{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:41:17Z","timestamp":1788306077869,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd004220","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T00:00:00Z","timestamp":1090195200000}}],"reference-count":38,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004220.pub2","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T07:08:53Z","timestamp":1090393733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Thyroid hormone supplementation for the prevention of morbidity and mortality in infants undergoing cardiac surgery"],"prefix":"10.1002","author":[{"given":"Simon J","family":"Dimmick","sequence":"first","affiliation":[{"name":"Royal North Shore Hospital; Radiology Department; Pacific Highway St. Leonards NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Badawi","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Westmead; Department of Neonatology; Corner of Hawkesbury Road and Hainsworth Street Westmead NSW Australia 2145"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha","family":"Randell","sequence":"additional","affiliation":[{"name":"Mid Staffordshire General Hospitals; Department of Endocrinology; Weston Road Stafford UK ST163 5A44"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,19]]},"reference":[{"key":"10.1002\/14651858.CD004220.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1067\/mtc.2001.116192","article-title":"A prospective randomized clinical study of thyroid hormone treatment after operations for complex congenital heart disease","volume":"122","author":"Chowdhury","year":"2001","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jtcvs.2005.04.025","article-title":"A randomized, double-blind, placebo-controlled pilot trial of triiodothyronine in neonatal heart surgery","volume":"130","author":"Mackie","year":"2005","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1067\/mtc.2000.108900","article-title":"Triiodothyronine repletion in infants during cardiopulmonary bypass for congenital heart disease","volume":"120","author":"Portman","year":"2000","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0140-6736(00)02576-9","article-title":"Tri-iodothyronine treatment in children after cardiac surgery: a double-blind, randomised, placebo-controlled study","volume":"356","author":"Bettendorf","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1017\/S104795110000946X","article-title":"Effects of triiodothyronine supplementation following modified Fontan procedure","volume":"7","author":"Mainwaring","year":"1997","journal-title":"Cardiology in the Young"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0006|cit6","unstructured":"Klein I Use of triiodothryonine in the postoperative period in pediatric patients undergoing heart surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ahj.2004.03.029","article-title":"The Triiodothyronine for Infants and Children undergoing Cardiopulmonary bypass (TRICC) study: Design and rationale","volume":"148","author":"Portman","year":"2004","journal-title":"American Heart Journal"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/bmj.311.7005.598","article-title":"Predictors of neonatal encephalopathy in full term infants","volume":"311","author":"Adamson","year":"1995","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1471-0528.2000.tb13344.x","article-title":"Maternal thyroid disease: a risk factor for newborn encephalopathy in term infants","volume":"107","author":"Badawi","year":"2000","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1203\/00006450-199703000-00012","article-title":"Transient secondary hypothyroidism in children after cardiac surgery","volume":"41","author":"Bettendorf","year":"1997","journal-title":"Pediatric Research"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0011|cit11","first-page":"378","article-title":"Use of thyroid hormones after cardiopulmonary bypass in children","volume":"7 (Suppl 1)","author":"Bialkowski","year":"1997","journal-title":"Cardiology in the Young"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1210\/jcem-65-1-83","article-title":"Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration","volume":"65","author":"Brabant","year":"1987","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1097\/00003246-199709000-00029","article-title":"Thyroid function in infants following cardiac surgery: comparative effects of iodinated and noniodinated topical antiseptics","volume":"25","author":"Brogan","year":"1997","journal-title":"Critical Care Medicine"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0003-4975(92)91446-G","article-title":"Cytokine response to cardiopulmonary bypass with membrane and bubble oxygenation","volume":"53","author":"Butler","year":"1992","journal-title":"The Annals of Thoracic Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0002-9149(99)00513-5","article-title":"Usefulness of triiodothyronine (T3) treatment after surgery for complex congenital heart disease in infants and children","volume":"84","author":"Chowdury","year":"1999","journal-title":"American Journal of Cardiology"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/0003-4975(93)90549-W","article-title":"Cardiac function in thyroid disease: clinical features and management considerations","volume":"56","author":"Dillmann","year":"1993","journal-title":"The Annals of Thoracic Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0306-5456(00)00155-8","article-title":"Maternal thyroid disease: a risk factor for newborn encephalopathy (letter)","volume":"108","author":"Girling","year":"2001","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1056\/NEJM199512073332302","article-title":"Thyroid hormone treatment after coronary-artery bypass surgery","volume":"333","author":"Klemperer","year":"1995","journal-title":"The New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0019|cit19","first-page":"357","article-title":"The thyroid gland","volume-title":"Textbook of Endocrinology","author":"Larsen","year":"1992"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/0003-4975(94)90459-6","article-title":"Suppression of the pituitary thyroid axis after cardiopulmonary bypass in the neonate","volume":"58","author":"Mainwaring","year":"1994","journal-title":"The Annals of Thoracic Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/01.CIR.101.12.1423","article-title":"Pharmacokinetic evaluation of triiodothyronine supplementation in children after modified Fontan procedure","volume":"101","author":"Mainwaring","year":"2000","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1017\/S1047951101000324","article-title":"Reduction in the levels of triidothyronine following the first stage of the Norwood reconstruction for hypoplastic left heart syndrome","volume":"11","author":"Mainwaring","year":"2001","journal-title":"Cardiology in the Young"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/026765918600100104","article-title":"The effect on intermediary metabolism of open-heart surgery with deep hypothermia and circulatory arrest in infants less than 10 kilograms body weight. A preliminary study","volume":"1","author":"Milne","year":"1986","journal-title":"Perfusion"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0022-5223(19)34965-7","article-title":"The effects of cardiopulmonary bypass on thyroid function in infants weighing less than five kilograms","volume":"103","author":"Mitchell","year":"1992","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0003-4975(94)00879-C","article-title":"Thyroid hormones homeostasis in pediatric patients during and after cardiopulmonary bypass","volume":"59","author":"Murzi","year":"1995","journal-title":"The Annals of Thoracic Surgery"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archpedi.1985.02140120077032","article-title":"Antecedents of cerebral palsy. I. Univariate analysis of risks","volume":"139","author":"Nelson","year":"1985","journal-title":"American Journal of Diseases of Children"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1159\/000177147","article-title":"Impact of triiodothyronine on the survival of high-risk patients undergoing open heart surgery","volume":"87","author":"Novitzky","year":"1996","journal-title":"Cardiology"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0028|cit28","first-page":"181","article-title":"Intravenous liothyronine sodium (T3) for myxodema coma - pharmaceutical considerations","volume":"14","author":"Odgers","year":"1984","journal-title":"Australian Journal of Pharmacy"},{"issue":"2","key":"10.1002\/14651858.CD004220.pub2-BIB0029|cit29","article-title":"Thyroid hormones for preventing neurodevelopmental impairment in preterm infants","author":"Osborn","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0030|cit30","volume-title":"Drug doses for children","author":"Schell","year":"2004"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0031|cit31","unstructured":"Shann F Drug Doses 11th Edition Parkville, Australia Collective Pty Ltd"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0032|cit32","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-5973-9_4","article-title":"Thyroid hormone control of brain and motor development: molecular, neuroanatomical, and behavioural studies","volume-title":"Advances in Perinatal Thyroidology","author":"Stein","year":"1991"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0002-9343(80)80003-9","article-title":"Decreased extrathyroidal triiodothyronine production in nonthyroidal illness: benefit or harm?","volume":"69","author":"Utiger","year":"1980","journal-title":"American Journal of Medicine"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/00003246-199422110-00008","article-title":"Dopamine suppresses pituitary function in infants and children","volume":"22","author":"Berghe","year":"1994","journal-title":"Critical Care Medicine"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1210\/jcem-71-6-1567","article-title":"Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man","volume":"71","author":"Poll","year":"1990","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/thy.1999.9.85","article-title":"Thyroid function in very preterm newborns: possible implications","volume":"9","author":"Wassenaer","year":"1999","journal-title":"Thyroid"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1161\/01.CIR.92.8.2226","article-title":"Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest","volume":"92","author":"Wernovsky","year":"1995","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD004220.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/clinchem\/45.7.1087","article-title":"Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin and free thyroxine","volume":"45","author":"Zurakowski","year":"1999","journal-title":"Clinical Chemistry"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD004220.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:31:59Z","timestamp":1628544719000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD004220.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Neonatal Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2004,7,19]]},"references-count":38,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004220.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,19]]}}}