{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:01:28Z","timestamp":1773284488221,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd004539","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T00:00:00Z","timestamp":1113955200000}}],"reference-count":162,"publisher":"Wiley","issue":"5","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004539.pub2","type":"journal-article","created":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T14:35:41Z","timestamp":1114180541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Antibiotic regimens for secondary peritonitis of gastrointestinal origin in adults"],"prefix":"10.1002","volume":"2012","author":[{"given":"Peng F","family":"Wong","sequence":"first","affiliation":[{"name":"Freeman Hospital; Department of Vascular Surgery; Freeman Road High Heaton Newcastle upon Tyne UK NE7 7DN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"Gilliam","sequence":"additional","affiliation":[{"name":"University Hospital of North Tees; Department of Surgery; Hardwick Stockton-on-Tees UK TS19 8PE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Queens Hospital; Directorate of Surgery; Rom Valley way Romford Essex UK RM7 0AG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Shenfine","sequence":"additional","affiliation":[{"name":"University Hospital of North Tees; Department of Surgery; Hardwick Stockton-on-Tees UK TS19 8PE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham N","family":"O'Dair","sequence":"additional","affiliation":[{"name":"University Hospital of North Tees; Department of Surgery; Hardwick Stockton-on-Tees UK TS19 8PE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Leaper","sequence":"additional","affiliation":[{"name":"Cardiff University; Department of Wound Healing; Heath Park Cardiff Wales UK CF14 4XN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,20]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/00365549609037950","article-title":"A comparison of imipenem\/cilastatin with the combination of cefuroxime and metronidazole in the treatment of intra-abdominal infections","volume":"28","author":"Angeras","year":"1996","journal-title":"Scandinavian Journal of Infectious Diseases"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/00365549709011863","article-title":"Imipenem\/cilastatin (1.5g daily) versus meropenem (3.0g daily) in patients with intra-abdominal infections: results of a prospective, randomized, multicentre trial","volume":"29","author":"Basoli","year":"1997","journal-title":"Scand J of Infect Dis"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0002-9610(82)90594-3","article-title":"Antibiotic management of surgically treated gangrenous or perforated appendicitis","volume":"144","author":"Berne","year":"1982","journal-title":"The American Journal of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00000658-198702000-00006","article-title":"Surgically treated gangrenous or perforated appendicitis","volume":"205","author":"Berne","year":"1987","journal-title":"Ann Surg"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0005|cit5","first-page":"18","article-title":"A clinical comparison of cefepime and metronidazole versus gentamicin and clindamycin in the antibiotic management of surgically treated advanced appendicitis","volume":"177","author":"Berne","year":"1993","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0006|cit6","first-page":"403","article-title":"Meropenem versus tobramycin with clindamycin in the antibiotic management of patients with advanced appendicitis","volume":"182","author":"Berne","year":"1996","journal-title":"Journal of the American College of Surgeons"},{"issue":"12","key":"10.1002\/14651858.CD004539.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1128\/AAC.36.12.2766","article-title":"Piperacillin-tazobactam versus imipenem-cilastatin for treatment of intra-abdominal infections","volume":"36","author":"Brismar","year":"1992","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/jac\/35.1.139","article-title":"Meropenem versus imipenem\/cilastatin in the treatment of intra-abdominal infections","volume":"35","author":"Brismar","year":"1995","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/00365549609037949","article-title":"Biapenem versus imipenem\/cilastatin in the treatment of complicated intra-abdominal infections: Report from a Swedish study group","volume":"28","author":"Brismar","year":"1996","journal-title":"Scandinavian Journal of Infectious Diseases"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0010|cit10","first-page":"1","article-title":"A comparative study of cefamandole versus gentamicin plus clindamycin in the treatment of documented or suspected bacterial peritonitis","volume":"158","author":"Busuttil","year":"1984","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"11","key":"10.1002\/14651858.CD004539.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archsurg.1996.01430230075014","article-title":"Management of intra-abdominal infections: The case for intraoperative cultures and comprehensive broad-spectrum antibiotic coverage","volume":"131","author":"Christou","year":"1996","journal-title":"Archives of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00000658-200008000-00016","article-title":"Comparison of intravenous\/oral ciprofloxacin plus metronidazole versus piperacillin\/tazobactam in the treatment of complicated intraabdominal infections","volume":"232","author":"Cohn","year":"2000","journal-title":"Annals of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/jac\/32.3.491","article-title":"Comparison of imipenem\/cilastatin with the combination of aztreonam and clindamycin in the treatment of intra-abdominal infections","volume":"32","author":"Groot","year":"1993","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"8","key":"10.1002\/14651858.CD004539.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1128\/AAC.44.8.2028-2033.2000","article-title":"Monotherapy with a broad-spectrum beta-lactam is as effective as its combination with an aminoglycoside in treatment of severe generalized peritonitis: a multicenter randomized controlled trial","volume":"44","author":"Dupont","year":"2000","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0015|cit15","first-page":"97","article-title":"Efficacy of two comparative antibiotic regimens in the treatment of serious intra-abdominal infections: Results of a multicenter study","volume":"14","author":"Eckhauser","year":"1992","journal-title":"Clinical Therapeutics"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00000658-198703000-00009","article-title":"Imipenem (N-F-Thienamycin) versus netilmicin plus clindamycin: A controlled and randomized comparison in intra-abdominal infections","volume":"205","author":"Gozenbach","year":"1987","journal-title":"Annals of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jac\/34.3.391","article-title":"Comparison of cefoperazone plus sulbactam with clindamycin plus gentamicin as treatment for intra-abdominal infections","volume":"34","author":"Greenberg","year":"1994","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/BF00299113","article-title":"Adjunctive antimicrobial therapy for complicated appendicitis: Bacterial overkill by combination therapy","volume":"18","author":"Hopkins","year":"1994","journal-title":"World Journal of Surgery"},{"issue":"573","key":"10.1002\/14651858.CD004539.pub2-BIB0019|cit19","first-page":"61","article-title":"Results of the North American trial of piperacillin\/tazobactam compared with clindamycin and gentamicin in the treatment of severe intra-abdominal infections","author":"Investigators of the Piperacillin\/Tazobactam Intra-abdominal Infection Study Group","year":"1994","journal-title":"European Journal of Surgery Supplement"},{"issue":"11","key":"10.1002\/14651858.CD004539.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1128\/AAC.42.11.2966","article-title":"Prospective randomized comparison of imipenem\/cilastatin and piperacillin\/tazobactam in nosocomial pneumonia and peritonitis","volume":"42","author":"Jaccard","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/jac\/25.3.423","article-title":"A randomized clinical study of cefoperazone and sulbactam versus gentamicin and clindamycin in the treatment of intra-abdominal infections","volume":"25","author":"Jauregui","year":"1990","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF01967440","article-title":"Meropenem versus imipenem\/cilastatin in the treatment of intraabdominal infections requiring surgery","volume":"12","author":"Kanellakopoulou","year":"1993","journal-title":"European Journal of Clinical Microbiological Infectious Diseases"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF01713053","article-title":"Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections","volume":"24","author":"Kempf","year":"1996","journal-title":"Infection"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0024|cit24","first-page":"143","article-title":"The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections","volume":"7","author":"Leal del Rosal","year":"1995","journal-title":"Journal of Chemotherapy"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0025|cit25","first-page":"7","article-title":"Treatment of acute bacterial peritonitis: A trial of imipenem\/cilastatin against ampicillin-metronidazole-gentamicin","volume":"52","author":"Leaper","year":"1987","journal-title":"Scandinavian Journal of Infectious Diseases"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0026|cit26","first-page":"648","article-title":"Treatment of intra-abdominal infections is appropriate with single-agent or combination antibiotic therapy","volume":"98","author":"Malangoni","year":"1985","journal-title":"Surgery"},{"issue":"9","key":"10.1002\/14651858.CD004539.pub2-BIB0027|cit27","first-page":"535","article-title":"Piperacillin compared with cefuroxime plus metronidazole in diffuse peritonitis","volume":"157","author":"Paakkonen","year":"1991","journal-title":"European Journal of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0028|cit28","first-page":"415","article-title":"Imipenem versus tobramycin-antianaerobe antibiotic therapy in intra-abdominal infections","volume":"33","author":"Poenaru","year":"1990","journal-title":"Canadian Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0029|cit29","first-page":"868","article-title":"Imipenem\/cilastatin versus gentamicin\/clindamycin for the treatment of serious bacterial infections","volume":"8382","author":"Report from a Scandinavian Study Group","year":"1984","journal-title":"The Lancet"},{"issue":"Pt 2 S","key":"10.1002\/14651858.CD004539.pub2-BIB0030|cit30","first-page":"475","article-title":"Comparison of cefotetan versus combination therapy in peritonitis and serious intra-abdominal sepsis","volume":"6","author":"Scott","year":"1987","journal-title":"Chemioterapia"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0031|cit31","first-page":"102","article-title":"Piperacillin\/tazobactam in comparison with clindamycin plus gentamicin in the treatment of intra-abdominal infections","volume":"56","author":"Shyr","year":"1995","journal-title":"Chinese Medical Journal"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00000658-198008000-00015","article-title":"Prospective, randomized, double-blinded comparison of metronidazole and tobramycin with clindamycin and tobramycin in the treatment of intra-abdominal sepsis","volume":"192","author":"Smith","year":"1980","journal-title":"Annals of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00000658-200101000-00013","article-title":"Results of a clinical trial of clinafloxacin versus imipenem\/cilastatin for intraabdominal infections","volume":"233","author":"Solomkin","year":"2001","journal-title":"Annals of Surgery"},{"issue":"Suppl 5","key":"10.1002\/14651858.CD004539.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"S583","DOI":"10.1093\/clinids\/8.Supplement_5.S583","article-title":"A randomized controlled trial of ampicillin plus sulbactam versus gentamicin and clindamycin in the treatment of intraabdominal infections: a preliminary report","volume":"8","author":"Study Group of Intra-abdominal Infections","year":"1986","journal-title":"Reviews of Infectious Diseases"},{"issue":"Suppl B","key":"10.1002\/14651858.CD004539.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/jac\/26.suppl_B.173","article-title":"A randomized multicentre trial of pefloxacin plus metronidazole and gentamicin plus metronidazole in the treatment of severe intra-abdominal infections","volume":"26","author":"Report from a Swedish Study Group","year":"1990","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/bjs.1800720404","article-title":"Antibiotic treatment during surgery for diffuse peritonitis: a prospective randomized study comparing the effects of cefuroxime and of a cefuroxime and metronidazole combination","volume":"72","author":"Tornqvist","year":"1985","journal-title":"British Journal of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s150100070027","article-title":"Cefminox versus metronidazole plus gentamicin in intra-abdominal infections: A prospective randomized controlled clinical trial","volume":"28","author":"Torres","year":"2000","journal-title":"Infections"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00000658-199302000-00004","article-title":"Efficacy of a beta-lactamase inhibitor combination for serious intra-abdominal infections","volume":"217","author":"Walker","year":"1993","journal-title":"Annals of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0039|cit39","first-page":"303","article-title":"The role of pseudomonas species in patients treated with ampicillin and sulbactam for gangrenous and perforated appendicitis","volume":"161","author":"Yellin","year":"1985","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0924-8579(98)00104-6","article-title":"Meropenem (1.5 g\/day) is as effective as imipenem\/cilastatin (2 g\/day) for the treatment of moderately severe intra-abdominal infections","volume":"11","author":"Zanetti","year":"1999","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/000313489906500201","article-title":"Ticarcillin\/clavulanate versus imipenem\/cilistatin for the treatment of infections associated with gangrenous and perforated appendicitis","volume":"65","author":"Allo","year":"1999","journal-title":"The American Surgeon"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0042|cit42","first-page":"185","article-title":"Stratified duration of prophylactic antimicrobial treatment in emergency abdominal surgery","volume":"153","author":"Andaker","year":"1987","journal-title":"Acta Chirurgica Scandinavica"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1179\/joc.1996.8.2.130","article-title":"An open, multicenter clinical trial of piperacillin\/tazobactam in the treatment of pediatric patients with intra-abdominal infections","volume":"8","author":"Arguedas","year":"1996","journal-title":"Journal of Chemotherapy"},{"issue":"Suppl.","key":"10.1002\/14651858.CD004539.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1093\/clinids\/5.Supplement_1.S165","article-title":"Multicentered study of cefoperazone for treatment of intraabdominal infections and comparison of cefoperazone with cefamandole and clindamycin plus gentamicin for treatment of appendicitis and peritonitis","volume":"5","author":"Baird","year":"1983","journal-title":"Reviews of Infectious Diseases"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jac\/7.4.441","article-title":"Amoxycillin and clavulanic acid in intra-abdominal and pelvic sepsis","volume":"7","author":"Ball","year":"1981","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jac\/7.4.441","article-title":"Amoxycillin and clavulanic acid in intra-abdominal and pelvic sepsis","volume":"7","author":"Ball","year":"1981","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0047|cit47","first-page":"28","article-title":"Clindamycin plus amikacin versus clindamycin plus aztreonam in established intraabdominal infections","volume":"116","author":"Barboza","year":"1994","journal-title":"Surgery"},{"issue":"12","key":"10.1002\/14651858.CD004539.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1001\/archsurg.1997.01430360040008","article-title":"A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections","volume":"132","author":"Barie","year":"1997","journal-title":"Arch Surg"},{"issue":"Suppl. C","key":"10.1002\/14651858.CD004539.pub2-BIB0049|cit49","first-page":"31","article-title":"Gangrenous and perforated appendicitis with peritonitis: treatment and bacteriology","volume":"12","author":"Bennion","year":"1990","journal-title":"Clinical Therapeutics"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD004539.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"S724","DOI":"10.1093\/clinids\/7.Supplement_4.S724","article-title":"Aztreonam plus clindamycin versus tobramycin plus clindamycin for the treatment of intraabdominal infections","volume":"7","author":"Birolini","year":"1985","journal-title":"Reviews of Infectious Diseases"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD004539.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000238721","article-title":"Comparison of aztreonam plus clindamycin with tobramycin plus clindamycin in the treatment of intra-abdominal infections","volume":"35","author":"Birolini","year":"1989","journal-title":"Chemotherapy"},{"issue":"Suppl B","key":"10.1002\/14651858.CD004539.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/jac\/14.suppl_B.213","article-title":"Short-term antibiotherapy for peritonitis: prospective, randomized trial comparing cefotaxime-metronidazole and clindamycin-tobramycin","volume":"12","author":"Biron","year":"1984","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"10","key":"10.1002\/14651858.CD004539.pub2-BIB0053|cit53","first-page":"613","article-title":"Ceftazidime\/clindamycin versus tobramycin\/clindamycin in the treatment of intra-abdominal infections","volume":"56","author":"Bubrick","year":"1990","journal-title":"The American Surgeon"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"S676","DOI":"10.1093\/clinids\/4.Supplement_3.S676","article-title":"Moxalactam in the treatment of intraabdominal sepsis and other surgical infections","volume":"4","author":"Busuttil","year":"1982","journal-title":"Review of Infectious Diseases"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0055|cit55","first-page":"223","article-title":"Randomized comparative trial of imipenem\/cilastatin versus aminoglycoside plus amoxycillin plus clindamycin in the treatment of severe intra- and post-operative infections","volume":"19","author":"Cakmakci","year":"1993","journal-title":"Drugs Experimental in Clinical Research"},{"issue":"1 (Part 2)","key":"10.1002\/14651858.CD004539.pub2-BIB0056|cit56","first-page":"221","article-title":"Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection","volume":"93","author":"Canadian Metronidazole-Clindamycin Study Group","year":"1983","journal-title":"Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0057|cit57","first-page":"295-296, 303-30","article-title":"Treatment of intra-abdominal infections: cost comparison of ampicillin\/sulbactam and clindamycin\/gentamicin","volume":"25","author":"Chin","year":"1990","journal-title":"Hospital Formulary"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD004539.pub2-BIB0058|cit58","first-page":"11","article-title":"Imipenem\/cilastatin versus aminoglycoside plus amoxicillin plus clindamycin in the treatment of serious postoperative infections","volume":"52","author":"Christen","year":"1987","journal-title":"Scandinavian Journal of Infectious Diseases"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/jac\/38.3.523","article-title":"Intravenous meropenem versus imipenem\/cilastatin in the treatment of serious bacterial infections in hospitalized patients","volume":"38","author":"Colardyn F and Faulkner KL on behalf of the Meropenem Serious Infection Study Group","year":"1996","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0060|cit60","first-page":"96","article-title":"A multicentre comparison of clindamycin and metronidazole in the treatment of anaerobic infections","volume":"26","author":"Collier","year":"1981","journal-title":"Scandinavian Journal of Infectious Diseases Supplement"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1128\/AAC.38.6.1309","article-title":"Prospective randomized comparison of imipenem monotherapy with imipenem plus netilmicin for treatment of severe infections in nonneutropenic patients","volume":"38","author":"Cometta","year":"1994","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/clinids\/21.3.544","article-title":"Meropenem versus tobramycin plus clindamycin for treatment of intraabdominal infections: Results of a prospective, randomized, double-blind clinical trial","volume":"21","author":"Condon","year":"1995","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/bjs.1800710223","article-title":"A Danish multicenter study: cefoxitin versus ampicillin + metronidazole in perforated appendicitis","volume":"71","author":"The Danish Multicenter Study Group","year":"1984","journal-title":"British Journal of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/j.1875-9114.1988.tb04089.x","article-title":"Randomized trial of imipenem\/cilastatin versus gentamicin plus clindamycin in the treatment of polymicrobial infections","volume":"8","author":"Danziger","year":"1988","journal-title":"Pharmacotherapy"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01963832","article-title":"Prospective randomized study of once-daily versus thrice-daily netilmicin regimens in patients with intraabdominal infections","volume":"9","author":"Vries","year":"1990","journal-title":"European Journal of Clinical Microbiological Infectious Diseases"},{"issue":"Suppl 6A","key":"10.1002\/14651858.CD004539.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"53S","DOI":"10.1016\/S0002-9610(98)00221-9","article-title":"Trovafloxacin in the treatment of intra-abdominal infections: Results of a double-blind, multicenter comparison with imipenem\/cilastatin","volume":"176","author":"Donahue","year":"1998","journal-title":"American Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0067|cit67","first-page":"297","article-title":"Ticarcillin\/clavulanate compared with clindamycin\/gentamicin (with or without ampicillin) for the treatment of intra-abdominal infections in pediatric and adult patients","volume":"61","author":"Dougherty","year":"1995","journal-title":"American Surgeon"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0068|cit68","first-page":"715","article-title":"A prospective randomized controlled trial of cefoxitin versus clindamycin-aminoglycoside in mixed anaerobic-aerobic infections","volume":"154","author":"Drusano","year":"1982","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"Suppl A","key":"10.1002\/14651858.CD004539.pub2-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/jac\/31.suppl_A.79","article-title":"A randomized multicenter trial of piperacillin\/tazobactam versus imipenem\/cilastatin in the treatment of severe intra-abdominal infections","volume":"31","author":"Eklund","year":"1993","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"Suppl B","key":"10.1002\/14651858.CD004539.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jac\/24.suppl_B.147","article-title":"Comparison of the safety and efficacy of parenteral ticarcillin\/clavulanate and clindamycin\/gentamicin in serious intra-abdominal infections","volume":"24","author":"Fink","year":"1989","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0071|cit71","first-page":"36","article-title":"Antibiotic therapy of intra-abdominal sepsis in the elderly: Experience with ticarcillin and clavulanic acid","volume":"172","author":"Fink","year":"1991","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"Suppl A","key":"10.1002\/14651858.CD004539.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/jac\/36.suppl_A.191","article-title":"Meropenem versus imipenem\/cilastatin in intra-abdominal infections requiring surgery","volume":"36","author":"Geroulanos SJ and the Meropenem Study Group","year":"1995","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"Suppl C","key":"10.1002\/14651858.CD004539.pub2-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/jac\/10.suppl_C.191","article-title":"A preliminary report on the use of ceftizoxime vs. clindamycin\/tobramycin for the therapy of intra-abdominal and pelvic infections","volume":"10","author":"Harding","year":"1982","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/00365548409070404","article-title":"Comparative study of netilmicin\/tinidazole versus netilmicin\/clindamycin in the treatment of severe abdominal infections","volume":"16","author":"Henning","year":"1984","journal-title":"Scandinavian Journal of Infectious Diseases"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD004539.pub2-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"S729","DOI":"10.1093\/clinids\/7.Supplement_4.S729","article-title":"Overall clinical experience with aztreonam in the treatment of intraabdominal infections","volume":"7","author":"Henry","year":"1985","journal-title":"Reviews of Infectious Diseases"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0076|cit76","first-page":"43","article-title":"Imipenem therapy for perforated and gangrenous appendicitis","volume":"162","author":"Heseltine","year":"1986","journal-title":"Surgery, Gynecoloy & Obstetrics"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jac\/23.5.773","article-title":"A multicentric study of netilmicin once daily versus thrice daily in patients with appendicitis and other intra-abdominal infections","volume":"23","author":"Hollender","year":"1989","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"Suppl D","key":"10.1002\/14651858.CD004539.pub2-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/jac\/23.suppl_D.47","article-title":"Cefmetazole treatment of intra-abdominal infection","volume":"23","author":"Holloway","year":"1989","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/BF01716286","article-title":"Ciprofloxacin versus cefotaxime regimens for the treatment of intra-abdominal infections","volume":"23","author":"Hoogkamp-Korstanje","year":"1995","journal-title":"Infections"},{"issue":"11","key":"10.1002\/14651858.CD004539.pub2-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/bjs.1800751126","article-title":"Management of severe intra-abdominal sepsis: Single agent antibiotic therapy with cefotetan versus combination therapy with ampicillin, gentamicin and metronidazole","volume":"75","author":"Huizinga","year":"1988","journal-title":"British Journal of Surgery"},{"issue":"Suppl A","key":"10.1002\/14651858.CD004539.pub2-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/jac\/36.suppl_A.179","article-title":"Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections","volume":"36","author":"Huizinga","year":"1995","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"Suppl B","key":"10.1002\/14651858.CD004539.pub2-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/jac\/24.suppl_B.141","article-title":"Ticarcillin\/clavulanate in the treatment of severe peritonitis","volume":"24","author":"Inthorn","year":"1989","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1128\/AAC.42.5.1233","article-title":"Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients","volume":"42","author":"Jaspers","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"9","key":"10.1002\/14651858.CD004539.pub2-BIB0084|cit84","first-page":"467","article-title":"A randomized controlled rial of moxalactam versus clindamycin\/tobramycin in the treatment of mixed anaerobic\/aerobic infections","volume":"52","author":"Joshi","year":"1986","journal-title":"The American Surgeon"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0085|cit85","first-page":"267","article-title":"Antibiotics in acute abdominal surgery. A clinical trial comparing the combination of ampicillin, mecillinam and metronidazole with cefoxitin alone","volume":"152","author":"Kasholm-Tengve","year":"1986","journal-title":"Acta Chirurgica Scandinavica"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD004539.pub2-BIB0086|cit86","first-page":"215","article-title":"Double-blind comparison of metronidazole plus gentamicin and clindamycin plus gentamicin in intra-abdominal infection","volume":"93","author":"Kirkpatrick","year":"1983","journal-title":"Surgery"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0087|cit87","first-page":"54","article-title":"Ceftazidime\/metronidazole versus netilmicin\/metronidazole in the treatment of perforated appendicitis in children","volume":"12","author":"Kooi","year":"1990","journal-title":"Clinical Therapeutics"},{"issue":"Suppl 5A","key":"10.1002\/14651858.CD004539.pub2-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"183S","DOI":"10.1016\/0002-9343(89)90054-5","article-title":"Brief report: Prospective, controlled, randomized, non-blind comparison of intravenous\/oral ciprofloxacin with intravenous ceftazidime in the treatment of severe surgical infections","volume":"87","author":"Leal del Rosal","year":"1989","journal-title":"The American Journal of Medicine"},{"issue":"8","key":"10.1002\/14651858.CD004539.pub2-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archsurg.1985.01390320013002","article-title":"Stratified outcome comparison of clindamycin-gentamicin versus chloramphenicol-gentamicin for treatment of intra-abdominal sepsis","volume":"120","author":"Lennard","year":"1985","journal-title":"Archives of Surgery"},{"issue":"Suppl 5A","key":"10.1002\/14651858.CD004539.pub2-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"160S","DOI":"10.1016\/0002-9343(89)90049-1","article-title":"Randomized, double-blind comparative study of intravenous ciprofloxacin versus ceftazidime in the treatment of serious infections","volume":"87","author":"Levine","year":"1989","journal-title":"The American Journal of Medicine"},{"issue":"Suppl C","key":"10.1002\/14651858.CD004539.pub2-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jac\/10.suppl_C.183","article-title":"Evaluation of ceftizoxime in acute peritonitis","volume":"10","author":"Lou","year":"1982","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0092|cit92","first-page":"397","article-title":"Ceftriaxone\/metronidazole is more effective than ampicillin\/netilmicin\/metronidazole in the treatment of bacterial peritonitis","volume":"157","author":"Luke","year":"1991","journal-title":"European Journal of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1742-1241.1999.tb11696.x","article-title":"Treatment of complicated intra-abdominal infections: Comparison of the tolerability and safety of intravenous\/oral trovafloxacin versus intravenous imipenem\/cilastatin switching to oral amoxycillin\/clavulanic acid","volume":"53","author":"Luke","year":"1999","journal-title":"International Journal of Clinical Practice"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0732-8893(97)00239-3","article-title":"Piperacillin\/tazobactam versus imipenem: A double-blind, randomized formulary feasibility study at a major teaching hospital","volume":"31","author":"Marra","year":"1998","journal-title":"Diagnostic Microbiology & infectious Diseases"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jac\/39.5.631","article-title":"A multi-centre study to compare meropenem and cefotaxime and metronidazole in the treatment of hospitalized patients with serious infections","volume":"39","author":"Mehtar","year":"1997","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/j.1875-9114.1998.tb03836.x","article-title":"Pharmacoeconomic analysis of ampicillin-sulbactam versus cefoxitin in the treatment of intraabdominal infections","volume":"18","author":"Messick","year":"1998","journal-title":"Pharmacotherapy"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0097|cit97","first-page":"536","article-title":"Piperacillin versus gentamicin-clindamycin combination in intra-abdominal infections","volume":"41","author":"Mullick","year":"1987","journal-title":"Current Therapeutic Research - Clinical and Experimental"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0098|cit98","first-page":"423","article-title":"Comparative study of parenteral piperacillin and cefoxitin in the treatment of surgical infections of the abdomen","volume":"157","author":"Najem","year":"1983","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0099|cit99","first-page":"255","article-title":"Piperacillin\/tazobactam versus imipenem\/cilastatin in the treatment of intra-abdominal infections","volume":"176","author":"Niinikoski","year":"1993","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"9","key":"10.1002\/14651858.CD004539.pub2-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1080\/11024159950189393","article-title":"Piperacillin\/tazobactam compared with cefuroxime\/metronidazole in the treatment of intra-abdominal infections","volume":"165","author":"Ohlin","year":"1999","journal-title":"European Journal of Surgery"},{"issue":"9","key":"10.1002\/14651858.CD004539.pub2-BIB0101|cit101","first-page":"598","article-title":"Prospective randomized study of piperacillin\/tazobactam therapy of surgically treated intra-abdominal infection","volume":"59","author":"Polk","year":"1993","journal-title":"American Surgeon"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0102|cit102","first-page":"253","article-title":"The treatment of gynaecological and intra-abdominal infections: A comparative study of cefotetan versus netilmicin plus clindamycin","volume":"7","author":"Poularas","year":"1988","journal-title":"Chemioterapia"},{"issue":"8","key":"10.1002\/14651858.CD004539.pub2-BIB0103|cit103","first-page":"715","article-title":"Perforated appendicitis and antibiotics. A survey and a controlled clinical trial","volume":"136","author":"Raahave","year":"1970","journal-title":"Acta Chirurgica Scandinavica"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/109629600321137","article-title":"Coverage of enterococci in community acquired secondary peritonitis: Results of a randomized trial","volume":"1","author":"Rohrborn","year":"2000","journal-title":"Surgical Infections"},{"issue":"7","key":"10.1002\/14651858.CD004539.pub2-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/bjs.1800810720","article-title":"Minimal antibiotic therapy after emergency abdominal surgery: a prospective study","volume":"81","author":"Schein","year":"1994","journal-title":"British Journal of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/jac\/34.5.813","article-title":"Aspoxicillin versus piperacillin in severe abdominal infections - a comparative phase III study","volume":"34","author":"Scheinin","year":"1994","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00000658-198307000-00007","article-title":"A randomized clinical trial of moxalactam alone versus tobramycin plus clindamycin in abdominal sepsis","volume":"198","author":"Schentag","year":"1983","journal-title":"Annals of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0108|cit108","first-page":"229","article-title":"Cefotetan in the treatment of serious intra-abdominal sepsis: a controlled clinical trial","volume":"VII","author":"Scott","year":"1987","journal-title":"International Journal of Clinical Pharmacological Research"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0109|cit109","first-page":"420","article-title":"Antimicrobial management of surgically treated gangrenous or perforated appendicitis: comparison of cefoxitin and clindamycin-gentamicin","volume":"9","author":"Sirinek","year":"1987","journal-title":"Clinical Therapeutics"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0110|cit110","first-page":"30","article-title":"A randomized trial of ticarcillin and clavulanate versus gentamicin and clindamycin in patients with complicated appendicitis","volume":"172","author":"Sirinek","year":"1991","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0111|cit111","first-page":"235","article-title":"Metronidazole and tobramycin in intra-abdominal sepsis","volume":"155","author":"Smith","year":"1982","journal-title":"Surgery, Gynecology & Obstetrics"},{"issue":"1 Part 2","key":"10.1002\/14651858.CD004539.pub2-BIB0112|cit112","first-page":"217","article-title":"Metronidazole in the treatment of intra-abdominal sepsis","volume":"93","author":"Smith","year":"1983","journal-title":"Surgery"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0113|cit113","doi-asserted-by":"crossref","first-page":"469","DOI":"10.7326\/0003-4819-101-4-469","article-title":"Cefotaxime compared with nafcillin plus tobramycin for serious bacterial infections. A randomized, double-blind trial","volume":"101","author":"Smith","year":"1984","journal-title":"Annals of Internal Medicine"},{"issue":"Suppl 6A","key":"10.1002\/14651858.CD004539.pub2-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0002-9343(85)90106-8","article-title":"Randomized trial of imipenem\/cilastatin versus gentamicin and clindamycin in mixed flora infections","volume":"78","author":"Solomkin","year":"1985","journal-title":"The American Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/00000658-199011000-00004","article-title":"Results of a multicenter trial comparing imipenem\/cilastatin to tobramycin\/clindamycin for intra-abdominal infections","volume":"212","author":"Solomkin","year":"1990","journal-title":"Annals of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000658-199603000-00012","article-title":"Results of a randomized trial comparing sequential intravenous\/oral treatment with ciprofloxacin plus metronidazole to imipenem\/cilastatin for intra-abdominal infections","volume":"223","author":"Solomkin","year":"1996","journal-title":"Annals of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.SLA.0000048551.32606.73","article-title":"Ertapenem versus piperacillin\/tazobactam in the treatment of complicated intraabdominal infections","volume":"237","author":"Solomkin","year":"2003","journal-title":"Annals of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archsurg.1988.01400300060009","article-title":"Moxalactam versus tobramycin-clindamycin. A randomized trial in secondary peritonitis","volume":"123","author":"Stellato","year":"1988","journal-title":"Archives of Surgery"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0119|cit119","first-page":"301","article-title":"Treatment of surgical infections with tobramycin","volume":"41","author":"Stone","year":"1975","journal-title":"The American Surgeon"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1093\/infdis\/137.Supplement.S103","article-title":"Cefamandole in treatment of peritonitis","volume":"137","author":"Stone","year":"1978","journal-title":"Journal of Infectious Diseases"},{"issue":"Suppl A","key":"10.1002\/14651858.CD004539.pub2-BIB0121|cit121","first-page":"67","article-title":"Clinical comparison of cefotaxime versus the combination of gentamicin plus clindamycin in the treatment of peritonitis and similar polymicrobial soft-tissue surgical sepsis","volume":"4","author":"Stone","year":"1981","journal-title":"Clinical Therapeutics"},{"issue":"A","key":"10.1002\/14651858.CD004539.pub2-BIB0122|cit122","first-page":"1","article-title":"Clinical evaluation of cefotaxime versus gentamicin plus clindamycin in the treatment of polymicorbial peritonitis","volume":"5","author":"Stone","year":"1982","journal-title":"Clinical Therapeutics"},{"issue":"Suppl","key":"10.1002\/14651858.CD004539.pub2-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"S439","DOI":"10.1093\/clinids\/4.Supplement_2.S439","article-title":"Clinical comparison of cefotaxime with gentamicin plus clindamycin in the treatment of peritonitis and other soft tissue infections","volume":"4","author":"Stone","year":"1982","journal-title":"Reviews of Infectious Diseases"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD004539.pub2-BIB0124|cit124","first-page":"230","article-title":"Metronidazole in the treatment of surgical sepsis","volume":"93","author":"Stone","year":"1983","journal-title":"Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archsurg.1983.01390020047009","article-title":"Third generation cephalosporins for polymicrobial surgical sepsis","volume":"118","author":"Stone","year":"1983","journal-title":"Archives of Surgery"},{"issue":"4A","key":"10.1002\/14651858.CD004539.pub2-BIB0126|cit126","first-page":"30","article-title":"Ceftriaxone versus combined gentamicin and clindamycin for polymicrobial surgical sepsis","volume":"148","author":"Stone","year":"1984","journal-title":"The American Journal of Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0127|cit127","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/00000658-198103000-00011","article-title":"A randomized comparison of cefoxitin with or without amikacin and clindamycin plus amikacin in surgical sepsis","volume":"193","author":"Tally","year":"1981","journal-title":"Annals of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1128\/AAC.29.2.244","article-title":"Randomized prospective study comparing moxalactam and cefoxitin with or without tobramycin for the treatment of serious surgical infections","volume":"29","author":"Tally","year":"1986","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"9","key":"10.1002\/14651858.CD004539.pub2-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/000313480006600919","article-title":"Complicated appendicitis: Is there a minimum intravenous antibiotic requirement? A prospective randomized trial","volume":"66","author":"Taylor","year":"2000","journal-title":"The American Surgeon"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/109629602762539535","article-title":"Ertapenem versus piperacillin-tazobactam for treatment of mixed anaerobic complicated intra-abdominal, complicated skin and skin structure, and acute pelvic infections","volume":"3","author":"Tellado","year":"2002","journal-title":"Surgical Infections"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1179\/joc.2004.16.1.62","article-title":"Management of complicated appendicitis and comparison of outcome with other primary sites of intra-abdominal infections: Results of a trial comparing ertapenem and piperacillin-tazobactam","volume":"16","author":"Teppler","year":"2004","journal-title":"Journal of Chemotherapy"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0132|cit132","first-page":"57","article-title":"Efficacy and safety of piperacillin\/tazobactam in intra-abdominal infections","volume":"Suppl 573","author":"Vestweber","year":"1994","journal-title":"European Journal of Surgery"},{"issue":"5 Pt 2","key":"10.1002\/14651858.CD004539.pub2-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2165\/00019053-199916050-00011","article-title":"Cost effectiveness of ciprofloxacin plus metronidazole versus imipenem-cilastatin in the treatment of intra-abdominal infections","volume":"16","author":"Walters","year":"1999","journal-title":"Pharmacoeconomics"},{"issue":"Suppl 7","key":"10.1002\/14651858.CD004539.pub2-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"S629","DOI":"10.1093\/clinids\/13.Supplement_7.S629","article-title":"Aztreonam plus clindamycin versus tobramycin plus clindamycin in the treatment of intraabdominal infections","volume":"13","author":"Williams","year":"1991","journal-title":"Reviews of Infectious Diseases"},{"issue":"5A","key":"10.1002\/14651858.CD004539.pub2-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9610(88)80215-0","article-title":"Cephalosporin therapy in intraabdominal infections. A multicenter randomized, comparative study of cefotetan, moxalactam and cefoxitin","volume":"155","author":"Wilson","year":"1988","journal-title":"The American Journal of Surgery"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD004539.pub2-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1093\/clinids\/24.Supplement_2.S197","article-title":"Results of a randomized, multicenter trial of meropenem versus clindamycin\/tobramycin for the treatment of intra-abdominal infections","volume":"24","author":"Wilson","year":"1997","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0002-9343(80)90386-1","article-title":"Piperacillin therapy for serious bacterial infections","volume":"69","author":"Winston","year":"1980","journal-title":"The American Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0138|cit138","first-page":"248","article-title":"Prospective randomized study of two different doses of clindamycin admixed with gentamicin in the management of perforated appendicitis","volume":"59","author":"Yellin","year":"1993","journal-title":"The American Surgeon"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0924-8579(02)00160-7","article-title":"Ertapenem monotherapy versus combination therapy with ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections in adults","volume":"20","author":"Yellin","year":"2002","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF01643754","article-title":"A randomised prospective controlled study of ciprofloxacin with metronidazole versus amoxicillin\/clavulanic acid with metronidazole in the treatment of intra-abdominal infection","volume":"19","author":"Yoshioka","year":"1991","journal-title":"Infection"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0141|cit141","volume-title":"Cochrane Reviewers\u2019 Handbook 4.2.2 [updated March 2004]. In: The Cochrane Library, Issue 1, 2004","author":"Alderson","year":"2004"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0142|cit142","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/archsurg.1983.01390030017003","article-title":"Prognosis in generalized peritonitis. Relation to cause and risk factors","volume":"118","author":"Bohnen","year":"1983","journal-title":"Archives of Surgery"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1001\/archsurg.1992.01420010097015","article-title":"Guidelines for clinical care: anti-infective agents for intra-abdominal infection. A Surgical Infection Society policy statement","volume":"127","author":"Bohnen","year":"1992","journal-title":"Archives of Surgery"},{"issue":"11","key":"10.1002\/14651858.CD004539.pub2-BIB0144|cit144","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1046\/j.1365-2168.1999.01258.x","article-title":"Surgical management of severe secondary peritonitis","volume":"86","author":"Bosscha","year":"1999","journal-title":"British Journal of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0145|cit145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archsurg.1993.01420140070011","article-title":"Surgical Infection Society intra-abdominal infection study. Prospective evaluation of management techniques and outcome","volume":"128","author":"Christou","year":"1993","journal-title":"Archives of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0146|cit146","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/archsurg.137.1.15","article-title":"The POSSUM system of surgical audit","volume":"137","author":"Copeland","year":"2002","journal-title":"Archives of Surgery"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0147|cit147","doi-asserted-by":"crossref","DOI":"10.1002\/9780470693926","volume-title":"Systematic reviews in health care: Meta-analysis in context","author":"Egger","year":"2001"},{"issue":"7","key":"10.1002\/14651858.CD004539.pub2-BIB0148|cit148","first-page":"277","article-title":"Antibiotic therapy in intra-abdominal infections: a review on randomised clinical trials","volume":"6","author":"Holzheimer","year":"2001","journal-title":"European Journal of Medical Research"},{"issue":"12","key":"10.1002\/14651858.CD004539.pub2-BIB0149|cit149","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/bjs.1800791216","article-title":"Comparison of POSSUM with APACHE II for prediction of outcome from a surgical high-dependency unit","volume":"79","author":"Jones","year":"1992","journal-title":"British Journal of Surgery"},{"issue":"10","key":"10.1002\/14651858.CD004539.pub2-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Critical Care Medicine"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0151|cit151","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/109629602761624171","article-title":"The Surgical Infection Society guidelines on antimicrobial therapy for intra-abdominal infections: an executive summary","volume":"3","author":"Mazuski","year":"2002","journal-title":"Surgical Infections"},{"issue":"3","key":"10.1002\/14651858.CD004539.pub2-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/109629602761624180","article-title":"The Surgical Infection Society guidelines on antimicrobial therapy for intra-abdominal infections: evidence for the recommendations","volume":"3","author":"Mazuski","year":"2002","journal-title":"Surgical Infections"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0153|cit153","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/bjs.1800820429","article-title":"Outcome of patients with abdominal sepsis treated in an intensive care unit","volume":"82","author":"McLauchlan","year":"1995","journal-title":"British Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD004539.pub2-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00268-002-6705-x","article-title":"Factors affecting mortality in generalized postoperative peritonitis: multivariate analysis in 96 patients","volume":"27","author":"Mulier","year":"2003","journal-title":"World Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0155|cit155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/clinids\/15.1.72","article-title":"Enterococcal infection in surgical patients: the mystery continues","volume":"15","author":"Nichols","year":"1992","journal-title":"Clinical Infectious Diseases"},{"issue":"5","key":"10.1002\/14651858.CD004539.pub2-BIB0156|cit156","first-page":"267","article-title":"Prospective evaluation of prognostic scoring systems in peritonitis. Peritonitis Study Group","volume":"159","author":"Ohmann","year":"1993","journal-title":"European Journal of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD004539.pub2-BIB0157|cit157","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archsurg.1996.01430180067014","article-title":"Prognosis in intra-abdominal infections. Multivariate analysis on 604 patients","volume":"131","author":"Pacelli","year":"1996","journal-title":"Archives of Surgery"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0158|cit158","volume-title":"Source control: A guide to the management of surgical infections","author":"Schein","year":"2002"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00000658-198407000-00005","article-title":"Antibiotics trials in intra-abdominal infections. A critical evaluation of study design and outcome reporting","volume":"200","author":"Solomkin","year":"1984","journal-title":"Annals of Surgery"},{"key":"10.1002\/14651858.CD004539.pub2-BIB0160|cit160","volume-title":"Intra-abdominal infections","author":"Tellado","year":"2000"},{"issue":"2","key":"10.1002\/14651858.CD004539.pub2-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/BF01664876","article-title":"Etappenlavage: advanced diffuse peritonitis managed by planned multiple laparotomies utilizing zippers, slide fastener, and Velcro analogue for temporary abdominal closure","volume":"14","author":"Wittmann","year":"1990","journal-title":"World Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD004539.pub2-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00000658-199607000-00003","article-title":"Management of secondary peritonitis","volume":"224","author":"Wittmann","year":"1996","journal-title":"Annals of Surgery"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004539.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T10:14:26Z","timestamp":1722680066000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004539.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Colorectal Cancer Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2005,4,20]]},"references-count":162,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004539.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,20]]}}}