{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:20:50Z","timestamp":1793136050780,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006259","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000}}],"reference-count":58,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006259.pub2","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T01:28:58Z","timestamp":1446859738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery"],"prefix":"10.1002","volume":"2015","author":[{"given":"Emily","family":"Cabourne","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust; 162 City Road London UK EC1V 2PD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan CK","family":"Clarke","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust; 162 City Road London UK EC1V 2PD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio G","family":"Schlottmann","sequence":"additional","affiliation":[{"name":"Organizacion Medica de Investigacion; Uruguay 725 PB Ciudad de Buenos Aires Argentina C1015ABO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R","family":"Evans","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine; Cochrane Eyes and Vision Group, ICEH; Keppel Street London UK WC1E 7HT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"issue":"9","key":"10.1002\/14651858.CD006259.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0161-6420(95)30875-5","article-title":"Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up","volume":"102","author":"Katz","year":"1995","journal-title":"Ophthalmology."},{"issue":"3","key":"10.1002\/14651858.CD006259.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0161-6420(92)31951-7","article-title":"Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery","volume":"99","author":"Skuta","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1002\/14651858.CD006259.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1001\/archopht.1991.01080120077030","article-title":"Trabeculectomy with mitomycin. A comparative study with fluorouracil","volume":"109","author":"Kitazawa","year":"1991","journal-title":"Archives of Ophthalmology."},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0161-6420(95)31051-2","article-title":"5-Fluorouracil and mitomycin C in pseudophakic patients","volume":"102","author":"Lamping","year":"1995","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2147\/OPTH.S17328","article-title":"Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: A randomized clinical trial","volume":"5","author":"Mostafaei","year":"2011","journal-title":"Clinical Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD006259.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00061198-199804000-00003","article-title":"Risk of hypotony after primary trabeculectomy with antifibrotic agents in a black west African population","volume":"7","author":"Singh","year":"1998","journal-title":"Journal of Glaucoma."},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0002-9394(14)70991-2","article-title":"Trabeculectomy with intraoperative 5-fluorouracil vs mitomycin C","volume":"123","author":"Singh","year":"1997","journal-title":"American Journal of Ophthalmology."},{"key":"10.1002\/14651858.CD006259.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/S0161-6420(00)00391-2","article-title":"Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil. Prospective randomized clinical trial","volume":"107","author":"Singh","year":"2000","journal-title":"Ophthalmology."},{"issue":"3","key":"10.1002\/14651858.CD006259.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0420.2006.00810.x","article-title":"The role of antimetabolites in filtration surgery for neovascular glaucoma: intermediate-term follow-up","volume":"85","author":"Sisto","year":"2007","journal-title":"Acta Ophthalmologica Scandinavica"},{"issue":"2","key":"10.1002\/14651858.CD006259.pub2-BIB0010|cit10","first-page":"209","article-title":"Comparative study on intraoperative low dose MMC versus intraoperative 5-FU in primary open angle glaucoma","volume":"75","author":"Uva","year":"1996","journal-title":"Bollettino di Oculistica"},{"issue":"4","key":"10.1002\/14651858.CD006259.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0002-9394(02)01627-6","article-title":"A prospective randomized trial comparing intraoperative 5-fluorouracil vs mitomycin C in primary trabeculectomy","volume":"134","author":"WuDunn","year":"2002","journal-title":"American Journal of Ophthalmology."},{"key":"10.1002\/14651858.CD006259.pub2-BIB0012|cit12","first-page":"347","article-title":"Application of mitomycin C and 5-Fluorouracil in the glaucoma filtering surgery","volume":"19","author":"Xinyu","year":"2001","journal-title":"Chinese Ophthalmic Research"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0013|cit13","first-page":"336","article-title":"Intraoperative mitomycin versus postoperative 5-fluorouracil in primary glaucoma filtering surgery","volume":"27","author":"Zadok","year":"1995","journal-title":"Annals of Ophthalmology Glaucoma"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0014|cit14","first-page":"24","article-title":"Assessment and modulation of bleb vascularity after enhanced trabeculectomy in high-risk patients","volume":"31","author":"Ashworth","year":"2003","journal-title":"Clinical and Experimental Ophthalmology"},{"issue":"5","key":"10.1002\/14651858.CD006259.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archopht.1995.01100050044028","article-title":"Effect of mitomycin C and fluorouracil-supplemented trabeculectomies on the anterior segment","volume":"113","author":"Dreyer","year":"1995","journal-title":"Archives of Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0016|cit16","first-page":"43","article-title":"Influence on tear film postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery","volume":"37","author":"Li","year":"2001","journal-title":"Chinese Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/bjo.84.6.586","article-title":"Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 1 Intraocular pressure control and complications","volume":"84","author":"Membrey","year":"2000","journal-title":"British Journal of Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/bjo.85.6.696","article-title":"Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 2 Visual field progression","volume":"85","author":"Membrey","year":"2001","journal-title":"British Journal of Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3341\/kjo.1994.8.1.6","article-title":"The effects of intraoperative mitomycin-C or 5-fluorouracil on glaucoma filtering surgery","volume":"8","author":"Oh","year":"1994","journal-title":"Korean Journal of Ophthalmology"},{"issue":"5","key":"10.1002\/14651858.CD006259.pub2-BIB0020|cit20","first-page":"441","article-title":"Comparative study of chemotherapy agents as contribution in chronic simple glaucoma surgery","volume":"65","author":"Rodriguez-Bermejo","year":"1993","journal-title":"Archivos de la Sociedad Espanola de Oftalmologia"},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0021|cit21","first-page":"38","article-title":"Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil","volume":"15","author":"Liu","year":"2015","journal-title":"International Eye Science"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0022|cit22","first-page":"485","article-title":"A comparative study between mitomycin and 5-FU to combined surgery. [Portuguese]","volume":"54","author":"Susanna Jr","year":"1995","journal-title":"Revista Brasileira De Oftalmologia"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0023|cit23","first-page":"140","article-title":"Prognosis for trabeculectomy with mitomycin C. [Japanese]","volume":"48","author":"Yamamoto","year":"1997","journal-title":"Folia Ophthalmologica Japonica"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0024|cit24","first-page":"730","article-title":"Mytomycin C versus 5-fluorouracil for trabeculectomy: A systematic review","volume":"10","author":"Abdu","year":"2010","journal-title":"Chinese Journal of Evidence-Based Medicine"},{"issue":"7","key":"10.1002\/14651858.CD006259.pub2-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0161-6420(98)97013-0","article-title":"The Advanced Glaucoma Intervention Study (AGIS): 4. Comparison of treatment outcomes within race. Seven-year results","volume":"105","author":"The Advanced Glaucoma Intervention Study","year":"1998","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/112067219700700109","article-title":"Clinical evaluation of the effect of mitomycin-C in re-operation for primary open angle glaucoma","volume":"7","author":"Andreanos","year":"1997","journal-title":"European Journal of Ophthalmology"},{"issue":"9","key":"10.1002\/14651858.CD006259.pub2-BIB0027|cit27","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004399.pub3","article-title":"Medical versus surgical interventions for open angle glaucoma","author":"Burr","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD006259.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9394(68)91288-9","article-title":"Trabeculectomy. Preliminary report of a new method","volume":"66","author":"Cairns","year":"1968","journal-title":"American Journal of Ophthalmology"},{"issue":"4","key":"10.1002\/14651858.CD006259.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0161-6420(97)30246-2","article-title":"A randomized study of mitomycin augmentation in combined phacoemulsification and trabeculectomy","volume":"104","author":"Carlson","year":"1997","journal-title":"Ophthalmology"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0002-9394(98)00223-2","article-title":"Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures","volume":"126","author":"Collaborative Normal-Tension Glaucoma Study Group","year":"1998","journal-title":"American Academy of Ophthalmology"},{"issue":"11","key":"10.1002\/14651858.CD006259.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/S0161-6420(96)30405-3","article-title":"A placebo-controlled, double-masked evaluation of mitomycin C in combined glaucoma and cataract procedures","volume":"103","author":"Cohen","year":"1996","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD006259.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00061198-199606000-00009","article-title":"Low-dose mitomycin C trabeculectomy in patients with advanced glaucoma","volume":"5","author":"Costa","year":"1996","journal-title":"Journal of Glaucoma"},{"issue":"3","key":"10.1002\/14651858.CD006259.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archopht.120.3.297","article-title":"Incidence of late-onset bleb-related complications following trabeculectomy with mitomycin","volume":"120","author":"DeBry","year":"2002","journal-title":"Archives of Ophthalmology"},{"issue":"3","key":"10.1002\/14651858.CD006259.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/0974-9233.56220","article-title":"The Moorfields Safer Surgery System","volume":"16","author":"Dhingra","year":"2009","journal-title":"Middle East African Journal of Ophthalmology"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0035|cit35","unstructured":"European Glaucoma Society Terminology and guidelines for glaucoma www.oogheelkunde.org\/uploads\/4D\/w6\/4Dw6MftS95uSq8OajRtEDQ\/EGS-2nd.pdf"},{"issue":"8","key":"10.1002\/14651858.CD006259.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/ceo.12097","article-title":"Mitomycin C versus 5-fluorouracil as an adjunctive treatment for trabeculectomy: a meta-analysis of randomized clinical trials","volume":"41","author":"Fendi","year":"2013","journal-title":"Clinical and Experimental Ophthalmology"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0002-9394(89)90853-2","article-title":"Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group","volume":"108","author":"The Fluorouracil Filtering Surgery Study Group","year":"1989","journal-title":"American Journal of Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD006259.pub2-BIB0038|cit38","first-page":"130","article-title":"How to identify randomized controlled trials in MEDLINE: ten years on","volume":"94","author":"Glanville","year":"2006","journal-title":"Journal of the Medical Library Association"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0161-6420(94)31223-1","article-title":"5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study","volume":"101","author":"Goldenfeld","year":"1994","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD006259.pub2-BIB0040|cit40","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001132.pub2","article-title":"5-Fluorouracil for glaucoma surgery","author":"Green","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD006259.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Archives of Ophthalmology"},{"issue":"11","key":"10.1002\/14651858.CD006259.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0043|cit43","unstructured":"Higgins JPT Altman DG Sterne JAC (editors) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"6","key":"10.1002\/14651858.CD006259.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archopht.120.6.701","article-title":"The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma","volume":"120","author":"Kass","year":"2002","journal-title":"Archives of Ophthalmology"},{"issue":"2","key":"10.1002\/14651858.CD006259.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/jop.2011.0117","article-title":"Intraoperative mitomycin C versus intraoperative 5-fluorouracil for trabeculectomy: a systematic review and meta-analysis","volume":"28","author":"Lin","year":"2012","journal-title":"Journal of Ocular Pharmacology and Therapeutics"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bmj.38506.594977.E0","article-title":"Treatment of ocular hypertension and open angle glaucoma: meta-analysis of randomised controlled trials","volume":"331","author":"Maier","year":"2005","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD006259.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/112067219700700108","article-title":"Low-dosage mitomycin C as an adjunct to trabeculectomy. A prospective controlled study","volume":"7","author":"Martini","year":"1997","journal-title":"European Journal of Ophthalmology"},{"issue":"10","key":"10.1002\/14651858.CD006259.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0161-6420(94)31120-1","article-title":"Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma","volume":"101","author":"Migdal","year":"1994","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1002\/14651858.CD006259.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/archopht.1992.01080200052023","article-title":"A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas","volume":"110","author":"Ophir","year":"1992","journal-title":"Archives of Ophthalmology"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0050|cit50","unstructured":"The Nordic Cochrane Centre. The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"8","key":"10.1002\/14651858.CD006259.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archopht.1997.01100160139001","article-title":"A long-term dose-response study of mitomycin in glaucoma filtration surgery","volume":"115","author":"Robin","year":"1997","journal-title":"Archives of Ophthalmology"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0052|cit52","first-page":"238","article-title":"A prospective, randomized study of 5-fluorouracil and filtration surgery","volume":"85","author":"Ruderman","year":"1987","journal-title":"Transactions of the American Ophthalmological Society"},{"issue":"10","key":"10.1002\/14651858.CD006259.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0161-6420(95)30832-9","article-title":"Adjunctive subconjunctival mitomycin C in glaucoma triple procedure","volume":"102","author":"Shin","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0161-6420(98)94032-5","article-title":"The role of adjunctive mitomycin C in secondary glaucoma triple procedure as compared to primary glaucoma triple procedure","volume":"105","author":"Shin","year":"1998","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1002\/14651858.CD006259.pub2-BIB0055|cit55","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003167.pub3","article-title":"Medical interventions for primary open angle glaucoma and ocular hypertension","author":"Vass","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD006259.pub2-BIB0056|cit56","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002897.pub2","article-title":"Intraoperative Mitomycin C for glaucoma surgery","author":"Wilkins","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD006259.pub2-BIB0057|cit57","first-page":"32","article-title":"The effect of mitomycin C on filtration surgery of glaucoma with poor prognosis","volume":"32","author":"Wu","year":"1996","journal-title":"Zhonghua Yan Ke Za Zhi"},{"issue":"4","key":"10.1002\/14651858.CD006259.pub2-BIB0058|cit58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006259","article-title":"Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery","author":"Clarke","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD006259.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T17:52:25Z","timestamp":1642441945000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006259.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Eyes and Vision Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006259.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,6]]}}}