{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:02:41Z","timestamp":1777960961999,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004031","type":"journal-article","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T17:16:55Z","timestamp":1069435015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ibuprofen for Alzheimer's disease"],"prefix":"10.1002","volume":"2010","author":[{"given":"Naji","family":"Tabet","sequence":"first","affiliation":[{"name":"University of Brighton; Postgraduate Medical School; Falmer Brighton UK BN1 9PH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Feldman","sequence":"additional","affiliation":[{"name":"Vancouver Hospital and Health Sciences Center; UBC Division of Neurology; S192-2211 Wesbrook Mall Vancouver British Columbia Canada V6T 2B5"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4,22]]},"reference":[{"key":"10.1002\/14651858.CD004031-BIB0001|cit1","unstructured":"Small GW Anti-inflammatory treatment for age-associated memory impairment: a double-blind placebo-controlled trial. Alzheimer's Disease Education and Referral Center (ADEAR)"},{"key":"10.1002\/14651858.CD004031-BIB0002|cit2","volume-title":"Diagnistic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1002\/14651858.CD004031-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"31466","DOI":"10.1074\/jbc.M201308200","article-title":"Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein","volume":"277","author":"Avramovich","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1002\/14651858.CD004031-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1006\/nbdi.2001.0451","article-title":"Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells","volume":"8","author":"Blasko","year":"2001","journal-title":"Neurobiology of Disease"},{"key":"10.1002\/14651858.CD004031-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3940(00)01294-5","article-title":"Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro","volume":"289","author":"Casper","year":"2000","journal-title":"Neuroscience Letters"},{"key":"10.1002\/14651858.CD004031-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003088-199834020-00002","article-title":"Clinical pharmacokinetics of ibuprofen: the first 30 years","volume":"34","author":"Davies","year":"1998","journal-title":"Clinical Pharmacokinetics"},{"key":"10.1002\/14651858.CD004031-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0197-4580(96)00108-X","article-title":"The role of complement and activated microglia in the pathogenesis of Alzheimer's disease","volume":"17","author":"Eikelenboom","year":"1996","journal-title":"Neurobiology of Aging"},{"key":"10.1002\/14651858.CD004031-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1471-4159.1997.68020704.x","article-title":"Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells","volume":"68","author":"Fiebich","year":"1997","journal-title":"Journal of Neurochemistry"},{"key":"10.1002\/14651858.CD004031-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0891-5849(98)00293-7","article-title":"Neuroimmunology processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development","volume":"26","author":"Floyd","year":"1999","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1002\/14651858.CD004031-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0006-2952(97)00143-3","article-title":"Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C","volume":"54","author":"Hamman","year":"1997","journal-title":"Biochemical Pharmacology"},{"key":"10.1002\/14651858.CD004031-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1517\/13543784.9.4.671","article-title":"Anti-inflammatory drugs: a hope for Alzheimer's disease?","volume":"9","author":"Hull","year":"2000","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"10.1002\/14651858.CD004031-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMoa010178","article-title":"Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease","volume":"345","author":"in t' Veld","year":"2001","journal-title":"North England Journal of Medicine"},{"key":"10.1002\/14651858.CD004031-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0197-4580(96)00114-5","article-title":"Molecular aspects of inflammatory and immune responses in Alzheimer's disease","volume":"17","author":"Kalaria","year":"1996","journal-title":"Neurobiology of Aging"},{"key":"10.1002\/14651858.CD004031-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1023\/A:1011115006856","article-title":"An investigation into the neuroprotective properties of ibuprofen","volume":"15","author":"Lambat","year":"2000","journal-title":"Metabolic Brain Disease"},{"key":"10.1002\/14651858.CD004031-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","article-title":"Ibuprofen suppresses plaque pathology and inflammation in mouse model for Alzheimer's disease","volume":"20","author":"Lim","year":"2000","journal-title":"Journal of Neurosciences"},{"key":"10.1002\/14651858.CD004031-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0197-4580(01)00299-8","article-title":"Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice","volume":"22","author":"Lim","year":"2001","journal-title":"Neurobiology of Aging"},{"key":"10.1002\/14651858.CD004031-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.47.2.425","article-title":"Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies","volume":"47","author":"McGeer","year":"1996","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD004031-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(00)00721-4","article-title":"Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells","volume":"408","author":"Ogawa","year":"2000","journal-title":"European Journal of Pharmacology"},{"key":"10.1002\/14651858.CD004031-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.48.3.626","article-title":"Risk of Alzheimer's disease and duration of NSAID use","volume":"48","author":"Stewart","year":"1997","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD004031-BIB0020|cit20","first-page":"127","article-title":"Free radicals as mediators of toxicity in Alzheimer's disease: a review and hypothesis","volume":"19","author":"Tabet","year":"2000","journal-title":"Adverse Drug Reactions and Toxicological Reviews"},{"issue":"2","key":"10.1002\/14651858.CD004031-BIB0021|cit21","article-title":"Indomethacin for the treatment of Alzheimer's disease patients","author":"Tabet","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004031-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/PL00007724","article-title":"Reversible dementia in elderly patients referred to a memory clinic","volume":"244","author":"Walstra","year":"1997","journal-title":"Journal of Neurology"},{"key":"10.1002\/14651858.CD004031-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/35102591","article-title":"A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity","volume":"414","author":"Weggen","year":"2001","journal-title":"Nature"},{"key":"10.1002\/14651858.CD004031-BIB0024|cit24","first-page":"837","article-title":"A pleiotropic antiathrogenic action of ibuprofen","volume":"7","author":"Zapolska-Downar","year":"2001","journal-title":"Medical Sciences Monitor"},{"issue":"2","key":"10.1002\/14651858.CD004031-BIB0025|cit25","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004031","article-title":"Ibuprofen for Alzheimer's disease","author":"Tabet","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD004031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:22:25Z","timestamp":1777911745000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004031"}},"subtitle":[],"editor":[{"name":"Cochrane Dementia and Cognitive Improvement Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2003,4,22]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004031","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,22]]}}}