{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:16:22Z","timestamp":1792178182381,"version":"4.4.0"},"update-to":[{"DOI":"10.1002\/14651858.cd004332","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T00:00:00Z","timestamp":1283817600000}}],"reference-count":141,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004332.pub2","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T19:24:10Z","timestamp":1283455450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Acamprosate for alcohol dependence"],"prefix":"10.1002","volume":"2011","author":[{"given":"Susanne","family":"R\u00f6sner","sequence":"first","affiliation":[{"name":"University of Munich; Psychiatric Hospital; Nu\u00dfbaumstr. 7 Munich Germany 80336"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hackl-Herrwerth","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Leucht","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lehert","sequence":"additional","affiliation":[{"name":"University of Mons; Statistics & Computer Sciences Dept; FUCAM 151 Chaussee de Binche Mons Belgium B-7000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Vecchi","sequence":"additional","affiliation":[{"name":"ASL RM\/E; Department of Epidemiology; Via di Santa Costanza, 53 Rome Italy 00198"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Soyka","sequence":"additional","affiliation":[{"name":"University of Munich; Psychiatric Hospital; Nu\u00dfbaumstr. 7 Munich Germany 80336"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,7]]},"reference":[{"key":"10.1002\/14651858.CD004332.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.295.17.2003","article-title":"Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomised controlled trial","volume":"295","author":"Anton","year":"2006","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.15288\/jsa.2004.65.136","article-title":"Acamprosate in alcohol dependence: a randomised controlled efficacy study in a standard clinical setting","volume":"65","author":"Baltieri","year":"2004","journal-title":"Journal of studies on alcohol"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0003|cit3","first-page":"149","article-title":"Acamprosate: multicenter Portuguese efficacy and tolerance evaluation study","volume":"18","author":"Barrias","year":"1997","journal-title":"Psiquiatria Clinica"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1530-0277.1998.tb04295.x","article-title":"Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: a controlled study","volume":"22","author":"Besson","year":"1998","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0005|cit5","unstructured":"Borg S Randomized controlled trial of acamprosate versus placebo in Swedish alcoholics Unpublished trial 2003"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/alcalc\/35.2.176","article-title":"United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol","volume":"35","author":"Chick","year":"2000","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000259166","article-title":"Acamprosate and prevention of relapse in alcoholics. Results of a randomised, placebo-controlled, double-blind study in out-patient alcoholics in The Netherlands, Belgium and Luxembourg","volume":"3","author":"Geerlings","year":"1997","journal-title":"European Addiction Research"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/alcalc\/36.5.413","article-title":"Acamprosate during and after acute alcohol withdrawal: a double-blind placebo-controlled study in Spain","volume":"36","author":"Gual","year":"2001","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archpsyc.60.1.92","article-title":"Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study","volume":"60","author":"Kiefer","year":"2003","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0010|cit10","first-page":"182","article-title":"Acamprosate--a stabilizing factor in long-term withdrawal of alcoholic patients","volume":"50","author":"Ladewig","year":"1993","journal-title":"Therapeutische Umschau"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0140-6736(85)91615-0","article-title":"Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics","volume":"1","author":"Lhuintre","year":"1985","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/oxfordjournals.alcalc.a045057","article-title":"Acamprosate appears to decrease alcohol intake in weaned alcoholics","volume":"25","author":"Lhuintre","year":"1990","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpsychires.2006.02.002","article-title":"Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation","volume":"40","author":"Mason","year":"2006","journal-title":"Journal of Psychiatric Research"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/j.1360-0443.2006.01555.x","article-title":"Naltrexone versus acamprosate in the treatment of alcohol dependence: A multi-centre, randomised, double-blind, placebo-controlled trial","volume":"101","author":"Morley","year":"2006","journal-title":"Addiction"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/alcalc\/agg038","article-title":"Acamprosate in Korean alcohol-dependent patients: a multi-centre, randomised, double-blind, placebo-controlled study","volume":"38","author":"Namkoong","year":"2003","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00787-003-0327-1","article-title":"Acamprosate and its efficacy in treating alcohol dependent adolescents","volume":"12","author":"Niederhofer","year":"2003","journal-title":"European Child & Adolescent Psychiatry"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0017|cit17","first-page":"239","article-title":"Double-blind randomised multi centre trial of acamprosate in maintaining abstinence from alcohol","volume":"30","author":"Paille","year":"1995","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/978-1-4612-2878-3_44","article-title":"Acamprosate in the treatment of alcohol dependence: A six month post detoxification study","volume-title":"Novel pharmacological interventions for alcoholism","author":"Pelc","year":"1992"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1192\/bjp.171.1.73","article-title":"Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study","volume":"171","author":"Pelc","year":"1997","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1111\/j.1360-0443.1997.tb02873.x","article-title":"Acamprosate treatment in a long-term community-based alcohol rehabilitation programme","volume":"92","author":"Poldrugo","year":"1997","journal-title":"Addiction"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0021|cit21","first-page":"65","article-title":"Does acamprosate diminish the appetite for alcohol in weaned alcoholics?","volume":"51","author":"Roussaux","year":"1996","journal-title":"Journal de Pharmacie de Belgique"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/archpsyc.1996.01830080023006","article-title":"Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence","volume":"53","author":"Sass","year":"1996","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/alcalc\/35.2.202","article-title":"Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebo-controlled study","volume":"35","author":"Tempesta","year":"2000","journal-title":"Alcohol and Alcoholism"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0140-6736(96)91682-7","article-title":"Comparison of acamprosate and placebo in long-term treatment of alcohol dependence","volume":"347","author":"Whitworth","year":"1996","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000077944","article-title":"Pharmacodynamic effects of acamprosate on markers of cerebral function in alcohol-dependent subjects administered as pretreatment and during alcohol abstinence","volume":"50","author":"Boeijinga","year":"2004","journal-title":"Neuropsychobiology"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/alcalc\/agm038","article-title":"Prescription procedures in medication for relapse prevention after inpatient treatment for alcohol use disorders in Switzerland","volume":"42","author":"Buri","year":"2007","journal-title":"Alcohol and Alcoholism"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1530-0277.2006.00082.x","article-title":"A pilot study of oxcarbazepine versus acamprosate in alcohol-dependent patients","volume":"30","author":"Croissant","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1002\/14651858.CD004332.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/alcalc\/agh187","article-title":"An open randomised study comparing disulfiram and acamprosate in the treatment of alcohol dependence","volume":"40","author":"Sousa","year":"2005","journal-title":"Alcohol and Alcoholism"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/alcalc\/37.4.375","article-title":"Does psychosocial treatment enhance the efficacy of acamprosate in patients with alcohol problems?","volume":"37","author":"Wildt","year":"2002","journal-title":"Alcohol and Alcoholism"},{"issue":"5","key":"10.1002\/14651858.CD004332.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1046\/j.1440-1614.2002.01019.x","article-title":"Cognitive behavioural therapy combined with the relapse-prevention medication acamprosate: are short-term treatment outcomes for alcohol dependence improved?","volume":"36","author":"Feeney","year":"2002","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"issue":"7","key":"10.1002\/14651858.CD004332.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/j.1530-0277.2008.00680.x","article-title":"Using topiramate or naltrexone for the treatment of alcohol-dependent patients","volume":"32","author":"Florez","year":"2008","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"17","key":"10.1002\/14651858.CD004332.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1024\/0369-8394.91.17.735","article-title":"Acamprosate and psychosocial intervention. An integrative treatment approach for prevention of alcohol dependent patients in Switzerland","volume":"91","author":"Fuchs","year":"2002","journal-title":"Praxis (Bern 1994)"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0011-393X(05)80480-1","article-title":"Effects of fluoxetine and Ca-acetyl-homotaurinate on alcohol intake in familial and nonfamilial","volume":"52","author":"Gerra","year":"1992","journal-title":"Current Therapeutic Research"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/alcalc\/agh056","article-title":"A comparison of two intensities of psychosocial intervention for alcohol dependent patients treated with acamprosate","volume":"39","author":"Hammarberg","year":"2004","journal-title":"Alcohol and Alcoholism"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.drugalcdep.2007.09.014","article-title":"The effect of acamprosate on alcohol and food craving in patients with alcohol dependence","volume":"93","author":"Han","year":"2008","journal-title":"Drug and Alcohol Dependence"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/01.jcp.0000084029.22282.bb","article-title":"Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjects","volume":"23","author":"Johnson","year":"2003","journal-title":"Journal of Clinical Psychopharmacoly"},{"issue":"6-7","key":"10.1002\/14651858.CD004332.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.addbeh.2009.03.014","article-title":"Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence","volume":"34","author":"Kampman","year":"2009","journal-title":"Addictive Behaviors"},{"issue":"6","key":"10.1002\/14651858.CD004332.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/alcalc\/agh088","article-title":"A pragmatic trial of acamprosate in the treatment of alcohol dependence in primary care","volume":"39","author":"Kiritze-Topor","year":"2004","journal-title":"Alcohol and Alcoholism"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/alcalc\/agm136","article-title":"A randomised, multi centre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence","volume":"43","author":"Laaksonen","year":"2008","journal-title":"Alcohol and Alcoholism"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0893-133X(02)00368-8","article-title":"A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone","volume":"27","author":"Mason","year":"2002","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1002\/14651858.CD004332.pub2-BIB0041|cit41","first-page":"964","article-title":"Treatment and prevention of alcohol-related problems and evidence based medicine","volume":"145","author":"Nespor","year":"2006","journal-title":"Casopis Lekaru Ceskych"},{"issue":"8","key":"10.1002\/14651858.CD004332.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.euroneuro.2007.02.012","article-title":"The effect of naltrexone and acamprosate on cue-induced craving, autonomic nervous system and neuroendocrine reactions to alcohol-related cues in alcoholics","volume":"17","author":"Ooteman","year":"2007","journal-title":"European Neuropsychopharmacoly"},{"issue":"10","key":"10.1002\/14651858.CD004332.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1530-0277.2002.tb02452.x","article-title":"The European NEAT program: an integrated approach using acamprosate and psychosocial support for the prevention of relapse in alcohol-dependent patients with a statistical modelling of therapy success prediction","volume":"26","author":"Pelc","year":"2002","journal-title":"Alcoholism Clinical and Experimental Research"},{"issue":"6","key":"10.1002\/14651858.CD004332.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"833","DOI":"10.15288\/jsa.2005.66.833","article-title":"The efficacy of compliance therapy in pharmacotherapy for alcohol dependence: a randomised controlled trial","volume":"66","author":"Reid","year":"2005","journal-title":"Journal of Studies on Alcohol"},{"issue":"5","key":"10.1002\/14651858.CD004332.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/alcalc\/36.5.419","article-title":"Naltrexone versus acamprosate: one year follow-up of alcohol dependence treatment","volume":"36","author":"Rubio","year":"2001","journal-title":"Alcohol and Alcoholism"},{"issue":"33","key":"10.1002\/14651858.CD004332.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1055\/s-2001-16502","article-title":"Adjuvant drug treatment of alcoholism with acamprosate: between sectorial budgets and disease management","volume":"126","author":"Rychlik","year":"2001","journal-title":"Deutsche Medizinische Wochenschrift"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0047|cit47","first-page":"1","article-title":"Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results from a non-blind, multicentre study","volume":"3","author":"Soyka","year":"2002","journal-title":"Drugs in Road Traffic"},{"issue":"9","key":"10.1002\/14651858.CD004332.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/j.1530-0277.2006.00180.x","article-title":"Effects of acamprosate on sleep during alcohol withdrawal: A double-blind placebo-controlled polysomnographic study in alcohol-dependent subjects","volume":"30","author":"Staner","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0049|cit49","unstructured":"Integrative Therapy in Alcoholism Ongoing study May 2003"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0050|cit50","unstructured":"Study of Acamprosate for Alcohol Dependence in a Family Medicine Clinic Ongoing study August 2006"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0051|cit51","unstructured":"Trial for the Treatment of Alcohol Dependence Ongoing study March 2003"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0052|cit52","unstructured":"Individually Adapted Therapy of Alcoholism Ongoing study November 2002"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0053|cit53","unstructured":"Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism Ongoing study September 2006"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0054|cit54","unstructured":"Acamprosate Initiated During Alcohol Detoxification Ongoing study October 2006"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0055|cit55","unstructured":"Acamprosate in Alcoholics With Comorbid Anxiety or Depression Ongoing study April 2006"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0056|cit56","unstructured":"Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism Ongoing study March 2007"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0057|cit57","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","article-title":"Chlorpromazine versus placebo for schizophrenia","author":"Adams","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0058|cit58","first-page":"21","article-title":"Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project","volume":"420","author":"Alonso","year":"2004","journal-title":"Acta Psychiatrica Scandinavia Supplement"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0059|cit59","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","article-title":"Antidepressants versus placebo for depression in primary care","author":"Arroll","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD004332.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/sj.npp.1300657","article-title":"The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat","volume":"30","author":"Bachteler","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0061|cit61","unstructured":"Berglund MA Franck J Fridell M Hakanson I Johansson BA Treatment of alcohol and drug abuse - an evidence-based review Swedish Council on Technology Assessment in Health Care (SBU) 2003"},{"issue":"7","key":"10.1002\/14651858.CD004332.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1360-0443.2004.00763.x","article-title":"Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review","volume":"99","author":"Bouza","year":"2004","journal-title":"Addiction"},{"issue":"6","key":"10.1002\/14651858.CD004332.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/sim.650","article-title":"A comparison of statistical methods for meta-analysis","volume":"20","author":"Brockwell","year":"2001","journal-title":"Statistics in Medicine"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00210-003-0795-3","article-title":"Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus","volume":"368","author":"Cano-Cebrian","year":"2003","journal-title":"Naunyn Schmiedebergs Archives of Pharmacology"},{"issue":"20","key":"10.1002\/14651858.CD004332.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1001\/jama.291.20.2457","article-title":"Empirical evidence for selective reporting of outcomes in randomised trials: comparison of protocols to published articles","volume":"291","author":"Chan","year":"2004","journal-title":"JAMA"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0269881103174017","article-title":"Does acamprosate improve reduction of drinking as well as aiding abstinence?","volume":"17","author":"Chick","year":"2003","journal-title":"Journal of Psychopharmacology"},{"issue":"6","key":"10.1002\/14651858.CD004332.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-0447.2008.01194.x","article-title":"Compelling or irrelevant? Using number needed to treat can help decide","volume":"117","author":"Citrome","year":"2008","journal-title":"Acta Psychiatrica Scandinavia"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s002130050009","article-title":"Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze","volume":"147","author":"Cole","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0069|cit69","first-page":"344","article-title":"Effects of acamprosate on ethanol-seeking and self-administration in the rat","volume":"25","author":"Czachowski","year":"2001","journal-title":"Alcoholism Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/9780470712184.ch9","article-title":"Chapter 9: Analysing data and undertaking meta-analyses","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Deeks","year":"2008"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"issue":"7109","key":"10.1002\/14651858.CD004332.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0073|cit73","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005032.pub2","article-title":"Alcoholics Anonymous and other 12-step programmes for alcohol dependence","author":"Ferri","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD004332.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0893-133X(97)00130-9","article-title":"Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats","volume":"18","author":"Heyser","year":"1998","journal-title":"Neuropsychopharmacology"},{"issue":"15","key":"10.1002\/14651858.CD004332.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/sim.918","article-title":"Meta-analysis of continuous outcome data from individual patients","volume":"20","author":"Higgins","year":"2001","journal-title":"Statistics in Medicine"},{"issue":"7414","key":"10.1002\/14651858.CD004332.pub2-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/9780470712184","article-title":"Chapter 9: Analysing data and undertaking meta-analyses","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2008"},{"issue":"Suppl","key":"10.1002\/14651858.CD004332.pub2-BIB0078|cit78","first-page":"130A","article-title":"Naltrexone and acamprosate: Meta-analysis of two medical treatments for alcoholism","volume":"26","author":"Hopkins","year":"2002","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"21","key":"10.1002\/14651858.CD004332.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1001\/jama.287.21.2801","article-title":"Quality of reporting of randomised trials as a measure of methodologic quality","volume":"287","author":"Huwiler-Muntener","year":"2002","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0080|cit80","unstructured":"ICAP International Center for Alcohol Policies International Drinking Guidelines Report Nr. 14 2003"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0081|cit81","unstructured":"International Conference on Harmonisation Guideline for Good ClinicalPractice E6(R1). (http:\/\/www.ich.org\/LOB\/media\/MEDIA482.pdf) 1996"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0082|cit82","article-title":"Cognitive-Behavioral Coping Skills Therapy Manual: A Clinical Research Guide fro Therapists Treating Individuals with Alcohol Abuse and Dependence","volume-title":"NIAAA Project MATCH Monograph Series","volume":"3","author":"Kadden","year":"1992"},{"issue":"2","key":"10.1002\/14651858.CD004332.pub2-BIB0083|cit83","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004148.pub3","article-title":"Effectiveness of brief alcohol interventions in primary care populations","author":"Kaner","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0084|cit84","first-page":"153","article-title":"On the loss-of-control phenomenon in alcoholism","volume":"67","author":"Keller","year":"1972","journal-title":"British Journal of Addiction"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0924-2708.2004.00093.x","article-title":"Long-term effects of pharmacotherapy on relapse prevention in alcohol dependence","volume":"16","author":"Kiefer","year":"2004","journal-title":"Acta Neuropsychiatrica"},{"issue":"7","key":"10.1002\/14651858.CD004332.pub2-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2165\/00019053-200725070-00006","article-title":"Direct and indirect costs attributable to alcohol consumption in Germany","volume":"25","author":"Konnopka","year":"2007","journal-title":"Pharmacoeconomics"},{"issue":"9","key":"10.1002\/14651858.CD004332.pub2-BIB0087|cit87","first-page":"1335","article-title":"Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis","volume":"25","author":"Kranzler","year":"2001","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/9780470712184.ch6","article-title":"Chapter 6: Searching for Studies","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Lefebvre","year":"2008"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0089|cit89","first-page":"157","article-title":"Review and discussion of statistical analysis of controlled clinical trials in alcoholism","volume":"2","author":"Lehert","year":"1993","journal-title":"Alcohol and Alcoholism Supplement"},{"issue":"2","key":"10.1002\/14651858.CD004332.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0741-8329(87)90006-1","article-title":"Lack of effects of Ca-acetyl homotaurinate on chronic and acute toxicities of ethanol in rats","volume":"4","author":"LeMagnen","year":"1987","journal-title":"Alcohol and Alcohilsm"},{"issue":"2","key":"10.1002\/14651858.CD004332.pub2-BIB0091|cit91","first-page":"343","article-title":"SAFTEE: a technique for the systematic assessment of side effects in clinical trials","volume":"22","author":"Levine","year":"1986","journal-title":"Psychopharmacol Bulletin"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0092|cit92","doi-asserted-by":"crossref","DOI":"10.4159\/9780674040243","volume-title":"The science of reviewing research","author":"Light","year":"1984"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0093|cit93","unstructured":"Lipha Pharmaceuticals Inc Clincial Background Materials for Psychopharmacologic Drugs Advisory Committee Meeting NDA 21-431 2002"},{"issue":"9","key":"10.1002\/14651858.CD004332.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1360-0443.1995.tb01088.x","article-title":"Acamprosate in alcohol dependence: how does it work?","volume":"90","author":"Littleton","year":"1995","journal-title":"Addiction"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0095|cit95","first-page":"3","article-title":"Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence","volume":"12 Supplement 1","author":"Littleton","year":"2003","journal-title":"American Journal of Addiction"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.ALC.0000108656.81563.05","article-title":"The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis","volume":"28","author":"Mann","year":"2004","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"7","key":"10.1002\/14651858.CD004332.pub2-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1530-0277.2008.00690.x","article-title":"Acamprosate: recent findings and future research directions","volume":"32","author":"Mann","year":"2008","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0098|cit98","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0099|cit99","volume-title":"Relapse prevention","author":"Marlatt","year":"1985"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.bjp.0705059","article-title":"The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine","volume":"138","author":"McGeehan","year":"2003","journal-title":"British Journal of Pharmacology"},{"issue":"8","key":"10.1002\/14651858.CD004332.pub2-BIB0101|cit101","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005191.pub2","article-title":"Brief interventions for heavy alcohol users admitted to general hospital wards","author":"McQueen","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0102|cit102","volume-title":"Motivational Enhancement Therapy manual: A clinical research guide for therapists treating individuals with alcohol abuse and dependence","author":"Miller","year":"1994"},{"issue":"15","key":"10.1002\/14651858.CD004332.pub2-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1001\/jama.285.15.1992","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"285","author":"Moher","year":"2001","journal-title":"JAMA"},{"issue":"7","key":"10.1002\/14651858.CD004332.pub2-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0105|cit105","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","article-title":"Active placebos versus antidepressants for depression","author":"Moncrieff","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD004332.pub2-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1360-0443.2006.01310.x","article-title":"Rates and predictors of relapse after natural and treated remission from alcohol use disorders","volume":"101","author":"Moos","year":"2006","journal-title":"Addiction"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1530-0277.1998.tb03871.x","article-title":"Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain","volume":"22","author":"Naassila","year":"1998","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"5","key":"10.1002\/14651858.CD004332.pub2-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/ije\/21.5.837","article-title":"Intention-to-treat analysis: implications for quantitative and qualitative research","volume":"21","author":"Newell","year":"1992","journal-title":"International Journal of Epidemiology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1037\/1089-2680.2.2.175","article-title":"Confirmation Bias: A Ubiquitous Phenomenon","volume":"2","author":"Nickerson","year":"1998","journal-title":"Review of General Psychology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0110|cit110","volume-title":"Twelve Step Facilitation Therapy manual. A clinical research guide for therapists treating individuals with alcohol abuse and dependence","author":"Nowinski","year":"1995"},{"issue":"1-2","key":"10.1002\/14651858.CD004332.pub2-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(02)01272-4","article-title":"Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release","volume":"437","author":"Olive","year":"2002","journal-title":"European Journal of Pharmacology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0112|cit112","volume-title":"Medical Management Treatment Manual. A Clinical Research Guide for MedicallyTrained Clinicians Providing Pharmacotherapy as Part of the Treatment for AlcoholDependence","volume":"2","author":"Pettinati","year":"2004"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/ije\/dym087","article-title":"Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials","volume":"36","author":"Pildal","year":"2007","journal-title":"International Journal of Epidemiology"},{"issue":"7","key":"10.1002\/14651858.CD004332.pub2-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1056\/NEJM198708133170706","article-title":"Statistical problems in the reporting of clinical trials. A survey of three medical journals","volume":"317","author":"Pocock","year":"1987","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15288\/jsa.1997.58.7","article-title":"Matching alcoholism treatment to client heterogeneity: Project Match posttreatment drinking outcomes","volume":"58","author":"Project Match Research Group","year":"1997","journal-title":"Journal of Studies on Alcoholism"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00004714-199202000-00002","article-title":"General versus systematic inquiry about emergent clinical events with SAFTEE: implications for clinical research","volume":"12","author":"Rabkin","year":"1992","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"9682","key":"10.1002\/14651858.CD004332.pub2-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD004332.pub2-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jclinepi.2006.09.009","article-title":"Evidence synthesis combining individual patient data and aggregate data: a systematic review identified current practice and possible methods","volume":"60","author":"Riley","year":"2007","journal-title":"Journal of Clinical Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0269881107078308","article-title":"Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes","volume":"22","author":"R\u00f6sner","year":"2008","journal-title":"Journal of Psychopharmacology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2288-8-79","article-title":"Undue reliance on I(2) in assessing heterogeneity may mislead","volume":"8","author":"R\u00fccker","year":"2008","journal-title":"BMC Medical Research Methodology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1201\/9781420036961.ch31","article-title":"Meta-analysis of pharmacotherapeutic trials","volume-title":"Handbook of Alcoholism","author":"Schoechlin","year":"2000"},{"issue":"18","key":"10.1002\/14651858.CD004332.pub2-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1001\/jama.1995.03530180050029","article-title":"Subverting randomisation in controlled trials","volume":"274","author":"Schulz","year":"1995","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1176\/ajp.127.12.1653","article-title":"The Michigan Alcoholism Screening Test (MAST): The quest for a new diagnostic instrument","volume":"127","author":"Selzer","year":"1971","journal-title":"American Journal of Psychiatry"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1037\/0021-843X.91.3.199","article-title":"Alcohol dependence syndrome: measurement and validation","volume":"91","author":"Skinner","year":"1982","journal-title":"Journal of Abnormal Psychology"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0125|cit125","volume-title":"Alcohol Dependence Scale: Users Guide","author":"Skinner","year":"1984"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0126|cit126","unstructured":"Slattery J Chick J Prevention of Relapse in Alcohol Dependence Health Technology Assesment Report 2003"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"225","DOI":"10.15288\/jsa.1988.49.225","article-title":"The reliability of alcohol abusers' self-reports of drinking and life events that occurred in the distant past","volume":"49","author":"Sobell","year":"1988","journal-title":"Journal of Studies on Alcohol"},{"issue":"5","key":"10.1002\/14651858.CD004332.pub2-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0306-4603(92)90011-J","article-title":"Alcohol abusers' perceptions of the accuracy of their self-reports of drinking: implications for treatment","volume":"17","author":"Sobell","year":"1992","journal-title":"Addictive Behaviors"},{"issue":"1-3","key":"10.1002\/14651858.CD004332.pub2-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(96)00174-4","article-title":"Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat","volume":"305","author":"Spanagel","year":"1996","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1002\/14651858.CD004332.pub2-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0165-6147(97)89800-8","article-title":"Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes","volume":"18","author":"Spanagel","year":"1997","journal-title":"Trends in Pharmacological Sciences"},{"issue":"3","key":"10.1002\/14651858.CD004332.pub2-BIB0131|cit131","first-page":"61","article-title":"Acamprosate--new preclinical research aspects","volume":"145 Supplement","author":"Spanagel","year":"2003","journal-title":"MMW, Fortschritte der Medizin"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0132|cit132","doi-asserted-by":"publisher","DOI":"10.1002\/14651858","article-title":"Opioid antagonists for alcohol dependence","author":"Srisurapanont","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3-4","key":"10.1002\/14651858.CD004332.pub2-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/jnci\/88.3-4.206","article-title":"False-positive results in clinical trials: multiple significance tests and the problem of unreported comparisons","volume":"88","author":"Tannock","year":"1996","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0134|cit134","unstructured":"The Nordic Cochrane Centre Review Manager (RevMan). 5.0 2008"},{"issue":"24","key":"10.1002\/14651858.CD004332.pub2-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/1097-0258(20001230)19:24<3417::AID-SIM614>3.0.CO;2-L","article-title":"A multilevel model framework for meta-analysis of clinical trials with binary outcomes","volume":"19","author":"Turner","year":"2000","journal-title":"Statistics in Medicine"},{"issue":"2-3","key":"10.1002\/14651858.CD004332.pub2-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00213-004-1991-7","article-title":"Predictors of acamprosate efficacy: results from a pooled analysis of seven European trials including 1485 alcohol-dependent patients","volume":"178","author":"Verheul","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1002\/14651858.CD004332.pub2-BIB0137|cit137","unstructured":"WHO The World Health Report: Reducing risk, promoting healthy life The World Health Report 2002"},{"issue":"5","key":"10.1002\/14651858.CD004332.pub2-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1191\/0962280205sm415oa","article-title":"Outcome selection bias in meta-analysis","volume":"14","author":"Williamson","year":"2005","journal-title":"Statistical Methods in Medical Research"},{"issue":"7644","key":"10.1002\/14651858.CD004332.pub2-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.39465.451748.AD","article-title":"Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study","volume":"336","author":"Wood","year":"2008","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD004332.pub2-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(93)90682-8","article-title":"Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors","volume":"231","author":"Zeise","year":"1993","journal-title":"European Jorunal of Pharmacology"},{"issue":"4","key":"10.1002\/14651858.CD004332.pub2-BIB0141|cit141","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1527-3458.2003.tb00260.x","article-title":"Pharmacology of acamprosate: an overview","volume":"9","author":"Zornoza","year":"2003","journal-title":"CNS Drug Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD004332.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T15:02:50Z","timestamp":1750086170000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004332.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Drugs and Alcohol Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,9,7]]},"references-count":141,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004332.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,7]]}}}