{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:56:27Z","timestamp":1771563387293,"version":"3.50.1"},"publisher-location":"Chichester, UK","reference-count":43,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd004970.pub4","type":"reference-entry","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T15:51:58Z","timestamp":1276617118000},"source":"Crossref","is-referenced-by-count":7,"title":["Interventions for replacing missing teeth: treatment of perimplantitis"],"prefix":"10.1002","author":[{"given":"Marco","family":"Esposito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriella","family":"Grusovin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Tzanetea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Piattelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen V","family":"Worthington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,16]]},"reference":[{"issue":"5","key":"10.1002\/14651858.CD004970.pub4-BIB1|cit1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bjoms.2004.06.005","article-title":"Sustained release of doxycycline for the treatment of peri-implantitis: randomised controlled trial","volume":"42","author":"B\u00fcchter","year":"2004","journal-title":"British Journal of Oral and Maxillofacial Surgery"},{"issue":"3","key":"10.1002\/14651858.CD004970.pub4-BIB2|cit2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-0501.2005.01141.x","article-title":"Treatment of peri-implantitis by the Vector system","volume":"16","author":"Karring","year":"2005","journal-title":"Clinical Oral Implants Research"},{"issue":"1","key":"10.1002\/14651858.CD004970.pub4-BIB3|cit3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0501.2004.01084.x","article-title":"Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part I: clinical outcome","volume":"16","author":"Romeo","year":"2005","journal-title":"Clinical Oral Implants Research"},{"issue":"2","key":"10.1002\/14651858.CD004970.pub4-BIB4|cit4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1600-0501.2006.01318.x","article-title":"Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part II: radiographic outcome","volume":"18","author":"Romeo","year":"2007","journal-title":"Clinical Oral Implants Research"},{"issue":"1","key":"10.1002\/14651858.CD004970.pub4-BIB5|cit5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-0501.2004.01051.x","article-title":"Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis: a pilot study","volume":"16","author":"Schwarz","year":"2005","journal-title":"Clinical Oral Implants Research"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB6|cit6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00784-006-0070-3","article-title":"Nonsurgical treatment of moderate and advanced periimplantitis lesions: a controlled clinical study","volume":"10","author":"Schwarz","year":"2006","journal-title":"Clinical Oral Investigations"},{"issue":"7","key":"10.1002\/14651858.CD004970.pub4-BIB7|cit7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1600-051X.2006.00936.x","article-title":"Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series","volume":"33","author":"Schwarz","year":"2006","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1002\/14651858.CD004970.pub4-BIB8|cit8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1600-051X.2009.01443.x","article-title":"Surgical regenerative treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: a four-year clinical follow-up report","volume":"36","author":"Schwarz","year":"2009","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1002\/14651858.CD004970.pub4-BIB9|cit9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-051X.2007.01168.x","article-title":"Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane","volume":"35","author":"Schwarz","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"issue":"3","key":"10.1002\/14651858.CD004970.pub4-BIB10|cit10","first-page":"173","article-title":"Effects of non-surgical treatment modalities on peri-implantitis","volume":"37","author":"Tang","year":"2002","journal-title":"Chinese Journal of Stomatology"},{"issue":"3","key":"10.1002\/14651858.CD004970.pub4-BIB11|cit11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00008505-200009030-00010","article-title":"Conventional versus laser-assisted therapy of periimplantitis: a five-year comparative study","volume":"9","author":"Bach","year":"2000","journal-title":"Implant Dentistry"},{"issue":"5","key":"10.1002\/14651858.CD004970.pub4-BIB12|cit12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1600-051X.2006.00919.x","article-title":"Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial","volume":"33","author":"Renvert","year":"2006","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1002\/14651858.CD004970.pub4-BIB13|cit13","first-page":"154","article-title":"Treatment of incipient peri-implant infections using topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement","volume":"6 Suppl 4","author":"Renvert","year":"2004","journal-title":"Journal of the International Academy of Periodontology"},{"key":"10.1002\/14651858.CD004970.pub4-BIB14|cit14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1902\/jop.2008.070347","article-title":"Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial","volume":"79","author":"Renvert","year":"2008","journal-title":"Journal of Periodontology"},{"key":"10.1002\/14651858.CD004970.pub4-BIB15|cit15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1600-051X.2009.01421.x","article-title":"Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results","volume":"36","author":"Renvert","year":"2009","journal-title":"Journal of Clinical Periodontololgy"},{"key":"10.1002\/14651858.CD004970.pub4-BIB16|cit16","first-page":"181","article-title":"Effect of Dentomycin on clinical and microbiological parameters of peri-implantitis","volume":"75 (Special Iss","author":"Tarpey","year":"1996","journal-title":"Journal of Dental Research"},{"key":"10.1002\/14651858.CD004970.pub4-BIB17|cit17","volume-title":"Osseointegrated Implants in the Treatment of the Edentulous Jaw. Experience from a 10-year Period","author":"Br\u00e5nemark","year":"1977"},{"key":"10.1002\/14651858.CD004970.pub4-BIB18|cit18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD004970.pub4-BIB19|cit19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB20|cit20","first-page":"473","article-title":"Differential diagnosis and treatment strategies for biologic complications and failing oral implants: a review of the literature","volume":"14","author":"Esposito","year":"1999","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB21|cit21","article-title":"Interventions for replacing missing teeth: different types of dental implants","author":"Esposito","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD004970.pub4-BIB22|cit22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0895-4356(92)90054-Q","article-title":"Variance imputation for overviews of clinical trials with continuous response","volume":"45","author":"Follmann","year":"1992","journal-title":"Journal of Clinical Epidemiology"},{"issue":"1","key":"10.1002\/14651858.CD004970.pub4-BIB23|cit23","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003069.pub3","article-title":"Interventions for replacing missing teeth: maintaining and recovering soft tissue health around dental implants","author":"Grusovin","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD004970.pub4-BIB24|cit24","first-page":"374","article-title":"Lethal photosensitization, autogenous bone, and e-PTFE membrane for the treatment of peri-implantitis: preliminary results","volume":"15","author":"Haas","year":"2000","journal-title":"The International Journal of Oral and Maxillofacial Implants"},{"key":"10.1002\/14651858.CD004970.pub4-BIB25|cit25","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions version 5.0.2 (updated September 2009). The Cochrane Collaboration, 2009 Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"issue":"2","key":"10.1002\/14651858.CD004970.pub4-BIB26|cit26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-0501.1996.070208.x","article-title":"Loss of osseointegration caused by occlusal load of oral implants. A clinical and radiographic study in monkeys","volume":"7","author":"Isidor","year":"1996","journal-title":"Clinical Oral Implants Research"},{"issue":"10","key":"10.1002\/14651858.CD004970.pub4-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1902\/jop.2003.74.10.1415","article-title":"Five-year clinical, microbiological, and radiological outcome following treatment of peri-implantitis in man","volume":"74","author":"Leonhardt","year":"2003","journal-title":"Journal of Periodontology"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB28|cit28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1034\/j.1600-0501.1992.030402.x","article-title":"Antimicrobial treatment of peri-implant infections","volume":"3","author":"Mombelli","year":"1992","journal-title":"Clinical Oral Implants Research"},{"key":"10.1002\/14651858.CD004970.pub4-BIB29|cit29","series-title":"Proceedings of the 3rd European Workshop on Periodontology. Implant Dentistry","first-page":"281","article-title":"Prevention and therapy of peri-implant infections","author":"Mombelli","year":"1999"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB30|cit30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1034\/j.1600-0501.2001.012004287.x","article-title":"Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results","volume":"12","author":"Mombelli","year":"2001","journal-title":"Clinical Oral Implants Research"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB31|cit31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1034\/j.1600-0501.1994.050409.x","article-title":"Experimentally induced peri-implant mucositis. A clinical study in humans","volume":"5","author":"Pontoriero","year":"1994","journal-title":"Clinical Oral Implants Research"},{"issue":"6","key":"10.1002\/14651858.CD004970.pub4-BIB32|cit32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1034\/j.1600-051X.2003.00296.x","article-title":"Treatment of peri-implant infections: a literature review","volume":"30","author":"Roos-Jans\u00e5ker","year":"2003","journal-title":"Journal of Clinical Periodontology"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB33|cit33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-051X.2006.00906.x","article-title":"Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions","volume":"33","author":"Roos-Jans\u00e5ker","year":"2006","journal-title":"Journal of Clinical Periodontology"},{"issue":"7","key":"10.1002\/14651858.CD004970.pub4-BIB34|cit34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1600-051X.2007.01102.x","article-title":"Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: a prospective cohort study","volume":"34","author":"Roos-Jans\u00e5ker","year":"2007","journal-title":"Journal of Clinical Periodontology"},{"issue":"8","key":"10.1002\/14651858.CD004970.pub4-BIB35|cit35","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1600-051X.2007.01098.x","article-title":"Submerged healing following surgical treatment of peri-implantitis: a case series","volume":"34","author":"Roos-Jans\u00e5ker","year":"2007","journal-title":"Journal Clinical Periodontology"},{"key":"10.1002\/14651858.CD004970.pub4-BIB36|cit36","unstructured":"Sahrmann P Attin T Schmidlin PR Regenerative treatment of peri-implantitis using bone substitutes and membrane: A systematic review Clinical Implant Dentistry and Related Research"},{"key":"10.1002\/14651858.CD004970.pub4-BIB37|cit37","first-page":"140","article-title":"Surgical treatment of peri-implantitis","volume":"19 Suppl","author":"Schou","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"issue":"3","key":"10.1002\/14651858.CD004970.pub4-BIB38|cit38","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003069","article-title":"Interventions for replacing missing teeth: maintaining and re-establishing healthy tissues around dental implants","author":"Esposito","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004970.pub4-BIB39|cit39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.0906-6713.2003.03317.x","article-title":"Maintaining and re-establishing health around osseointegrated oral implants: a Cochrane systematic review comparing the efficacy of various treatments","volume":"33","author":"Esposito","year":"2003","journal-title":"Periodontology 2000"},{"issue":"4","key":"10.1002\/14651858.CD004970.pub4-BIB40|cit40","article-title":"Interventions for replacing missing teeth: treatment of perimplantitis","author":"Esposito","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD004970.pub4-BIB41|cit41","article-title":"Interventions for replacing missing teeth: treatment of perimplantitis","author":"Esposito","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD004970.pub4-BIB42|cit42","article-title":"Interventions for replacing missing teeth: treatment of perimplantitis","author":"Esposito","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004970.pub4-BIB43|cit43","first-page":"111","article-title":"The efficacy of interventions to treat perimplantitis. \u00a0A Cochrane systematic review of randomized controlled clinical trials","volume":"1","author":"Esposito","year":"2008","journal-title":"European Journal of Oral Implantology"}],"updated-by":[{"DOI":"10.1002\/14651858.cd004970.pub5","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD004970.pub4\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:42:56Z","timestamp":1628545376000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD004970.pub4"}},"subtitle":[],"editor":[{"given":"Marco","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,6,16]]},"references-count":43,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004970.pub4","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD004970.pub5","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2010,6,16]]}}}