{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:54:06Z","timestamp":1777373646355,"version":"3.51.4"},"publisher-location":"Chichester, UK","reference-count":60,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd003424.pub2","type":"reference-entry","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T19:27:52Z","timestamp":1334258872000},"source":"Crossref","is-referenced-by-count":9,"title":["Drug therapies for reducing gastric acidity in people with cystic fibrosis"],"prefix":"10.1002","author":[{"given":"Sze May","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo J","family":"Francini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"10.1002\/14651858.CD003424.pub2-BIB1|cit1","series-title":"Proceedings of the 18th European Cystic Fibrosis Conference; 1993; Madrid","first-page":"PD99","article-title":"CF patients with significant malabsorption: effects of a high lipase enzyme preparation and ranitidine [abstract]","author":"Bowler","year":"1993"},{"issue":"5 Pt 1","key":"10.1002\/14651858.CD003424.pub2-BIB2|cit2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0016-5085(80)90776-3","article-title":"Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis","volume":"78","author":"Boyle","year":"1980","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1002\/14651858.CD003424.pub2-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/BF01296016","article-title":"Use of famotidine in severe exocrine pancreatic insufficiency with persistent maldigestion on enzymatic replacement therapy: A long term study in cystic fibrosis","volume":"37","author":"Carroccio","year":"1992","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1002\/14651858.CD003424.pub2-BIB4|cit4","series-title":"Proceedings of the 12th annual meeting of the European Working Group Cystic Fibrosis","first-page":"109","article-title":"The influence of long-term cimetidine as an adjuvant to pancreatic enzyme therapy in cystic fibrosis [abstract]","author":"Chalmers","year":"1983"},{"key":"10.1002\/14651858.CD003424.pub2-BIB5|cit5","first-page":"A978","article-title":"Influence of long-term of cimetidine as an adjuvant to pancreatic enzyme therapy in cystic fibrosis [abstract]","volume":"24","author":"Chalmers","year":"1983","journal-title":"Gut"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB6|cit6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1651-2227.1985.tb10930.x","article-title":"The influence of long term cimetidine as an adjuvant to pancreatic enzyme therapy in cystic fibrosis","volume":"74","author":"Chalmers","year":"1985","journal-title":"Acta Paediatrica Scandinavia"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD003424.pub2-BIB7|cit7","first-page":"S73","article-title":"The impact of omeprazole on children with cystic fibrosis (CF) who require high dose pancreatic enzymes: A pilot study [abstract]","volume":"31","author":"Chung","year":"2000","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1002\/14651858.CD003424.pub2-BIB8|cit8","series-title":"20th Annual Meeting Cystic Fibrosis Club Abstracts; 1979 May 1; Atlanta, Georgia","first-page":"37","article-title":"The effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis [abstract]","author":"Durie","year":"1979"},{"issue":"9","key":"10.1002\/14651858.CD003424.pub2-BIB9|cit9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/gut.21.9.778","article-title":"Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis","volume":"21","author":"Durie","year":"1980","journal-title":"Gut"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB10|cit10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00005176-200207000-00017","article-title":"Ranitidine and Omeprazole as adjuvant therapy to pancrealipase to improve fat absorption in patients with cystic fibrosis","volume":"35","author":"Francisco","year":"2002","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1002\/14651858.CD003424.pub2-BIB11|cit11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/00365529009093147","article-title":"Ranitidine compared with the dimethylprostagalndin E2 analogue enprostil as adjunct to pancreatic enzyme replacement in adult cystic fibrosis","volume":"178 Suppl","author":"Heijerman","year":"1990","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"3","key":"10.1002\/14651858.CD003424.pub2-BIB12|cit12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-114-3-200","article-title":"Omeprazole enhances the efficacy of pancreatin (pancrease) in cystic fibrosis","volume":"114","author":"Heijerman","year":"1991","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD003424.pub2-BIB13|cit13","series-title":"Proceedings of the 17th European Cystic Fibrosis Conference; 1991 June 18-21; Copenhagen","first-page":"145","article-title":"Omeprazole enhances the efficacy of pancreatin (pancrease*) in cystic fibrosis [abstract]","author":"Heijermann","year":"1991"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01296765","article-title":"Improvement of fecal fat excretion after addition of omeprazole to pancrease in cystic fibrosis is related to residual exocrine function of the pancreas","volume":"38","author":"Heijerman","year":"1993","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1002\/14651858.CD003424.pub2-BIB15|cit15","series-title":"Proceedings of the 20th Annual Meeting Cystic Fibrosis Club Abstracts; 1979 May 1; Atlanta, Georgia","first-page":"57","article-title":"Failure of antacids to improve the effectiveness and\/or utilization of pancreatic extracts in children with cystic fibrosis [abstract]","author":"Lubin","year":"1979"},{"issue":"11","key":"10.1002\/14651858.CD003424.pub2-BIB16|cit16","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00431-003-1309-5","article-title":"Omeprazol, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymes","volume":"162","author":"Proesmans","year":"2003","journal-title":"European Journal of Pediatrics"},{"key":"10.1002\/14651858.CD003424.pub2-BIB17|cit17","series-title":"Proceedings of the 2nd North American Cystic Fibrosis Conference; 1988 Sep 28 - Oct 01; Orlando","first-page":"135","article-title":"Effect of misoprostol on malabsorption in cystic fibrosis [abstract]","author":"Robinson","year":"1988"},{"issue":"9","key":"10.1002\/14651858.CD003424.pub2-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1136\/adc.63.9.1081","article-title":"Effect of misoprostol on fat malabsorption in cystic fibrosis","volume":"63","author":"Robinson","year":"1988","journal-title":"Archives of Disease in Childhood"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB19|cit19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00005176-199007000-00007","article-title":"Placebo-controlled trial of misoprostol in cystic fibrosis","volume":"11","author":"Robinson","year":"1990","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB20|cit20","first-page":"66","article-title":"Long term cimetidine in children with cystic fibrosis: a randomized double blind study","volume":"18","author":"Schoni","year":"1984","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD003424.pub2-BIB21|cit21","series-title":"22nd Cystic Fibrosis Club Abstracts","first-page":"164","article-title":"Enteric coated microspheres of sodium bicarbonate do not enhance the effectiveness of pancrease [abstract]","author":"Weber","year":"1981"},{"key":"10.1002\/14651858.CD003424.pub2-BIB22|cit22","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/00005176-198811001-00009","article-title":"Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: Comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages","volume":"Suppl 1","author":"Ansaldi-Balocco","year":"1988","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"6","key":"10.1002\/14651858.CD003424.pub2-BIB23|cit23","first-page":"475","article-title":"The effect of cimetidine on meals-stimulated gastric function and exogenous pancreatic enzymes in cystic fibrosis","volume":"36","author":"Cameron","year":"1982","journal-title":"Human Nutrition Clinical Nutrition"},{"key":"10.1002\/14651858.CD003424.pub2-BIB24|cit24","series-title":"22nd Annual Meeting Cystic Fibrosis Club Abstracts; 1981 May 1; San Francisco, California","first-page":"107","article-title":"Effects of chronic cimetidine (C) administration on growth in cystic fibrosis patients [abstract]","author":"Cox","year":"1981"},{"issue":"4","key":"10.1002\/14651858.CD003424.pub2-BIB25|cit25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0022-3476(96)70358-X","article-title":"Ultrasound measurement of gastric emptying time in patients with cystic fibrosis and effect of ranitidine on delayed gastric emptying","volume":"128","author":"Cucchiara","year":"1996","journal-title":"Journal of Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD003424.pub2-BIB26|cit26","first-page":"223","article-title":"Malabsorption in cystic fibrosis: Failure to respond to cimetidine [abstract]","volume":"11","author":"Dudley","year":"1981","journal-title":"Australian and New Zealand Journal of Medicine"},{"key":"10.1002\/14651858.CD003424.pub2-BIB27|cit27","series-title":"Proceedings of the 10th Annual North American Cystic Fibrosis Conference; 1996 Oct 24-27; Orlando","first-page":"319","article-title":"Comparison of 3 day fat balance studies performed at home versus in the CRC in subjects with CF [abstract]","author":"Francisco","year":"1996"},{"issue":"Suppl","key":"10.1002\/14651858.CD003424.pub2-BIB28|cit28","first-page":"S63","article-title":"Simultaneously measured duodenal and gastric pH in patients with cystic fibrosis: effect of omeprazole [abstract]","volume":"54","author":"Geus","year":"1999","journal-title":"Netherlands Journal of Medicine"},{"issue":"8255","key":"10.1002\/14651858.CD003424.pub2-BIB29|cit29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0140-6736(81)91276-9","article-title":"Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: Effectiveness of an enteric-coated preparation with and without antacids and cimetidine","volume":"2","author":"Gow","year":"1981","journal-title":"The Lancet"},{"key":"10.1002\/14651858.CD003424.pub2-BIB30|cit30","first-page":"106","article-title":"Comparative trial of measures to prevent acid-peptic inactivation of pancreatic insufficiency due to cystic fibrosis","volume":"12","author":"Shepherd","year":"1982","journal-title":"Australian and New Zealand Journal of Medicine"},{"issue":"10","key":"10.1002\/14651858.CD003424.pub2-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/BF01300190","article-title":"Carbohydrate malabsorption is minimal in school-age cystic fibrosis children","volume":"32","author":"Hoffman","year":"1987","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1002\/14651858.CD003424.pub2-BIB32|cit32","series-title":"Proceedings of the 11th European Cystic Fibrosis Conference; Brussels, 1982","first-page":"208","article-title":"The role of maldigestion and gastric inhibitory polypeptide (GIP) in the defective insulin secretion in cystic fibrosis (CF) [abstract]","author":"Kerr","year":"1982"},{"key":"10.1002\/14651858.CD003424.pub2-BIB33|cit33","series-title":"Proceedings of the 3rd North American Cystic Fibrosis Conference; 1989 Oct 11-14; Florida","first-page":"138","article-title":"Effects of cisapride in patients with cystic fibrosis (CF) and chronic distal intestinal obstruction syndrome (DIOS) [abstract]","author":"Koletzko","year":"1989"},{"issue":"5","key":"10.1002\/14651858.CD003424.pub2-BIB34|cit34","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0022-3476(05)83350-5","article-title":"Effects of cisapride in patients with cystic fibrosis and distal intestinal obstruction syndrome (DIOS)","volume":"117","author":"Koletzo","year":"1990","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD003424.pub2-BIB35|cit35","series-title":"Proceedings of the 11th International Cystic Fibrosis Conference; 1992","first-page":"WP11","article-title":"PGE1 in cystic fibrosis: lack of effect on fecal, serum and sweat electrolytes [abstract]","author":"Lloyd-Still","year":"1992"},{"issue":"11","key":"10.1002\/14651858.CD003424.pub2-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1177\/009127009803801104","article-title":"Pharmocokinetics of famotidine in patients with cystic fibrosis","volume":"38","author":"Maish","year":"1998","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.1002\/14651858.CD003424.pub2-BIB37|cit37","first-page":"310","article-title":"Famotidine (FAM) pharmacokinetics (PK) in patients with cystic fibrosis (CF) [abstract]","volume":"Suppl 14","author":"Maish","year":"1997","journal-title":"Pediatric Pulmonology"},{"key":"10.1002\/14651858.CD003424.pub2-BIB38|cit38","series-title":"Proceedings of the 13th European Working Group Cystic Fibrosis; 1985 Nov 3-8; Jerusalem","first-page":"116","article-title":"The effect of the additional ranitidine to pancrease on duodenal contents in cystic fibrosis [abstract]","author":"Miller","year":"1985"},{"key":"10.1002\/14651858.CD003424.pub2-BIB39|cit39","first-page":"A612","article-title":"Combined ranitidine and enteric coated microspheres (Pancrease) improves maldigestion in cystic fibrosis [abstract]","volume":"27","author":"Miller","year":"1986","journal-title":"Gut"},{"issue":"3","key":"10.1002\/14651858.CD003424.pub2-BIB40|cit40","first-page":"207","article-title":"Failure of oral N-acetylcysteine to improve the malabsorption of cystic fibrosis","volume":"17","author":"Mitchell","year":"1981","journal-title":"Australian Paediatric Journal"},{"issue":"8427","key":"10.1002\/14651858.CD003424.pub2-BIB41|cit41","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(85)92106-3","article-title":"Cisapride in cystic fibrosis","volume":"1","author":"Prinsen","year":"1985","journal-title":"The Lancet"},{"issue":"4","key":"10.1002\/14651858.CD003424.pub2-BIB42|cit42","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00005176-198911000-00027","article-title":"Cisapride and cystic fibrosis [letter]","volume":"9","author":"Santamaria","year":"1989","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"8633","key":"10.1002\/14651858.CD003424.pub2-BIB43|cit43","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0140-6736(89)91357-3","article-title":"Cisparide and cystic fibrosis [letter]","volume":"1","author":"Smith","year":"1989","journal-title":"The Lancet"},{"key":"10.1002\/14651858.CD003424.pub2-BIB44|cit44","series-title":"Proceedings of the 10th International Cystic Fibrosis Congress; 1988 March 5-10; Sydney","first-page":"181","article-title":"The effect of cisapride on gastrointestinal function in cystic fibrosis (CF) [abstract]","author":"Smith","year":"1988"},{"key":"10.1002\/14651858.CD003424.pub2-BIB45|cit45","series-title":"15th Annual Meeting of the European Working Group for Cystic Fibrosis; 1987; Oslo; Norway","first-page":"71","article-title":"Enteric-coated microspheres of pancreatin versus non enteric-coated pancreatin combined with cimetidine in cystic fibrosis [abstract]","author":"Stead","year":"1987"},{"issue":"6","key":"10.1002\/14651858.CD003424.pub2-BIB46|cit46","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2036.1988.tb00720.x","article-title":"Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine","volume":"2","author":"Stead","year":"1988","journal-title":"Alimentary pharmacology & therapeutics"},{"issue":"3","key":"10.1002\/14651858.CD003424.pub2-BIB47|cit47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00192559","article-title":"Cyclosporin pharmacokinetics in heart-lung transplant recipients with cystic fibrosis. Effects of pancreatic enzymes and ranitidine","volume":"46","author":"Tsang","year":"1994","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"9","key":"10.1002\/14651858.CD003424.pub2-BIB48|cit48","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1136\/gut.26.9.892","article-title":"Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis","volume":"26","author":"Zentler-Munro","year":"1985","journal-title":"Gut"},{"issue":"5","key":"10.1002\/14651858.CD003424.pub2-BIB49|cit49","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1007\/BF02087549","article-title":"Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy","volume":"39","author":"Bruno","year":"1994","journal-title":"Digestive Disease and Science"},{"key":"10.1002\/14651858.CD003424.pub2-BIB50|cit50","unstructured":"CF Foundation Annual Data Report National Patient Registry 1994"},{"issue":"15","key":"10.1002\/14651858.CD003424.pub2-BIB51|cit51","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/sim.1205","article-title":"Meta-analysis combining parallel and cross-over clinical trials. 1: Continuous outcomes","volume":"21","author":"Curtin","year":"2002","journal-title":"Statistics in Medicine"},{"issue":"3","key":"10.1002\/14651858.CD003424.pub2-BIB52|cit52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/bega.2001.0195","article-title":"Gastric acid suppression and treatment of severe pancreatic exocrine insufficiency","volume":"15","author":"DiMagno","year":"2001","journal-title":"Best Practice and Research in Clinical Gastroenterology"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB53|cit53","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"7414","key":"10.1002\/14651858.CD003424.pub2-BIB54|cit54","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"7303","key":"10.1002\/14651858.CD003424.pub2-BIB55|cit55","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","article-title":"Systematic reviews in health care: Assessing the quality of controlled clinical trials","volume":"323","author":"J\u00fcni","year":"2001","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD003424.pub2-BIB56|cit56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1651-2227.1978.tb16273.x","article-title":"Relative underweight in cystic fibrosis and its prognostic value","volume":"67","author":"Kraemer","year":"1978","journal-title":"Acta Paediatrica Scandinavica"},{"issue":"4","key":"10.1002\/14651858.CD003424.pub2-BIB57|cit57","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/adc.66.4.495","article-title":"Energy content of stools in normal healthy controls and patients with cystic fibrosis","volume":"66","author":"Murphy","year":"1991","journal-title":"Archives of Disease in Childhood"},{"key":"10.1002\/14651858.CD003424.pub2-BIB58|cit58","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1651-2227.1985.tb14933.x","article-title":"Influence of respiratory exacerbations on lung function, variables on nutritional status in CF patients","volume":"317 Suppl","author":"Neijens","year":"1985","journal-title":"Acta Paediatrica Scandinavica"},{"issue":"2","key":"10.1002\/14651858.CD003424.pub2-BIB59|cit59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0016-5085(79)90278-6","article-title":"Reduced intraluminal bile acid concentrations and fat maldigestion in pancreatic insufficiency: Correction by treatment","volume":"77","author":"Regan","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD003424.pub2-BIB60|cit60","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1097\/00005176-198400031-00018","article-title":"Intraduodenal events in cystic fibrosis","volume":"3 Suppl","author":"Weber","year":"1984","journal-title":"Journal of Pediatric Gastroenterology Nutrition"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD003424.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:20:18Z","timestamp":1628544018000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD003424.pub2"}},"subtitle":[],"editor":[{"given":"Sze May","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":60,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd003424.pub2","relation":{},"subject":[],"published":{"date-parts":[[2012,4,18]]}}}