{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:47:37Z","timestamp":1767134857697,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd004302","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T00:00:00Z","timestamp":1090195200000}}],"reference-count":27,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004302.pub2","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T03:08:53Z","timestamp":1090379333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease"],"prefix":"10.1002","volume":"2011","author":[{"given":"Paolo","family":"Bongioanni","sequence":"first","affiliation":[{"name":"University of Pisa; Neurorehabilitation Unit, Neuromuscular Disease Section, Department of Neuroscience; Via Paradisa, 2 Pisa Italy 56100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Reali","sequence":"additional","affiliation":[{"name":"University of Cagliari; Department of Cytomorphology; SS554, Bivio Sestu - Cittadella Universitaria Monserrato, Cagliari Italy 09042"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Sogos","sequence":"additional","affiliation":[{"name":"University of Cagliari; Department of Cytomorphology; SS554, Bivio Sestu - Cittadella Universitaria Monserrato, Cagliari Italy 09042"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,19]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD004302.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1212\/WNL.46.5.1244","article-title":"A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis","volume":"46","author":"ALS CNTF Treatment Study Group","year":"1996","journal-title":"Neurology"},{"issue":"2","key":"10.1002\/14651858.CD004302.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ana.410390215","article-title":"A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis","volume":"39","author":"Miller","year":"1996","journal-title":"Annals of Neurology"},{"issue":"6","key":"10.1002\/14651858.CD004302.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00002826-199512000-00003","article-title":"The pharmacokinetics of subcutaneously administered recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis: relation to parameters of the acute phase response","volume":"18","author":"ALS CNTF Treatment Study (ACTS) Phase I-II Study Group","year":"1995","journal-title":"Clinical Neuropharmacology"},{"issue":"6","key":"10.1002\/14651858.CD004302.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00002826-199512000-00004","article-title":"A phase I study of recombinant human ciliary neurotrophic factor (rhCNTF) in patients with amyotrophic lateral sclerosis","volume":"18","author":"ALS CNTF Treatment Study (ACTS) Phase I-II Study Group","year":"1995","journal-title":"Clinical Neuropharmacology"},{"issue":"5","key":"10.1002\/14651858.CD004302.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.47.5.1329","article-title":"Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis","volume":"47","author":"Miller","year":"1996","journal-title":"Neurology"},{"issue":"6","key":"10.1002\/14651858.CD004302.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nm0696-696","article-title":"Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients","volume":"2","author":"Aebischer","year":"1996","journal-title":"Nature Medicine"},{"issue":"11","key":"10.1002\/14651858.CD004302.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1523\/JNEUROSCI.10-11-03507.1990","article-title":"Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines","volume":"10","author":"Arakawa","year":"1990","journal-title":"Journal of Neuroscience"},{"issue":"7","key":"10.1002\/14651858.CD004302.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1212\/WNL.52.7.1427","article-title":"A controlled trial of recombinant methionyl human BDNF in ALS","volume":"52","author":"BDNF Study Group (Phase III)","year":"1999","journal-title":"Neurology"},{"issue":"2","key":"10.1002\/14651858.CD004302.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1212\/WNL.51.2.583","article-title":"A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis","volume":"51","author":"Borasio","year":"1998","journal-title":"Neurology"},{"issue":"5","key":"10.1002\/14651858.CD004302.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders"},{"issue":"11","key":"10.1002\/14651858.CD004302.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1111\/j.1460-9568.1997.tb01665.x","article-title":"GDNF is a trophic factor for adult rat corticospinal neurons and promotes their long-term survival after axotomy in vivo","volume":"9","author":"Giehl","year":"1997","journal-title":"European Journal of Neuroscience"},{"key":"10.1002\/14651858.CD004302.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0022-510X(95)00081-C","article-title":"Beneficial effects of insulin-like growth factor on wobbler mouse motorneuron disease","volume":"129 Suppl","author":"Hantai","year":"1995","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1002\/14651858.CD004302.pub2-BIB0013|cit13","doi-asserted-by":"crossref","DOI":"10.1002\/9780470712184","volume-title":"Cochrane Handbook for Systematic Reviews of Intervention Version 5.0.0 (updated February 2008)","author":"Higgins","year":"2008"},{"issue":"2","key":"10.1002\/14651858.CD004302.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/exnr.1996.6367","article-title":"BDNF prevents and reverses adult rat motor neuron degeneration and induces axonal outgrowth","volume":"144","author":"Kishino","year":"1997","journal-title":"Experimental Neurology"},{"issue":"6","key":"10.1002\/14651858.CD004302.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.49.6.1621","article-title":"Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS\/IGF-I Study Group","volume":"49","author":"Lai","year":"1997","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD004302.pub2-BIB0016|cit16","first-page":"304","article-title":"Safety, tolerability and pharmacokinetics of recombinant human ciliary neurotrophic factor (rhCNTF) in patients with amyotrophic lateral sclerosis","volume":"34","author":"Miller","year":"1993","journal-title":"Annals of Neurology"},{"issue":"4","key":"10.1002\/14651858.CD004302.pub2-BIB0017|cit17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002064.pub2","article-title":"Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis\/motor neuron disease","author":"Mitchell","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5175","key":"10.1002\/14651858.CD004302.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.8066451","article-title":"Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF","volume":"265","author":"Mitsumoto","year":"1994","journal-title":"Science"},{"issue":"2","key":"10.1002\/14651858.CD004302.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ana.410360205","article-title":"The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease","volume":"36","author":"Mitsumoto","year":"1994","journal-title":"Annals of Neurology"},{"issue":"3","key":"10.1002\/14651858.CD004302.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/14660820050515197","article-title":"A phase I\/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis","volume":"1","author":"Ochs","year":"2000","journal-title":"Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders"},{"issue":"6406","key":"10.1002\/14651858.CD004302.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/360755a0","article-title":"Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death","volume":"360","author":"Oppenheim","year":"1992","journal-title":"Nature"},{"issue":"1","key":"10.1002\/14651858.CD004302.pub2-BIB0022|cit22","first-page":"94","article-title":"Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (Phase I trial)","volume":"40","author":"Penn","year":"1997","journal-title":"Neurosurgery"},{"issue":"6","key":"10.1002\/14651858.CD004302.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1460-9568.1995.tb01122.x","article-title":"Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse","volume":"7","author":"Sagot","year":"1995","journal-title":"European Journal of Neuroscience"},{"issue":"6386","key":"10.1002\/14651858.CD004302.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/358502a0","article-title":"Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy","volume":"358","author":"Sendtner","year":"1992","journal-title":"Nature"},{"issue":"18","key":"10.1002\/14651858.CD004302.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1523\/JNEUROSCI.17-18-06999.1997","article-title":"Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motorneurons in adult mice","volume":"17","author":"Sendtner","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"10.1002\/14651858.CD004302.pub2-BIB0026|cit26","article-title":"Neurotrophic factors","volume-title":"Amyotrophic Lateral Sclerosis","author":"Sendtner","year":"2000"},{"issue":"6406","key":"10.1002\/14651858.CD004302.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/360753a0","article-title":"Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death","volume":"360","author":"Yan","year":"1992","journal-title":"Nature"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD004302.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:46:20Z","timestamp":1759920380000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004302.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Neuromuscular Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2004,7,19]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004302.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,19]]}}}