{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:11:33Z","timestamp":1775067093973,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd005612.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000}}],"reference-count":43,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd005612.pub4","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T11:31:41Z","timestamp":1562671901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pregabalin add-on for drug-resistant focal epilepsy"],"prefix":"10.1002","author":[{"given":"Mariangela","family":"Panebianco","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, University of Liverpool; Department of Molecular and Clinical Pharmacology; Clinical Sciences Centre for Research and Education, Lower Lane Liverpool UK L9 7LJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Bresnahan","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Liverpool; Department of Molecular and Clinical Pharmacology; Clinical Sciences Centre for Research and Education, Lower Lane Liverpool UK L9 7LJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Hemming","sequence":"additional","affiliation":[{"name":"University of Birmingham; Public Health, Epidemiology and Biostatistics; Edgbaston Birmingham UK B15 2TT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony G","family":"Marson","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Liverpool; Department of Molecular and Clinical Pharmacology; Clinical Sciences Centre for Research and Education, Lower Lane Liverpool UK L9 7LJ"},{"name":"The Walton Centre NHS Foundation Trust; Liverpool UK"},{"name":"Liverpool Heath Partners; Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD005612.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.0013-9580.2004.31203.x","article-title":"Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures","volume":"45","author":"Arroyo","year":"2004","journal-title":"Epilepsia"},{"issue":"91","key":"10.1002\/14651858.CD005612.pub4-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.eplepsyres.2010.05.008","article-title":"A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures","volume":"1","author":"Baulac","year":"2010","journal-title":"Epilepsy Research"},{"issue":"3","key":"10.1002\/14651858.CD005612.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1212\/01.WNL.0000150932.48688.BE","article-title":"Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy","volume":"64","author":"Beydoun","year":"2005","journal-title":"Neurology"},{"issue":"12","key":"10.1002\/14651858.CD005612.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/j.1528-1167.2005.00341.x","article-title":"Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study","volume":"46","author":"Elger","year":"2005","journal-title":"Epilepsia"},{"issue":"10","key":"10.1002\/14651858.CD005612.pub4-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1212\/01.WNL.0000068024.20285.65","article-title":"Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures","volume":"60","author":"French","year":"2003","journal-title":"Neurology"},{"issue":"8","key":"10.1002\/14651858.CD005612.pub4-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/epi.12690","article-title":"Adjunctive use of controlled-release pregabalin in adults with treatment-resistant partial seizures: a double-blind, randomized, placebo-controlled trial","volume":"55","author":"French","year":"2014","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1212\/WNL.0000000000003118","article-title":"Adjunctive pregabalin vs gabapentin for focal seizures","volume":"87","author":"French","year":"2016","journal-title":"Neurology"},{"issue":"3","key":"10.1002\/14651858.CD005612.pub4-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1528-1167.2008.01954.x","article-title":"Pregabalin add-on therapy using a flexible, optimized dose schedule in refractory partial epilepsies: a double-blind, randomized, placebo-controlled, multicenter trial","volume":"50","author":"Lee","year":"2009","journal-title":"Epilepsia"},{"issue":"7","key":"10.1002\/14651858.CD005612.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/epi.12679","article-title":"Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial","volume":"55","author":"Zaccara","year":"2014","journal-title":"Epilepsia"},{"issue":"1","key":"10.1002\/14651858.CD005612.pub4-BIB0010|cit10","first-page":"49","article-title":"Comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy","volume":"9","author":"Taghdiri","year":"2015","journal-title":"Iranian Journal of Child Neurology"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD005612.pub4-BIB0011|cit11","first-page":"172","article-title":"Comparative dosage adjustment of levetiracetam and pregabalin as adjunctive therapy for refractory partial epilepsy with polytherapy. A prospective observational randomized study","volume":"47","author":"Russi","year":"2006","journal-title":"Epilepsia"},{"issue":"Suppl 7","key":"10.1002\/14651858.CD005612.pub4-BIB0012|cit12","first-page":"69","article-title":"Open label, randomised, cross-over trial in epilepsy patients with cryptogenic focal, refractory epilepsy, comparing levetiracetam and pregabalin as add-on therapy","volume":"484","author":"Tata","year":"2007","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0013|cit13","unstructured":"Bakhshandeh MK Comparison of the effect of zonisamide and pregabalin as adjunctive therapy in control of interactable epilepsy in children Iranian Registry of Clinical Trials 2012"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD005612.pub4-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0013-9580.2004.455003.x","article-title":"Pregabalin pharmacology and its relevance to clinical practice","volume":"45","author":"Ben-Menachem","year":"2004","journal-title":"Epilepsia"},{"issue":"10","key":"10.1002\/14651858.CD005612.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/11536200-000000000-00000","article-title":"A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin","volume":"49","author":"Bockbrader","year":"2010","journal-title":"Clinical Pharmacokinetics"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.seizure.2009.07.005","article-title":"Retention rate of pregabalin in drug-resistant epilepsy: 1-year follow-up, single-centre observation in 105 consecutive, adult patients","volume":"18","author":"Brandt","year":"2009","journal-title":"Seizure"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1528-1167.2005.19204.x","article-title":"Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy","volume":"46","author":"Brodie","year":"2005","journal-title":"Epilepsia"},{"issue":"8968","key":"10.1002\/14651858.CD005612.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0140-6736(95)91208-8","article-title":"Remission of epilepsy: results from the National General Practice Study of Epilepsy","volume":"346","author":"Cockerell","year":"1995","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0019|cit19","first-page":"104","article-title":"Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships","volume":"10","author":"Delahoy","year":"2010","journal-title":"BioMed Central"},{"issue":"2","key":"10.1002\/14651858.CD005612.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0028-3908(01)00172-1","article-title":"Inhibition of neuronal (Ca2+) influx by gabapentin and pregabalin in human neocortex","volume":"42","author":"Fink","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0021|cit21","unstructured":"Available from gradepro.org GRADEpro Guideline Development Tool McMaster University, 2015 (developed by Evidence Prime, Inc.)"},{"issue":"12","key":"10.1002\/14651858.CD005612.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1586\/ern.09.114","article-title":"Management of the patient with medically refractory epilepsy","volume":"9","author":"Granata","year":"2009","journal-title":"Expert Review of Neurotherapeutics"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.seizure.2005.11.005","article-title":"Pregabalin: a new antiepileptic drug for refractory epilepsy","volume":"15","author":"Hamandi","year":"2006","journal-title":"Seizure"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0024|cit24","volume-title":"Epilepsy: Frequency, Causes and Consequences","author":"Hauser","year":"1990"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0025|cit25","unstructured":"Higgins JPT Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"4","key":"10.1002\/14651858.CD005612.pub4-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1528-1157.1989.tb05317.x","article-title":"Guidelines for clinical evaluation of antiepileptic drugs","volume":"30","author":"Commission on Antiepileptic Drugs of the International League Against Epilepsy","year":"1989","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/bmj.c365","article-title":"The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews","volume":"340","author":"Kirkham","year":"2010","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0028|cit28","unstructured":"Lefebvre C Manheimer E Glanville J Chapter 6: Searching for studies. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from handbook.cochrane.org"},{"issue":"4","key":"10.1002\/14651858.CD005612.pub4-BIB0029|cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002896.pub2","article-title":"Vagus nerve stimulation for partial seizures","author":"Panebianco","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD005612.pub4-BIB0030|cit30","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001909.pub2","article-title":"Lamotrigine add-on for drug-resistant partial epilepsy","author":"Ramaratnam","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD005612.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2147\/NDT.S4716","article-title":"Pregabalin for the management of partial epilepsy","volume":"4","author":"Ryvlin","year":"2008","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"g6501","DOI":"10.1136\/bmj.g6501","article-title":"Selective reporting bias of harm outcomes within studies: findings from a cohort of systematic reviews","volume":"349","author":"Saini","year":"2014","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD005612.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0034|cit34","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A editor(s) Grade Working Group GRADE handbook for grading quality of evidence and strength of recommendations Available from www.guidelinedevelopment.org\/handbook"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0035|cit35","unstructured":"StataCorp LP Stata Statistical Software: Release 14 2015"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/1097-0258(20001230)19:24<3417::AID-SIM614>3.0.CO;2-L","article-title":"A multilevel model framework for meta-analysis of clinical trials with binary outcomes","volume":"19","author":"Turner","year":"2000","journal-title":"Statistics in Medicine"},{"issue":"Spec No. 1","key":"10.1002\/14651858.CD005612.pub4-BIB0037|cit37","first-page":"5S376","article-title":"Quality-of-life scales for patients with drug-resistant partial epilepsy","volume":"160","author":"Villeneuve","year":"2004","journal-title":"Reviews of Neurology (Paris)"},{"issue":"7","key":"10.1002\/14651858.CD005612.pub4-BIB0038|cit38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010541.pub2","article-title":"Surgery for epilepsy","author":"West","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD005612.pub4-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s00228-012-1213-x","article-title":"The adverse event profile of pregabalin across different disorders: a meta-analysis","volume":"68","author":"Zaccara","year":"2012","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"10","key":"10.1002\/14651858.CD005612.pub4-BIB0040|cit40","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009429.pub2","article-title":"Pregabalin monotherapy for epilepsy","author":"Zhou","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD005612.pub4-BIB0041|cit41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005612","article-title":"Pregabalin add-on for drug-resistant partial epilepsy","author":"Lozsadi","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD005612.pub4-BIB0042|cit42","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005612.pub2","article-title":"Pregabalin add-on for drug-resistant partial epilepsy","author":"Pulman","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD005612.pub4-BIB0043|cit43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005612.pub3","article-title":"Pregabalin add-on for drug-resistant partial epilepsy","author":"Pulman","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd005612.pub5","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD005612.pub4\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:51:36Z","timestamp":1628545896000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD005612.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Epilepsy Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,9]]},"references-count":43,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd005612.pub4","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD005612.pub5","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,9]]}}}