"17","article-title":"The safety and practicality of selective head cooling in asphyxiated human newborn infants, a retrospective study","volume":"50","author":"Kilani","year":"2002","journal-title":"Lebanese Medical Journal"},{"key":"10.1002\/14651858.CD003311.pub2-BIB19|cit19","first-page":"107","article-title":"Cardiovascular and respiratory status in mechanically ventilated asphyxiated term infants: comparison between hypothermic and control group","volume":"75","author":"Lista","year":"2004","journal-title":"Acta Bio Medica Ateneo Parmense"},{"key":"10.1002\/14651858.CD003311.pub2-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s001340051020","article-title":"Induced brain hypothermia in asphyxiated human newborn infants: a retrospective chart analysis of physiological and adverse effects","volume":"25","author":"Simbruner","year":"1999","journal-title":"Intensive Care Medicine"},{"key":"10.1002\/14651858.CD003311.pub2-BIB21|cit21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1542\/peds.106.1.92","article-title":"Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy","volume":"106","author":"Thoresen","year":"2000","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB22|cit22","first-page":"64","article-title":"Safety study of hypothermia for treatment of hypoxic-ischemic brain damage in term neonates","volume":"23","author":"Zhou","year":"2002","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1002\/14651858.CD003311.pub2-BIB23|cit23","first-page":"460","article-title":"Effects of hypothermia on cardiac function in neonates with asphyxia","volume":"41","author":"Zhou","year":"2003","journal-title":"Zhonghua Erke Zazhi (Chinese Journal of Pediatrics)"},{"key":"10.1002\/14651858.CD003311.pub2-BIB24|cit24","series-title":"Hot Topics in Neonatology","article-title":"Efficacy and safety of selective head cooling with mild systemic hypothermia after neonatal hypoxic ischemic encephalopathy","author":"Shao","year":"2006"},{"key":"10.1002\/14651858.CD003311.pub2-BIB25|cit25","unstructured":"Jacobs SE Stewart M Inder TE Doyle LW Morley C A randomised controlled trial of whole body cooling on the outcome of term babies with hypoxic ischaemic encephalopathy"},{"key":"10.1002\/14651858.CD003311.pub2-BIB26|cit26","unstructured":"Simbruner G Induced systemic hypothermia in asphyxiated newborn infants: a randomized, controlled, multicenter study"},{"key":"10.1002\/14651858.CD003311.pub2-BIB27|cit27","unstructured":"Azzopardi D Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy"},{"issue":"4","key":"10.1002\/14651858.CD003311.pub2-BIB28|cit28","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001048.pub2","article-title":"Therapeutic hypothermia for head injury","author":"Alderson","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD003311.pub2-BIB29|cit29","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1136\/bmj.317.7172.1549","article-title":"Antenatal risk factors for newborn encephalopathy: the Western Australian case-control study","volume":"317","author":"Badawi","year":"1998","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD003311.pub2-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1136\/bmj.317.7172.1554","article-title":"Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study","volume":"317","author":"Badawi","year":"1998","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD003311.pub2-BIB31|cit31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.107.3.480","article-title":"Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia","volume":"107","author":"Battin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB32|cit32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1542\/peds.111.2.244","article-title":"Treatment of term infants with head cooling and mild systemic hypothermia (35C and 34.5C) after perinatal asphyxia","volume":"22","author":"Battin","year":"2003","journal-title":"Pediatrics"},{"issue":"4","key":"10.1002\/14651858.CD003311.pub2-BIB33|cit33","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001247","article-title":"Cooling therapy for acute stroke","author":"Correia","year":"1999","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD003311.pub2-BIB34|cit34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0022-3476(98)70279-3","article-title":"An optimality score for the neurologic examination of the term newborn","volume":"133","author":"Dubowitz","year":"1998","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1006\/bbrc.1995.2895","article-title":"Specific inhibition of apoptosis after cerebral hypoxic-ischemia by moderate post-insult hypothermia","volume":"217","author":"Edwards","year":"1995","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1002\/14651858.CD003311.pub2-BIB36|cit36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1469-8749.2000.tb00693.x","article-title":"Birth defects in children with newborn encephalopathy","volume":"42","author":"Felix","year":"2000","journal-title":"Developmental Medicine and Child Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB37|cit37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0022-3476(81)80555-0","article-title":"Hypoxic ischemic encephalopathy in term neonates: perinatal factors and outcome","volume":"98","author":"Finer","year":"1981","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB38|cit38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jclinepi.2004.09.013","article-title":"Uncertainty method improved on best-worst case analysis in a binary meta-analysis","volume":"58","author":"Gamble","year":"2005","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1046\/j.1471-4159.1995.65041704.x","article-title":"Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia","volume":"65","author":"Globus","year":"1995","journal-title":"Journal of Neurochemistry"},{"key":"10.1002\/14651858.CD003311.pub2-BIB40|cit40","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1469-8749.1992.tb11407.x","article-title":"When and why do brain cells die?","volume":"34","author":"Gluckman","year":"1992","journal-title":"Developmental Medicine and Child Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB41|cit41","doi-asserted-by":"crossref","first-page":"152A","DOI":"10.1203\/00006450-199704001-00917","article-title":"Substantial neuronal loss with prolonged selective head cooling begun 5.5h after cerebral ischemia in the fetal sheep","volume":"41","author":"Gunn","year":"1997","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB42|cit42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia","volume":"99","author":"Gunn","year":"1997","journal-title":"Journal of Clinical Investigation"},{"key":"10.1002\/14651858.CD003311.pub2-BIB43|cit43","first-page":"435A","article-title":"Is cerebral hypothermia a possible neuroprotective strategy after asphyxia in the premature fetus?","volume":"49","author":"Gunn","year":"2001","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB44|cit44","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1203\/00006450-199704000-00009","article-title":"Posthypoxic hypothermia in newborn piglets","volume":"41","author":"Haaland","year":"1997","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB45|cit45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/siny.1999.0112","article-title":"Mechanisms of perinatal brain injury","volume":"5","author":"Inder","year":"2000","journal-title":"Seminars in Neonatology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB46|cit46","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1203\/00006450-199404000-00010","article-title":"Modest hypothermia provides partial neuroprotection for ischemic neonatal brain","volume":"35","author":"Laptook","year":"1994","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB47|cit47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1203\/00006450-199707000-00004","article-title":"Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia","volume":"42","author":"Laptook","year":"1997","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB48|cit48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0140-6736(86)90718-X","article-title":"Comparison of two methods of predicting outcome in perinatal asphyxia","volume":"8472","author":"Levene","year":"1986","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD003311.pub2-BIB49|cit49","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1203\/00006450-199412000-00003","article-title":"Delayed (\"secondary\") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy","volume":"36","author":"Lorek","year":"1994","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB50|cit50","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJM199702203360803","article-title":"Treatment of traumatic brain injury with moderate hypothermia","volume":"336","author":"Marion","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD003311.pub2-BIB51|cit51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1203\/00006450-199607000-00002","article-title":"Proton magnetic spectroscopy of the brain in the normal preterm and term infants, and early changes after perinatal hypoxia-ischemia","volume":"40","author":"Penrice","year":"1996","journal-title":"Pediatric Research"},{"issue":"1","key":"10.1002\/14651858.CD003311.pub2-BIB52|cit52","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002138","article-title":"Hypothermia to reduce neurological damage following coronary artery bypass surgery (Review)","author":"Rees","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD003311.pub2-BIB53|cit53","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1469-8749.1992.tb11432.x","article-title":"Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year","volume":"34","author":"Roth","year":"1992","journal-title":"Developmental Medicine and Child Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB54|cit54","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1469-8749.1997.tb07372.x","article-title":"Relation of deranged cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years","volume":"39","author":"Roth","year":"1997","journal-title":"Developmental Medicine and Child Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB55|cit55","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress","volume":"33","author":"Sarnat","year":"1976","journal-title":"Archives of Neurology"},{"key":"10.1002\/14651858.CD003311.pub2-BIB56|cit56","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"Thoresen","year":"1995","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB57|cit57","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1136\/fn.74.1.F3","article-title":"Posthypoxic cooling of neonatal rats provides protection against brain injury","volume":"74","author":"Thoresen","year":"1996","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD003311.pub2-BIB58|cit58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1203\/00006450-200009000-00015","article-title":"Numerical modeling of temperature distributions within the neonatal head","volume":"48","author":"Leeuwen","year":"2000","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003311.pub2-BIB59|cit59","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1542\/peds.85.6.961","article-title":"Current and potentially new management strategies for perinatal hypoxic-ischemic encephalopathy","volume":"85","author":"Vannucci","year":"1990","journal-title":"Pediatrics"},{"key":"10.1002\/14651858.CD003311.pub2-BIB60|cit60","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.STR.22.4.516","article-title":"Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep","volume":"22","author":"Williams","year":"1991","journal-title":"Stroke"},{"issue":"4","key":"10.1002\/14651858.CD003311.pub2-BIB61|cit61","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encepalopathy","author":"Jacobs","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd003311.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD003311.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T11:15:18Z","timestamp":1684062918000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD003311.pub2"}},"subtitle":[],"editor":[{"given":"Susan E","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,10,17]]},"references-count":61,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd003311.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD003311.pub3","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2007,10,17]]}}}