{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:22:07Z","timestamp":1790788927148,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd004349.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000}}],"reference-count":125,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004349.pub3","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T09:13:48Z","timestamp":1608282828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Blood pressure targets in adults with hypertension"],"prefix":"10.1002","volume":"2020","author":[{"given":"Jose Agustin","family":"Arguedas","sequence":"additional","affiliation":[{"name":"Depto de Farmacologia Clinica, Facultad de Medicina; Universidad de Costa Rica; San Pedro de Montes de Oca Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viriam","family":"Leiva","sequence":"additional","affiliation":[{"name":"Escuela de Enfermeria, Facultad de Medicina; University of Costa Rica; San Jose Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pharmacology and Therapeutics; University of British Columbia; Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"issue":"suppl 2","key":"10.1002\/14651858.CD004349.pub3-BIB0001|cit1","first-page":"B54","article-title":"Effect of blood pressure control on diabetic complications in patients with hypertension and type 2 diabetes","volume":"23","author":"Estacio","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1001286","article-title":"Effects of intensive blood-pressure control in type-2 diabetes mellitus","volume":"362","author":"The ACCORD Study Group","year":"2010","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(09)61340-4","article-title":"Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open label randomised trial","volume":"374","author":"Verdecchia","year":"2009","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/08037059309077529","article-title":"The Hypertension Optimal Treatment Study (The HOT Study)","volume":"2","author":"Hansson","year":"1993","journal-title":"Blood Pressure"},{"issue":"9118","key":"10.1002\/14651858.CD004349.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0140-6736(98)04311-6","article-title":"Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial","volume":"351","author":"Hansson","year":"1998","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/08037059509077613","article-title":"The Hypertension Optimal Treatment (HOT) Study: 12-month data on blood pressure and tolerability with special reference to age and gender","volume":"4","author":"Hansson","year":"1995","journal-title":"Blood Pressure"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/08037059709062088","article-title":"The Hypertension Optimal Treatment (HOT) Study: 24-month data on blood pressure and tolerability","volume":"6","author":"Hansson","year":"1997","journal-title":"Blood Pressure"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3109\/08037059409102281","article-title":"The Hypertension Optimal Treatment (HOT) Study. Patient characteristics: randomization, risk profiles, and early blood pressure results","volume":"3","author":"Hansson","year":"1994","journal-title":"Blood Pressure"},{"issue":"suppl 1","key":"10.1002\/14651858.CD004349.pub3-BIB0009|cit9","first-page":"S9","article-title":"The Hypertension Optimal Treatment study and the importance of lowering blood pressure","volume":"17","author":"Hansson","year":"1999","journal-title":"Journal of Hypertension"},{"issue":"4","key":"10.1002\/14651858.CD004349.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00004872-200304000-00024","article-title":"Benefits and risks of more intensive blood pressure lowering in hypertensive patients of the HOT study with different risk profiles: does a J-shaped curve exist in smokers?","volume":"21","author":"Zanchetti","year":"2003","journal-title":"Journal of Hypertension"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1097\/00004872-200106000-00021","article-title":"Effects of individual factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study","volume":"19","author":"Zanchetti","year":"2001","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"i708","DOI":"10.1136\/bmj.i708","article-title":"Different systolic blood pressure targets for people with history of stroke or transient ischaemic attack: PAST-BP (Prevention After Stroke-Blood Pressure) randomized controlled trial","volume":"352","author":"Mant","year":"2016","journal-title":"BMJ"},{"issue":"9463","key":"10.1002\/14651858.CD004349.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(05)71082-5","article-title":"Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised, controlled trial","volume":"365","author":"Ruggenenti","year":"2005","journal-title":"Lancet"},{"issue":"7","key":"10.1002\/14651858.CD004349.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1097\/01.ASN.0000018407.60002.B9","article-title":"Cardiac and renal effects of standard versus rigorous blood pressure control in autosomal-dominant polycystic kidney disease: results of a seven year prospective randomized trial","volume":"13","author":"Schrier","year":"2002","journal-title":"Journal of the American Society of Nephrology"},{"issue":"19","key":"10.1002\/14651858.CD004349.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/CIRCULATIONAHA.116.026230","article-title":"Effect of aggressive blood pressure control on the recurrence of atrial fibrillation after catheter ablation. A randomized, open label clinical trial (SMAC-AF Substrate Modification with Aggressive Blood Pressure Control)","volume":"135","author":"Parkash","year":"2017","journal-title":"Circulation"},{"issue":"22","key":"10.1002\/14651858.CD004349.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Williamson","year":"2015","journal-title":"New England Journal of Medicine"},{"issue":"9891","key":"10.1002\/14651858.CD004349.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(13)60852-1","article-title":"Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial","volume":"382","author":"Benavente","year":"2013","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD004349.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ki.1995.361","article-title":"\"Strict\" blood pressure control and progression of renal disease in hypertensive nephrosclerosis","volume":"48","author":"Toto","year":"1995","journal-title":"Kidney International"},{"issue":"19","key":"10.1002\/14651858.CD004349.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1001\/jama.288.19.2421","article-title":"Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease","volume":"288","author":"Bakris","year":"2002","journal-title":"JAMA"},{"issue":"12","key":"10.1002\/14651858.CD004349.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.amjhyper.2006.05.011","article-title":"Effect of intensive blood pressure control with valsartan on urinary albumin excretion in normotensive patients with type 2 diabetes","volume":"19","author":"Estacio","year":"2006","journal-title":"American Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1046\/j.1523-1755.2002.00213.x","article-title":"Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes","volume":"61","author":"Schrier","year":"2002","journal-title":"Kidney International"},{"issue":"11","key":"10.1002\/14651858.CD004349.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1603460","article-title":"Intensive blood-pressure lowering in patients with acute cerebral hemorrhage","volume":"375","author":"Qureshi","year":"2016","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD004349.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3109\/08037059409102265","article-title":"The BBB Study Group: the effect of intensified antihypertensive treatment on the level of blood pressure, side-effects, morbidity and mortality in \"well treated\" hypertensive patients","volume":"3","author":"Hansson L for the BBB Study Group","year":"1994","journal-title":"Blood Pressure"},{"issue":"9","key":"10.1002\/14651858.CD004349.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00004872-198809000-00002","article-title":"The BBB study: a prospective randomized study of intensified antiihypertensive treatment","volume":"6","author":"The BBB Study Group","year":"1988","journal-title":"Journal of Hypertension"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJMoa1404595","article-title":"Less-tight versus tight control of hypertension in pregnancy","volume":"372","author":"Magee","year":"2015","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1002\/14651858.CD004349.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s001250050614","article-title":"Hypertension in Diabetes Study IV. Therapeutic requirements to maintain tight blood pressure control","volume":"39","author":"Hypertension in Diabetes Study Group","year":"1996","journal-title":"Diabetologia"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/hr.2012.125","article-title":"Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure","volume":"35","author":"Asayama","year":"2012","journal-title":"Hypertension Research"},{"issue":"12","key":"10.1002\/14651858.CD004349.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1291\/hypres.31.2115","article-title":"Principal results of the Japanese Trial to Assess Optimal Systolic blood pressure in elderly hypertensive patients (JATOS)","volume":"31","author":"JATOS Study Group","year":"2008","journal-title":"Hypertension Research"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0272-6386(99)70036-3","article-title":"Effect on intensive blood pressure control on the course of type 1 diabetic nephropathy","volume":"34","author":"Lewis","year":"1999","journal-title":"American Journal of Kidney Diseases"},{"issue":"10","key":"10.1002\/14651858.CD004349.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"754","DOI":"10.7326\/0003-4819-123-10-199511150-00003","article-title":"Blood pressure control, proteinuria, and the progression of renal disease: the Modification of Diet in Renal Disease Study","volume":"123","author":"Peterson","year":"1995","journal-title":"Annals of Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.7326\/0003-4819-142-5-200503010-00009","article-title":"The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the Modification of Diet in Renal Disease Study","volume":"142","author":"Sarnak","year":"2005","journal-title":"Annals of Internal Medicine"},{"issue":"14","key":"10.1002\/14651858.CD004349.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1001\/jama.299.14.1678","article-title":"Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes","volume":"299","author":"Howard","year":"2008","journal-title":"JAMA"},{"issue":"2","key":"10.1002\/14651858.CD004349.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/HYPERTENSIONAHA.109.138529","article-title":"Effect of intensive versus standard blood pressure lowering on diastolic function in patients with uncontrolled hypertension and diastolic dysfunction","volume":"55","author":"Solomon","year":"2010","journal-title":"Hypertension"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1056\/NEJMoa021778","article-title":"Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes","volume":"348","author":"Goede","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/bmj.317.7160.703","article-title":"Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38","volume":"317","author":"UK Prospective Diabetes Study Group","year":"1998","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD004349.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/HYPERTENSIONAHA.109.146035","article-title":"Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study","volume":"56","author":"Ogihara","year":"2010","journal-title":"Hypertension"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/jch.12094","article-title":"Effects of intensive antihypertensive treatment on Chinese hypertensive patients older than 70 years","volume":"15","author":"Wei","year":"2013","journal-title":"Journal of Clinical Hypertension (Greenwich)"},{"issue":"1","key":"10.1002\/14651858.CD004349.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4158\/CS-2018-0535","article-title":"Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2019 Executive Summary","volume":"25","author":"Garber","year":"2019","journal-title":"Endocrine Practice"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0039|cit39","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.2337\/dc16-S011","article-title":"Cardiovascular disease and risk management","volume":"39(Suppl1)","author":"American Diabetes Association","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2337\/dc19-S010","article-title":"Cardiovascular disease and risk management: standards of medical care in diabetes - 2019","volume":"42(suppl 1)","author":"American Diabetes Association","year":"2019","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1002\/14651858.CD004349.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"e004536","DOI":"10.1161\/JAHA.116.004536","article-title":"Implications of blood pressure measurement technique for implementation of Systolic Blood Pressure Intervention Trial (SPRINT)","volume":"6","author":"Agarwal","year":"2017","journal-title":"Journal of the American Heart Association"},{"issue":"21","key":"10.1002\/14651858.CD004349.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1161\/CIRCULATIONAHA.107.183885","article-title":"Treatment of hypertension in the prevention and management of ischemic heart disease. A scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention","volume":"115","author":"Rosendorff","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"10.1002\/14651858.CD004349.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/HCO.0b013e32833a6dee","article-title":"Blood pressure targets: are clinical guidelines wrong?","volume":"25","author":"Arguedas","year":"2010","journal-title":"Current Opinion in Cardioliology"},{"issue":"10","key":"10.1002\/14651858.CD004349.pub3-BIB0045|cit45","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008277.pub2","article-title":"Blood pressure targets for hypertension in people with diabetes mellitus","author":"Arguedas","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD004349.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/HJH.0000000000000065","article-title":"Clinical practice guideline for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension","volume":"32","author":"Weber","year":"2014","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/2047487318800741","article-title":"Effect of intensive blood pressure lowering on cardiovascular outcomes based on cardiovascular risk: a secondary analysis of the SPRINT trial","volume":"26","author":"Attar","year":"2019","journal-title":"European Journal of Preventive Cardiology"},{"issue":"23","key":"10.1002\/14651858.CD004349.pub3-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1093\/eurheartj\/ehq328","article-title":"J-curve revisited: an analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) Trial","volume":"31","author":"Bangalore","year":"2010","journal-title":"European Heart Journal"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0049|cit49","first-page":"707","article-title":"Optimal systolic blood pressure target after SPRINT: Insights from a network meta-analysis of randomized trials","volume":"130","author":"Bangalore","year":"2017","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1001\/jama.2010.310","article-title":"Stopping randomized trials early for benefit and estimation of treatment effects. Systematic review and meta-regression analysis","volume":"303","author":"Bassler","year":"2010","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/bmj.328.7440.634","article-title":"British Hypertension Society Guidelines for hypertension management 2004 (BHS-IV): summary","volume":"328","author":"Williams","year":"2004","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(03)14739-3","article-title":"Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials","volume":"362","author":"Blood Pressure Lowering Treatment Trialists' Collaboration","year":"2003","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(14)61212-5","article-title":"Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data","volume":"384","author":"Blood Pressure Lowering Treatment Trialists\u2019 Collaboration","year":"2014","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"i717","DOI":"10.1136\/bmj.i717","article-title":"Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses","volume":"352","author":"Brunstr\u00f4m","year":"2016","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD004349.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jamacardio.2017.1421","article-title":"Systolic blood pressure reduction and risk of cardiovascular disease and mortality. A systematic review and network meta-analysis","volume":"2","author":"Bundy","year":"2017","journal-title":"JAMA Cardiology"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0056|cit56","first-page":"160","article-title":"Effect of intensive versus standard blood pressure control on major adverse cardiac events and serious adverse events: a bivariate analysis of randomized controlled trials","volume":"40","author":"Chi","year":"2018","journal-title":"Clinical and Experimental Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"130","DOI":"10.7326\/0003-4819-159-2-201307160-00008","article-title":"Conceptual and technical challenges in network meta-analysis","volume":"159","author":"Cipriani","year":"2013","journal-title":"Annals of Internal Medicine"},{"issue":"8","key":"10.1002\/14651858.CD004349.pub3-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006742.pub2","article-title":"Pharmacotherapy for mild hypertension","author":"Diao","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD004349.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/HYPERTENSIONAHA.111.179143","article-title":"Relation between blood pressure and vascular events and mortality in patients with manifest vascular disease. J-curve revisited","volume":"59","author":"Dorresteijn","year":"2012","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1056\/NEJMe1513991","article-title":"A SPRINT to the finish","volume":"373","author":"Drazen","year":"2015","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)","year":"2018","journal-title":"European Heart Journal"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/HJH.0b013e3281fc975a","article-title":"2007 Guidelines for the management of arterial hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"25","author":"Mancia","year":"2007","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","article-title":"Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis","volume":"387","author":"Ettehad","year":"2016","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3949\/ccjm.78a.10101","article-title":"Goal directed antihypertensive therapy: lower may not always be better","volume":"78","author":"Filippone","year":"2011","journal-title":"Cleveland Clinic Journal of Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2337\/dc11-s245","article-title":"Blood pressure: the lower, the better. The con side","volume":"34 (suppl 2)","author":"Grossman","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/00004872-200304000-00004","article-title":"Observational epidemiological studies: values and limitations","volume":"21","author":"Gueyffier","year":"2001","journal-title":"Journal of Hypertension"},{"issue":"2","key":"10.1002\/14651858.CD004349.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s40292-018-0258-z","article-title":"Which target blood pressure in year 2018? Evidence form recent clinical trials","volume":"25","author":"Heimark","year":"2018","journal-title":"High Blood Pressure & Cardiovascular Prevention"},{"issue":"7414","key":"10.1002\/14651858.CD004349.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0069|cit69","doi-asserted-by":"crossref","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, 2019 Available from www.training.cochrane.org\/handbook","DOI":"10.1002\/9781119536604"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cjca.2020.02.086","article-title":"Hypertension Canada's 2020 Comprehensive guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children","volume":"36","author":"Rabi","year":"2020","journal-title":"Canadian Journal of Cardiology"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0140-6736(05)70240-3","article-title":"Treatment with drugs to lower blood pressure and blood cholesterol based on an individual\u2019s absolute cardiovascular risk","volume":"365","author":"Jackson","year":"2005","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report","volume":"289","author":"Joint National Committee on Prevention","year":"2003","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"Evidence based guideline for the management of high blood pressure in adults. Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0074|cit74","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease","volume":"43 (5 Suppl 1)","author":"Kidney Disease Outcomes Quality Initiative (K\/DOQI)","year":"2004","journal-title":"American Journal of Kidney Disease"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.1996.03530440051036","article-title":"Blood pressure as a cardiovascular risk factor: prevention and treatment","volume":"275","author":"Kannel","year":"1996","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1161\/CIRCULATIONAHA.118.037669","article-title":"How strong is the evidence to support blood pressure treatment goal of 130\/80 mm Hg?","volume":"138","author":"Kaul","year":"2018","journal-title":"Circulation"},{"issue":"7","key":"10.1002\/14651858.CD004349.pub3-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/HYPERTENSIONAHA.116.07257","article-title":"Unattended blood pressure measurements in the systolic blood pressure intervention trial: implications for entry and achieved blood pressure values compared with other trials","volume":"67","author":"Kjeldsen","year":"2016","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/bmj.328.7440.593","article-title":"Guidelines from the British Hypertension Society. The lower the pressure the better","volume":"328","author":"Laurent","year":"2004","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0140-6736(15)01344-6","article-title":"Blood pressure lowering trials: wrapping up the topic?","volume":"387","author":"Laurent","year":"2016","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"b1665","DOI":"10.1136\/bmj.b1665","article-title":"Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies","volume":"338","author":"Law","year":"2009","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/CIRCULATIONAHA.116.023264","article-title":"Should patients with cardiovascular risk factors receive intensive treatment of hypertension to < 120\/80 mm Hg target? An antagonist view from the HOPE-3 Trial (Heart Outcomes Evaluation-3)","volume":"134","author":"Lonn","year":"2016","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/00004872-200304000-00010","article-title":"Intensive blood pressure treatment: beneficial for all but the smoking hypertensives?","volume":"21","author":"Lund-Johansen","year":"2003","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"e1001293","DOI":"10.1371\/journal.pmed.1001293","article-title":"Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: a systematic review and meta-analysis","volume":"9","author":"Lv","year":"2012","journal-title":"PLOS Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0140-6736(00)04017-4","article-title":"Reliable assessment of the effects of treatment on mortality and major morbidity, II: observational studies","volume":"357","author":"MacMahon","year":"2001","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/jamainternmed.2017.4377","article-title":"Association between more intensive vs less intensive blood pressure lowering and risk of mortality in chronic kidney disease stages 3 to 5. A systematic review and meta-analysis","volume":"177","author":"Malhotra","year":"2017","journal-title":"JAMA Internal Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2337\/dc11-s244","article-title":"Antihypertensive treatment and blood pressure in diabetic and non-diabetic patients. The lower the better?","volume":"34 (Suppl 2)","author":"Mancia","year":"2011","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1002\/14651858.CD004349.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"2013 ESH\/ESC Guidelines for the management of arterial hypertension; the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"31","author":"Mancia","year":"2013","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pcad.2016.09.002","article-title":"A case for less intensive blood pressure control: It matters to achieve target blood pressure early and sustained below 140\/90 mm Hg","volume":"59","author":"Mariampillai","year":"2016","journal-title":"Progress in Cardiovascular Diseases"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0090|cit90","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000028.pub3","article-title":"Pharmacotherapy for hypertension in adults 60 years or older","author":"Musini","year":"2019","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0091|cit91","unstructured":"National Institute for Health and Care Excellence Hypertension in adults: diagnosis and management: clinical guideline 127 https:\/\/www.nice.org.uk\/guidance\/cg127\/chapter\/1-recommendations (accessed Jan 15, 2016)"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0092|cit92","volume-title":"Hypertension in adults: diagnosis and management","author":"National Institute for Health and Care Excellence","year":"2019"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa0801317","article-title":"Telmisartan, ramipril or both in patients at high risk for vascular events","volume":"358","author":"ONTARGET Investigators","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.116.023263","article-title":"Should patients with cardiovascular risk factors receive intensive treatment of hypertension to < 120\/80 mm Hg target? A protagonist view from the SPRINT Trial (Systolic Blood Pressure Intervention Trial)","volume":"134","author":"Oparil","year":"2016","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"692","DOI":"10.7326\/M15-3123","article-title":"Let's not sprint to judgement about new blood pressure goals","volume":"164","author":"Ortiz","year":"2016","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.2337\/dc11-s243","article-title":"Benefits of tight blood pressure control in diabetic patients with hypertension. Importance of early and sustained implementation of effective treatment strategies","volume":"34 (Suppl 2)","author":"Parati","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMe1513301","article-title":"Redefining blood-pressure targets. SPRINT starts the marathon","volume":"373","author":"Perkovic","year":"2015","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(07)61778-4","article-title":"Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths","volume":"370","author":"Prospective Studies Collaboration","year":"2007","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people","volume":"383","author":"Rapsomaniki","year":"2014","journal-title":"Lancet"},{"issue":"9","key":"10.1002\/14651858.CD004349.pub3-BIB0101|cit101","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010315.pub4","article-title":"Blood pressure targets for the treatment of people with hypertension and cardiovascular disease","author":"Saiz","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0102|cit102","doi-asserted-by":"crossref","unstructured":"Sch\u00fcnemann HJ Higgins JP Vist GE Glasziou P Akl EA Skoetz N Chapter 14: Completing \u2018Summary of findings\u2019 tables and grading the certainty of the evidenceIn: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, 2019 Available from www.training.cochrane.org\/handbook","DOI":"10.1002\/9781119536604.ch14"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0103|cit103","doi-asserted-by":"crossref","unstructured":"Sch\u00fcnemann HJ Vist GE Higgins JP Santesso N Deeks JJ Glasziou P Chapter 15: Interpreting results and drawing conclusions. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, 2019 Available from www.training.cochrane.org\/handbook","DOI":"10.1002\/9781119536604.ch15"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1001\/jamainternmed.2017.2924","article-title":"Injurious falls and syncope in older community-dwelling adults meeting inclusion criteria for SPRINT","volume":"177","author":"Sexton","year":"2017","journal-title":"JAMA International Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1097\/HJH.0b013e32832d7370","article-title":"Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial study","volume":"27","author":"Sleight","year":"2009","journal-title":"Journal of Hypertension"},{"issue":"5","key":"10.1002\/14651858.CD004349.pub3-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archinte.1993.00410050036006","article-title":"Blood pressure, systolic and diastolic, and cardiovascular risks. US population data","volume":"153","author":"Stamler","year":"1993","journal-title":"Archives of Internal Medicine"},{"issue":"Suppl V","key":"10.1002\/14651858.CD004349.pub3-BIB0107|cit107","first-page":"V65","article-title":"The relative importance of selective risk factors for various manifestations of cardiovascular disease among men and women from 35 to 64 years. 30 years of follow-up in the Framingham Study","volume":"75","author":"Kannel","year":"1987","journal-title":"Circulation"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"184","DOI":"10.7326\/M14-0773","article-title":"Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis","volume":"162","author":"Sundstr\u00f6m","year":"2015","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1097\/HJH.0000000000000380","article-title":"Effects of blood pressure lowering on outcome incidence in hypertension: 3. Effects in patients at different levels of cardiovascular risk - overview and meta-analyses of randomized trials","volume":"32","author":"Thomopoulos","year":"2014","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/HJH.0000000000000881","article-title":"Effects of blood pressure lowering on outcome incidence in hypertension: 7. Effects of more vs. less intensive blood pressure lowering and different achieved blood pressure levels - updated overview and meta-analyses of randomized trials","volume":"34","author":"Thomopoulos","year":"2016","journal-title":"J Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1097\/HJH.0000000000000972","article-title":"Effects of blood pressure lowering treatment in hypertension: 8. Outcome reductions vs discontinuations because of adverse drug events","volume":"34","author":"Thomopoulos","year":"2016","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1001\/jamainternmed.2017.0197","article-title":"Association of intensive blood pressure control and kidney disease progression in nondiabetic patients with chronic kidney disease. A systematic review and meta-analysis","volume":"177","author":"Tsai","year":"2017","journal-title":"JAMA Intern Med"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1161\/HYPERTENSIONAHA.116.07608","article-title":"More versus less intensive blood pressure-lowering strategy. Cumulative evidence and trial sequential analysis","volume":"68","author":"Verdecchia","year":"2016","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1001\/jama.2016.2628","article-title":"Interpretation of clinical trials that stopped early","volume":"315","author":"Viele","year":"2016","journal-title":"JAMA"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/01.HYP.34.6.1181","article-title":"J-shaped relation between blood pressure and stroke in treated hypertensives","volume":"34","author":"Vok\u00f3","year":"1999","journal-title":"Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00004872-200311000-00002","article-title":"2003 World Health Organization (WHO)\/International Society of Hypertension (ISH) statement on management of hypertension","volume":"21","author":"World Health Organization","year":"2003","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0140-6736(15)00805-3","article-title":"Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis","volume":"387","author":"Xie","year":"2016","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1056\/NEJMclde1513565","article-title":"Blood-pressure control","volume":"373","author":"Yeh","year":"2015","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD004349.pub3-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/00004872-200304000-00024","article-title":"Benefits and risks of more intensive blood pressure lowering in hypertensive patients of the HOT study with different risk profiles: does a J-shaped curve exist in smokers?","volume":"21","author":"Zanchetti","year":"2003","journal-title":"Journal of Hypertension"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1097\/HJH.0b013e32832e9500","article-title":"Bottom blood pressure or bottom cardiovascular risk? How far can cardiovascular risk be reduced?","volume":"27","author":"Zanchetti","year":"2009","journal-title":"Journal of Hypertension"},{"issue":"9","key":"10.1002\/14651858.CD004349.pub3-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1097\/HJH.0000000000000253","article-title":"Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence","volume":"32","author":"Zanchetti","year":"2014","journal-title":"Journal of Hypertension"},{"issue":"6","key":"10.1002\/14651858.CD004349.pub3-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.116.303641","article-title":"Randomized controlled trials of blood pressure lowering in hypertension. A critical reapparaisal","volume":"116","author":"Zanchetti","year":"2015","journal-title":"Circulation Research"},{"issue":"3","key":"10.1002\/14651858.CD004349.pub3-BIB0123|cit123","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004349","article-title":"Treatment blood pressure targets for hypertension","author":"Arguedas","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004349.pub3-BIB0124|cit124","unstructured":"Arguedas JA Blood pressure targets in the treatment of patients with elevated blood pressure Master's Thesis, Department of Pharmacology & Therapeutics, University of British Columbia"},{"issue":"3","key":"10.1002\/14651858.CD004349.pub3-BIB0125|cit125","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004349","article-title":"Treatment blood pressure targets for hypertension","author":"Arguedas","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T19:01:19Z","timestamp":1673636479000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004349.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Hypertension Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":125,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004349.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}