{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:53:28Z","timestamp":1785855208197,"version":"3.56.0"},"update-to":[{"DOI":"10.1002\/14651858.cd004515","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T00:00:00Z","timestamp":1161129600000}}],"reference-count":39,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004515.pub2","type":"journal-article","created":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T19:25:39Z","timestamp":1170789939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Valerian for anxiety disorders"],"prefix":"10.1002","author":[{"given":"Lincoln Sakiara","family":"Miyasaka","sequence":"first","affiliation":[{"name":"Brazilian Cochrane Centre; Universidade Federal de S\u00e3o Paulo Rua de Pedro Toledo 598, Vila Clementino S\u00e3o Paulo SP Brazil 04039-001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro N","family":"Atallah","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo \/ Escola Paulista de Medicina; Brazilian Cochrane Centre; Rua Pedro de Toledo 598  Vila Clementino S\u00e3o Paulo SP Brazil CEP 04039-001"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Soares","sequence":"additional","affiliation":[{"name":"Brazilian Cochrane Centre; Universidade Federal de S\u00e3o Paulo Rua de Pedro Toledo 598, Vila Clementino S\u00e3o Paulo SP Brazil 04039-001"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"10.1002\/14651858.CD004515.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ptr.1027","article-title":"Effect of valepotriates (valerian extract) in Generalised Anxiety Disorder: a randomised placebo-controlled pilot study","volume":"16","author":"Andreatini","year":"2002","journal-title":"Phytotherapy Research"},{"issue":"2","key":"10.1002\/14651858.CD004515.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1472-8206.1997.tb00179.x","article-title":"A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study versus placebo","volume":"11","author":"Bourin","year":"1997","journal-title":"Fundamental and Clinical Pharmacology"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0367-326X(99)00018-0","article-title":"Tolerability and efficacy of valerian\/lemon balm in healthy volunteers ( a double-blind placebo controlled multicentre study)","volume":"70","author":"Cerny","year":"1999","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1002\/14651858.CD004515.pub2-BIB0004|cit4","first-page":"191","article-title":"Clinical comparative evaluation of a stabilized valeriana extract and placebo","volume":"104","author":"Delsignore","year":"1992","journal-title":"A Folha Medica"},{"issue":"37","key":"10.1002\/14651858.CD004515.pub2-BIB0005|cit5","first-page":"2140","article-title":"Valerian and Melissa - Mild Psychopharmaceuticals","volume":"42","author":"Maisenbacher","year":"1992","journal-title":"Therapiewoche"},{"issue":"1,2","key":"10.1002\/14651858.CD004515.pub2-BIB0006|cit6","first-page":"1","article-title":"Treatment of anxiety with a homeopathic remedy","volume":"48","author":"McCutcheon","year":"1996","journal-title":"Journal of Applied Nutrition"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0007|cit7","first-page":"4659","article-title":"Treatment of moderately severe anxiety states","volume":"41","author":"Panijel","year":"1985","journal-title":"Therapiewoche"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0008|cit8","first-page":"126","article-title":"Tratamento dei disturbi d'ansia de grado lieve e medio con prodotti a base naturale: valutazione dell\"efficacia e tollerabilit\u00e0 del Sedatol","volume":"15","author":"Rabezzana","year":"1995","journal-title":"Riv It Biol Med"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1192\/bjp.171.6.524","article-title":"Brazilian multicentric study of psychiatric morbidity: Methodological features and prevalence estimates","volume":"171","author":"Almeida-Filho","year":"1997","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0010|cit10","volume-title":"Diagnostic and statistical manual of mental disorders (DSM-III-R)","author":"American Psychiatric Association","year":"1987"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0011|cit11","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)","author":"American Psychiatric Association","year":"1994"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0012|cit12","volume-title":"British Herbal Compendium Vol. 1","author":"British Herbal Medicine Association","year":"1992"},{"issue":"12","key":"10.1002\/14651858.CD004515.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s001270050098","article-title":"Prevalence of psychiatric disorder in the general population: Results of the Netherland Mental Health Survey and Incidence Study (NEMESIS)","volume":"33","author":"Bijl","year":"1998","journal-title":"Social Psychiatry & Psychiatric Epidemiology"},{"issue":"6","key":"10.1002\/14651858.CD004515.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1037\/0022-006X.55.6.883","article-title":"The effects of relaxation training with cognitive or nondirective therapy and the role of relaxation-induced anxiety in the treatment of generalized anxiety disorder","volume":"55","author":"Borkovec","year":"1987","journal-title":"Journal of Consulting & Clinical Psychology"},{"issue":"4","key":"10.1002\/14651858.CD004515.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1037\/0022-006X.61.4.611","article-title":"Efficacy of applied relaxation and cognitive behavioral therapy in the treatment of generalized anxiety disorder","volume":"61","author":"Borkovec","year":"1993","journal-title":"Journal of Consulting & Clinical Psychology"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0016|cit16","volume-title":"Cochrane Collaboration Handbook","author":"Clarke","year":"2000"},{"issue":"2","key":"10.1002\/14651858.CD004515.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-2000-7972","article-title":"Critical evaluation of the effect of valerian extract on sleep structure and sleep quality","volume":"33","author":"Donath","year":"2000","journal-title":"Pharmacopsychiatry"},{"issue":"2","key":"10.1002\/14651858.CD004515.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0005-7894(97)80048-2","article-title":"Cognitive behavioural and pharmacological treatment of generalized anxiety disorders: Preliminary meta-analysis","volume":"28","author":"Gould","year":"1997","journal-title":"Behavior Therapy"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"British Journal of Medical Psychology"},{"issue":"1","key":"10.1002\/14651858.CD004515.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-2007-971547","article-title":"Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis","volume":"42","author":"Hendriks","year":"1981","journal-title":"Planta Medica"},{"issue":"4","key":"10.1002\/14651858.CD004515.pub2-BIB0021|cit21","article-title":"Psychological therapies for generalised anxiety disorder","author":"Hunot","year":"2006","journal-title":"Cochrane Library"},{"issue":"1","key":"10.1002\/14651858.CD004515.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"issue":"1","key":"10.1002\/14651858.CD004515.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","article-title":"Lifetime and 12 month prevalence of DSM III-R psychiatric disorders in United States","volume":"51","author":"Kessler","year":"1994","journal-title":"Archives of General Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD004515.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1055\/s-2007-969430","article-title":"Aqueous extract of valerian reduces latency to fall asleep in man","volume":"51","author":"Leathwood","year":"1985","journal-title":"Planta Medica"},{"issue":"12","key":"10.1002\/14651858.CD004515.pub2-BIB0025|cit25","first-page":"2066","article-title":"Psychoexperimental studies on the effect of a valepotriate combination as well as the combined effects of valtratum and alcohol","volume":"24","author":"Mayer","year":"1974","journal-title":"Arzneimittel-Forschung"},{"issue":"6","key":"10.1002\/14651858.CD004515.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1176\/appi.ajp.157.5.669","article-title":"Quality of life in individuals with anxiety disorders","volume":"157","author":"Mendlowicz","year":"2000","journal-title":"American Journal of Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD004515.pub2-BIB0027|cit27","first-page":"291","article-title":"In vitro study on the interaction of extracts and pure compounds from Valeriana officinalis roots with GABA, benzodiazepine and barbiturate receptors in rat brain","volume":"64","author":"Mennini","year":"1993","journal-title":"Fitoterapia"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0028|cit28","first-page":"1007","article-title":"Pharmacological studies on a mixture of valepotrietes isolated from Valeriana officinalis","volume":"27","author":"Petkov","year":"1974","journal-title":"Doklady Bolgarskoi Akademii Nauk"},{"issue":"3","key":"10.1002\/14651858.CD004515.pub2-BIB0029|cit29","article-title":"Kava extract for treating anxiety","author":"Pittler","year":"2002","journal-title":"Cochrane Library"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1192\/pb.12.3.107","article-title":"Benzodiazepines and dependance: a college statement","volume":"12","author":"Priest","year":"1988","journal-title":"Bulletin of the Royal College of Psychiatrists"},{"issue":"7","key":"10.1002\/14651858.CD004515.pub2-BIB0031|cit31","first-page":"663","article-title":"Treatment of nervous sleep disorders and unrest with a sedative of purely vegetable origin","volume":"36","author":"Schmidt-Voigt","year":"1986","journal-title":"Therapiewoche"},{"issue":"5","key":"10.1002\/14651858.CD004515.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias: Dimension of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"issue":"2","key":"10.1002\/14651858.CD004515.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1389-9457(99)00015-5","article-title":"Valerian for insomnia: a systematic review of randomized clinical trials","volume":"1","author":"Stevinson","year":"2000","journal-title":"Sleep Medicine"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0034|cit34","volume-title":"Relaxation training and related techniques in behavioural modifications: Principles and clinical applications","author":"Taylor","year":"1978"},{"key":"10.1002\/14651858.CD004515.pub2-BIB0035|cit35","volume-title":"The nature and the treatment of anxiety disorders","author":"Taylor","year":"1988"},{"issue":"3","key":"10.1002\/14651858.CD004515.pub2-BIB0036|cit36","first-page":"316","article-title":"Psychopharmacologic effect of valepotriates","volume":"19","author":"Eickstedt","year":"1969","journal-title":"Arzneimittel-Forschung"},{"issue":"3","key":"10.1002\/14651858.CD004515.pub2-BIB0037|cit37","first-page":"109","article-title":"Therapy of insomnia. The efficacy and tolerability of valerian","volume":"3","author":"Vorbach","year":"1996","journal-title":"Psychopharmakotherapie"},{"issue":"8","key":"10.1002\/14651858.CD004515.pub2-BIB0038|cit38","first-page":"1745","article-title":"Management of common anxiety disorders","volume":"50","author":"Walley","year":"1994","journal-title":"American Family Physician"},{"issue":"11","key":"10.1002\/14651858.CD004515.pub2-BIB0039|cit39","first-page":"480","article-title":"Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia, a randomized double blind comparative clinical study","volume":"7","author":"Ziegler","year":"2002","journal-title":"European Journal of Medical Research"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004515.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:36:19Z","timestamp":1628544979000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD004515.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Common Mental Disorders Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2006,10,18]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004515.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,18]]}}}