{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:40:37Z","timestamp":1784616037826,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006273.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000}}],"reference-count":74,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006273.pub4","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:54:06Z","timestamp":1695963246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Medically assisted hydration for adults receiving palliative care"],"prefix":"10.1002","volume":"2023","author":[{"given":"Emma J","family":"Buchan","sequence":"additional","affiliation":[{"name":"Queensland Health; Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Haywood","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences, Griffith University; Gold Coast Australia"},{"name":"Mater Research Institute \u2013 The University of Queensland; Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Syrmis","sequence":"additional","affiliation":[{"name":"Department of Palliative Care; St Vincent\u2019s Private Hospital; Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Good","sequence":"additional","affiliation":[{"name":"Mater Research Institute \u2013 The University of Queensland; Brisbane Australia"},{"name":"Department of Palliative Care; St Vincent's Private Hospital; Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"10.1002\/14651858.CD006273.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1200\/JCO.2005.04.069","article-title":"Effects of parenteral hydration in terminally ill cancer patients: a preliminary study","volume":"23","author":"Bruera","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0002|cit2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1200\/jco.2012.44.6518","article-title":"Parenteral hydration in patients with advanced cancer: a multicenter, double-blind, placebo-controlled randomized trial","volume":"21","author":"Bruera","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.12968\/ijpn.2000.6.8.9060","article-title":"Hypodermoclysis for control of dehydration in terminal-stage cancer","volume":"6","author":"Cerchietti","year":"2000","journal-title":"International Journal of Palliative Nursing"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"733-43","DOI":"10.1177\/0269216317741572","article-title":"A cluster randomised feasibility trial of clinically assisted hydration in cancer patients in the last days of life","volume":"32","author":"Davies","year":"2018","journal-title":"Palliative Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0005|cit5","first-page":"337","article-title":"End-of-life issues in advanced dementia: Part 2: management of poor nutritional intake, dehydration, and pneumonia","volume":"61","author":"Arcand","year":"2015","journal-title":"Canadian Family Physician"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0006|cit6","doi-asserted-by":"publisher","first-page":"206","DOI":"10.5301\/NTM.2014.12866","article-title":"Nutrition and\/or hydration at the end of life","volume":"32","author":"Bozzetti","year":"2014","journal-title":"Nutritional Therapy and Metabolism"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s00520-014-2591-7","article-title":"Nutrition, hydration, and patient's preferences at the end of life","volume":"23","author":"Bozzetti","year":"2015","journal-title":"Supportive Care in Cancer"},{"issue":"10","key":"10.1002\/14651858.CD006273.pub4-BIB0008|cit8","first-page":"E1","article-title":"Dehydration in terminal illness: Which path forward?","volume":"67","author":"Brar","year":"2018","journal-title":"The Journal of Family Practice"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD006273.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"TPS320","DOI":"10.1200\/jco.2010.28.15_suppl.tps320","article-title":"A randomized, controlled trial of parenteral hydration in patients with advanced cancer","volume":"28","author":"Bruera","year":"2010","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00520-015-2703-z","article-title":"Author's response to: Bozzetti F, nutrition, hydration, and patient's preferences at the end of life","volume":"23","author":"B\u00fckki","year":"2015","journal-title":"Supportive Care in Cancer"},{"issue":"21-22","key":"10.1002\/14651858.CD006273.pub4-BIB0011|cit11","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.1111\/jocn.15036","article-title":"Availability and perceived usefulness of guidelines and protocols for subcutaneous hydration in palliative care settings","volume":"28","author":"Caba\u00f1ero-Mart\u00ednez","year":"2019","journal-title":"Journal of Clinical Nursing"},{"issue":"2","key":"10.1002\/14651858.CD006273.pub4-BIB0012|cit12","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1177\/0148607116676593","article-title":"Subcutaneous infusion of fluids for hydration or nutrition: a review","volume":"42","author":"Caccialanza","year":"2018","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"e7150","DOI":"10.5867\/medwave.2018.01.7149","article-title":"Is parenteral hydration beneficial in terminally ill cancer patients?","volume":"18","author":"Canihuante","year":"2018","journal-title":"Medwave"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0014|cit14","first-page":"14","article-title":"Subcutaneous rehydration in patients in terminal phase of dementia","volume":"154","author":"Chalany","year":"2015","journal-title":"Casopis Lekaru Ceskych"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006273.pub4-BIB0015|cit15","first-page":"A480","article-title":"The incidence of artificial feeding tube complications in non surgical upper GI cancer patients","volume":"64","author":"Chowdhury","year":"2015","journal-title":"Gut"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD006273.pub4-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"9025","DOI":"10.1200\/jco.2012.30.15_suppl.9025","article-title":"Parenteral hydration (PH) in advanced cancer patients: a multi-center, double-blind, placebo-controlled randomized trial","volume":"30","author":"Dalal","year":"2012","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0017|cit17","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/s13063-015-0988-3","article-title":"Alternative forms of hydration in patients with cancer in the last days of life: study protocol for a randomised controlled trial","volume":"16","author":"Davies","year":"2015","journal-title":"Trials"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.clnu.2016.02.006","article-title":"ESPEN guideline on ethical aspects of artificial nutrition and hydration","volume":"35","author":"Druml","year":"2016","journal-title":"Clinical Nutrition"},{"issue":"9-10","key":"10.1002\/14651858.CD006273.pub4-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/jocn.13683","article-title":"How and why are subcutaneous fluids administered in an advanced illness population: a systematic review","volume":"26","author":"Forbat","year":"2017","journal-title":"Journal of Clinical Nursing"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/bmjspcare-2013-000562","article-title":"What influences attitudes towards clinically assisted hydration in the care of dying patients? A review of the literature","volume":"5","author":"Gent","year":"2015","journal-title":"BMJ Supportive and Palliative Care"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0021|cit21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006273.pub3","article-title":"Medically assisted hydration for adult palliative care patients","author":"Good","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"31 Suppl 1","key":"10.1002\/14651858.CD006273.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1200\/JCO.2017.35.31_suppl.82","article-title":"Is it possible for caregivers to administer subcutaneous hydration to patients with advanced cancer at home? Feasibility and perceptions","volume":"35","author":"Grez","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"11","key":"10.1002\/14651858.CD006273.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/jjco\/hyw105","article-title":"Guidelines for parenteral fluid management for terminal cancer patients","volume":"46","author":"Higashiguchi","year":"2016","journal-title":"Japanese Journal of Clinical Oncology"},{"issue":"12","key":"10.1002\/14651858.CD006273.pub4-BIB0024|cit24","first-page":"558","article-title":"Artificial hydration at the end of life - treating the patient, family or physician","volume":"44","author":"Ho","year":"2015","journal-title":"Annals of the Academy of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/SPC.0000000000000171","article-title":"The last days of life: symptom burden and impact on nutrition and hydration in cancer patients","volume":"9","author":"Hui","year":"2015","journal-title":"Current Opinion in Supportive and Palliative care"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"S274","DOI":"10.1016\/S0959-8049(13)70061-3","article-title":"Oral nutritional support can shorten the duration of parenteral hydration in end-of-life cancer patients: a randomized exploratory trial","volume":"49","author":"Ishiki","year":"2013","journal-title":"European Journal of Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"105-11","DOI":"10.1080\/01635581.2015.976312","article-title":"Oral nutritional support can shorten the duration of parenteral hydration in end-of-life cancer patients: a randomized controlled trial","volume":"67","author":"Ishiki","year":"2015","journal-title":"Nutrition and Cancer"},{"issue":"5","key":"10.1002\/14651858.CD006273.pub4-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.mcna.2016.04.019","article-title":"The role of intravenous fluids and enteral or parenteral nutrition in patients with life-limiting Illness","volume":"100","author":"Lembeck","year":"2016","journal-title":"The Medical Clinics of North America"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0029|cit29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1136\/bmjspcare-2018-001729","article-title":"Hydration and symptoms in the last days of life","volume":"11","author":"Lokker","year":"2021","journal-title":"BMJ Supportive and Palliative Care"},{"issue":"9","key":"10.1002\/14651858.CD006273.pub4-BIB0030|cit30","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/ggi.13741","article-title":"International review of national-level guidelines on end-of-life care with focus on the withholding and withdrawing of artificial nutrition and hydration","volume":"19","author":"Mayers","year":"2019","journal-title":"Geriatrics and Gerontology International"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s00520-002-0358-z","article-title":"Fluid status of terminally ill cancer patients with intestinal obstruction: an exploratory observational study","volume":"10","author":"Morita","year":"2002","journal-title":"Supportive Care in Cancer"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/annonc\/mdi121","article-title":"Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies","volume":"16","author":"Morita","year":"2005","journal-title":"Annals of Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006273.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jpainsymman.2005.06.015","article-title":"Artificial hydration therapy, laboratory findings, and fluid balance in terminally ill patients with abdominal malignancies","volume":"31","author":"Morita","year":"2006","journal-title":"Journal of Pain and Symptom Management"},{"issue":"9","key":"10.1002\/14651858.CD006273.pub4-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/jpm.2013.0557","article-title":"The volume of hydration in terminally ill cancer patients with hydration-related symptoms: a prospective study","volume":"17","author":"Nakajima","year":"2014","journal-title":"Journal of Palliative Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/SPC.0000000000000089","article-title":"Indications and practice of artificial hydration for terminally ill cancer patients","volume":"8","author":"Nakajima","year":"2014","journal-title":"Current Opinion in Supportive and Palliative Care"},{"issue":"2 Suppl 1","key":"10.1002\/14651858.CD006273.pub4-BIB0036|cit36","first-page":"S173","article-title":"The effects of artificial hydration and nutrition therapy for terminally ill cancer patients based on the Japanese clinical guideline","volume":"26","author":"Nakajima","year":"2018","journal-title":"Supportive Care in Cancer"},{"issue":"1 Suppl 1","key":"10.1002\/14651858.CD006273.pub4-BIB0037|cit37","first-page":"138","article-title":"How to distinguish starvation from refractory cachexia in terminal cancer patients and how to perform nutritional support?","volume":"32","author":"Nobuhisa","year":"2018","journal-title":"Palliative Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jpainsymman.2012.08.018","article-title":"Hydration in advanced cancer: can bioelectrical impedance analysis improve the evidence base? A systematic review of the literature","volume":"46","author":"Nwosu","year":"2013","journal-title":"Journal of Pain and Symptom Management"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0039|cit39","first-page":"S210","article-title":"Parenteral hydration: Review of prevalence and rationale in hospice inpatients","volume":"23","author":"O'Connor","year":"2015","journal-title":"Supportive Care in Cancer"},{"issue":"8","key":"10.1002\/14651858.CD006273.pub4-BIB0040|cit40","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1089\/jpm.2018.0020","article-title":"Use of artificial hydration at the end of life: A survey of Australian and New Zealand palliative medicine doctors","volume":"21","author":"Oehme","year":"2018","journal-title":"Journal of Palliative Medicine"},{"issue":"11","key":"10.1002\/14651858.CD006273.pub4-BIB0041|cit41","doi-asserted-by":"publisher","first-page":"1266-70","DOI":"10.1089\/jpm.2014.0082","article-title":"A randomized phase II study to assess the effectiveness of fluid therapy or intensive nutritional support on survival in patients with advanced cancer who cannot be nourished via enteral route","volume":"17","author":"Oh","year":"2014","journal-title":"Journal of Palliative Medicine"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"ix111","DOI":"10.1093\/annonc\/mdv531.24","article-title":"Preference of cancer patients for parenteral nutrition in the end of life: in-depth interview from a pilot study","volume":"26","author":"Oh","year":"2015","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1016\/S0261-5614(13)60399-4","article-title":"The association between artificial hydration and symptoms in terminally ill cancer patients","volume":"32","author":"Otani","year":"2013","journal-title":"Clinical Nutrition"},{"issue":"2 Suppl","key":"10.1002\/14651858.CD006273.pub4-BIB0044|cit44","first-page":"S356","article-title":"Artificial hydration at the end of life","volume":"19","author":"Poulose","year":"2010","journal-title":"Proceedings of Singapore Healthcare"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0045|cit45","doi-asserted-by":"publisher","first-page":"h6631","DOI":"10.1136\/bmj.h6631","article-title":"Care of adults in the last days of life: summary of NICE guidance","volume":"351","author":"Ruegger","year":"2015","journal-title":"BMJ"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/NHH.0000000000000550","article-title":"Artificial nutrition and hydration in people with late-stage dementia","volume":"35","author":"Smith","year":"2017","journal-title":"Home Healthcare Now"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0047|cit47","first-page":"15","article-title":"Should dying patients be given hydration and nutrition?","volume":"139","author":"Strand","year":"2019","journal-title":"Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin, Ny raekke"},{"issue":"2 Suppl 1","key":"10.1002\/14651858.CD006273.pub4-BIB0048|cit48","doi-asserted-by":"publisher","first-page":"S303-4","DOI":"10.1007\/s00520-011-1184-y","article-title":"Food or medicine: perceptions of advanced cancer patients and their caregivers regarding artificial hydration during the last weeks of life","volume":"19","author":"Torres-Vigil","year":"2011","journal-title":"Supportive Care in Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0049|cit49","doi-asserted-by":"publisher","first-page":"276-9","DOI":"10.1136\/bmjspcare-2012-000205","article-title":"Food or medicine: ethnic variations in perceptions of advanced cancer patients and their caregivers regarding artificial hydration during the last weeks of life","volume":"2","author":"Torres-Vigil","year":"2012","journal-title":"BMJ Supportive and Palliative Care"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0050|cit50","volume-title":"Studying Fluid Status and the Dying: The Challenge of Clinical Research in Palliative Care [MSc thesis]","author":"Viola","year":"1997"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"k3869","DOI":"10.1136\/bmj.k3869","article-title":"Clinically assisted nutrition and hydration","volume":"362","author":"Wade","year":"2018","journal-title":"BMJ"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/104990919401100607","article-title":"The effect of intravenous fluid infusion on blood and urine parameters of hydration and on state of consciousness in terminal cancer patients","volume":"11","author":"Wailer","year":"1994","journal-title":"American Journal of Hospice and Palliative Care"},{"issue":"2","key":"10.1002\/14651858.CD006273.pub4-BIB0053|cit53","first-page":"2","article-title":"Artificial nutrition and hydration can both prolong a person's life and dying process","volume":"45","author":"Xue Qi Tan","year":"2018","journal-title":"Singapore Nursing Journal"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0054|cit54","doi-asserted-by":"publisher","first-page":"1001-12","DOI":"10.1016\/j.jpainsymman.2011.06.028","article-title":"Effect of parenteral hydration therapy based on the Japanese national clinical guideline on quality of life, discomfort, and symptom intensity in patients with advanced cancer","volume":"43","author":"Yamaguchi","year":"2012","journal-title":"Journal of Pain and Symptom Management"},{"issue":"6","key":"10.1002\/14651858.CD006273.pub4-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1016\/j.jpainsymman.2016.10.203","article-title":"The use of artificial nutrition and hydration in an inpatient hospice in Singapore","volume":"52","author":"Yap","year":"2016","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0056|cit56","unstructured":"Covidence Veritas Health Innovation 2014"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0057|cit57","volume-title":"Oxford Textbook of Palliative Medicine","author":"Doyle","year":"2004"},{"issue":"2","key":"10.1002\/14651858.CD006273.pub4-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmjspcare-2013-000501","article-title":"Association between parenteral fluids and symptoms in hospital end-of-life care: an observational study of 280 patients","volume":"5","author":"Fritzson","year":"2015","journal-title":"BMJ Supportive and Palliative Care"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0059|cit59","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime)"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0060|cit60","unstructured":"Higgins JPT Churchill R Chandler J Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0 (updated June 2017). Cochrane, 2017 Available from training.cochrane.org\/handbook\/archive\/v5.2"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0061|cit61","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021 Available from training.cochrane.org\/handbook\/archive\/v6.2"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0062|cit62","unstructured":"Higgins JPT Lasserson T Chandler J Tovey D Thomas J Flemyng E Methodological Expectations of Cochrane Intervention Reviews. Version February 2021 Cochrane: London"},{"issue":"1","key":"10.1002\/14651858.CD006273.pub4-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/bmjspcare-2020-002600","article-title":"What is the impact of clinically assisted hydration in the last days of life? A systematic literature review and narrative synthesis","volume":"11","author":"Kingdon","year":"2021","journal-title":"BMJ Supportive and Palliative Care"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/0973-1075.73668","article-title":"Artificial hydration at the end of life in an oncology ward in Singapore","volume":"16","author":"Krishna","year":"2010","journal-title":"Indian Journal of Palliative Care"},{"issue":"7","key":"10.1002\/14651858.CD006273.pub4-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/ebmed-2017-110668","article-title":"Rating the certainty in evidence in the absence of a single estimate of effect","volume":"22","author":"Murad","year":"2017","journal-title":"Evidence Based Medicine"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0068|cit68","unstructured":"National Institute for Health and Care Excellence Care of dying adults in the last days of life. Quality statement 4: Hydration. 2017 Available from www.nice.org.uk\/guidance\/qs144"},{"issue":"3","key":"10.1002\/14651858.CD006273.pub4-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/SPC.0b013e3283492ae0","article-title":"Variation in attitudes towards artificial hydration at the end of life: a systematic literature review","volume":"5","author":"Raijmakers","year":"2011","journal-title":"Current Opinion in Supportive and Palliative Care"},{"issue":"7408","key":"10.1002\/14651858.CD006273.pub4-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/bmj.327.7408.198","article-title":"Novel consent process for research in dying patients unable to give consent","volume":"327","author":"Rees","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0071|cit71","unstructured":"Review Manager Web (RevMan Web) The Cochrane Collaboration 2022"},{"issue":"4","key":"10.1002\/14651858.CD006273.pub4-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1200\/JCO.1997.15.4.1697","article-title":"Methodologic issues in effectiveness research on palliative cancer care: a systematic review","volume":"15","author":"Rinck","year":"1997","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006273.pub4-BIB0073|cit73","unstructured":"World Health Organization WHO definition of palliative care Available from www.who.int\/cancer\/palliative\/definition\/en\/"},{"issue":"2","key":"10.1002\/14651858.CD006273.pub4-BIB0074|cit74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006273.pub2","article-title":"Medically assisted hydration for adult palliative care patients","author":"Good","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T23:17:32Z","timestamp":1760483852000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006273.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Pain, Palliative and Supportive Care Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":74,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006273.pub4","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]}}}