{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:06:37Z","timestamp":1778043997951,"version":"3.51.4"},"update-to":[{"DOI":"10.1002\/14651858.cd004182.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T00:00:00Z","timestamp":1138147200000}}],"reference-count":39,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004182.pub3","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T23:08:27Z","timestamp":1137712107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["D-penicillamine for primary sclerosing cholangitis"],"prefix":"10.1002","volume":"2010","author":[{"given":"Sarah Louise","family":"Klingenberg","sequence":"first","affiliation":[{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital; Cochrane Hepato-Biliary Group; Blegdamsvej 9 Copenhagen Denmark DK-2100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendong","family":"Chen","sequence":"additional","affiliation":[{"name":"Toronto Health Economics and Technology Assessment Collaborative (THETA), University of Toronto; Departments of Health Policy Management and Evaluation, and Pharmacy; Room 679, 6th floor, Leslie L. Dan Pharmacy Building 144 College Street Toronto Ontario Canada M5S 3M2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,25]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD004182.pub3-BIB0001|cit1","first-page":"1205","article-title":"Randomized trial of penicillamine in primary sclerosing cholangitis","volume":"6","author":"LaRusso","year":"1986","journal-title":"Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD004182.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/0016-5085(88)90180-1","article-title":"Prospective trial of penicillamine in primary sclerosing cholangitis","volume":"95","author":"LaRusso","year":"1988","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1002\/14651858.CD004182.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00000658-199101000-00004","article-title":"Cholangiocarcinoma complicating primary sclerosing cholangitis","volume":"213","author":"Rosen","year":"1991","journal-title":"Annals of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004182.pub3-BIB0004|cit4","first-page":"99","article-title":"Primary sclerosing cholangitis","volume":"48","author":"Alba","year":"2002","journal-title":"Minerva Gastroenterologica e Dietologica"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0005|cit5","first-page":"152","article-title":"Principles of statistical analysis","volume-title":"Practical statistics for medical research","author":"Altman","year":"1999"},{"issue":"1","key":"10.1002\/14651858.CD004182.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/hep.510300101","article-title":"Primary sclerosing cholangitis","volume":"30","author":"Angulo","year":"1999","journal-title":"Hepatology"},{"issue":"6","key":"10.1002\/14651858.CD004182.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/hep.1840050613","article-title":"A prospective clinical trial of D-penicillamine in the treatment of primary biliary cirrhosis","volume":"5","author":"Bodenheimer","year":"1985","journal-title":"Hepatology"},{"issue":"1","key":"10.1002\/14651858.CD004182.pub3-BIB0008|cit8","first-page":"181","article-title":"Primary sclerosing cholangitis in inflammatory bowel disease: diagnosis and therapy","volume":"24","author":"Broome","year":"2002","journal-title":"Research and Clinical Forums"},{"issue":"1","key":"10.1002\/14651858.CD004182.pub3-BIB0009|cit9","first-page":"37","article-title":"Management of primary sclerosing cholangitis and its complications in adult patients","volume":"65","author":"Broome","year":"2002","journal-title":"Acta Gastro Enterologica Belgica"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000171085","article-title":"Primary sclerosing cholangitis","volume":"2","author":"Chapman","year":"1984","journal-title":"Survey of Digestive Diseases"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0011|cit11","doi-asserted-by":"crossref","unstructured":"Chen W Gluud C Bile acids for primary sclerosing cholangitis The Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD003626. DOI: 10.1002\/14651858.CD003626","DOI":"10.1002\/14651858.CD003626"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0012|cit12","doi-asserted-by":"crossref","unstructured":"Chen W Gluud C Glucocorticosteroids for primary sclerosing cholangitis The Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD004036.pub2. DOI: 10.1002\/14651858.CD004036.pub2","DOI":"10.1002\/14651858.CD004036.pub2"},{"issue":"8","key":"10.1002\/14651858.CD004182.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1365-2036.2005.02407.x","article-title":"Review article: current management of primary sclerosing cholangitis","volume":"21","author":"Cullen","year":"2005","journal-title":"Alimentary Pharmacology and Therapeutics"},{"issue":"3","key":"10.1002\/14651858.CD004182.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/sim.4780060325","article-title":"Methods for combining randomized clinical trials: strengths and limitations","volume":"6","author":"DeMets","year":"1987","journal-title":"Statistics in Medicine"},{"issue":"3","key":"10.1002\/14651858.CD004182.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"issue":"16","key":"10.1002\/14651858.CD004182.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJM198504183121602","article-title":"Trial of penicillamine in advanced primary biliary cirrhosis","volume":"312","author":"Dickson","year":"1985","journal-title":"New England Journal of Medicine"},{"issue":"7109","key":"10.1002\/14651858.CD004182.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0018|cit18","first-page":"322","article-title":"Alcoholic hepatitis: no glucocorticosteroids?","volume-title":"Steatohepatitis (NASH and ASH), Falk Symposium 121","author":"Gluud","year":"2001"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0019|cit19","doi-asserted-by":"crossref","unstructured":"Gong Y Frederiksen SL Gluud C D-penicillamine for primary biliary cirrhosis The Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004789.pub2. DOI: 10.1002\/14651858.CD004789.pub2","DOI":"10.1002\/14651858.CD004385.pub2"},{"issue":"2","key":"10.1002\/14651858.CD004182.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0016-5085(85)90326-9","article-title":"Abnormalities in tests of copper metabolism in primary sclerosing cholangitis","volume":"89","author":"Gross","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0021|cit21","volume-title":"International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice1997 CFR & ICH Guidelines","volume":"1","author":"International Conference on Harmonisation Expert Working Group","year":"1997"},{"issue":"11","key":"10.1002\/14651858.CD004182.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD004182.pub3-BIB0023|cit23","first-page":"1205","article-title":"Randomized trial of penicillamine in primary sclerosing cholangitis [AASLD abstract]","volume":"6","author":"LaRusso","year":"1986","journal-title":"Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD004182.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/0016-5085(88)90180-1","article-title":"Prospective trial of penicillamine in primary sclerosing cholangitis","volume":"95","author":"LaRusso","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0025|cit25","first-page":"1121","article-title":"Sclerosing cholangitis","volume-title":"Oxford textbook of clinical hepatology","author":"LaRusso","year":"1999"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0026|cit26","first-page":"649","article-title":"Primary sclerosing cholangitis","volume-title":"Schiff's Diseases of the Liver","author":"Lazaridis","year":"1999"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0027|cit27","first-page":"555","article-title":"The syndrome of primary sclerosing cholangitis","volume":"9","author":"Ludwig","year":"1990","journal-title":"Progress in Liver Diseases"},{"issue":"4","key":"10.1002\/14651858.CD004182.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1053\/bega.2001.0211","article-title":"Medical and endoscopic treatment in primary sclerosing cholangitis","volume":"15","author":"Meier","year":"2001","journal-title":"Best Practice & Research Clinical Gastroenterology"},{"issue":"9128","key":"10.1002\/14651858.CD004182.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD004182.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/0016-5085(95)90220-1","article-title":"Colchicine treatment of primary sclerosing cholangitis","volume":"108","author":"Olsson","year":"1995","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1002\/14651858.CD004182.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/BF02723693","article-title":"Wilson's disease","volume":"69","author":"Pandit","year":"2002","journal-title":"Indian Journal of Pediatrics"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0032|cit32","first-page":"133","article-title":"The inadequacy of small trials","volume-title":"Clinical Trials. A Practical Approach","author":"Pocock","year":"1983"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0033|cit33","unstructured":"The Cochrane Collaboration Review Manager (RevMan) 2003"},{"issue":"5","key":"10.1002\/14651858.CD004182.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0035|cit35","first-page":"477","article-title":"Hepatolenticular degeneration. Wilson's disease","volume-title":"Diseases of the liver and biliary system","author":"Sherlock","year":"1975"},{"key":"10.1002\/14651858.CD004182.pub3-BIB0036|cit36","doi-asserted-by":"crossref","unstructured":"Suarez-Almazor ME Belseck E Spooner CH Penicillamine for treating rheumatoid arthritis The Cochrane Database of Systematic Reviews 2000, Issue 4. Art. No.: CD001460. DOI: 10.1002\/14651858.CD001460","DOI":"10.1002\/14651858.CD001460"},{"issue":"4","key":"10.1002\/14651858.CD004182.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11910-002-0007-4","article-title":"Diagnosis and treatment of Wilson's disease","volume":"2","author":"Subramanian","year":"2002","journal-title":"Current Neurology and Neuroscience Reports"},{"issue":"10","key":"10.1002\/14651858.CD004182.pub3-BIB0038|cit38","first-page":"402","article-title":"Treatment of primary Sjogren's syndrome with D-penicillamine: a pilot study","volume":"60","author":"ter Borg","year":"2002","journal-title":"The Netherlands Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD004182.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0016-5085(80)90131-6","article-title":"Clinicopathologic features of the syndrome of primary sclerosing cholangitis","volume":"79","author":"Wiesner","year":"1980","journal-title":"Gastroenterology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004182.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:51:29Z","timestamp":1767840689000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004182.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Hepato-Biliary Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2006,1,25]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004182.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,25]]}}}