{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:20:04Z","timestamp":1775920804884,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd003458.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000}}],"reference-count":60,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd003458.pub5","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T22:38:00Z","timestamp":1415831880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V)"],"prefix":"10.1002","volume":"2014","author":[{"given":"Rosaline","family":"Quinlivan","sequence":"first","affiliation":[{"name":"UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery and Great Ormond Street; MRC Centre for Neuromuscular Diseases and Dubowitz Neuromuscular Centre; PO Box 114 London UK WC1B 3BN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Martinuzzi","sequence":"additional","affiliation":[{"name":"Medea Scientific Institute; The Conegliano-Pieve Research Centre; Via Costa Alta 37 Conegliano Italy 31015"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Schoser","sequence":"additional","affiliation":[{"name":"Friedrich-Baur Institute Ludwig-Maximilians University Munich; Department of Neurology; Ziemssenstr. 1a D-80336 Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"issue":"12","key":"10.1002\/14651858.CD003458.pub5-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/adc.2008.146548","article-title":"Carbohydrate- and protein-rich diets in McArdle disease: effects on exercise capacity","volume":"79","author":"Andersen","year":"2008","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1001\/archneur.65.6.786","article-title":"Effect of oral sucrose before exercise on work capacity in McArdle disease","volume":"65","author":"Andersen","year":"2008","journal-title":"Archives of Neurology"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0003|cit3","first-page":"30","article-title":"McArdle's disease: molecular genetics, clinical heterogeneity and a therapeutic trial","volume":"30 Suppl","author":"Beynon","year":"1998","journal-title":"Muscle & Nerve"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0004|cit4","first-page":"748","article-title":"Depot-glucagon in the treatment of McArdle's disease","volume":"15","author":"Day","year":"1985","journal-title":"Australian and New Zealand Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD003458.pub5-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/archneur.1990.00530040023014","article-title":"Are high-protein diets effective in McArdle's Disease?","volume":"47","author":"Kushner","year":"1990","journal-title":"Archives of Neurology"},{"issue":"7","key":"10.1002\/14651858.CD003458.pub5-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/mus.880090710","article-title":"A double-blind placebo-controlled crossover study of verapamil in exertional muscle pain","volume":"9","author":"Lane","year":"1986","journal-title":"Muscle & Nerve"},{"issue":"5","key":"10.1002\/14651858.CD003458.pub5-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1212\/WNL.51.5.1456","article-title":"Oral branched-chain amino acids do not improve exercise capacity in McArdle disease","volume":"51","author":"MacLean","year":"1998","journal-title":"Neurology"},{"issue":"1","key":"10.1002\/14651858.CD003458.pub5-BIB0008|cit8","first-page":"64","article-title":"Chronic therapy for McArdle disease: the randomized controlled trial with ACE inhibitor","volume":"26","author":"Martinuzzi","year":"2007","journal-title":"Acta Myologica"},{"issue":"3","key":"10.1002\/14651858.CD003458.pub5-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mus.20937","article-title":"Randomised, placebo-controlled, double-blind pilot trial of ramipril in McArdle's disease","volume":"37","author":"Martinuzzi","year":"2008","journal-title":"Muscle & Nerve"},{"issue":"1-2","key":"10.1002\/14651858.CD003458.pub5-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0022-510X(90)90020-N","article-title":"Dantrolene sodium does influence the second-wind phenomenon in McArdle's disease. Electrophysioloical evidence during exercise in a double-blind placebo-controlled, cross-over study in 5 patients","volume":"100","author":"Poels","year":"1990","journal-title":"Journal of the Neurological Sciences"},{"issue":"1-2","key":"10.1002\/14651858.CD003458.pub5-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0022-510X(95)00320-2","article-title":"A double blind, placebo controlled, crossover trial of D-ribose in McArdle's disease","volume":"136","author":"Steele","year":"1996","journal-title":"Journal of the Neurological Sciences"},{"issue":"26","key":"10.1002\/14651858.CD003458.pub5-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1056\/NEJMoa031836","article-title":"The effect of oral sucrose on exercise tolerance in patients with McArdle's disease","volume":"349","author":"Vissing","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"7","key":"10.1002\/14651858.CD003458.pub5-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1001\/archneur.57.7.956","article-title":"Creatine therapy in myophosphorylase deficiency (McArdle disease). A placebo-controlled crossover trial","volume":"57","author":"Vorgerd","year":"2000","journal-title":"Archives of Neurology"},{"issue":"1","key":"10.1002\/14651858.CD003458.pub5-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archneur.59.1.97","article-title":"Effect of high-dose creatine therapy on symptoms of exercise intolerance in McArdle disease: double-blind, placebo-controlled crossover study","volume":"59","author":"Vorgerd","year":"2002","journal-title":"Archives of Neurology"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/archneurol.2009.93","article-title":"Effect of changes in fat availability on exercise capacity in McArdle disease","volume":"66","author":"Andersen","year":"2009","journal-title":"Archives of Neurology"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ana.20565","article-title":"Treatment of glycogenosis type V with ketogenic diet","volume":"58","author":"Busch","year":"2005","journal-title":"Annals of Neurology"},{"issue":"9","key":"10.1002\/14651858.CD003458.pub5-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archneur.59.9.1395","article-title":"Spontaneous \"second wind\" and glucose-induced \"second wind\" in McArdle disease","volume":"59","author":"Haller","year":"2002","journal-title":"Archives of Neurology"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1600-0404.1990.tb01007.x","article-title":"Improved energy kinetics following high protein diet in McArdle's syndrome. A 31P magnetic resonance spectroscopy study","volume":"81","author":"Jensen","year":"1990","journal-title":"Acta Neurologica Scandinavica"},{"issue":"11","key":"10.1002\/14651858.CD003458.pub5-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1212\/WNL.34.11.1471","article-title":"Metabolic basis of improved exercise tolerance: Muscle phosphorylase deficiency after glucagon administration","volume":"34","author":"Kono","year":"1984","journal-title":"Neurology"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1152\/jappl.1985.59.6.1991","article-title":"Muscle fatigue in McArdle's disease studied by 31P-NMR: effect of glucose infusion","volume":"59","author":"Lewis","year":"1985","journal-title":"Journal of Applied Physiology"},{"issue":"7","key":"10.1002\/14651858.CD003458.pub5-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/mus.880070706","article-title":"A comparative study on glucagon effect between McArdle disease and Tarui disease","volume":"7","author":"Mineo","year":"1984","journal-title":"Muscle & Nerve"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/003693300304800206","article-title":"Exercise to exhaustion in the second-wind phase of exercise in case of McArdle's disease with and without creatine supplementation","volume":"48","author":"O'Reilly","year":"2003","journal-title":"Scottish Medical Journal"},{"issue":"3-4","key":"10.1002\/14651858.CD003458.pub5-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0960-8966(98)00004-2","article-title":"Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study","volume":"8","author":"Phoenix","year":"1998","journal-title":"Neuromuscular Disorders"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0024|cit24","unstructured":"Schoser B Individual patient data (supplied 2008) Data on file"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1212\/01.wnl.0000194212.31318.fc","article-title":"Gentamicin treatment in McArdle disease: failure to correct myophosphorylase deficiency","volume":"66","author":"Schroers","year":"2006","journal-title":"Neurology"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1056\/NEJM198502073120607","article-title":"Myopathy in McArdle's syndrome: improvement with a high protein diet","volume":"312","author":"Slonim","year":"1985","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00000441-197503000-00008","article-title":"McArdle's syndrome: the reaction to a fat rich diet","volume":"269","author":"Viskoper","year":"1975","journal-title":"American Journal of Medical Sciences"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0028|cit28","first-page":"61","article-title":"Treatment of glycogenosys type V (McArdle disease) with creatine and ketogenic diet with clinical scores and with 31P-MRS on working leg muscle","volume":"26","author":"Vorgerd","year":"2007","journal-title":"Acta Myologica"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF01666823","article-title":"McArdle's disease: successful symptomatic therapy by high dose oral administration of ribose","volume":"69","author":"Wagner","year":"1991","journal-title":"Klinische Wochenschrift"},{"issue":"1","key":"10.1002\/14651858.CD003458.pub5-BIB0030|cit30","first-page":"53","article-title":"McArdle disease: molecular genetic update","volume":"26","author":"Andreu","year":"2007","journal-title":"Acta Myologica"},{"issue":"4","key":"10.1002\/14651858.CD003458.pub5-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1172\/JCI7866","article-title":"Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice","volume":"104","author":"Barton-Davis","year":"1999","journal-title":"Journal of Clinical Investigation"},{"issue":"8","key":"10.1002\/14651858.CD003458.pub5-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/hmg\/2.8.1291","article-title":"McArdle's disease: a nonsense mutation in exon 1 of the muscle glycogen phosphorylase gene explains some but not all cases","volume":"2","author":"Bartram","year":"1993","journal-title":"Human Molecular Genetics"},{"issue":"8272","key":"10.1002\/14651858.CD003458.pub5-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0140-6736(82)91767-6","article-title":"Beneficial effects of dantrolene sodium in exercise-induced muscle pains: calcium mediated?","volume":"1","author":"Bertorini","year":"1982","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1002\/mus.880181406","article-title":"McArdle's disease: molecular genetics and metabolic consequences of the phenotype","volume":"3","author":"Beynon","year":"1995","journal-title":"Muscle & Nerve"},{"issue":"5","key":"10.1002\/14651858.CD003458.pub5-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Medicine and Science in Sports and Exercise"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/(SICI)1097-4598(199606)19:6<764::AID-MUS12>3.0.CO;2-L","article-title":"Impairment of muscle mitochondrial oxidative metabolism in McArdle's disease","volume":"19","author":"Stefano","year":"1996","journal-title":"Muscle & Nerve"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bjsm.2007.038992","article-title":"The I allele of the ACE gene is associated with improvement in exercise capacity in women with McArdle disease","volume":"42","author":"G\u00f3mez-Gallego","year":"2008","journal-title":"British Journal of Sports Medicine"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0002-9343(83)90614-9","article-title":"Low levels of muscle pyridoxine in McArdle's syndrome","volume":"74","author":"Haller","year":"1983","journal-title":"American Journal of Medicine"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0039|cit39","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009] The Cochrane Collaboration, 2009. Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0040|cit40","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/(SICI)1098-1004(1998)12:1<27::AID-HUMU4>3.0.CO;2-#","article-title":"Molecular diagnosis of McArdle's disease: revised genomic structure of the phosphorylase gene and identification of a novel mutation","volume":"12","author":"Kubisch","year":"1998","journal-title":"Human Mutation"},{"issue":"12","key":"10.1002\/14651858.CD003458.pub5-BIB0042|cit42","first-page":"1355","article-title":"Brief periods of occlusion and re-perfusion increase skeletal muscle force output in humans","volume":"43","author":"Libonati","year":"1998","journal-title":"Cardiologia"},{"issue":"8","key":"10.1002\/14651858.CD003458.pub5-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.nmd.2007.04.006","article-title":"The 577X allele of the ACTN3 gene is associated with improved exercise capacity in women with McArdle's disease","volume":"17","author":"Lucia","year":"2007","journal-title":"Neuromuscular Disorders"},{"issue":"4","key":"10.1002\/14651858.CD003458.pub5-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.10499","article-title":"Phenotype modulators in myophosphorylase deficiency","volume":"53","author":"Martinuzzi","year":"2003","journal-title":"Annals of Neurology"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0045|cit45","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown","volume":"10","author":"McArdle","year":"1951","journal-title":"Clinical Science"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0046|cit46","first-page":"18","article-title":"A functional disorder of muscle associated with the absence of phosphorylase","volume":"3","author":"Mommaerts","year":"1959","journal-title":"Proceedings of the National Academy of Science USA"},{"issue":"8","key":"10.1002\/14651858.CD003458.pub5-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1212\/01.wnl.0000343002.74480.e4","article-title":"Fat metabolism during exercise in patients with McArdle disease","volume":"72","author":"Orngreen","year":"2009","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0002-9343(61)90075-4","article-title":"A metabolic myopathy due to absence of muscle phosphorylase","volume":"30","author":"Pearson","year":"1961","journal-title":"American Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD003458.pub5-BIB0049|cit49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007931.pub2","article-title":"Physical training for McArdle disease","author":"Quinlivan","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0050|cit50","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"3","key":"10.1002\/14651858.CD003458.pub5-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neulet.2007.06.025","article-title":"Genotype modulators of clinical severity in McArdle disease","volume":"422","author":"Rubio","year":"2007","journal-title":"Neuroscience Letters"},{"issue":"1","key":"10.1002\/14651858.CD003458.pub5-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1212\/WNL.50.1.6","article-title":"Why do patients with McArdle's disease have decreased exercise capacity?","volume":"50","author":"Ruff","year":"1998","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1172\/JCI103983","article-title":"Chronic progressive myopathy with myoglobinuria: demonstration of a glycogenolytic defect in muscle","volume":"108","author":"Schmidt","year":"1959","journal-title":"Journal of Clinical Investigation"},{"key":"10.1002\/14651858.CD003458.pub5-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/(SICI)1097-4598(199712)20:12<1502::AID-MUS4>3.0.CO;2-C","article-title":"A randomised controlled trial of creatine monohydrate in patients with mitochondrial cytopathies","volume":"20","author":"Tarnopolsky","year":"1997","journal-title":"Muscle & Nerve"},{"issue":"6","key":"10.1002\/14651858.CD003458.pub5-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1152\/jappl.1997.83.6.2055","article-title":"Long term creatine intake is beneficial to muscle performance during resistance training","volume":"83","author":"Vandenberghe","year":"1997","journal-title":"Journal of Applied Physiology"},{"issue":"8","key":"10.1002\/14651858.CD003458.pub5-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1172\/JCI555","article-title":"Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies","volume":"108","author":"Vissing","year":"1998","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"10.1002\/14651858.CD003458.pub5-BIB0057|cit57","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003458","article-title":"Pharmacological and nutritional treatment for McArdle's disease (Glycogen storage disease type V)","author":"Quinlivan","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD003458.pub5-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003458.pub2","article-title":"Pharmacological and nutritional treatment for McArdle's disease (Glycogen Storage Disease type V)","author":"Quinlivan","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD003458.pub5-BIB0059|cit59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003458.pub3","article-title":"Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V)","author":"Quinlivan","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD003458.pub5-BIB0060|cit60","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003458.pub4","article-title":"Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V)","author":"Quinlivan","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD003458.pub5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:53:27Z","timestamp":1742712807000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD003458.pub5"}},"subtitle":[],"editor":[{"name":"Cochrane Neuromuscular Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"references-count":60,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd003458.pub5","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]}}}