{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:32:40Z","timestamp":1771104760533,"version":"3.50.1"},"publisher-location":"Chichester, UK","reference-count":89,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd004094","type":"reference-entry","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T22:16:55Z","timestamp":1069453015000},"source":"Crossref","is-referenced-by-count":5,"title":["Long-term pharmacotherapy for obesity and overweight"],"prefix":"10.1002","author":[{"given":"R","family":"Padwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SK","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DCW","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,22]]},"reference":[{"key":"10.1002\/14651858.CD004094-BIB1|cit1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0002-9343(98)00411-2","article-title":"Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine","volume":"106","author":"Apfelbaum","year":"1999","journal-title":"American Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB2|cit2","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1097\/00004872-200211000-00026","article-title":"Orlistat improves blood pressure control in obese subjects with treated but inadequately controlled hypertension","volume":"20","author":"Bakris","year":"2002","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004094-BIB3|cit3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1742-1241.2002.tb11307.x","article-title":"Randomised trial of the effect of orlistat on body weight and cardiovascular disease risk profile in obese patients: UK Multimorbidity Study","volume":"56","author":"Broom","year":"2002","journal-title":"International Journal of Clinical Practice"},{"key":"10.1002\/14651858.CD004094-BIB4|cit4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.281.3.235","article-title":"Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat","volume":"281","author":"Davidson","year":"1999","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB5|cit5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.281.3.235","article-title":"Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat","volume":"281","author":"Davidson","year":"1999","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB6|cit6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.ijo.0801128","article-title":"One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor","volume":"24","author":"Finer","year":"2000","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB7|cit7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1001\/archfami.9.2.160","article-title":"Orlistat in the long-term treatment of obesity in primary care settings","volume":"9","author":"Hauptman","year":"200","journal-title":"Archives of Family Medicine"},{"key":"10.1002\/14651858.CD004094-BIB8|cit8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1001\/archfami.9.2.160","article-title":"Orlistat in the long-term treatment of obesity in primary care settings","volume":"9","author":"Hauptman","year":"2000","journal-title":"Archives of Family Medicine"},{"issue":"21","key":"10.1002\/14651858.CD004094-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2337\/diacare.21.8.1288","article-title":"Role of orlistat in the treatment of obese patients with type 2 diabetes","author":"Hollander","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004094-BIB10|cit10","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0140-6736(00)03491-7","article-title":"Effect of sibutramine on weight maintenance after weight loss: a randomised trial","volume":"356","author":"James","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004094-BIB11|cit11","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2337\/diacare.25.6.1033","article-title":"Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes","volume":"25","author":"Kelley","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004094-BIB12|cit12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1365-2796.2000.00720.x","article-title":"The effect of orlistat on body weight and coronary heart disease risk profile in obese patients: The Swedish Multimorbidity Study","volume":"248","author":"Lindgarde","year":"2000","journal-title":"Journal of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1001\/archinte.160.14.2185","article-title":"Efficacy and safety of sibutramine in obese white and african american patients with hypertension","volume":"160","author":"McMahon","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB14|cit14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.jhh.1001298","article-title":"Sibutramine is safe and effective for weight loss in obese patients whose hypertension is well controlled by angiotensin converting enzyme inhibitors","volume":"16","author":"McMahon","year":"2002","journal-title":"Journal of Human Hypertension"},{"key":"10.1002\/14651858.CD004094-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2337\/diacare.25.7.1123","article-title":"Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin","volume":"25","author":"Miles","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004094-BIB16|cit16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/oby.2000.8","article-title":"Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity","volume":"8","author":"Rossner","year":"200","journal-title":"Obesity Research"},{"key":"10.1002\/14651858.CD004094-BIB17|cit17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/oby.2000.8","article-title":"Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity","volume":"8","author":"Rossner","year":"2000","journal-title":"Obesity Research"},{"key":"10.1002\/14651858.CD004094-BIB18|cit18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(97)11509-4","article-title":"Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients","volume":"352","author":"Sjostrom","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004094-BIB19|cit19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(97)11509-4","article-title":"Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients","volume":"352","author":"Sjostrom","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004094-BIB20|cit20","first-page":"505","article-title":"Randomized placebo-controlled trial of long-term treatment with sibutramine in mild to moderate obesity","volume":"50","author":"Smith","year":"2001","journal-title":"Journal of Family Practice"},{"key":"10.1002\/14651858.CD004094-BIB21|cit21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0011-393X(02)80066-2","article-title":"Effects of orlistat, simvastatin, and orlistat plus simvastatin in obese patients with hypercholesterolemia: a randomized, open-label trial","volume":"63","author":"Derosa","year":"2002","journal-title":"Current Therapeutic Research, Clinical and Experimental"},{"key":"10.1002\/14651858.CD004094-BIB22|cit22","first-page":"21","article-title":"A prospective controlled trial of outpatients treatment for obesity","volume":"37","author":"Gilbert","year":"1983","journal-title":"Human Nutrition. Clinical Nutrition"},{"key":"10.1002\/14651858.CD004094-BIB23|cit23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1463-1326.2002.00237.x","article-title":"The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial","volume":"4","author":"Hanefeld","year":"2002","journal-title":"Diabetes, Obesity and Metabolism"},{"key":"10.1002\/14651858.CD004094-BIB24|cit24","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/archinte.160.9.1321","article-title":"Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults","volume":"160","author":"Heymsfield","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/ajcn\/69.6.1108","article-title":"Orlistat, a liase inhibitor, for weight maintenance after conventional dieting: a 1-y study","volume":"69","author":"Hill","year":"1999","journal-title":"American Journal of Clinical Nutrition"},{"issue":"Suppl 3","key":"10.1002\/14651858.CD004094-BIB26|cit26","first-page":"S24","article-title":"A one-year trial to assess the value of orlistat in the management of obesity","volume":"21","author":"James","year":"1997","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB27|cit27","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2337\/diacare.22.6.896","article-title":"Pharmacologic induction of weight loss to treat type 2 diabetes","volume":"22","author":"Redmon","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004094-BIB28|cit28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/archinte.161.2.218","article-title":"Benefits of Lifestyle Modification in the Pharmacologic Treatment of Obesity","volume":"161","author":"Wadden","year":"2001","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB29|cit29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/clpt.1992.68","article-title":"Long-term weight control: The national heart, lung, and blood institute funded multimodal intervention study","volume":"51","author":"Weintraub","year":"1992","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1002\/14651858.CD004094-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1001\/jama.286.11.1331","article-title":"Long-term weight loss with sibutramine","volume":"286","author":"Wirth","year":"2001","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB31|cit31","unstructured":""},{"key":"10.1002\/14651858.CD004094-BIB32|cit32","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/00004872-199816121-00024","article-title":"Treatment with orlistat reduces cardiovascular risk in obese patients","volume":"16","author":"Zavoral","year":"1998","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004094-BIB33|cit33","unstructured":"XENDOS Ongoing study"},{"key":"10.1002\/14651858.CD004094-BIB34|cit34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/sj.ijo.0800875","article-title":"Weight loss increases and fat loss decreases all-cause mortality rate: results from two independent cohort studies","volume":"23","author":"Allison","year":"1999","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB35|cit35","doi-asserted-by":"crossref","first-page":"737","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00022","article-title":"Long-term effects of change in body weight on all-cause mortality","volume":"119","author":"Andres","year":"1993","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB36|cit36","first-page":"483","article-title":"The cost of obesity in Canada","volume":"160","author":"Birmingham","year":"1999","journal-title":"Canadian Medical Association Journal"},{"issue":"Supp 2","key":"10.1002\/14651858.CD004094-BIB37|cit37","first-page":"2112S","article-title":"Effect of degree of weight loss on health benefits","volume":"3","author":"Blackburn","year":"1995","journal-title":"Obesity Research"},{"key":"10.1002\/14651858.CD004094-BIB38|cit38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0140-6736(98)22029-0","article-title":"Obesity: a time bomb to be defused","volume":"352","author":"Bray","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004094-BIB39|cit39","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/35007544","article-title":"Medicinal strategies in the treatment of obesity","volume":"404","author":"Bray","year":"2000","journal-title":"Nature"},{"key":"10.1002\/14651858.CD004094-BIB40|cit40","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.2337\/diabetes.51.9.2796","article-title":"Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of inslin resistance in high-risk hispanic women","volume":"51","author":"Buchanan","year":"2002","journal-title":"Diabetes"},{"key":"10.1002\/14651858.CD004094-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1056\/NEJM199910073411501","article-title":"Body-mass index and mortality in a prospective cohort of U.S. adults","volume":"341","author":"Calle","year":"1999","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB42|cit42","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0140-6736(02)08905-5","article-title":"Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial","volume":"359","author":"Chiasson","year":"2002","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004094-BIB43|cit43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7326\/0003-4819-122-7-199504010-00001","article-title":"Weight gain as a risk factor for clinical diabetes mellitus in women","volume":"122","author":"Colditz","year":"1995","journal-title":"Annals of Internal Medicine"},{"issue":"2","key":"10.1002\/14651858.CD004094-BIB44|cit44","article-title":"Surgery for morbid obesity","author":"Colquitt","year":"2003","journal-title":"The Cochrane Library"},{"key":"10.1002\/14651858.CD004094-BIB45|cit45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB46|cit46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD004094-BIB47|cit47","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1001\/archinte.161.13.1581","article-title":"Impact of overweight on the risk of developing common chronic diseases during a 10-year period","volume":"161","author":"Field","year":"2001","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB48|cit48","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.288.14.1723","article-title":"Prevalence and trends in obesity among US adults, 1999-2000","volume":"288","author":"Flegal","year":"2002","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB49|cit49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/oxfordjournals.aje.a009844","article-title":"Prospective study of intentionality of weight loss and mortality in older women: the Iowa Women's Health Study","volume":"149","author":"French","year":"1999","journal-title":"American Journal of Epidemiology"},{"key":"10.1002\/14651858.CD004094-BIB50|cit50","first-page":"397","article-title":"Beneficial effects of modest weight loss","volume":"16","author":"Goldstein","year":"1992","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB51|cit51","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0889-8529(05)70367-4","article-title":"Obesity surgery","volume":"25","author":"Greenway","year":"1996","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"10.1002\/14651858.CD004094-BIB52|cit52","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.ijo.0801889","article-title":"Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials","volume":"26","author":"Haddock","year":"2002","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB53|cit53","unstructured":"Health Canada Health Canada investigates safety of MERIDIA\u00ae (Sibutramine) http:\/\/www.hc-sc.gc.ca\/english\/protection\/warnings\/2002\/2002_21e.htm"},{"key":"10.1002\/14651858.CD004094-BIB54|cit54","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/bmj.319.7211.670","article-title":"What is meant by intention to treat analysis? Survey of published randomised controlled trials","volume":"319","author":"Hollis","year":"1999","journal-title":"British Medical Journal"},{"key":"10.1002\/14651858.CD004094-BIB55|cit55","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1001\/jama.289.14.1785","article-title":"Behaviours in relation to risk of obesity and type 2 diabetes melllitus in women","volume":"289","author":"Hu","year":"2003","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB56|cit56","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1056\/NEJM199809103391102","article-title":"A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation","volume":"339","author":"Jick","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB57|cit57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/9780470693926.ch5","article-title":"Assessing the quality of randomised controlled trials","volume-title":"Systematic Reviews in Health Care","author":"Juni","year":"2001"},{"key":"10.1002\/14651858.CD004094-BIB58|cit58","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJMoa020245","article-title":"Obesity and risk of heart failure","volume":"347","author":"Kenchaiah","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB59|cit59","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1056\/NEJM199809103391101","article-title":"The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs","volume":"339","author":"Khan","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB60|cit60","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1152\/physrev.1994.74.4.761","article-title":"Regional adiposity and morbidity","volume":"74","author":"Kissbah","year":"1994","journal-title":"Physiological Reviews"},{"key":"10.1002\/14651858.CD004094-BIB61|cit61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/35007508","article-title":"Obesity as a medical problem","volume":"404","author":"Kopelman","year":"2000","journal-title":"Nature"},{"key":"10.1002\/14651858.CD004094-BIB62|cit62","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1345\/aph.18319","article-title":"Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity","volume":"33","author":"Luque","year":"1999","journal-title":"Annals of Pharmacotherapy"},{"key":"10.1002\/14651858.CD004094-BIB63|cit63","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM199509143331101","article-title":"Body weight and mortality among women","volume":"333","author":"Manson","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB64|cit64","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2165\/00003495-199856020-00007","article-title":"Orlistat","volume":"52","author":"McNeely","year":"1998","journal-title":"Drugs"},{"key":"10.1002\/14651858.CD004094-BIB65|cit65","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/S0140-6736(99)04149-5","article-title":"Improving the quality of reporting of meta-analysis of randomized controlled trials: the QUOROM statement","volume":"354","author":"Moher","year":"1999","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004094-BIB66|cit66","doi-asserted-by":"crossref","first-page":"764","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00026","article-title":"Methods for voluntary weight loss and control","volume":"119","author":"NIH","year":"1993","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB67|cit67","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/j.1550-8528.1994.tb00108.x","article-title":"Towards prevention of obesity: research directions","volume":"2","year":"1994","journal-title":"Obes Res"},{"issue":"18","key":"10.1002\/14651858.CD004094-BIB68|cit68","doi-asserted-by":"crossref","DOI":"10.3310\/hta5180","article-title":"A rapid and systematic review of the clinical effectiveness and cost effectiveness of orlistat in the management of obesity","volume":"5","author":"O'Meara","year":"2001","journal-title":"Health Technology Assessment"},{"issue":"6","key":"10.1002\/14651858.CD004094-BIB69|cit69","doi-asserted-by":"crossref","DOI":"10.3310\/hta6060","article-title":"The clinical effectiveness and cost effectiveness of sibutramine in the management of obesity: a technology assessment","volume":"6","author":"O'Meara","year":"2002","journal-title":"Health Technology Assessment"},{"key":"10.1002\/14651858.CD004094-BIB70|cit70","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/jama.288.14.1728","article-title":"Prevalence and trends in overweight among US children and adolescents, 1999-2000","volume":"288","author":"Ogden","year":"2002","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB71|cit71","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jama.1997.03540430051032","article-title":"A prospective study of body mass index, weight change, and risk of stroke in women","volume":"277","author":"Rexrode","year":"1997","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB72|cit72","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/oxfordjournals.aje.a117385","article-title":"Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men","volume":"141","author":"Rimm","year":"1995","journal-title":"American Journal of Epidemiology"},{"key":"10.1002\/14651858.CD004094-BIB73|cit73","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias: dimensions of methodologic quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD004094-BIB74|cit74","first-page":"S13","article-title":"The impact of obesity on health status: some implications for health care costs","volume":"19(Suppl 6)","author":"Seidell","year":"1996","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB75|cit75","series-title":"Poster presented at the International Congress of Obesity, Sao Paulo, Brazil","article-title":"XENDOS (Xenical in the prevention of diabetes in obese subjects): A landmark study","author":"Sjostrom"},{"key":"10.1002\/14651858.CD004094-BIB76|cit76","doi-asserted-by":"crossref","DOI":"10.1002\/9780470693926.ch11","article-title":"Investigating and dealing with publication and other biases","volume-title":"Systematic Reviews in Health Care","author":"Sterne","year":"2001"},{"key":"10.1002\/14651858.CD004094-BIB77|cit77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199801013380101","article-title":"The effect of age on the association between body-mass index and mortality","volume":"338","author":"Stevens","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB78|cit78","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJM200105033441801","article-title":"Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance","volume":"344","author":"Toumilehto","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB79|cit79","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1001\/archinte.158.17.1855","article-title":"Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults","volume":"158","author":"Expert","year":"1998","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB80|cit80","unstructured":"Bray GA Health hazards associated with obesity UpToDate Clinical Reference Library [CD-ROM] 2001"},{"key":"10.1002\/14651858.CD004094-BIB81|cit81","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0895-4356(98)00131-0","article-title":"The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus","volume":"51","author":"Verhagen","year":"1998","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD004094-BIB82|cit82","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/sj.ijo.0801787","article-title":"A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study","volume":"25","author":"Visscher","year":"2001","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1002\/14651858.CD004094-BIB83|cit83","doi-asserted-by":"crossref","first-page":"688","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00012","article-title":"Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials","volume":"119","author":"Wadden","year":"1993","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB84|cit84","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJM199809103391103","article-title":"An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo","volume":"339","author":"Weissman","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004094-BIB85|cit85","unstructured":"World Health Organisation (WHO) Obesity: Preventing and managing the Global Epidemic - Report of a WHO Consultation on Obesity, 3-5 June 1997 WHO\/NUT\/NCD\/98.1 1998"},{"key":"10.1002\/14651858.CD004094-BIB86|cit86","doi-asserted-by":"crossref","first-page":"731","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00021","article-title":"The association between weight loss and increased longevity. A review of the evidence","volume":"119","author":"Williamson","year":"1993","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004094-BIB87|cit87","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/oxfordjournals.aje.a117386","article-title":"Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40-64 years","volume":"141","author":"Williamson","year":"1995","journal-title":"American Journal of Epidemiology"},{"key":"10.1002\/14651858.CD004094-BIB88|cit88","first-page":"1499","article-title":"Type 2 diabetic subjects lose less weight than their overweight spouses","volume":"23","author":"Wing","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004094-BIB89|cit89","first-page":"1307","article-title":"Obesity drug sibutramine (Meridia): hypertension and cardiac arrhythmias","volume":"166","author":"Wooltorton","year":"2002","journal-title":"Canadian Medical Association Journal"}],"updated-by":[{"DOI":"10.1002\/14651858.cd004094.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2003,10,20]],"date-time":"2003-10-20T00:00:00Z","timestamp":1066608000000}}],"container-title":["The Cochrane Database of Systematic Reviews (Protocol)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD004094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T13:50:27Z","timestamp":1704981027000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD004094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,22]]},"references-count":89,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004094","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD004094.pub2","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2002,7,22]]}}}