{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:45:22Z","timestamp":1767134722241,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd005009","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T00:00:00Z","timestamp":1192579200000}}],"reference-count":48,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd005009.pub2","type":"journal-article","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T12:19:30Z","timestamp":1192018770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intermittent versus continuous androgen suppression for prostatic cancer"],"prefix":"10.1002","volume":"2012","author":[{"given":"Paulo","family":"De Conti","sequence":"first","affiliation":[{"name":"Av Jo\u00e3o Franceschi, 1335 - Jardim Alvorada Ja\u00fa S\u00e3o Paulo Brazil 17210150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro N","family":"Atallah","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo \/ Escola Paulista de Medicina; Brazilian Cochrane Centre; Rua Pedro de Toledo 598 Vila Clementino S\u00e3o Paulo SP Brazil CEP 04039-001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homero O","family":"Arruda","sequence":"additional","affiliation":[{"name":"Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo GO","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo; Brazilian Cochrane Centre; Rua Pedro de Toledo 598 S\u00e3o Paulo SP Brazil 04039-001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina P","family":"El Dib","sequence":"additional","affiliation":[{"name":"Botucatu School of Medicine, UNESP - Univ Estadual Paulista; Department of Surgery; Distrito de Rubi\u00e3o J\u00fanior, s\/n Botucatu S\u00e3o Paulo Brazil 18603-970"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J","family":"Wilt","sequence":"additional","affiliation":[{"name":"VAMC; General Internal Medicine (111-0); One Veterans Drive Minneapolis Minnesota USA 55417"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,17]]},"reference":[{"issue":"Suppl","key":"10.1002\/14651858.CD005009.pub2-BIB0001|cit1","first-page":"A 531","article-title":"Phase III study of intermittent MAB versus continuous MAB international cooperative study","volume":"419","author":"Calais","year":"2002","journal-title":"European Urology"},{"issue":"3","key":"10.1002\/14651858.CD005009.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3816\/CGC.2002.n.018","article-title":"Intermittent versus continuous total androgen blockade in the treatment of patients with advanced hormone-naive prostate cancer: results of a prospective randomized multicenter trial","volume":"1","author":"Leval","year":"2002","journal-title":"Clinical Prostate Cancer"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0003|cit3","article-title":"Intermittent androgen suppression in the treatment of advanced prostate cancer","author":"Schasfoort","year":"2002","journal-title":"EAU TULP"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0004|cit4","first-page":"276","article-title":"Metastatic adenocarcinoma of the prostate: comparison between continuous and intermittent hormonal treatment","volume":"26","author":"Hering","year":"2000","journal-title":"Braz J Urol"},{"issue":"1","key":"10.1002\/14651858.CD005009.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/pros.20171","article-title":"Effectiveness of adjuvant intermittent endocrine therapy following neoadjuvant endocrine therapy and external beam radiation therapy in men with locally advanced prostate cancer","volume":"63","author":"Yamanaka","year":"2005","journal-title":"Prostate"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1159\/000020353","article-title":"Intermittent androgen suppression in the treatment of metastatic prostate cancer","volume":"38","author":"Bouchot","year":"2000","journal-title":"European Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0090-4295(98)00547-0","article-title":"Intermittent androgen suppression in the management of prostate cancer","volume":"53","author":"Crook","year":"1999","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1046\/j.1464-410X.2003.04015.x","article-title":"Intermittent androgen suppression in patients with prostate cancer","volume":"91","author":"Taille","year":"2003","journal-title":"BJU Int"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0090-4295(99)80092-2","article-title":"Intermittent androgen suppression in the treatment of prostate cancer: a preliminary report","volume":"45","author":"Goldenberg","year":"1995","journal-title":"Urology"},{"issue":"3","key":"10.1002\/14651858.CD005009.pub2-BIB0010|cit10","first-page":"287","article-title":"Clinical Experience: with intermittent androgen suppression in prostate cancer: minimum of 3 years' follow-up","volume":"3","author":"Goldenberg","year":"1999","journal-title":"Molecular Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0090-4295(01)01114-1","article-title":"Intermittent androgen deprivation: update of cycling characteristics in patients without clinically apparent metastatic prostate cancer","volume":"58","author":"Grossfeld","year":"2001","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1097\/01.ju.0000154780.72631.85","article-title":"A prospective analysis of the time to normalization of serum androgens following 6 months of androgen deprivation therapy in patients on a randomized phase III clinical trial using limited hormonal therapy","volume":"173","author":"Gulley","year":"2005","journal-title":"The Journal of Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0090-4295(96)00381-0","article-title":"Intermittent androgen suppression with leuprolide and flutamide for prostate cancer: a pilot study","volume":"48","author":"Higano","year":"1996","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1464-410x.1998.00521.x","article-title":"A pilot study of intermittent androgen deprivation in advanced prostate cancer","volume":"81","author":"Horwich","year":"1998","journal-title":"British Journal of Urology"},{"issue":"24","key":"10.1002\/14651858.CD005009.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1200\/JCO.2006.06.4246","article-title":"Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162)","volume":"24","author":"Hussain","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1002\/1097-0142(19861201)58:11<2546::AID-CNCR2820581131>3.0.CO;2-N","article-title":"Intermittent endocrine therapy for advanced prostate cancer","volume":"587","author":"Klotz","year":"1986","journal-title":"Cancer"},{"issue":"5","key":"10.1002\/14651858.CD005009.pub2-BIB0017|cit17","first-page":"335","article-title":"A phase II study of intermittent androgen suppression (IAS) in men with a rising serum PSA after radiation for localized prostate cancer","volume":"159","author":"Klotz","year":"1998","journal-title":"Journal of Urology"},{"issue":"2","key":"10.1002\/14651858.CD005009.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.pcan.4500792","article-title":"The relationship between the androgen receptor CAG repeat polymorphism length and the response to intermittent androgen suppression therapy for advanced prostate cancer","volume":"8","author":"Klotz","year":"2005","journal-title":"Prostate Cancer and Prostatic Diseases"},{"issue":"(Suppl 1)","key":"10.1002\/14651858.CD005009.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000052304","article-title":"Intermittent complete androgen blockade in PSA relapse after radical prostatectomy and incidental prostate cancer","volume":"35","author":"Kurek","year":"1999","journal-title":"Eur Urol"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000079690","article-title":"Long-Term outcomes in patients with prostate cancer managed with intermittent androgen suppression","volume":"73","author":"Lane","year":"2004","journal-title":"Urology International"},{"issue":"52","key":"10.1002\/14651858.CD005009.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/sj.pcan.4500317","article-title":"Intermittent versus continuous hormone deprivation in metastatic prostate cancer: preliminary data from an ongoing European study","volume":"2","author":"Mottet","year":"1999","journal-title":"Prostate Cancer and Prostatic Diseases"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0090-4295(96)00373-1","article-title":"Intermittent androgen deprivation after PSA-complete response as a strategy to reduce induction of hormone-resistant prostate cancer","volume":"49","author":"Oliver","year":"1997","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.urology.2004.03.032","article-title":"Intermittent androgen suppression for locally advanced and metastatic prostate cancer: preliminary report of a prospective multicenter study","volume":"64","author":"Sato","year":"2004","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s003450000155","article-title":"Intermittent androgen deprivation (IAD) in patients with biochemical failure after radical retropubic prostatectomy (RRP) for clinically localized prostate cancer","volume":"18","author":"Sciarra","year":"2000","journal-title":"World Journal of Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1634\/theoncologist.5-1-45","article-title":"Intermittent androgen deprivation in prostate cancer patients: factors predictive of prolonged time off therapy","volume":"5","author":"Strum","year":"2000","journal-title":"Oncologist"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0090-4295(98)00251-9","article-title":"Current status of intermittent androgen suppression in the treatment of prostate cancer","volume":"52","author":"Theyer","year":"1998","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0027|cit27","unstructured":"Ongoing study"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0028|cit28","unstructured":"Ongoing study"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0029|cit29","unstructured":"Ongoing study"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0030|cit30","unstructured":"Ongoing study"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0031|cit31","unstructured":"American Cancer Society [online] Atlanta Available from URL: http:\/\/cancer.org 2006"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0032|cit32","doi-asserted-by":"crossref","unstructured":"Akakura K Bruchovsky N Goldenberg SL Rennie PS Buckley AR Sullivan LD Effects of intermitent androgen supression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen Cancer 1993 2782 90","DOI":"10.1002\/1097-0142(19930501)71:9<2782::AID-CNCR2820710916>3.0.CO;2-Z"},{"issue":"7066","key":"10.1002\/14651858.CD005009.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/bmj.313.7066.1200","article-title":"Detecting skewness fron summary information.","volume":"313","author":"Altman","year":"1996","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/(SICI)1097-0215(19960917)67:6<785::AID-IJC6>3.0.CO;2-N","article-title":"Cell proliferation and apoptosis during prostatic tumor xenograft involution and regrowth after castration","volume":"67","author":"Bladou","year":"1996","journal-title":"Int J. Cancer"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0035|cit35","first-page":"2275","article-title":"Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma","volume":"50","author":"Bruchovsky","year":"1990","journal-title":"Cancer Res"},{"issue":"(5 Suppl)","key":"10.1002\/14651858.CD005009.pub2-BIB0036|cit36","first-page":"1287","article-title":"Aphase II study of intermittent androgen suppression (IAS) in men with a rising serum PSA after radiation for localized prostate cancer","volume":"158","author":"Bruchovsky","year":"1998","journal-title":"J Urol"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"(S3):S9","DOI":"10.1038\/sj.pcan.4500335","article-title":"Phase III study on intermittent MAB vs cont\u00ednuos MAB: an international co-operative study","volume":"2","author":"Carneiro","year":"1999","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"5","key":"10.1002\/14651858.CD005009.pub2-BIB0038|cit38","first-page":"423","article-title":"Optimal Search Strategy for Clinical Trials in the Latin American and Caribbean Health Science Literature Database (LILACS)","volume":"115","author":"Castro","year":"1997","journal-title":"S\u00e3o Paulo Medical Journal"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0039|cit39","unstructured":"Clarke M Oxman AD Selection bias. Cochrane Reviewers' Handbook 4.1.6 [updated January 2003] Section 6.3 In The Cochrane Library 2003"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/bmj.309.6964.1286","article-title":"Identifying relevant studies for systematic reviews","volume":"309","author":"Dickersin","year":"1994","journal-title":"B M J"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0090-4295(97)00488-3","article-title":"Intermittent androgen deprivation for clinically localized prostate cancer: initial experience","volume":"51","author":"Grossfeld","year":"1998","journal-title":"Urology"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archsurg.1941.01210140043004","article-title":"The effects of castration on advanced carcinoma of the prostate gland","volume":"43","author":"Huggins","year":"1941","journal-title":"Arch Surg"},{"issue":"(1)","key":"10.1002\/14651858.CD005009.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jaddad","year":"1996","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0090-4295(02)01639-4","article-title":"Can combined androgen blockade provide long-term control or possible cure of localized cancer?","volume":"60","author":"Labrie","year":"2002","journal-title":"Urology"},{"issue":"(Suppl 1)","key":"10.1002\/14651858.CD005009.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000052305","article-title":"Intermittent complete androgen blockade in metastatic prostate cancer","volume":"35","author":"Rambeaud","year":"1999","journal-title":"Eur Urol"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0960-0760(90)90430-S","article-title":"Loss of androgen dependence is associated with an increase in tumorigenic stem cells and resistance to cell-death genes","volume":"37","author":"Rennie","year":"1990","journal-title":"J. Steroid Biochem Mol Biol"},{"key":"10.1002\/14651858.CD005009.pub2-BIB0047|cit47","first-page":"282a","article-title":"Intermittent androgen suppression delays time to androgen-independent progression in the LN CaP prostate tumor model","volume":"153","author":"Sato","year":"1995","journal-title":"J. Urol."},{"issue":"A","key":"10.1002\/14651858.CD005009.pub2-BIB0048|cit48","first-page":"701","article-title":"Intermittent versus continuous total androgen blockade in the treatment of patients with advanced hormone na\u00efve prostate cancer: results of randomized prospective multicenter clinical trial","volume":"168","author":"Waltregny","year":"2002","journal-title":"Urol"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD005009.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T19:11:33Z","timestamp":1731870693000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD005009.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Urology Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2007,10,17]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd005009.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,17]]}}}