{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:51:34Z","timestamp":1783691494504,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd004036.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000}}],"reference-count":50,"publisher":"Wiley","issue":"3","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004036.pub3","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T11:01:34Z","timestamp":1263812494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glucocorticosteroids for primary sclerosing cholangitis"],"prefix":"10.1002","volume":"2010","author":[{"given":"Vanja","family":"Giljaca","sequence":"first","affiliation":[{"name":"Clinical Hospital Centre Rijeka; Department of Gastroenterology; Kresimirova 42 Rijeka Croatia 51000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Poropat","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre Rijeka; Department of Gastroenterology; Kresimirova 42 Rijeka Croatia 51000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Stimac","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre Rijeka; Department of Gastroenterology; Kresimirova 42 Rijeka Croatia 51000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital; Cochrane Hepato-Biliary Group; Blegdamsvej 9 Copenhagen Denmark DK-2100"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD004036.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0168-8278(86)80155-6","article-title":"Biliary lavage with corticosteroids in primary sclerosing cholangitis. A clinical, cholangiographic and bacteriological study","volume":"3","author":"Allison","year":"1986","journal-title":"Journal of Hepatology"},{"issue":"8","key":"10.1002\/14651858.CD004036.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1572-0241.2000.02267.x","article-title":"Budesonide or prednisone in combination with ursodeoxycholic acid in primary sclerosing cholangitis: a randomised double-blind pilot study. Belgian-Dutch PSC Study Group","volume":"95","author":"Hoogstraten","year":"2000","journal-title":"The American Journal of Gastroenterology"},{"issue":"9","key":"10.1002\/14651858.CD004036.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/j.1572-0241.2000.02323.x","article-title":"Oral budesonide in the treatment of primary sclerosing cholangitis","volume":"95","author":"Angulo","year":"2000","journal-title":"American Journal of Gastroenterology"},{"issue":"9","key":"10.1002\/14651858.CD004036.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1080\/00365520310005172","article-title":"Long-term effect of corticosteroid treatment in primary sclerosing cholangitis patients","volume":"38","author":"Boberg","year":"2003","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"5","key":"10.1002\/14651858.CD004036.pub3-BIB0005|cit5","first-page":"1037","article-title":"Positive corticosteroid response in early sclerosing cholangitis","volume":"86","author":"Burgert","year":"1984","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1002\/14651858.CD004036.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/BF01296045","article-title":"Therapeutic investigations in primary sclerosing cholangitis","volume":"31","author":"Grijm","year":"1986","journal-title":"Digestive Diseases and Sciences"},{"issue":"1","key":"10.1002\/14651858.CD004036.pub3-BIB0007|cit7","first-page":"57","article-title":"The combination of prednisone and colchicine in patients with primary sclerosing cholangitis","volume":"86","author":"Lindor","year":"1991","journal-title":"The American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.7326\/0003-4819-131-12-199912210-00006","article-title":"Combined therapy with azathioprine, prednisolone and ursodiol in patients with primary sclerosing cholangitis","volume":"131","author":"Schramm","year":"1999","journal-title":"Annals of Internal Medicine"},{"issue":"3","key":"10.1002\/14651858.CD004036.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00000658-199803000-00014","article-title":"Primary sclerosing cholangitis: resect, dilate, or transplant?","volume":"227","author":"Ahrendt","year":"1998","journal-title":"Annals of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD004036.pub3-BIB0010|cit10","first-page":"1037","article-title":"Positive corticosteroid response in early sclerosing cholangitis","volume":"86","author":"Burgert","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11894-003-0004-z","article-title":"The management of primary sclerosing cholangitis","volume":"5","author":"Chapman","year":"2003","journal-title":"Current Gastroenterology Reports"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11894-006-0067-8","article-title":"Pirmary sclerosing cholangitis: diagnosis and management","volume":"8","author":"Charatcharoenwitthaya","year":"2006","journal-title":"Current Gastroenterology Reports"},{"issue":"1","key":"10.1002\/14651858.CD004036.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF01887799","article-title":"Sclerosing cholangitis: broad spectrum of radiographic features","volume":"9","author":"Chen","year":"1984","journal-title":"Gastrointestinal Radiology"},{"issue":"2","key":"10.1002\/14651858.CD004036.pub3-BIB0014|cit14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003626","article-title":"Bile acids for primary sclerosing cholangitis (Cochrane review)","author":"Chen","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0015|cit15","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/j.1365-2036.2005.02407.x","article-title":"Review article: current management of primary sclerosing cholangitis","volume":"21","author":"Cullen","year":"2005","journal-title":"Alimentary Pharmacology and Therapeutics"},{"issue":"1","key":"10.1002\/14651858.CD004036.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/hep.1840130119","article-title":"Dual association of HLA DR2 and DR3 with primary sclerosing cholangitis","volume":"13","author":"Donaldson","year":"1991","journal-title":"Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD004036.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00042737-200012040-00016","article-title":"Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination","volume":"12","author":"Fracchia","year":"2000","journal-title":"European Journal of Gastroenterology & Hepatology"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0018|cit18","unstructured":"Gluud C Nikolova D Klingenberg SL Whitfield K Alexakis N Als-Nielsen B Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)) 2009, Issue 4. Art. No.: LIVER"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.suc.2008.07.010","article-title":"Primary sclerosing cholangitis","volume":"88","author":"Gordon","year":"2008","journal-title":"Surgical Clinics of America"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0020|cit20","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008] The Cochrane Colloboration, 2008. Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0021|cit21","volume-title":"Code of Federal Regulations & International Conference on Harmonization Guidelines","author":"International Conference on Harmonisation Expert Working Group","year":"1997"},{"issue":"11","key":"10.1002\/14651858.CD004036.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodological quality and discrepancies between large and small randomised trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"issue":"14","key":"10.1002\/14651858.CD004036.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJM198404053101407","article-title":"Current concepts. Primary sclerosing cholangitis","volume":"310","author":"LaRusso","year":"1984","journal-title":"The New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0024|cit24","first-page":"1121","article-title":"Sclerosing cholangitis","volume-title":"Oxford Textbook of Clinical Hepatology","volume":"II","author":"LaRusso","year":"1999"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0025|cit25","first-page":"171","article-title":"Chronic active hepatitis: overlap with primary biliary cirrhosis and primary sclerosing cholangitis","volume-title":"Chronic active hepatitis: the Mayo Clinic experience","author":"Lindor","year":"1986"},{"issue":"4","key":"10.1002\/14651858.CD004036.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-2008-1040588","article-title":"Recent advances in the management of primary sclerosing cholangitis","volume":"7","author":"Lindor","year":"1987","journal-title":"Seminars in Liver Disease"},{"issue":"1","key":"10.1002\/14651858.CD004036.pub3-BIB0027|cit27","first-page":"57","article-title":"The combination of prednisone and colchicine in patients with primary sclerosing cholangitis","volume":"86","author":"Lindor","year":"1991","journal-title":"The American Journal of Gastroenterology"},{"issue":"2","key":"10.1002\/14651858.CD004036.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/gut.19.2.85","article-title":"Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease","volume":"19","author":"Long","year":"1978","journal-title":"Gut"},{"issue":"6","key":"10.1002\/14651858.CD004036.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep.1840010612","article-title":"Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis","volume":"1","author":"Ludwig","year":"1981","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0030|cit30","first-page":"193","article-title":"Primary sclerosing cholangitis","volume-title":"Liver pathology-contemporary issues in surgical pathology","author":"Ludwig","year":"1986"},{"issue":"1","key":"10.1002\/14651858.CD004036.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-2008-1040417","article-title":"Small-duct primary sclerosing cholangitis","volume":"11","author":"Ludwig","year":"1991","journal-title":"Seminars in Liver Disease"},{"issue":"4","key":"10.1002\/14651858.CD004036.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.1840100405","article-title":"A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss","volume":"10","author":"Mitchison","year":"1989","journal-title":"Hepatology"},{"issue":"9128","key":"10.1002\/14651858.CD004036.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD004036.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0016-5085(95)90463-8","article-title":"HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis","volume":"108","author":"Olerup","year":"1995","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1002\/14651858.CD004036.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0026-895X(25)09239-9","article-title":"Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes","volume":"41","author":"Pichard","year":"1992","journal-title":"Molecular Pharmacology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD004036.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0168-8278(00)80421-3","article-title":"Chronic cholestatic diseases","volume":"32","author":"Poupon","year":"2000","journal-title":"Journal of Hepatology"},{"issue":"5","key":"10.1002\/14651858.CD004036.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0016-5085(83)80085-7","article-title":"Familial occurrence of primary sclerosing cholangitis and ulcerative colitis","volume":"85","author":"Quigley","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0038|cit38","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan). Version 5.0. 2008"},{"issue":"5","key":"10.1002\/14651858.CD004036.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"issue":"21","key":"10.1002\/14651858.CD004036.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.3748\/wjg.14.3338","article-title":"Clinical features and management of primary sclerosing cholangitis","volume":"14","author":"Silveira","year":"2008","journal-title":"World Journal of Gastroenterology"},{"issue":"8","key":"10.1002\/14651858.CD004036.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1155\/2008\/824168","article-title":"Primary sclerosing cholangitis","volume":"22","author":"Silveira","year":"2008","journal-title":"Canadian Journal of Gastroenterology"},{"issue":"3","key":"10.1002\/14651858.CD004036.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0168-8278(97)80421-7","article-title":"Efficacy of ursodeoxycholic acid treatment and endoscopic dilation of major duct stenoses in primary sclerosing cholangitis. An 8-year prospective study","volume":"26","author":"Stiehl","year":"1997","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD004036.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.2174\/092986707781368388","article-title":"Current treatments of primary sclerosing cholangitis","volume":"14","author":"Vacca","year":"2007","journal-title":"Current Medical Chemistry"},{"issue":"8","key":"10.1002\/14651858.CD004036.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1572-0241.2000.02267.x","article-title":"Budesonide or prednisone in combination with ursodeoxycholic acid in primary sclerosing cholangitis: a randomised double-blind pilot study","volume":"95","author":"Hoogstraten","year":"2000","journal-title":"American Journal of Gastroenterology"},{"issue":"7","key":"10.1002\/14651858.CD004036.pub3-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0046-8177(85)80158-1","article-title":"Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis","volume":"16","author":"Wee","year":"1985","journal-title":"Human Pathology"},{"issue":"5","key":"10.1002\/14651858.CD004036.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"581","DOI":"10.7326\/0003-4819-102-5-581","article-title":"Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts?","volume":"102","author":"Wee","year":"1985","journal-title":"Annals of Internal Medicine"},{"issue":"1 Pt 1","key":"10.1002\/14651858.CD004036.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0016-5085(85)80141-4","article-title":"Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis","volume":"88","author":"Wiesner","year":"1985","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1002\/14651858.CD004036.pub3-BIB0048|cit48","first-page":"84","article-title":"Combined treatment with ursodeoxycholic acid and prednisone in primary biliary cirrhosis","volume":"44","author":"Wolfhagen","year":"1994","journal-title":"The Netherlands Journal of Medicine"},{"issue":"7644","key":"10.1002\/14651858.CD004036.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.39465.451748.AD","article-title":"Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: Meta-epidemiological study","volume":"336","author":"Wood","year":"2008","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"3","key":"10.1002\/14651858.CD004036.pub3-BIB0050|cit50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004036.pub2.","article-title":"Clucocorticosteroids for primary sclerosing cholangitis","author":"Chen","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004036.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:16:39Z","timestamp":1776114999000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004036.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Hepato-Biliary Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,1,20]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004036.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,20]]}}}