{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:41:53Z","timestamp":1783471313722,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd004424","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T00:00:00Z","timestamp":1208908800000}}],"reference-count":49,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004424.pub2","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T05:56:47Z","timestamp":1208757407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Antiepileptic drugs for preventing seizures in people with brain tumors"],"prefix":"10.1002","volume":"2010","author":[{"given":"Ivo W","family":"Tremont-Lukats","sequence":"first","affiliation":[{"name":"Louisiana State University; Neurology; 1111 Medical Center Boulevard Suite S-750 Marrero Louisiana USA 77072"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo O","family":"Ratilal","sequence":"additional","affiliation":[{"name":"Hospital de S\u00e3o Jos\u00e9; Department of Neurosurgery; Rua Jos\u00e9 Ant\u00f3nio Serrano Lisboa Portugal 1150-199"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Armstrong","sequence":"additional","affiliation":[{"name":"University of Texas - MD Anderson Cancer Center; 1515 Holcombe Boulevard Neuro-Oncology Department, Box 431 Houston Texas USA 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Gilbert","sequence":"additional","affiliation":[{"name":"University of Texas - MD Anderson Cancer Center; 1515 Holcombe Boulevard Neuro-Oncology Department, Box 431 Houston Texas USA 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,23]]},"reference":[{"issue":"2","key":"10.1002\/14651858.CD004424.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S0317167100053361","article-title":"Prophylactic anticonvulsants in patients with brain tumour","volume":"30","author":"Forsyth","year":"2003","journal-title":"The Canadian Journal of Neurological Sciences. Le Journal Canadien des Sciences Neurologiques"},{"issue":"1-2","key":"10.1002\/14651858.CD004424.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01420191","article-title":"Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours","volume":"103","author":"Franceschetti","year":"1990","journal-title":"Acta Neurochirurgica"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1212\/WNL.46.4.985","article-title":"A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors","volume":"46","author":"Glantz","year":"1996","journal-title":"Neurology"},{"issue":"5","key":"10.1002\/14651858.CD004424.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0090-3019(89)90067-0","article-title":"Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures","volume":"31","author":"Lee","year":"1989","journal-title":"Surgical Neurology"},{"issue":"5","key":"10.1002\/14651858.CD004424.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3171\/jns.1983.58.5.0672","article-title":"Phenytoin and postoperative epilepsy. A double-blind study","volume":"58","author":"North","year":"1983","journal-title":"Journal of Neurosurgery"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0006|cit6","first-page":"53","article-title":"Pharmacologic prophylaxis of epileptic seizures occurring after surgery for intracranial tumors","volume":"39","author":"Avanzini","year":"1982","journal-title":"Bolletino Lega Italiana contro L'Epilessia"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/jnnp.67.4.474","article-title":"Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects","volume":"67","author":"Beenen","year":"1999","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"3","key":"10.1002\/14651858.CD004424.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1227\/00006123-198503000-00002","article-title":"Postoperative prophylactic anticonvulsant therapy in cerebral gliomas","volume":"16","author":"Boarini","year":"1985","journal-title":"Neurosurgery"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00165714","article-title":"Brain metastasis from melanoma","volume":"1","author":"Byrne","year":"1983","journal-title":"Journal of Neuro-oncology"},{"issue":"10","key":"10.1002\/14651858.CD004424.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1200\/JCO.1988.6.10.1621","article-title":"Should prophylactic anticonvulsants be administered to patients with newly-diagnosed cerebral metastases? A retrospective analysis","volume":"6","author":"Cohen","year":"1988","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD004424.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1528-1157.2002.24801.x","article-title":"Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: A randomized controlled study","volume":"43","author":"Santis","year":"2002","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0012|cit12","first-page":"529","article-title":"Prophylactic anticonvulsants for cancer patients with newly diagnosed brain metastases","volume":"15","author":"Dent","year":"1996","journal-title":"American Society of Clinical Oncology Proceedings"},{"issue":"9","key":"10.1002\/14651858.CD004424.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/jnnp.55.9.753","article-title":"Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?","volume":"55","author":"Foy","year":"1992","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0014|cit14","first-page":"413","article-title":"Postoperative seizures in patients operated on supratentorial neoplasms: A prospective study","volume":"62-63","author":"Franceschetti","year":"1988","journal-title":"Bolletino della Lega Italiana contro L'Epilessia"},{"issue":"1","key":"10.1002\/14651858.CD004424.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1212\/WNL.40.1.158","article-title":"The role of radiation therapy following resection of single brain metastasis from melanoma","volume":"40","author":"Hagen","year":"1990","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0016|cit16","first-page":"116","article-title":"A randomised double blind study of sodium valproate for the prevention of seizures in neurosurgical patients","volume":"58","author":"Holland","year":"1995","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0017|cit17","first-page":"327","article-title":"Seizure prophylaxis with phenytoin in patients with brain metastases","volume":"10","author":"Hung","year":"1991","journal-title":"American Society of Clinical Oncology Proceedings"},{"issue":"3","key":"10.1002\/14651858.CD004424.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF01411737","article-title":"Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels. Acta neurochirurgica","volume":"138","author":"Levati","year":"1996","journal-title":"Acta Neurochirurgica"},{"issue":"6","key":"10.1002\/14651858.CD004424.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0090-3019(81)90227-5","article-title":"The role of anticonvulsant medications in the management of patients with anaplastic gliomas","volume":"16","author":"Mahaley","year":"1981","journal-title":"Surgical Neurology"},{"issue":"3","key":"10.1002\/14651858.CD004424.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11060-006-9229-7","article-title":"Prevention of early postoperative seizures in patients with primary brain tumors: preliminary experience with oxcarbazepine","volume":"81","author":"Mauro","year":"2007","journal-title":"Journal of Neuro-oncology"},{"issue":"7","key":"10.1002\/14651858.CD004424.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1001\/archneur.1995.00540310091021","article-title":"The course of seizure disorders in patients with malignant gliomas","volume":"52","author":"Moots","year":"1995","journal-title":"Archives of Neurology"},{"issue":"10","key":"10.1002\/14651858.CD004424.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"647","DOI":"10.7887\/jcns.8.647","article-title":"A randomized controlled trial of zonisamide in postoperative epilepsy: A report of the Cooperative Group Study","volume":"8","author":"Nakamura","year":"1999","journal-title":"Japanese Journal of Neurosurgery"},{"issue":"8165","key":"10.1002\/14651858.CD004424.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0140-6736(80)90941-1","article-title":"Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy","volume":"1","author":"North","year":"1980","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2214\/ajr.140.4.787","article-title":"Diazepam prophylaxis of contrast media-induced seizures during computed tomography of patients with brain metastases","volume":"140","author":"Pagani","year":"1983","journal-title":"American Journal of Roentgenology"},{"issue":"10","key":"10.1002\/14651858.CD004424.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1002\/1097-0142(19841115)54:10<2200::AID-CNCR2820541022>3.0.CO;2-2","article-title":"Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography","volume":"54","author":"Pagani","year":"1984","journal-title":"Cancer"},{"issue":"2","key":"10.1002\/14651858.CD004424.pub2-BIB0026|cit26","first-page":"331","article-title":"Prospective study of postoperative seizure in intracranial meningioma","volume":"47","author":"Tsuji","year":"1993","journal-title":"The Japanese Journal of Psychiatry and Neurology"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0027|cit27","first-page":"231","article-title":"Phenytoin or sodium valproate for prophylaxis of postoperative epilepsy: a randomized comparison","volume":"26","author":"Zhang","year":"2000","journal-title":"Chinese Journal of Nervous and Mental Diseases"},{"issue":"10","key":"10.1002\/14651858.CD004424.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1212\/WNL.54.10.1886","article-title":"Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"54","author":"Glantz","year":"2000","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0029|cit29","first-page":"1153-6, 1159-60","article-title":"Seizure prophylaxis for brain tumour patients. Brief review and guide for family physicians","volume":"39","author":"Agbi","year":"1993","journal-title":"Canadian Family Physician Medecin de Famille Canadien"},{"issue":"6","key":"10.1002\/14651858.CD004424.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.hoc.2006.09.013","article-title":"Supportive care of brain tumor patients","volume":"20","author":"Batchelor","year":"2006","journal-title":"Hematology\/Oncology Clinics of North America"},{"issue":"1","key":"10.1002\/14651858.CD004424.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1472-6963-3-23","article-title":"Can surveying practitioners about their practices help identify priority clinical practice guideline topics?","volume":"3","author":"Brouwers","year":"2003","journal-title":"BMC Health Services Research"},{"issue":"12","key":"10.1002\/14651858.CD004424.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.4065\/79.12.1487","article-title":"\"Antiepileptic\" not \"antiepileptogenic\" drug therapy: ineffective prophylaxis of seizures","volume":"79","author":"Cascino","year":"2004","journal-title":"Mayo Clinic Proceedings"},{"issue":"3","key":"10.1002\/14651858.CD004424.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1227\/00006123-198509000-00021","article-title":"Anticonvulsant prophylaxis in neurological surgery","volume":"17","author":"Deutschman","year":"1985","journal-title":"Neurosurgery"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0034|cit34","first-page":"9","article-title":"Epilepsy in the cancer patient","volume-title":"Handbook of Neurology","volume":"25(69): Neuro-o","author":"Glantz","year":"1997"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0035|cit35","first-page":"388a","article-title":"Meta-analysis of anticonvulsant prophylaxis (ACP) in seizure-naive patients (pts) with brain tumors","volume":"17","author":"Glantz","year":"1998","journal-title":"American Society of Clinical Oncology Proceedings"},{"issue":"3","key":"10.1002\/14651858.CD004424.pub2-BIB0036|cit36","article-title":"Aproaches to summarising the validity of studies. Section 6.7. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]","author":"Higgins","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/01.wnl.0000168903.09277.8f","article-title":"Epileptic seizures during follow-up of patients treated for primary brain tumors","volume":"65","author":"Hildebrand","year":"2005","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0038|cit38","first-page":"254","article-title":"Brain tumours and epilepsy","volume-title":"Handbook of Clinical Neurology","volume":"16","author":"Ketz","year":"1974"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1059-1311(96)80023-9","article-title":"Effectiveness of antiepileptic prophylaxis used with supratentorial craniotomies: a meta-analysis","volume":"5","author":"Kuijlen","year":"1996","journal-title":"Seizure"},{"issue":"1","key":"10.1002\/14651858.CD004424.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1227\/00006123-198301000-00003","article-title":"Seizures during the immediate post-operative period","volume":"12","author":"Kvam","year":"1983","journal-title":"Neurosurgery"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/j.1875-9114.1991.tb04300.x","article-title":"Interaction of dexamethasone with phenytoin","volume":"11","author":"Lackner","year":"1991","journal-title":"Pharmacotherapy"},{"key":"10.1002\/14651858.CD004424.pub2-BIB0042|cit42","unstructured":"The Cochrane Collaboration RevMan Analyses [computer program]. Version 1.0 for Windows. In: Review Manager (RevMan) 4.2.10 2006"},{"issue":"4","key":"10.1002\/14651858.CD004424.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1528-1157.2002.13001.x","article-title":"The importance of drug interactions in epilepsy therapy","volume":"43","author":"Patsalos","year":"2002","journal-title":"Epilepsia"},{"issue":"29-30","key":"10.1002\/14651858.CD004424.pub2-BIB0044|cit44","first-page":"425","article-title":"Dexamethasone\/phenytoin interactions: neurooncological concerns","volume":"132","author":"Ruegg","year":"2002","journal-title":"Swiss Medical Weekly"},{"issue":"2","key":"10.1002\/14651858.CD004424.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11060-004-6912-4","article-title":"Results of a survey of neurosurgical practice patterns regarding the prophylactic use of anti-epilepsy drugs in patients with brain tumors","volume":"74","author":"Siomin","year":"2005","journal-title":"Journal of Neuro-oncology"},{"issue":"12","key":"10.1002\/14651858.CD004424.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.4065\/79.12.1489","article-title":"Seizure prophylaxis in patients with brain tumors: a meta-analysis","volume":"79","author":"Sirven","year":"2004","journal-title":"Mayo Clinic Proceedings"},{"issue":"6","key":"10.1002\/14651858.CD004424.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.seminoncol.2003.11.030","article-title":"Treating seizures in patients with brain tumors: Drug interactions between antiepileptic and chemotherapeutic agents","volume":"30 Suppl 19","author":"Vecht","year":"2003","journal-title":"Seminars in Oncology"},{"issue":"12","key":"10.1002\/14651858.CD004424.pub2-BIB0048|cit48","first-page":"10","article-title":"Optimizing therapy of seizures in patients with brain tumors","volume":"67 Suppl 4","author":"Vecht","year":"2006","journal-title":"Neurology"},{"issue":"3","key":"10.1002\/14651858.CD004424.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00001622-200205000-00008","article-title":"Medical management of patients with brain tumors","volume":"14","author":"Wen","year":"2002","journal-title":"Current Opinions in Oncology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004424.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T15:02:30Z","timestamp":1753455750000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004424.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Epilepsy Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,4,23]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004424.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,23]]}}}