{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:51:09Z","timestamp":1790920269933,"version":"4.1.0"},"publisher-location":"Chichester, UK","reference-count":55,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd003416.pub3","type":"reference-entry","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T18:34:06Z","timestamp":1239820446000},"source":"Crossref","is-referenced-by-count":22,"title":["Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection"],"prefix":"10.1002","author":[{"given":"Zabeena","family":"Pandian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siladitya","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozkan","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Serour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Templeton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"issue":"10","key":"10.1002\/14651858.CD003416.pub3-BIB1|cit1","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1093\/humrep\/14.10.2581","article-title":"Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial","volume":"14","author":"Gerris","year":"1999","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD003416.pub3-BIB2|cit2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S1472-6483(10)61444-7","article-title":"Prevention of multiple pregnancies after IVF in women 38 and older: a randomized study","volume":"13","author":"Heijnen","journal-title":"Reproductive BioMedicine Online; www.rbmonline.com\/Article\/2339 on web"},{"issue":"3","key":"10.1002\/14651858.CD003416.pub3-BIB3|cit3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/humrep\/deh672","article-title":"Two cycles with single embryo transfer versus one cycle with double embryo trransfer: a randomized controlled trial","volume":"20","author":"Lukassen","year":"2005","journal-title":"Human Reproduction"},{"issue":"9","key":"10.1002\/14651858.CD003416.pub3-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/humrep\/16.9.1900","article-title":"One versus two embryo transfer after IVF and ICSI: a randomized study","volume":"16","author":"Martikainen","year":"2001","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB5|cit5","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1056\/NEJMoa041032","article-title":"Elective Single-Embryo Transfer versus Double-Embryo Transfer in in Vitro Fertilization","volume":"351","author":"Ann","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"8","key":"10.1002\/14651858.CD003416.pub3-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1093\/humrep\/del112","article-title":"Single versus double embryo tansfer: cost-effectiveness analysis alongside a randomized controlled trial","volume":"21","author":"Fiddlers","year":"2006","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD003416.pub3-BIB7|cit7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/humrep\/dei359","article-title":"In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial","volume":"21","author":"Aafke PA van","year":"2006","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD003416.pub3-BIB8|cit8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0015-0282(16)56888-5","article-title":"How many embryos should be transferred in in vitro fertilization? A prospective randomized study","volume":"62","author":"Vauthier-Brouzes","year":"1994","journal-title":"Fertility and Sterility"},{"issue":"9563","key":"10.1002\/14651858.CD003416.pub3-BIB9|cit9","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(07)60360-2","article-title":"A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial","volume":"369","author":"Heijnen","year":"2007","journal-title":"The Lancet"},{"issue":"2","key":"10.1002\/14651858.CD003416.pub3-BIB10|cit10","first-page":"91","article-title":"Prevention of multiple pregnancies by restricting the number of transferred embryos: randomized control study","volume":"270","author":"Komori","journal-title":"Archives of Gynecology and Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD003416.pub3-BIB11|cit11","first-page":"113","article-title":"Pregnancy and Multiple Births rate after Transferring 2 or 3 Embryos","volume":"11","author":"F.","year":"2006","journal-title":"Journal of Research in Medical Sciences"},{"issue":"10","key":"10.1002\/14651858.CD003416.pub3-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/oxfordjournals.humrep.a137907","article-title":"Avoidance of triplet pregnancies by elective transfer of two good quality embryos","volume":"8","author":"Staessen","year":"1993","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD003416.pub3-BIB13|cit13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/humrep\/deh619","article-title":"Elective single embryo transfer (eSET) policy in the first three IVF\/ICSI treatment cycles","volume":"20","author":"Montfoort","year":"2005","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0002-9378(96)70669-5","article-title":"The current status of multifetal pregnancy reduction","volume":"174","author":"Berkowits","year":"1996","journal-title":"American Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD003416.pub3-BIB15|cit15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJM199407283310407","article-title":"The economic impact of multiple gestation pregnancies and the contribution of assisted-reproduction techniques to their incidence","volume":"331","author":"Callahan","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD003416.pub3-BIB16|cit16","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1093\/humrep\/dem311","article-title":"Babies born after ART treatment cost more than non ART babies.A cost analysis of inpatient birth admission costs of singletion and multiple gestation pregnancies","volume":"22","author":"Chambers","year":"2007","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB17|cit17","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1093\/humrep\/13.10.2663","article-title":"Avoiding multiple pregnancies in in-vitro fertilization: who's afraid of single embryo transfer?","volume":"13","author":"Coetsier","year":"1998","journal-title":"Human Reproduction"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD003416.pub3-BIB18|cit18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/humrep\/11.suppl_4.110","article-title":"The outcome of multiple pregnancy","volume":"11","author":"Doyle","year":"1996","journal-title":"Human Reproduction"},{"issue":"7","key":"10.1002\/14651858.CD003416.pub3-BIB19|cit19","first-page":"1856","article-title":"Multiple gestation pregnancy","volume":"15","year":"2000","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD003416.pub3-BIB20|cit20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/humrep\/16.4.790","article-title":"Prevention of twin pregnancies after IVF\/ICSI by single embryo transfer","volume":"16","year":"2001","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD003416.pub3-BIB21|cit21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/humupd\/dml053","article-title":"Economic evaluations of single versus double embryo transfer in IVF","volume":"13","author":"Fiddelers","journal-title":"Human Reproduction Update"},{"key":"10.1002\/14651858.CD003416.pub3-BIB22|cit22","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0015-0282(16)57850-9","article-title":"Pregnancies and births resulting from in vitro fertilization: French national registry, analysis of data 1986 to 1990","volume":"64","year":"1995","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD003416.pub3-BIB23|cit23","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0015-0282(16)60134-6","article-title":"An assessment of alternative policies for embryo transfer in an in vitro fertilization-embryo transfer program","volume":"50","author":"Frydman","year":"1988","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD003416.pub3-BIB24|cit24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/oxfordjournals.humrep.a137727","article-title":"Assessment at one year of the psychological consequences of having triplets","volume":"7","author":"Garel","year":"1992","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/S0015-0282(97)81457-4","article-title":"Psychological consequences of having triplets: a four-year follow up study","volume":"67","author":"Garel","year":"1997","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD003416.pub3-BIB26|cit26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/humrep\/deh188","article-title":"A real life prospective health economic study of elective single embryo transfer versus two embryo transfer in first IVF\/ICSI cycles","volume":"19","author":"Gerris","year":"2004","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB27|cit27","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/oxfordjournals.humrep.a136312","article-title":"Embryo score to predict implantation after in-vitro fertilization: based on 957 single embryo transfers","volume":"10","author":"Giorgetti","year":"1995","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB28|cit28","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0015-0282(16)58220-X","article-title":"Attitudes of in vitro fertilization and intrauterine insemination couples toward multiple gestation pregnancy and multifetal pregnancy reduction","volume":"65","author":"Goldfarb","year":"1996","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD003416.pub3-BIB29|cit29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0015-0282(01)03243-5","article-title":"A prediction model for selecting patients undergoing in vitro fertilisation for elective single embryo transfer","volume":"77","author":"Hunault","year":"2002","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD003416.pub3-BIB30|cit30","first-page":"711","article-title":"Does a shift to two embryo transfers after in vitro fertilisation decrease the success and multiple birth rate? An analysis of assisted reproduction technologies in Sweden 1991-1996","volume":"Program suppl.","author":"Karlstrom","year":"1999","journal-title":"Fertility and Sterility"},{"issue":"8","key":"10.1002\/14651858.CD003416.pub3-BIB31|cit31","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/humrep\/dem120","article-title":"Reducing the number of embryos transferred in Sweden-impact on delivery and multiple birth rates","volume":"22","author":"Karlstrom","year":"2007","journal-title":"Human reproduction"},{"issue":"3","key":"10.1002\/14651858.CD003416.pub3-BIB32|cit32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1471-0528.2007.01584.x","article-title":"Selective single blastocyst transfer reduces the multiple pregnancy rate and increases pregnancy rates: a pre- and postintervention study","volume":"115","author":"Khalaf","journal-title":"BJOG"},{"issue":"1","key":"10.1002\/14651858.CD003416.pub3-BIB33|cit33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1471-0528.2005.00790.x","article-title":"The costs to the NHS of multiple births after IVF treatment in the UK","volume":"113","author":"William","year":"2006","journal-title":"BJOG: An international Journal of Obstetrics & Gynaecology"},{"key":"10.1002\/14651858.CD003416.pub3-BIB34|cit34","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1093\/humrep\/13.10.2664","article-title":"An embryo too many?","volume":"13","author":"Lieberman","year":"1998","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB35|cit35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/humrep\/15.2.319","article-title":"Experience with the elective transfer of two embryos under the conditions of the German embryo protection law: results of a retrospective data analysis of 2573 transfer cycles","volume":"15","author":"Ludwig","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB36|cit36","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0015-0282(98)00220-9","article-title":"Probabilities for singleton and multiple pregnancies after in vitro fertilization","volume":"70","author":"Martin","year":"1998","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD003416.pub3-BIB37|cit37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/00332747.1996.11024779","article-title":"Multifetal pregnancy reduction: psychodynamic implications","volume":"59","author":"McKinney","year":"1996","journal-title":"Psychiatry"},{"key":"10.1002\/14651858.CD003416.pub3-BIB38|cit38","first-page":"334","article-title":"Multiple Births","volume-title":"Resource implications of multiple births","author":"Mugford","year":"1995"},{"issue":"11","key":"10.1002\/14651858.CD003416.pub3-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa053524","article-title":"In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos","volume":"354","author":"Papanikolaou","year":"2006","journal-title":"New England Journal of Medicine"},{"issue":"10","key":"10.1002\/14651858.CD003416.pub3-BIB40|cit40","first-page":"613","article-title":"The influence of number of embryos transferred on pregnancy outcome in women undergoing in vitro fertilization and embryo transfer (IVF-ET)","volume":"79","author":"Preutthipan","year":"1996","journal-title":"Journal of the Medical Association of Thailand"},{"issue":"1","key":"10.1002\/14651858.CD003416.pub3-BIB41|cit41","first-page":"53","article-title":"Elective fetal reduction: the ultimate elective surgery","volume":"13","author":"Rorty","year":"1996","journal-title":"Journal of Contemporary Health Law and Policy"},{"key":"10.1002\/14651858.CD003416.pub3-BIB42|cit42","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0140-6736(05)72459-4","article-title":"Swedish in vitro fertilisation study","volume":"355","author":"Sebire","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD003416.pub3-BIB43|cit43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM199808273390901","article-title":"Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization","volume":"339","author":"Templeton","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD003416.pub3-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/S0140-6736(05)72942-1","article-title":"A check on limiting multiple births","volume":"355","author":"Templeton","year":"2000","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD003416.pub3-BIB45|cit45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/humrep\/dei298","article-title":"Randomized single versus double embryo transfer: obstetric and paediatric outcome and a cost-effectiveness analysis","volume":"21","author":"Ann Thurin","year":"2006","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD003416.pub3-BIB46|cit46","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/humrep\/16.6.1140","article-title":"Elective single embryo transfer: the value of cryopreservation","volume":"16","author":"Titinen","year":"2001","journal-title":"Human Reproduction"},{"issue":"11","key":"10.1002\/14651858.CD003416.pub3-BIB47|cit47","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/humrep\/deh446","article-title":"What is the most relevant standard of success in assisted reproduction? The value of cryopreservation on cumulative pregnancy rates per single oocyte retrieval should not be forgotten","volume":"19","author":"A","year":"2004","journal-title":"Human Reproduction"},{"issue":"L1","key":"10.1002\/14651858.CD003416.pub3-BIB48|cit48","first-page":"13","article-title":"Multiple births causing joy and concern","volume":"Mar 2","author":"Tilghman","year":"1997","journal-title":"The New York Times"},{"issue":"9","key":"10.1002\/14651858.CD003416.pub3-BIB49|cit49","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1093\/humrep\/14.9.2392","article-title":"Elective transfer of one embryo results in an acceptable pregnancy rate and eliminates the risk of multiple birth","volume":"14","author":"Vilska","year":"1999","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB50|cit50","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/humrep\/15.4.944","article-title":"Incidence of congenital malformations in children born after ICSI","volume":"15","author":"Wennerholm","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB51|cit51","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1080\/j.1600-0412.2000.079005384.x","article-title":"Danish National IVF Registry 1994 and 1995. Treatment, pregnancy outcome and complications during pregnancy.","volume":"79","author":"Westergaard","year":"2000","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"10.1002\/14651858.CD003416.pub3-BIB52|cit52","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/humrep\/13.1.88","article-title":"Cost effectiveness analysis of in-vitro fertilization: estimated cost per successful pregnancy after transfer of one or two embryos","volume":"13","author":"Wolner-Hanssen","year":"1998","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB53|cit53","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humrep\/12.4.699","article-title":"The optimal number of embryos to be transferred in shared oocyte donation: walking the thin line between low pregnancy rates and multiple pregnancies","volume":"12","author":"Yaron","year":"1997","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD003416.pub3-BIB54|cit54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1017\/S0001566000001744","article-title":"Incidence of handicaps in multiple births and associated factors","volume":"44","author":"Yokoyama","year":"1995","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"issue":"2004","key":"10.1002\/14651858.CD003416.pub3-BIB55|cit55","article-title":"Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection","author":"Pandian","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd003416.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD003416.pub3\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T16:48:28Z","timestamp":1710262108000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD003416.pub3"}},"subtitle":[],"editor":[{"given":"Zabeena","family":"Pandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,4,15]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd003416.pub3","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD003416.pub4","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2009,4,15]]}}}