{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:11:26Z","timestamp":1768003886108,"version":"3.49.0"},"update-to":[{"DOI":"10.1002\/14651858.cd004996.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T00:00:00Z","timestamp":1169596800000}}],"reference-count":46,"publisher":"Wiley","issue":"1","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd004996.pub3","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T08:35:23Z","timestamp":1169714123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antioxidant supplements for non-alcoholic fatty liver disease and\/or steatohepatitis"],"prefix":"10.1002","volume":"2010","author":[{"given":"Flavio","family":"Lirussi","sequence":"first","affiliation":[{"name":"WHO Regional Office for Europe, European Office for Investment for Health and Development; Scientist, Socioeconomic Determinants of NCDs; Campo Santo Stefano, San Marco 2847 Venice Italy I-30124"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau; Servei de Cardiologia; Sant Antoni Mar\u00eda Claret 167 Barcelona Spain 08025"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Orando","sequence":"additional","affiliation":[{"name":"Universit\u00e1 Degli Studi di Firenze; Instituto di Anestesia e Rianimazione; Azienda Ospedaliero-Universitaria di Careggi Viale della Maternit\u00e1 Firenze Italy 50134"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Orlando","sequence":"additional","affiliation":[{"name":"University of Padua Medical School; Department of Medical and Surgical Sciences; via Giustiani, 2 Padova Italy 35128"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Angelico","sequence":"additional","affiliation":[{"name":"IV Divisione di Clinica Medica - Policlinico Umberto 1; Dipartimento di Medicina Sperimentale e Patologia; Centro per l'Atero-trombosi, Universit\u00e0 La Sapienza viale del Policlinico 155 Rome Italy 00161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,24]]},"reference":[{"key":"10.1002\/14651858.CD004996.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1572-0241.2005.41583.x","article-title":"A randomized controlled trial of metformin versus Vitamin E or prescriptive diet in nonalcoholic fatty liver disease","volume":"100","author":"Bugianesi","year":"2005","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1111\/j.1572-0241.2003.08699.x","article-title":"Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis","volume":"98","author":"Harrison","year":"2003","journal-title":"The American Journal of Gastroenterology"},{"issue":"2","key":"10.1002\/14651858.CD004996.pub3-BIB0003|cit3","first-page":"722","article-title":"Efficacy and safety of oral betaine glucuronate in non-alcoholic steatohepatitis","volume":"50","author":"Miglio","year":"2000","journal-title":"Leber-Therapeutika"},{"issue":"10","key":"10.1002\/14651858.CD004996.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1046\/j.1440-1746.2003.03156.x","article-title":"N-acetylcysteine in the treatment of non-alcoholic steatohepatitis","volume":"18","author":"Pamuk","year":"2003","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"4","key":"10.1002\/14651858.CD004996.pub3-BIB0005|cit5","first-page":"269","article-title":"The clinical comparison of reduced glutathione and DanNingPlan in the treatment of nonalcoholic steatohepatitis","volume":"4","author":"Rui","year":"2001","journal-title":"Chinese General Practice"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0006|cit6","first-page":"48","article-title":"Vitamin E treatment in pediatric obesity-related liver disease: a randomized study","volume":"38","author":"Vajro","year":"2004","journal-title":"Journal of Pediatric Gastroenterology"},{"issue":"9","key":"10.1002\/14651858.CD004996.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1111\/j.1572-0241.2001.04129.x","article-title":"Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study","volume":"96","author":"Abdelmalek","year":"2001","journal-title":"The American Journal of Gastroenterology"},{"issue":"7-8","key":"10.1002\/14651858.CD004996.pub3-BIB0008|cit8","first-page":"290","article-title":"Glutathione in the treatment of chronic fatty liver diseases","volume":"86","author":"Dentico","year":"1995","journal-title":"Recenti Progressi in Medicina"},{"issue":"10","key":"10.1002\/14651858.CD004996.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1046\/j.1365-2036.2001.01083.x","article-title":"Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study","volume":"15","author":"Hasegawa","year":"2001","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"2","key":"10.1002\/14651858.CD004996.pub3-BIB0010|cit10","first-page":"413","article-title":"Cytokines and NASH: a pilot study of the effect of lifestyle modification and vitamin E","volume":"38","author":"Kugelmas","year":"2003","journal-title":"Liver Failure and Liver Disease"},{"issue":"6","key":"10.1002\/14651858.CD004996.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0022-3476(00)05040-X","article-title":"Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study","volume":"136","author":"Lavine","year":"2000","journal-title":"The Journal of Pediatrics"},{"issue":"2","key":"10.1002\/14651858.CD004996.pub3-BIB0012|cit12","first-page":"92","article-title":"Diisopropylamine dichloroacetate in the treatment of nonalcoholic fatty liver disease: a multicenter random double-blind controlled trial","volume":"13","author":"Lu","year":"2005","journal-title":"Chinese Journal of Hepatology"},{"issue":"3","key":"10.1002\/14651858.CD004996.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00004836-200303000-00015","article-title":"Probucol in the treatment of nonalcoholic steatohepatitis","volume":"36","author":"Merat","year":"2003","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S1542-3565(04)00457-4","article-title":"A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis","volume":"2","author":"Sanyal","year":"2004","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0015|cit15","first-page":"193","article-title":"Effects of new pharmacological complex (sylibin+vitamin E+phospolipids) on some markers of metabolic syndrome and of a liver fibrosis in patients with non-alcoholic fatty liver disease: a preliminary open pilot study","volume":"51","author":"Trappoliere","year":"2005","journal-title":"Minerva Gastroenterologica e Dietologica"},{"issue":"Supplement 2","key":"10.1002\/14651858.CD004996.pub3-BIB0016|cit16","first-page":"4","article-title":"A 2-years multicenter randomized placebo-controlled study testing UDCA in combination with vitamin E to treat NASH","volume":"12","author":"Dufour","year":"2005","journal-title":"Journal of Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0017|cit17","unstructured":"Angelico F Burattin M Alessandri C Del Ben M Lirussi F Drugs improving insulin resistance for non-alcoholic fatty liver disease and\/or non-alcoholic steatohepatitis Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"16","author":"Angulo","year":"2002","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD004996.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1053\/bega.2002.0327","article-title":"Treatment of non-alcoholic steatohepatitis","volume":"16","author":"Angulo","year":"2002","journal-title":"Best Practice & Research. Clinical Gastroenterology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0016-5085(94)90235-6","article-title":"Non-alcoholic steatohepatitis: an expanded clinical entity","volume":"107","author":"Bacon","year":"1994","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1002\/14651858.CD004996.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hep.510230513","article-title":"Prediction of risk of liver disease by alcohol intake, sex and age: a prospective population study","volume":"23","author":"Becker","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archsurg.133.1.84","article-title":"Unsuspected cirrhosis discovered during obesity operations","volume":"133","author":"Brolin","year":"1998","journal-title":"Archives of Surgery"},{"issue":"9","key":"10.1002\/14651858.CD004996.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/hep.510290347","article-title":"Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease","volume":"29","author":"Calwell","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2001-12927","article-title":"Etiopathogenesis of non-alcoholic steatohepatitis","volume":"21","author":"Chitturi","year":"2001","journal-title":"Seminars in Liver Diseases"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/jhep.2002.30692","article-title":"NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome","volume":"35","author":"Chitturi","year":"2002","journal-title":"Hepatology"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD004996.pub3-BIB0027|cit27","first-page":"S5","article-title":"The epidemiology of nonalcoholic fatty liver disease in adults","volume":"40","author":"Clark","year":"2006","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"3","key":"10.1002\/14651858.CD004996.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/sim.4780060325","article-title":"Methods for combining randomized clinical trials: strengths and limitations","volume":"6","author":"DeMets","year":"1987","journal-title":"Statistics in Medicine"},{"issue":"7109","key":"10.1002\/14651858.CD004996.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1440-1746.2003.02989.x","article-title":"Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?","volume":"18","author":"Farrell","year":"2003","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"2 Suppl 1","key":"10.1002\/14651858.CD004996.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0032|cit32","unstructured":"Gluud C Als-Nielsen B D'Amico G Fingerhut A Gluud LL Khan S Hepato-Biliary Group About The Cochrane Collaboration (Cochrane Review Groups (CRGs)) 2006, Issue 3. Art. No.: LIVER"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0033|cit33","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006] The Cochrane Library, Issue 4, 2006 Chichester, UK John Wiley & sons, Ltd"},{"issue":"9","key":"10.1002\/14651858.CD004996.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1464-5491.2005.01582.x","article-title":"Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults","volume":"22","author":"Jimba","year":"2005","journal-title":"Diabetic Medicine"},{"issue":"11","key":"10.1002\/14651858.CD004996.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-135-11-200112040-00010","article-title":"Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses","volume":"135","author":"Kjaergard","year":"2001","journal-title":"Annals of Internal Medicine"},{"issue":"6","key":"10.1002\/14651858.CD004996.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD004996.pub3-BIB0037|cit37","first-page":"S11","article-title":"Natural history of nonalcoholic steatohepatitis","volume":"40","author":"Liou","year":"2006","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"3","key":"10.1002\/14651858.CD004996.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00004836-200203000-00013","article-title":"Update on nonalcoholic fatty liver disease","volume":"34","author":"McCullough","year":"2002","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"1","key":"10.1002\/14651858.CD004996.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-142-1-200501040-00110","article-title":"Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality","volume":"142","author":"Miller","year":"2005","journal-title":"Annals of Internal Medicine"},{"issue":"9128","key":"10.1002\/14651858.CD004996.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0140-6736(98)01085-X","article-title":"Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?","volume":"352","author":"Moher","year":"1998","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD004996.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1053\/jhep.2003.50193","article-title":"Nonalcoholic steatohepatitis: summary of an AASLD single topic conference","volume":"37","author":"Neuschwander-Tetri","year":"2003","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/jhep.2000.17894","article-title":"Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study","volume":"32","author":"Poonawala","year":"2000","journal-title":"Hepatology"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0043|cit43","unstructured":"Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2003"},{"issue":"5","key":"10.1002\/14651858.CD004996.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/jama.1995.03520290060030","article-title":"Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials","volume":"273","author":"Schulz","year":"1995","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD004996.pub3-BIB0045|cit45","unstructured":"Wang RT Koretz RL Yee HF Weight reduction for non-alcoholic fatty liver (Protocol) The Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD004996.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1053\/jhep.2002.32483","article-title":"Nonalcoholic fatty liver disease: an agenda for clinical research","volume":"35","author":"Younossi","year":"2002","journal-title":"Hepatology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD004996.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T19:31:27Z","timestamp":1754681487000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD004996.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Hepato-Biliary Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2007,1,24]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd004996.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,24]]}}}