{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:45:16Z","timestamp":1767134716324,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd004448.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000}}],"reference-count":45,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004448.pub5","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T01:01:41Z","timestamp":1428541301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phytomedicines (medicines derived from plants) for sickle cell disease"],"prefix":"10.1002","author":[{"given":"Oluseyi","family":"Oniyangi","sequence":"first","affiliation":[{"name":"National Hospital; Paediatrics Department; Plot 132 Central District (Phase II) PMB 425 Garki Abuja Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian H","family":"Cohall","sequence":"additional","affiliation":[{"name":"University of the West Indies; Faculty of Medical Sciences; Cave Hill St Michael Barbados"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD004448.pub5-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/tropej\/fmh097","article-title":"Clinical evaluation of extract of Cajanus cajan (Ciklavit) in sickle cell anaemia","volume":"51","author":"Akinsulie","year":"2005","journal-title":"Journal of Tropical Paediatrics"},{"issue":"2","key":"10.1002\/14651858.CD004448.pub5-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1211\/fact.2002.00158","article-title":"Indiginous Nigerian medicinal plants may be useful in the management of sickle-cell disorder [comment]","volume":"7","author":"Fonnebo","year":"2002","journal-title":"Focus on Alternative and Complementory Therapies"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0004|cit3","unstructured":"Wambebe C Chemistry and clinical evaluation of NIPRISAN in patients with sickle cell anemia [abstract] The National Sickle Cell Disease Program 30th Annual Meeting Conference Proceedings, Sept 2002 2002 46"},{"issue":"4","key":"10.1002\/14651858.CD004448.pub5-BIB0003|cit4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1078\/0944-7113-00040","article-title":"Double-blind, placebo-controlled, randomised cross-over clinical trial of NIPRISAN in patients with sickle cell disorder","volume":"8","author":"Wambebe","year":"2001","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0011-393X(01)80039-4","article-title":"Efficacy of NIPRISAN in the prophylactic management of patients with sickle cell disease","volume":"62","author":"Wambebe","year":"2001","journal-title":"Current Therapeutic Research"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0006|cit6","first-page":"15","article-title":"Treatment of sickle cell disorders by ayurvedic medicine","volume":"17","author":"Panigrahi","year":"1997","journal-title":"Ancient Science of Life"},{"issue":"3","key":"10.1002\/14651858.CD004448.pub5-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF03190397","article-title":"Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats","volume":"26","author":"Adzu","year":"2001","journal-title":"European Journal of Drug Metabolism and Pharmacokinetics"},{"issue":"4","key":"10.1002\/14651858.CD004448.pub5-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2006-961475","article-title":"Antisickling activity of hydroxybenzoic acids in Cajanus cajan","volume":"58","author":"Akojie","year":"1992","journal-title":"Planta Medica"},{"issue":"12","key":"10.1002\/14651858.CD004448.pub5-BIB0009|cit9","first-page":"1065","article-title":"Evaluation of commonly used tribal and traditional remedies in Saudi Arabia","volume":"22","author":"Al-Awamy","year":"2001","journal-title":"Saudi Medical Journal"},{"issue":"9","key":"10.1002\/14651858.CD004448.pub5-BIB0010|cit10","first-page":"645","article-title":"The significance of gall stones in children with sickle cell anaemia","volume":"82","author":"Alexander-Reindorf","year":"1990","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0011|cit11","first-page":"39","article-title":"Acute and short-term toxicity of NIPRISAN in rats I: biochemical study","volume":"1","author":"Awodogan","year":"1996","journal-title":"Journal of Pharmacological Research and Development"},{"issue":"3","key":"10.1002\/14651858.CD004448.pub5-BIB0012|cit12","first-page":"289","article-title":"Burden of health-care of carers of children with sickle cell disease in Nigeria","volume":"18","author":"Brown","year":"2010","journal-title":"Health & Social Care in the Community"},{"issue":"7109","key":"10.1002\/14651858.CD004448.pub5-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/bmj.315.7109.656","article-title":"The management of patients with sickle cell disease","volume":"315","author":"Davies","year":"1997","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0014|cit14","doi-asserted-by":"crossref","unstructured":"Deeks JJ Higgins JPT Altman DG on behalf of the Cochrane Statistical Methods Group Chapter 9: \u00a0Analysing data and undertaking meta-analyses In: Higgins JPT, Green S (editors). Cochrane Handbook forSystematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The CochraneCollaboration, 2008. Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184.ch9"},{"issue":"6","key":"10.1002\/14651858.CD004448.pub5-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1055\/s-2007-969576","article-title":"The reversion of sickled cells by Cajanus cajan","volume":"1","author":"Ekeke","year":"1985","journal-title":"Planta Medica"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"3","key":"10.1002\/14651858.CD004448.pub5-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-1999-14083","article-title":"In vitro antisickling activity of a rearranged limonoid isolated from Khaya senegalensis","volume":"65","author":"Fall","year":"1999","journal-title":"Planta Medica"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0268-960X(89)90022-2","article-title":"The presentation, management and prevention of crisis in sickle cell disease in Africa","volume":"3","author":"Fleming","year":"1989","journal-title":"Blood Reviews"},{"issue":"2","key":"10.1002\/14651858.CD004448.pub5-BIB0019|cit19","first-page":"39","article-title":"Pharmacological Profile of NIPRD 94\/002\/1-0: A Novel Herbal Antisickling Agent","volume":"3","author":"Gamaniel","year":"1998","journal-title":"Journal of Pharmaceutical Research"},{"issue":"4","key":"10.1002\/14651858.CD004448.pub5-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1046\/j.1365-2141.1999.01275.x","article-title":"Mapping the prevalence of sickle cell and beta thalassaemia in England: estimating and validating ethnic-specific rates","volume":"104","author":"Hickman","year":"1999","journal-title":"British Journal of Haematology"},{"issue":"7414","key":"10.1002\/14651858.CD004448.pub5-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistence in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0022|cit22","doi-asserted-by":"crossref","unstructured":"Julian PT Higgins and Douglas G Altman on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group Chapter 8: \u00a0Assessing risk of bias in included studies In: Higgins JPT, Green S (editors). Cochrane Handbook forSystematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The CochraneCollaboration, 2008. Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184.ch8"},{"issue":"11","key":"10.1002\/14651858.CD004448.pub5-BIB0023|cit23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003427.pub3","article-title":"Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease","author":"Hirst","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"10.1002\/14651858.CD004448.pub5-BIB0024|cit24","first-page":"387","article-title":"Evaluation of Fagara zanthyloides root extract in sickle cell anemia blood in vitro","volume":"38","author":"Honig","year":"1975","journal-title":"Lloydia"},{"issue":"2","key":"10.1002\/14651858.CD004448.pub5-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ajh.10388","article-title":"Hydroxyurea-induced splenic regrowth in an adult patient with severe hemoglobin SC disease","volume":"74","author":"Huang","year":"2003","journal-title":"American Journal of Hematology"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0378-8741(88)90118-3","article-title":"Effect of cajaminose from Cajanus cajan on gelation and oxygen affinity of sickle cell haemoglobin","volume":"23","author":"Iwu","year":"1988","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-2141.2002.03593.x","article-title":"In vitro effects of NIPRISAN (Nix-0699): a naturally occurring, potent antisickling agent","volume":"118","author":"Iyamu","year":"2002","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"issue":"2","key":"10.1002\/14651858.CD004448.pub5-BIB0029|cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002202","article-title":"Hydroxyurea in sickle cell disease","author":"Jones","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5763","key":"10.1002\/14651858.CD004448.pub5-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/bmj.2.5763.710-d","article-title":"Malaria and sickle-cell disease","volume":"2","author":"Konotey-Ahulu","year":"1971","journal-title":"British Medical Journal"},{"issue":"2","key":"10.1002\/14651858.CD004448.pub5-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-2006-960044","article-title":"The in vitro effects of griffonin and ouabain on erythrocyte sodium content obtained from normal subjects and sickle cell patients","volume":"57","author":"Larmie","year":"1991","journal-title":"Planta Medica"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0032|cit32","unstructured":"Medical University of South Carolina Bias http:\/\/www.musc.edu\/dc\/icrebm\/bias.html"},{"issue":"9","key":"10.1002\/14651858.CD004448.pub5-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0277-9536(00)00245-8","article-title":"Malevolent ogbanje: recurrent reincarnation or sickle cell disease?","volume":"52","author":"Nzewi","year":"2001","journal-title":"Social Science and Medicine"},{"issue":"12","key":"10.1002\/14651858.CD004448.pub5-BIB0034|cit34","first-page":"1058","article-title":"Psycosocial burden of sickle cell disease on caregivers in a Nigerian setting","volume":"94","author":"Ohiaeri","year":"December 2002","journal-title":"J Nat Med Assoc"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/bcmd.2000.0368","article-title":"Green tea extract and aged garlic extract inhibit anion transport and sickle cell dehydration in vitro","volume":"27","author":"Ohnishi","year":"2001","journal-title":"Blood Cells, Molecules and Diseases"},{"issue":"3s","key":"10.1002\/14651858.CD004448.pub5-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"1085S","DOI":"10.1093\/jn\/131.3.1085S","article-title":"In vitro effects of aged garlic extract and other nutritional supplements on sickle erythrocytes","volume":"131","author":"Ohnishi","year":"2001","journal-title":"Journal of Nutrition"},{"issue":"8","key":"10.1002\/14651858.CD004448.pub5-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/ptr.1026","article-title":"The kinetics of reversal of pre-sickled erythrocytes by the aqueous extract of Cajanus cajan seeds","volume":"16","author":"Ogoda Onah","year":"2002","journal-title":"Phytotherapy Research"},{"issue":"4","key":"10.1002\/14651858.CD004448.pub5-BIB0038|cit38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003489.pub2","article-title":"Malaria chemoprophylaxis in sickle cell disease","author":"Oniyangi","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1-2","key":"10.1002\/14651858.CD004448.pub5-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0378-8741(89)90089-5","article-title":"Effect of Zanthoxylum xanthyloides and some substituted benzoic acids on glucose-6-phosphate and 6-phosphogluconate dehydrogenases in HbSS red cells","volume":"27","author":"Osoba","year":"1989","journal-title":"Journal of Ethnopharmacology"},{"issue":"23","key":"10.1002\/14651858.CD004448.pub5-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease: life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0041|cit41","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2008"},{"key":"10.1002\/14651858.CD004448.pub5-BIB0042|cit42","volume-title":"Sickle Cell Disease","author":"Serjeant","year":"2001"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0378-8741(87)90137-1","article-title":"Medicinal plants in Mozambique and their popular use","volume":"19","author":"Verzar","year":"1987","journal-title":"Journal of Ethnopharmacology"},{"issue":"10","key":"10.1002\/14651858.CD004448.pub5-BIB0044|cit44","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004448.pub3","article-title":"Phytomedicines (medicines derived from plants) for sickle cell disease","author":"Oniyangi","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD004448.pub5-BIB0045|cit45","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004448.pub4","article-title":"Phytomedicines (medicines derived from plants) for sickle cell disease","author":"Oniyangi","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd004448.pub6","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004448.pub5\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T04:40:15Z","timestamp":1717821615000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD004448.pub5"}},"subtitle":[],"editor":[{"name":"Cochrane Cystic Fibrosis and Genetic Disorders Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":45,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004448.pub5","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,6]]}}}