{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:00:51Z","timestamp":1792796451945,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006386.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000}}],"reference-count":602,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006386.pub4","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T14:43:42Z","timestamp":1640011422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy"],"prefix":"10.1002","volume":"2021","author":[{"given":"Ambika","family":"Parmar","sequence":"additional","affiliation":[{"name":"Medical Oncology; Sunnybrook Odette Cancer Center; Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaelina","family":"Macluskey","sequence":"additional","affiliation":[{"name":"Unit of Oral Surgery and Medicine; University of Dundee; Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Mc Goldrick","sequence":"additional","affiliation":[{"name":"Department of Public Health; NHS Fife; Fife UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I","family":"Conway","sequence":"additional","affiliation":[{"name":"Glasgow Dental School; University of Glasgow; Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Glenny","sequence":"additional","affiliation":[{"name":"Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health; The University of Manchester; Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E","family":"Clarkson","sequence":"additional","affiliation":[{"name":"Division of Oral Health Sciences; School of Dentistry, University of Dundee; Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen V","family":"Worthington","sequence":"additional","affiliation":[{"name":"Cochrane Oral Health; Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester; Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin KW","family":"Chan","sequence":"additional","affiliation":[{"name":"Sunnybrook Odette Cancer Centre; Sunnybrook Health Sciences Centre; Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"10.1002\/14651858.CD006386.pub4-BIB0001|cit1","first-page":"82","volume-title":"Adjuvant Therapy of Cancer","volume":"vii","author":"Adelstein","year":"1993"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/1097-0142(19900415)65:8<1685::AID-CNCR2820650804>3.0.CO;2-S","article-title":"Simultaneous versus sequential combined technique therapy for squamous cell head and neck cancer","volume":"65","author":"Adelstein","year":"1990","journal-title":"Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","article-title":"An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer","volume":"21","author":"Adelstein","year":"2003","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/MLG.0b013e31815b48f4","article-title":"Long-term results of a phase III randomized trial of postoperative radiotherapy with or without carboplatin in patients with high-risk head and neck cancer","volume":"118","author":"Argiris","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1200\/jco.2007.25.18_suppl.6078","article-title":"Phase III randomized trial of postoperative radiotherapy (RT) with or without carboplatin (Cb) in patients (pts) with head and neck squamous cell carcinoma (HNSCC)","volume":"25, no.\u00a018_supp","author":"Johnson","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ijrobp.2005.09.041","article-title":"French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin\/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: results at 2 years (FNCLCC-GORTEC)","volume":"64","author":"Bensadoun","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"Suppl 14","key":"10.1002\/14651858.CD006386.pub4-BIB0007|cit7","first-page":"489S","article-title":"Phase III multicenter randomized study of concurrent twice-a-day radiotherapy with and without cisplatin (BiRCF) in unresectable pharyngeal carcinoma. Results at 18 months (FNCLCC-GORTEC): 5504","volume":"22","author":"Bensadoun","year":"2004","journal-title":"Journal of Clinical Oncology"},{"issue":"19","key":"10.1002\/14651858.CD006386.pub4-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0009|cit9","first-page":"116","article-title":"Results of EORTC phase III trial 22931 comparing, in post-operative setting, radiotherapy (RT) and radiotherapy combined to cisplatin (RT-CT) in locally advanced head and neck (H&N) squamous cell carcinomas (SCC)","volume":"178","author":"Bernier","year":"2002","journal-title":"Strahlentherapie Und Onkologie"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD006386.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"S267","DOI":"10.1016\/S0959-8049(01)81481-7","article-title":"Results of EORTC phase III trial 22931 comparing postoperatively, radiotherapy (RT) to concurrent chemo-radiotherapy (RT-CT) with high dose cisplatin in locally advanced head and neck (H&N) carcinomas (SCC)","volume":"37","author":"Bernier","year":"2001","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0011|cit11","first-page":"55S","article-title":"Comparison of a post-operative chemotherapy with post-operative Co-60 radiotherapy in patients with advanced oral cavity carcinomas. Report of a randomised study","volume":"3","author":"Bitter","year":"1979","journal-title":"Deutsche Zeitschrift fur Mund, Kiefer und Gesichtschirurgie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0012|cit12","first-page":"264","article-title":"Postoperative chemotherapy versus postoperative cobalt 60 radiation in patients with advanced oral carcinoma. Report on a randomized study","volume":"3","author":"Bitter","year":"1981","journal-title":"Head and Neck Surgery"},{"issue":"25","key":"10.1002\/14651858.CD006386.pub4-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1056\/NEJM199806183382503","article-title":"Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer","volume":"338","author":"Brizel","year":"1998","journal-title":"New England Journal of Medicine"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.ijrobp.2007.07.022","article-title":"Hyperfractionated radiotherapy versus hyperfractionated radiotherapy and concomitant chemotherapy in locally advanced head and neck cancer","volume":"69","author":"Kasibhatla","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/hed.2890080304","article-title":"Survival results from a phase III study of simultaneous versus 1-hour sequential methotrexate-5-fluorouracil chemotherapy in head and neck cancer","volume":"8","author":"Browman","year":"1986","journal-title":"Head & Neck Surgery"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1200\/JCO.1994.12.12.2648","article-title":"Placebo-controlled randomized trial of infusional fluorouracil during standard radiotherapy in locally advanced head and neck cancer","volume":"12","author":"Browman","year":"1994","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1200\/JCO.1993.11.5.863","article-title":"The Head and Neck Radiotherapy Questionnaire: a morbidity\/quality-of-life instrument for clinical trials of radiation therapy in locally advanced head and neck cancer","volume":"11","author":"Browman","year":"1993","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/02841868909111183","article-title":"Induction chemotherapy in advanced head and neck cancer. Preliminary results of a randomized study","volume":"28","author":"Brunin","year":"1989","journal-title":"Acta Oncologica"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0019|cit19","first-page":"893","article-title":"Role of neoadjuvant chemotherapy in the treatment of advanced head and neck tumors. Results of two randomized therapeutical trials conducted at the Institut Curie on 208 patients","volume":"79","author":"Brunin","year":"1992","journal-title":"Bulletin du Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0020|cit20","doi-asserted-by":"crossref","unstructured":"Budach V Geismar D Lammert I Stuschke M Jahnke KD Baumann M Accelerated hyperfractionated radiation therapy to 70.6 Gy plus 5-FU\/MMC (c-HART) is more effective than HART to 77.6 Gy alone for locally advanced head and neck cancer. Four year results of the German ARO 95-6 trial in 384 patients (abstract 49) 45th Annual ASTRO meeting (Abstract 49); Salt Lake City, 19-23 October 2003 2003","DOI":"10.1016\/S0360-3016(03)00925-8"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.2005.07.010","article-title":"Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the Radiotherapy Cooperative Clinical Trials group of the German Cancer Society 95-06 prospective randomized trial","volume":"23","author":"Budach","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.ijrobp.2007.07.021","article-title":"Mitomycin-C and 5-fluoro-uracil containing chemotherapy with concurrent hyperfractionated accelerated radiotherapy (C-HART) of 70.6 Gy is more effective than dose escalated HART of 77.6 Gy alone - 10 year results of the German multi centre phase III randomised trial (ARO 95-06)","volume":"69","author":"Budach","year":"2007","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0023|cit23","first-page":"636","article-title":"Chemo-radiotherapy in advanced head and neck tumors. Personal experience","volume":"83","author":"Buffoli","year":"1992","journal-title":"Radiologia Medica"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0024|cit24","first-page":"149","article-title":"Gemcitabine concurrent with radiation therapy for locally advanced head and neck carcinomas","volume":"8","author":"Chauhan","year":"2008","journal-title":"African Health Sciences"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0025|cit25","first-page":"581","article-title":"Randomized trial of initial chemotherapy with cisplatin alone or in combination in 241 advanced carcinomas of the upper respiratory and digestive tract","volume":"105","author":"Chauvergne","year":"1988","journal-title":"Annales d Oto-Laryngologie et de Chirurgie Cervico-Faciale"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0026|cit26","first-page":"9","article-title":"A randomized study comparing cisplatin alone or combined in the palliative treatment of carcinoma of the head and neck. Analysis of a series of 209 patients","volume":"75","author":"Chauvergne","year":"1988","journal-title":"Bulletin du Cancer"},{"issue":"25","key":"10.1002\/14651858.CD006386.pub4-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1200\/JCO.2013.54.6309","article-title":"Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer","volume":"32","author":"Cohen","year":"2014","journal-title":"Journal of Clinical Oncology"},{"issue":"19","key":"10.1002\/14651858.CD006386.pub4-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1002\/1097-0142(20011201)92:11<2856::AID-CNCR10132>3.0.CO;2-6","article-title":"Alternating chemoradiotherapy versus partly accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck: results from a phase III randomized trial","volume":"92","author":"Corvo","year":"2001","journal-title":"Cancer"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1200\/JCO.1995.13.6.1493","article-title":"Randomized trial of neoadjuvant cisplatin and fluorouracil versus carboplatin and fluorouracil in patients with stage IV-M0 head and neck cancer","volume":"13","author":"De Andres","year":"1995","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1053\/j.seminoncol.2004.09.002","article-title":"Concomitant radiochemotherapy or accelerated radiotherapy: analysis of two randomized trials of the French Head and Neck Cancer Group (GORTEC)","volume":"31","author":"Bourhis","year":"2004","journal-title":"Seminars in Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0032|cit32","first-page":"166","article-title":"Radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stages III and IV oropharynx carcinoma. Results of the 94.01 randomised study from the French group of Radiation Oncology for Head and Neck Cancer (GORTEC). 'Management.of Head and Neck Tumors: What are the challenges for the third millennium?'","volume":"53","author":"Calais","year":"1999","journal-title":"Acta Otorhinolaryngologica Belgica"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0033|cit33","doi-asserted-by":"crossref","unstructured":"Calais G Alfonsi M Bardet E Sire C Bourgeois H Bergerot C Randomized study comparing radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stages III and IV oropharynx carcinoma (ARCORO). Preliminary results of the 94.01 study from the French Group of Radiation Oncology for Head and Cancer (GORTEC) ASCO; 1988 1998 385a","DOI":"10.1016\/S0360-3016(98)80142-9"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0034|cit34","first-page":"S78","article-title":"Radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stages III and IV oropharynx carcinoma. Results of the 94.01 randomized study from the French Group of Radiation Oncology for Head and Neck Cancer (GORTEC)","volume":"48","author":"Calais","year":"1998","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0360-3016(01)01826-0","article-title":"Radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stages III and IV oropharynx carcinoma. Final results of the 94-01 Gortec randomized study","volume":"51","author":"Calais","year":"2001","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"24","key":"10.1002\/14651858.CD006386.pub4-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/jnci\/91.24.2081","article-title":"Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma","volume":"91","author":"Calais","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0037|cit37","first-page":"48","article-title":"Stage III and IV cancers of the oropharynx: results of a randomized study of Gortec comparing radiotherapy alone with concomitant chemotherapy","volume":"87 Spec No","author":"Calais","year":"2000","journal-title":"Bulletin du Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0360-3016(01)01894-6","article-title":"Late toxicity results of randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced stage oropharynx carcinoma (GORTEC 94-01)","volume":"51","author":"Denis","year":"2001","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1200\/JCO.2004.08.021","article-title":"Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma","volume":"22","author":"Denis","year":"2004","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0360-3016(02)03819-1","article-title":"Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT\/SOMA, RTOG\/EORTC, and NCI-CTC scoring systems","volume":"55","author":"Denis","year":"2003","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S1278-3218(00)80016-5","article-title":"Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma","volume":"4","author":"Ezra","year":"2000","journal-title":"Cancer Radiotherapie"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD006386.pub4-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000227257","article-title":"Neoadjuvant chemotherapy with carboplatin\/5-fluorouracil in head and neck cancer","volume":"50","author":"Depondt","year":"1993","journal-title":"Oncology"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD006386.pub4-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/0959-8049(93)91385-X","article-title":"A phase III study comparing induction chemotherapy by carboplatin (CBDCA) and 5 fluorouracil (5 FU) before locoregional treatment (LRT) versus locoregional treatment alone in head and neck carcinomas","volume":"29","author":"Martin","year":"1993","journal-title":"European Journal of Cancer"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0360-3016(98)00321-6","article-title":"Continuous hyperfractionated accelerated radiotherapy with\/without mitomycin C in head and neck cancer","volume":"42","author":"Dobrowsky","year":"1998","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0167-8140(00)00233-4","article-title":"Continuous hyperfractionated accelerated radiotherapy with\/without mitomycin C in head and neck cancers","volume":"57","author":"Dobrowsky","year":"2000","journal-title":"Radiotherapy and Oncology"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1054\/bjoc.2000.1512","article-title":"Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma. French Groupe d'Etude des Tumeurs de la Tete et du Cou (GETTEC)","volume":"83","author":"Domenge","year":"2000","journal-title":"British Journal of Cancer"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"s86","DOI":"10.1016\/0959-8049(95)95646-N","article-title":"Induction chemotherapy before radiotherapy in oropharyngeal carcinoma","volume":"31A","author":"Domenge","year":"1995","journal-title":"European Journal of Cancer"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/0014-2964(77)90151-7","article-title":"Preliminary results of a randomized E.O.R.T.C. study comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx","volume":"13","author":"Cachin","year":"1977","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0049|cit49","first-page":"275","article-title":"Ten-year results of a randomized trial comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx: experience of the European Organization for Research and Treatment of Cancer","volume":"6","author":"Eschwege","year":"1988","journal-title":"National Cancer Institute Monograph"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0050|cit50","unstructured":"Fazekas JT Pajak TF Marcial VA RTOG randomized trial - 79-15: Misonizadole adjuvant to radiotherapy in advanced head and neck squamous cancers American Society of Clinical Oncology 20th Annual Meeting; 1984 1984 185"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0360-3016(80)90379-X","article-title":"Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx","volume":"6","author":"Fazekas","year":"1980","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0360-3016(83)90382-6","article-title":"Tumor regression and other prognosticators in advanced head and neck cancers: a sequel to the RTOG methotrexate study","volume":"9","author":"Fazekas","year":"1983","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0053|cit53","first-page":"213","article-title":"Methotrexate and radiation therapy in the treatment of advanced squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx, and hypopharynx (preliminary report of a controlled clinical trial of the Radiation Therapy Oncology Group)","volume":"4","author":"Kramer","year":"1975","journal-title":"Canadian Journal of Otolaryngology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.radonc.2020.01.016","article-title":"Randomized phase-III-trial of concurrent chemoradiation for locally advanced head and neck cancer comparing dose reduced radiotherapy with paclitaxel\/cisplatin to standard radiotherapy with fluorouracil\/cisplatin: the PacCis-trial","volume":"144","author":"Fietkau","year":"2020","journal-title":"Radiotherapy and Oncology"},{"issue":"14","key":"10.1002\/14651858.CD006386.pub4-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1200\/JCO.2004.12.012","article-title":"Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase ii trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck","volume":"22","author":"Garden","year":"2004","journal-title":"Journal of Clinical Oncology"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"S411","DOI":"10.1016\/j.ijrobp.2006.07.771","article-title":"Results of Radiation Therapy Oncology Group 97-03 - A randomized phase II trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck: long term results and late toxicities","volume":"66","author":"Garden","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0057|cit57","first-page":"185","article-title":"Treatment of locally advanced squamous-cell carcinoma of the head and neck with concurrent radio-chemotherapy: randomized comparison of cisplatin versus carboplatin","volume":"2","author":"Gasparini","year":"1993","journal-title":"International Journal of Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0058|cit58","first-page":"147","article-title":"Cisplatin (CDDP) versus carboplatin (CRP) and concomitant radiotherapy in stage III-IV squamous cell carcinomas (SCC) of head and neck (HN): preliminary results of a randomized trial","volume":"15","author":"Testolin","year":"1992","journal-title":"Folia Oncologica"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD006386.pub4-BIB0059|cit59","first-page":"S146","article-title":"Cisplatin (CDDP) versus carboplatin (CRP) and concomitant radiotherapy (RT) in stage III-IV squamous cell carcinomas (SCC) of head and neck (H&N): preliminary results of a randomized trial","volume":"27","author":"Testolin","year":"1991","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1093\/annonc\/mdx299","article-title":"Induction TPF followed by concomittant treatment versus concomittant treatment alone in locally advanced head and neck cancer. A phase II-III trial","volume":"28","author":"Ghi","year":"2017","journal-title":"Annals of Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0061|cit61","article-title":"Chemotherapy + alternating hyperfractionated radiotherapy vs. hyperfractionated radiotherapy alone in patients with inoperable stage III and IV epidermoid carcinoma","volume":"84","author":"Giglio","year":"1997","journal-title":"Prensa Medica Argentina"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0062|cit62","first-page":"317","article-title":"No recurrences beyond the second year of follow up in inoperable stage III and IV squamous cell carcinoma of the head and neck patients (IOHN). Final report of a randomized trial of alternating chemotherapy (CT) + hyperfractionated radiotherapy (RT) vs RT alone","volume":"15","author":"Giglio","year":"1999","journal-title":"Amercian Society of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0063|cit63","article-title":"Alternating chemotherapy (CT) + hyperfractionated radiotherapy (RT) vs RT alone in inoperable stage III and IV squamous cell carcinoma of head and neck (IOHN) a randomized trial","author":"Giglio","year":"1996","journal-title":"American Society of Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0064|cit64","first-page":"575","article-title":"Effectiveness of different regimes of combined treatment (cisplatin + radiotherapy) for intraoral and oropharyngeal cancer","volume":"53","author":"Gladkov","year":"2007","journal-title":"Voprosy Onkologii"},{"issue":"9 Suppl 10","key":"10.1002\/14651858.CD006386.pub4-BIB0065|cit65","first-page":"90","article-title":"Neoadjuvant therapy with cisplatin\/fluorouracil vs cisplatin\/UFT in locally advanced squamous cell head and neck cancer","volume":"11","author":"Gonzalez-Larriba","year":"1997","journal-title":"Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0066|cit66","unstructured":"Valverde JJ Gonzalez JL Dominguez S Lopez PM Alonso MC Adrover E Neoadjuvant chemotherapy (CT) with cisplatin (CDDP) and 5-fluorouracil (5FU) vs cisplatin and ftorafur-uracil (UFT) in advanced squamous head and neck cancer (SHNC) (909) Proceedings of the Annual Meeting of the American Society of Clinical Oncology; 1993 1993"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD006386.pub4-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0959-8049(01)80619-5","article-title":"Radiotherapy with or without mitomycin C in the treatment of locally advanced head and neck cancer. Results from the IAEA multicentre randomised trial","volume":"37","author":"Grau","year":"2001","journal-title":"European Journal of Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0068|cit68","first-page":"S16","article-title":"Radiotherapy combined with mitomycin C in the treatment of locally advanced head and neck cancer. First report from the IAEA-CRP E3.30.13 randomised multicentre study","volume":"58","author":"Grau","year":"2001","journal-title":"Radiotherapy and Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0167-8140(03)00020-3","article-title":"Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial","volume":"67","author":"Grau","year":"2003","journal-title":"Radiotherapy and Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0009-9260(87)80327-6","article-title":"A randomised clinical trial to contrast radiotherapy with radiotherapy and methotrexate given synchronously in head and neck cancer","volume":"38","author":"Gupta","year":"1987","journal-title":"Clinical Radiology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0071|cit71","first-page":"339","article-title":"Concomitant methotrexate and radiotherapy in advanced head and neck cancer: 15-year follow-up of a randomized clinical trial","volume":"13","author":"Gupta","year":"2001","journal-title":"Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0072|cit72","doi-asserted-by":"crossref","unstructured":"Gupta D Shukla P Bisht S Dhawan A Pant M Bhatt M A prospective comparison of sequential chemoradiation vs concurrent chemoradiation in locally advanced oropharyngeal carcinoma Cancer Biology & Therapy 2009 8 3 213 7","DOI":"10.4161\/cbt.8.3.7484"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0924-4212(96)85319-9","article-title":"Comparison of concomitant radiotherapy and chemotherapy with radiotherapy alone in advanced cancers of the head and neck: results of a randomized trial","volume":"83","author":"Haddad","year":"1996","journal-title":"Bulletin du Cancer. Radiotherapie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1470-2045(13)70011-1","article-title":"Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial","volume":"14","author":"Haddad","year":"2013","journal-title":"Lancet Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/annonc\/mdt461","article-title":"A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer","volume":"25","author":"Hitt","year":"2014","journal-title":"Annals of Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0076|cit76","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s12094-020-02467-8","article-title":"Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer Group (TTCC) 2503 trial","volume":"23","author":"Hitt","year":"2021","journal-title":"Clinical and Translational Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/1097-0142(19870801)60:3<301::AID-CNCR2820600306>3.0.CO;2-V","article-title":"Adjuvant chemotherapy for advanced head and neck squamous carcinoma: final report of the head and neck contracts program","volume":"60","year":"1987","journal-title":"Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/1097-0142(19870801)60:3<301::AID-CNCR2820600306>3.0.CO;2-V","article-title":"Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the head and neck contracts program","volume":"60","author":"Endicott","year":"1987","journal-title":"Cancer"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1200\/JCO.1990.8.5.838","article-title":"Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the Head and Neck Contracts Program","volume":"8","author":"Jacobs","year":"1990","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1177\/019459988509300604","article-title":"Randomized study of adjuvant chemotherapy for head and neck cancer","volume":"93","author":"Holoye","year":"1985","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0081|cit81","doi-asserted-by":"crossref","unstructured":"Holoye PY Kun L Toohill R Byherdt R Prospective, randomized trial of adjuvant chemotherapy in head and neck (H\/N) cancer (abstract) American Society of Clinical Oncology; 1984 1984 183 (abs no C712)","DOI":"10.1177\/019459988509300604"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0360-3016(86)90090-8","article-title":"A randomized study of adjuvant chemotherapy for cancer of the upper aerodigestive tract","volume":"12","author":"Kun","year":"1986","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1288\/00005537-198704000-00002","article-title":"The effects of delay in standard treatment due to induction chemotherapy in two randomized prospective studies","volume":"97","author":"Toohill","year":"1987","journal-title":"Laryngoscope"},{"issue":"Suppl 5","key":"10.1002\/14651858.CD006386.pub4-BIB0084|cit84","first-page":"127","article-title":"Hyperfractionated radiation therapy with or without simultaneous cisplatin (DDP) in patients with stage III and IV carcinomas of the head and neck. A phase III randomized trial of the Swiss Group for Clinical Cancer Research (SAKK)","volume":"13","author":"Huguenin","year":"2002","journal-title":"Annals of Oncology"},{"issue":"23","key":"10.1002\/14651858.CD006386.pub4-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1200\/JCO.2004.12.193","article-title":"Concomitant cisplatin significantly improves locoregional control in advanced head and neck cancers treated with hyperfractionated radiotherapy","volume":"22","author":"Huguenin","year":"2004","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0086|cit86","doi-asserted-by":"crossref","unstructured":"Huguenin P Glanzmann C Taussky D Lutolf UM Schmid S Moe K Hyperfractionated radiotherapy and simultaneous cisplatin for stage-III and -IV carcinomas of the head and neck. Long-term results including functional outcome Strahlentherapie und Onkologie 1998 174 8 397 402","DOI":"10.1007\/BF03038560"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0360-3016(92)90002-Y","article-title":"Induction chemotherapy in advanced head and neck tumors: results of two randomized trials","volume":"23","author":"Jaulerry","year":"1992","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"17","key":"10.1002\/14651858.CD006386.pub4-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1200\/JCO.2004.10.076","article-title":"Radiation therapy with or without concurrent low-dose daily chemotherapy in locally advanced, nonmetastatic squamous cell carcinoma of the head and neck","volume":"22","author":"Jeremic","year":"2004","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-8140(97)00048-0","article-title":"Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: a prospective randomized trial","volume":"43","author":"Jeremic","year":"1997","journal-title":"Radiotherapy and Oncology"},{"issue":"17","key":"10.1002\/14651858.CD006386.pub4-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1200\/JCO.2004.10.076","article-title":"Radiation therapy with or without concurrent low-dose daily chemotherapy in locally advanced, nonmetastatic squamous cell carcinoma of the head and neck","volume":"22","author":"Jeremic","year":"2004","journal-title":"Journal of Clinical Oncology"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s004320100269","article-title":"Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced, unresectable, nonmetastatic squamous cell carcinoma of the head and neck","volume":"127","author":"Jeremic","year":"2001","journal-title":"Journal of Cancer Research & Clinical Oncology"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1200\/JCO.2000.18.7.1458","article-title":"Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: a prospective randomized trial","volume":"18","author":"Jeremic","year":"2000","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/S0959-8049(99)81038-7","article-title":"Hyperfractionated radiotherapy (Hfx RT) with or without concurrent low dose daily cisplatin (CDDP) in locally advanced unresectable squamous cell carcinoma of the head and neck (SCC H&N). A prospective randomized trial","volume":"35","author":"Jeremic","year":"1999","journal-title":"European Journal of Cancer (1990)"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1148\/116.3.709","article-title":"Methotrexate and radiation therapy in the treatment of advanced head and neck tumors","volume":"116","author":"Knowlton","year":"1975","journal-title":"Radiology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0936-6555(05)80211-0","article-title":"Radiation, pepleomycin and hyperthermia in the therapy of locally advanced squamous cell carcinomas of the buccal mucosa","volume":"2","author":"Krishnamurthi","year":"1990","journal-title":"Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3109\/02841869609084005","article-title":"Feasibility of non-cisplatin-based induction chemotherapy and concurrent chemoradiotherapy in advanced head and neck cancer","volume":"35","author":"Kumar","year":"1996","journal-title":"Acta Oncologica"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1053\/ejso.2001.1171","article-title":"Prospective randomized study of post-operative chemotherapy with levamisole and UFT for head and neck carcinoma","volume":"27","author":"Lam","year":"2001","journal-title":"European Journal of Surgical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0098|cit98","first-page":"392a (abs No 13","article-title":"Radiotherapy (RT) vs. chemotherapy (CT) followed by RT in resected and negative-margins head and neck cancers (HNC). Intergroup Study 0034: final analysis","volume":"16","author":"Al-Sarraf","year":"1997","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0360-3016(00)00457-0","article-title":"The influence of beam energy on the outcome of postoperative radiotherapy in head and neck cancer patients: secondary analysis of RTOG 85-03","volume":"47","author":"Aref","year":"2000","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0360-3016(92)90664-4","article-title":"Adjuvant chemotherapy for resectable squamous cell carcinoma of the head and neck. Report on Intergroup Study 0034","volume":"23","author":"Hong","year":"1992","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jso.2930550303","article-title":"Chemotherapy as predictor of compliance","volume":"55","author":"Jacobs","year":"1994","journal-title":"Journal of Surgical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0360-3016(92)90642-U","article-title":"Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034","volume":"23","author":"Laramore","year":"1992","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"S1","key":"10.1002\/14651858.CD006386.pub4-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0360-3016(91)90569-P","article-title":"Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report on Intergroup Study 0034","volume":"21","author":"Laramore","year":"1991","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1002\/cncr.21785","article-title":"Mature results from a randomized phase II trial of cisplatin plus 5-fluorouracil and radiotherapy with or without tirapazamine in patients with resectable stage IV head and neck squamous cell carcinomas","volume":"106","author":"Le","year":"2006","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0105|cit105","first-page":"1522","article-title":"A randomized phase II trial of tirpazamine in advanced squamous cell carcinoma of the head and neck: a preliminary report of radiation related toxicity","volume":"209P","author":"Le","year":"1998","journal-title":"Radiology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0106|cit106","unstructured":"Pinto H Le Q Terris D Bloch D Goffinet DR Brown JM Randomized trial of tirapazamine\/cisplatin\/fluorouracil versus cisplatin\/fluorouracil for organ preservation in advanced resectable head and neck cancer (abstract) ASCO; 2002 2002 abs no 904"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0107|cit107","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-8140(97)01922-1","article-title":"Neoadjuvant chemotherapy with cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the head and neck: a randomized phase III study","volume":"43","author":"Lewin","year":"1997","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0108|cit108","unstructured":"Grandi C Licitra L Cavina R Guzzo M Mariani L Colli S Surgery vrs primary chemotherapy and surgery in cancer of the oral cavity: preliminary report of final results of a randomised study (abstract) 5th International Conference on Head and Neck Cancer; 2000 29 July-2 August; San Francisco, California, USA 2000 141 (abs no 297)"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0109|cit109","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/0959-8049(93)91423-I","article-title":"Surgery versus primary chemotherapy plus surgery in squamous cell carcinoma of the oral cavity: preliminary report of a randomized study","volume":"29Y","author":"Grandi","year":"1993","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0110|cit110","unstructured":"Licitra L Grandi C Cavina R Guzzo M Mariani L Lo Vullo S Primary chemotherapy (pCT) for patients with operable oral cavity cancer: results of a randomized study (abstract) American Society of Clinical Oncology (ASCO); 2001 2001 (abs no 890)"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2003.06.146","article-title":"Primary chemotherapy in resectable oral cavity squamous cell cancer: a randomized controlled trial","volume":"21","author":"Licitra","year":"2003","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0112|cit112","first-page":"199","article-title":"Preliminary results of a randomized study on preoperative intra-arterial chemotherapy combined with surgery and irradiation for carcinomas of the floor of the mouth","volume":"201","author":"Luboinski","year":"1985","journal-title":"Progress in Clinical & Biological Research"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0113|cit113","first-page":"465","article-title":"Induction chemotherapy in the treatment of squamous carcinomas of the tongue and floor of mouth","volume":"14","author":"Mamelle","year":"1989","journal-title":"Clinical Otolaryngology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jso.2930590203","article-title":"Combination chemotherapy as induction therapy for advanced resectable head and neck cancer","volume":"59","author":"Maipang","year":"1995","journal-title":"Journal of Surgical Oncology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0115|cit115","first-page":"S44","article-title":"Preliminary report of a prospective randomised trial of cisplatin vs cisplatin-etoposide for advanced head and neck squamous cell cancer","volume":"14","author":"Marechal","year":"1985","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"3 Pt B","key":"10.1002\/14651858.CD006386.pub4-BIB0116|cit116","first-page":"455","article-title":"A phase III of cisplatinum versus cisplatinum-etoposide for previously untreated squamous cell carcinoma of the head and neck","volume":"7","author":"Marechal","year":"1987","journal-title":"Anticancer Research"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0117|cit117","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4103\/sajc.sajc_18_17","article-title":"Safety and efficacy of weekly versus three-weekly paclitaxel plus platinum neoadjuvant chemotherapy in patients with locally advanced squamous cell head and neck carcinoma: a pilot study","volume":"7","author":"Mathur","year":"2018","journal-title":"South Asian Journal of Cancer"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/hed.2880140202","article-title":"Induction chemotherapy in head and neck cancer: results of a phase III trial","volume":"14","author":"Mazeron","year":"1992","journal-title":"Head & Neck"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1023\/A:1008244110004","article-title":"Treatment with cisplatin and fluorouracil alternating with radiation favourably affects prognosis of inoperable squamous cell carcinoma of the head and neck: results of a multivariate analysis on 273 patients","volume":"8","author":"Benasso","year":"1997","journal-title":"Annals of Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0120|cit120","first-page":"653","article-title":"Sequential or alternate chemo-radiotherapy in the treatment of advanced head and neck tumors. Results of a randomized study","volume":"75","author":"Corvo","year":"1988","journal-title":"Radiologia Medica"},{"issue":"S1","key":"10.1002\/14651858.CD006386.pub4-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0360-3016(90)90844-A","article-title":"Sequential vs alternative chemo-radiotherapy in advanced head and neck tumors. Report on a randomized study","volume":"19","author":"Corvo","year":"1990","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/1097-0142(19910215)67:4<915::AID-CNCR2820670410>3.0.CO;2-8","article-title":"Combined chemotherapy and radiation therapy in advanced inoperable squamous cell carcinoma of the head and neck. The final report of a randomized trial","volume":"67","author":"Merlano","year":"1991","journal-title":"Cancer"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1288\/00005537-199005000-00017","article-title":"Randomized comparison of two chemotherapy, radiotherapy schemes for stage III and IV unresectable squamous cell carcinoma of the head and neck","volume":"100","author":"Merlano","year":"1990","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1200\/JCO.1988.6.4.627","article-title":"Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study","volume":"6","author":"Merlano","year":"1988","journal-title":"Journal of Clinical Oncology"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1023\/A:1008244110004","article-title":"Treatment with cisplatin and fluorouracil alternating with radiation favourably affects prognosis of inoperable squamous cell carcinoma of the head and neck: results of a multivariate analysis on 273 patients","volume":"8","author":"Benasso","year":"1997","journal-title":"Annals of Oncology"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jnci\/88.9.583","article-title":"Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck","volume":"88","author":"Merlano","year":"1996","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0127|cit127","unstructured":"Merlano M Corvo R Brema F Benasso M Bacigalupo A Toma S Alternating chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. A randomized trial (abstract) Annual Meeting of the American Society of Clinical Oncology; 1989 1989 175 (abs no 682)"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0128|cit128","first-page":"A49","article-title":"Alternating chemotherapy (CT) and radiotherapy (RT) vs neo adjuvant CT in advanced head and neck cancer","volume":"18","author":"Merlano","year":"1986","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"16","key":"10.1002\/14651858.CD006386.pub4-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJM199210153271602","article-title":"Treatment of advanced squamous-cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy","volume":"327","author":"Merlano","year":"1992","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0901-5027(05)80288-7","article-title":"Preoperative radiochemotherapy and radical surgery in comparison with radical surgery alone. A prospective, multicentric, randomized DOSAK study of advanced squamous cell carcinoma of the oral cavity and the oropharynx (a 3-year follow-up)","volume":"23","author":"Mohr","year":"1994","journal-title":"International Journal of Oral & Maxillofacial Surgery"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0277-5379(82)90189-4","article-title":"A randomized EORTC trial comparing intra-arterial infusion with methotrexate vs bleomycin as initial therapy in carcinoma of the oral cavity","volume":"18","author":"Molinari","year":"1982","journal-title":"European Journal of Cancer & Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0132|cit132","first-page":"228","article-title":"Clinical significance of radiation therapy combined with chemotherapy","volume":"156","author":"Morita","year":"1980","journal-title":"Strahlentherapie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-8140(83)80013-9","article-title":"Combined radiation and drugs: the effect of intra-arterial chemotherapy followed by radiotherapy in head and neck cancer","volume":"1","author":"Arcangeli","year":"1983","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/1097-0142(197803)41:3<900::AID-CNCR2820410317>3.0.CO;2-I","article-title":"The relevance of tumour size and cell kinetics as predictors of radiation response in head and neck cancer","volume":"41","author":"Nervi","year":"1978","journal-title":"Cancer"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1200\/JCO.2017.74.9457","article-title":"Once-a-week verus once-every-3-weeks cisplatin chemoradiation for locally advanced head and neck cancer: a phase III randomized non-inferiority trial","volume":"36","author":"Noronha","year":"2018","journal-title":"Journal of Clinical Oncology"},{"issue":"15","key":"10.1002\/14651858.CD006386.pub4-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1200\/JCO.2017.35.15_suppl.6007","article-title":"Phase III randomized trial comparing weekly versus three-weekly (W3W) cisplatin in patients receiving chemoradiation for locally advanced head and neck cancer","volume":"35","author":"Noronha","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"45","key":"10.1002\/14651858.CD006386.pub4-BIB0137|cit137","first-page":"2433","article-title":"Randomized study of cisplatin-based combination chemotherapy for the treatment of planocellular cancer of the head and neck region","volume":"141","author":"Olasz","year":"2000","journal-title":"Orvosi Hetilap"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0138|cit138","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cdp.2003.11.007","article-title":"Results and failures with or without cisplatin containing induction chemotherapy in the treatment of squamous cell carcinoma of the head and neck","volume":"28","author":"Olasz","year":"2004","journal-title":"Cancer Detection & Prevention"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0139|cit139","unstructured":"Crispino SP Olmi C Fallai F Rossi S Marsoni A Tinazzi M Conventional radiotherapy (RT) versus accelerated hyperfractionated RT versus conventional RT and concomitant chemotherapy in locally advanced oropharyngeal carcinoma (ORO-93\/01) (abstract) Annual Meeting of the American Society of Clinical Oncology; 1997 1997 (abs no 1423)"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/030089160609200108","article-title":"Long-term results of conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus concomitant radiotherapy and chemotherapy in locoregionally advanced carcinoma of the oropharynx","volume":"92","author":"Fallai","year":"2006","journal-title":"Tumori"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0141|cit141","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0360-3016(02)03792-6","article-title":"Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy - a multicenter randomized trial","volume":"55","author":"Olmi","year":"2003","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0142|cit142","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/0959-8049(95)95673-T","article-title":"Conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus conventional radiotherapy and concomitant chemotherapy in advanced oropharyngeal carcinoma: a randomized clinical trial","volume":"31Y","author":"Olmi","year":"1995","journal-title":"European Journal of Cancer"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jnci\/86.4.265","article-title":"Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo","volume":"86","author":"Paccagnella","year":"1994","journal-title":"Journal of the National Cancer Institute"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD006386.pub4-BIB0144|cit144","first-page":"S209 (abs no 12","article-title":"Chemotherapy (CT) plus loco-regional treatment (LRT) versus LRT alone in stage III-IV head and neck cancer","volume":"27","author":"Zorat","year":"1991","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0145|cit145","doi-asserted-by":"crossref","unstructured":"Zorat PL Loreggian L Paccagnella A Gava A Mione CA Bordin F Randomized phase III trial of neoadjuvant chemotherapy (CT) in head and neck (H&N) cancer patients: an update based on 10 years' follow up (abstract) Annual Meeting of the American Society of Clinical Oncology; 2004 2004 494","DOI":"10.1200\/jco.2004.22.90140.5532"},{"issue":"22","key":"10.1002\/14651858.CD006386.pub4-BIB0146|cit146","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/jnci\/djh306","article-title":"Randomized phase III trial of neoadjuvant chemotherapy in head and neck cancer: 10-year follow-up","volume":"96","author":"Zorat","year":"2004","journal-title":"Journal of the National Cancer Institute"},{"issue":"Suppl 8","key":"10.1002\/14651858.CD006386.pub4-BIB0147|cit147","article-title":"Concomitant chemoradiotherapy (CT\/RT) vs induction chemotherapy with docetaxel\/cisplatin\/5fluorouracil (TPF) followed by CT\/RT in locally advanced head and neck cancer. Final results of phase II study","volume":"19","author":"Ghi","year":"2008","journal-title":"Annals of Oncology"},{"issue":"Suppl 9","key":"10.1002\/14651858.CD006386.pub4-BIB0148|cit148","first-page":"179","article-title":"Randomized phase II-III trial of concomitant CT\/RT versus TPF followed by concomitant CT\/RT in locally advanced squamous cell carcinoma of head & neck (LASCCHN). Results of the phase II part of the study","volume":"17","author":"Ghi","year":"2006","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0149|cit149","first-page":"18S (abs no 551","article-title":"Randomized phase II trial of concomitant CT\/RT versus TPF followed by concomitant CT\/RT in locally advanced squamous cell carcinoma of the head and neck (LASCCHN)","volume":"24","author":"Paccagnella","year":"2006","journal-title":"Journal of Clinical Oncology (2006 ASCO Annual Meeting Proceedings Part I); 2006"},{"issue":"Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"(abs no 6000)","DOI":"10.1200\/jco.2008.26.15_suppl.6000","article-title":"Concomitant chemoradiotherapy (CT\/RT) vs neoadjuvant chemotherapy with docetaxel\/cisplatin\/5-fluorouracil (TPF) followed by CT\/RT in locally advanced head and neck cancer. Final results of a phase II randomized study","volume":"26","author":"Paccagnella","year":"2008","journal-title":"Journal of Clinical Oncology"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0151|cit151","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/annonc\/mdp573","article-title":"Concomitant chemoradiotherapy versus induction docetaxel, cisplatin and 5 fluorouracil (TPF) followed by concomitant chemoradiotherapy in locally advanced head and neck cancer: a phase II randomized study","volume":"21","author":"Paccagnella","year":"2010","journal-title":"Annals of Oncology"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1016\/j.ijrobp.2006.07.372","article-title":"Randomized phase II trial of concomitant chemoradiotherapy (CT\/RT) versus docetaxel, cisplatin and 5-fluorouracil (TPF) followed by concomitant CT\/RT in locally advanced head and neck squamous cell carcinoma (HNSCC)","volume":"66","author":"Turcato","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0153|cit153","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/02841868509134421","article-title":"Combined bleomycin treatment and radiation therapy in squamous cell carcinoma of the head and neck region","volume":"24","author":"Parvinen","year":"1985","journal-title":"Acta Radiologica - Oncology"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/1097-0142(19810501)47:9<2259::AID-CNCR2820470926>3.0.CO;2-Q","article-title":"A randomized comparison of radiotherapy with a radiotherapy - chemotherapy combination in stage IV carcinoma of the head and neck","volume":"47","author":"Petrovich","year":"1981","journal-title":"Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0155|cit155","first-page":"18","article-title":"Randomized comparison of radiotherapy (RT) and radiotherapy-chemotherapy (RT + CT) combination in stage IV carcinoma of the head and neck","volume":"6","author":"Petrovich","year":"1979","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD006386.pub4-BIB0156|cit156","first-page":"S138","article-title":"Randomized trial of sequential versus simultaneous chemo and radiotherapy (CT-xRT) in patients (PTS) with locally advanced unresectable squamous cell carcinoma of the head and neck (LAU-SCCHN)","volume":"27","author":"Cognetti","year":"1991","journal-title":"European Journal of Cancer"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0157|cit157","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/oxfordjournals.annonc.a058905","article-title":"A randomized phase II study comparing sequential versus simultaneous chemo-radiotherapy in patients with unresectable locally advanced squamous cell cancer of the head and neck","volume":"5","author":"Pinnaro","year":"1994","journal-title":"Annals of Oncology"},{"issue":"17","key":"10.1002\/14651858.CD006386.pub4-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"Posner","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0159|cit159","first-page":"771","article-title":"A randomized trial between two neoadjuvant chemotherapy protocols: CDDP + 5-FU versus CDDP + VP16 in advanced cancer of the head and neck","volume":"14","author":"Pr\u00e9vost","year":"2005","journal-title":"Oncology Reports"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0160|cit160","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0002-9610(05)80199-0","article-title":"Perioperative chemotherapy in patients with oral cancer","volume":"168","author":"Rao","year":"1994","journal-title":"American Journal of Surgery"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jso.2930470106","article-title":"Perioperative chemotherapy in oral cancer","volume":"47","author":"Rao","year":"1991","journal-title":"Journal of Surgical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hed.20937","article-title":"First-year quality of life assessment of an intraarterial (radplat) versus intravenous chemoradiation phase III trial","volume":"31","author":"Ackerstaff","year":"2009","journal-title":"Head and Neck"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0163|cit163","first-page":"E488","article-title":"Late follow-up of the randomized radiation and concomittant high-dose intra-arterial or intravenous cisplatin (radplat) trial for advanced head and neck cancer","volume":"38","author":"Heukelom","year":"2016","journal-title":"Head and Neck"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0164|cit164","unstructured":"Rasch C Salverda G Schornagel J Kroger R Wiggenraud R Buter J Intra-arterial versus intravenous chemoradiation for advanced head and neck cancer, early results of a multi-institutional trial 48th Annual Meeting of ASTRO; 2006 2006 S1"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/cncr.24916","article-title":"Intra-arterial versus intravenous chemoradiation for advanced head and neck cancer: results of a randomized phase 3 trial","volume":"116","author":"Rasch","year":"2010","journal-title":"Cancer"},{"issue":"21","key":"10.1002\/14651858.CD006386.pub4-BIB0166|cit166","first-page":"6","article-title":"Weekly versus three-weekly cisplatin-based concurrent chemoradiotherapy as definitive treatment in head and neck cancer - where do we stand?","volume":"1","author":"Rawat","year":"2016","journal-title":"Gulf Journal of Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0167|cit167","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1200\/JCO.1987.5.2.278","article-title":"Adjuvant methotrexate escalated to toxicity for resectable stage III and IV squamous head and neck carcinomas - a prospective, randomized study","volume":"5","author":"Rentschler","year":"1987","journal-title":"Journal of Clinical Oncology"},{"issue":"11-12","key":"10.1002\/14651858.CD006386.pub4-BIB0168|cit168","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0014-2964(73)90026-1","article-title":"Intra-arterial methotrexate in head and neck tumors","volume":"9","author":"Richard","year":"1973","journal-title":"European Journal of Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/1097-0142(197409)34:3<491::AID-CNCR2820340303>3.0.CO;2-G","article-title":"Intra-arterial methotrexate chemotherapy and telecobalt therapy in cancer of the oral cavity and oropharynx","volume":"34","author":"Richard","year":"1974","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0170|cit170","first-page":"81","article-title":"Intra-arterial infusion. An adjuvant to surgery of oral carcinoma. A randomized EORTC study","volume":"4","author":"Richard","year":"1983","journal-title":"Journal Europeen de Radiotherapie"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0171|cit171","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0277-5379(91)90125-W","article-title":"Randomised EORTC head and neck cooperative group trial of preoperative intra-arterial chemotherapy in oral cavity and oropharynx carcinoma","volume":"27","author":"Richard","year":"1991","journal-title":"European Journal of Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0172|cit172","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1200\/JCO.2005.01.072","article-title":"Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)","volume":"23","author":"Rischin","year":"2005","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0173|cit173","first-page":"(abs no 1992)","article-title":"Preliminary results of TROG 98.02 - a randomized phase II study of 5-fluorouracil, cisplatin and radiation versus tirapazamine, cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (abstract)","volume":"22","author":"Rischin","year":"2003","journal-title":"Proceedings of the American Society of Clinical Oncology; 2003"},{"issue":"18","key":"10.1002\/14651858.CD006386.pub4-BIB0174|cit174","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1200\/JCO.2009.27.4449","article-title":"Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group","volume":"28","author":"Rischin","year":"2010","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0175|cit175","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/030089161009600210","article-title":"Radiotherapy alone or with concomitant daily low-dose carboplatin in locally advanced, unresectable head and neck cancer: definitive results of a phase III study with a follow-up period of up to ten years","volume":"96","author":"Ruo Redda","year":"2010","journal-title":"Tumori"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0176|cit176","first-page":"XC07","article-title":"A comparative study on weekly versus three weekly cisplatinum based chemoradiation in loally advanced head and neck cancers","volume":"11","author":"Sahoo","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0177|cit177","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00178472","article-title":"A randomized trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma","volume":"249","author":"Salvajoli","year":"1992","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0178|cit178","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1288\/00005537-198811000-00011","article-title":"Preoperative chemotherapy in advanced resectable head and neck cancer: final report of the Southwest Oncology Group","volume":"98","author":"Schuller","year":"1988","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0179|cit179","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1001\/archotol.1989.01860310072026","article-title":"Analysis of treatment failure patterns. A Southwest Oncology Group Study","volume":"115","author":"Schuller","year":"1989","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD006386.pub4-BIB0180|cit180","first-page":"S61","article-title":"Cisplatin plus 5-fluorouracil vs cisplatin plus vinorelbine as neoadjuvant treatment in locally advanced head and neck cancer. Preliminary results of a randomized trial","volume":"35","author":"Segura","year":"1999","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0181|cit181","first-page":"466","article-title":"Cristalin-5-fluorouracilo versus cisplatin-vinorelbine in the treatment of locally advanced head and neck epidermoid carcinomas","volume":"25","author":"Segura","year":"2002","journal-title":"Oncologia"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0182|cit182","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0009-9260(80)80069-9","article-title":"Combined bleomycin and radiotherapy in oral cancer","volume":"31","author":"Shanta","year":"1980","journal-title":"Clinical Radiology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0183|cit183","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0009-9260(77)80157-8","article-title":"Combined therapy of oral cancer bleomycin and radiation: a clinical trial","volume":"28","author":"Shanta","year":"1977","journal-title":"Clinical Radiology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0184|cit184","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0360-3016(95)00525-4","article-title":"Radiotherapy, combined with simultaneous chemotherapy with mitomycin C and bleomycin for inoperable head and neck cancer - preliminary report","volume":"32","author":"Smid","year":"1995","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0185|cit185","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1016\/0959-8049(93)91892-O","article-title":"Concomitant radiotherapy and chemotherapy of inoperable head and neck squamous cell carcinomas","volume":"Suppl 6","author":"Zakotnik","year":"1993","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0186|cit186","first-page":"173","article-title":"Concomitant radiotherapy and mitomycin C with bleomycin in inoperable head and neck cancer","volume":"31","author":"Zakotnik","year":"1997","journal-title":"Radiology and Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0187|cit187","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0360-3016(98)00157-6","article-title":"Concomitant radiotherapy with mitomycin C and bleomycin compared with radiotherapy alone in inoperable head and neck cancer: final report","volume":"41","author":"Zakotnik","year":"1998","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"Suppl 8","key":"10.1002\/14651858.CD006386.pub4-BIB0188|cit188","first-page":"121","article-title":"Concomitant radiotherapy and mitomycin C with bleomycin in inoperable head and neck cancer","volume":"5","author":"Zakotnik","year":"1994","journal-title":"Annals of Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0189|cit189","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.ijrobp.2005.10.039","article-title":"Efficacy of intensified hyperfractionated and accelerated radiotherapy and concurrent chemotherapy with carboplatin and 5-fluorouracil: updated results of a randomized multicentric trial in advanced head-and-neck cancer","volume":"64","author":"Semrau","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0190|cit190","unstructured":"Hyperfractionated (HF) accelerated (ACC) radiochemotherapy (RCT) versus HF\/ACC radiotherapy (RT) in advanced head and neck (HN) cancer (abstract) ASCO; 2000 2000 411a"},{"issue":"Suppl 6","key":"10.1002\/14651858.CD006386.pub4-BIB0191|cit191","first-page":"38 (abs no 126)","article-title":"Benefits and toxicities of accelerated radiochemo- versus accelerated radiotherapy in advanced head and neck cancer - results of a German randomized study","volume":"37","author":"Staar","year":"2001","journal-title":"European Journal of Cancer"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0192|cit192","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0360-3016(01)01544-9","article-title":"Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy - results of a multicentric randomized German trial in advanced head-and-neck cancer","volume":"50","author":"Staar","year":"2001","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0193|cit193","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0360-3016(02)02909-7","article-title":"Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy - results of a multicentric randomized German trial in advanced head-and-neck cancer","volume":"54","author":"Staar","year":"2002","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0194|cit194","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/(SICI)1097-0142(19991015)86:8<1381::AID-CNCR1>3.0.CO;2-V","article-title":"Intra-arterial preoperative cytostatic treatment versus preoperative irradiation: a prospective, randomized study of lingual and sublingual carcinomas","volume":"86","author":"Szabo","year":"1999","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0195|cit195","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-3-642-81332-0_47","article-title":"Adjuvant treatment of tongue and floor of the mouth cancers","volume":"68","author":"Szpirglas","year":"1978","journal-title":"Recent Results in Cancer Research"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0196|cit196","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-3-642-81332-0_47","volume-title":"Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II. Adjuvant Therapies of the Various Primary Tumors","author":"Szpirglas","year":"1979"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0197|cit197","unstructured":"Szpirglas H Nizri D Marneur M Neoadjuvant chemotherapy. A randomized trial before radiotherapy in oral and oropharyngeal carcinomas: end results 2nd International Head and Neck Oncology Research Conference; 1988 1988 261 4"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0198|cit198","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00066-015-0829-z","article-title":"Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage III\u2013IV unresectable head and neck cancer","volume":"191","author":"Takacsi-Nagy","year":"2015","journal-title":"Strahlenther Onkol"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0199|cit199","first-page":"417","article-title":"Induction chemotherapy with carboplatin and ftorafur in advanced head and neck cancer. A randomized study","volume":"15","author":"Tejedor","year":"1992","journal-title":"American Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0200|cit200","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3389\/fonc.2020.01284","article-title":"Randomized controlled study comparing efficacy and toxicity of weekly vs. 3-weekly induction chemotherapy in locally advanced head and neck squamous cell carcinoma","volume":"10","author":"Tousif","year":"2020","journal-title":"Frontiers in Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0201|cit201","first-page":"340","article-title":"Combined modality treatment in head and neck cancer: an update on the UKHAN trial","volume":"8","author":"Monson","year":"1996","journal-title":"Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0202|cit202","unstructured":"Tobias J Monson K Gupta N MacDougall H Glaholm J Peto J Does chemotherapy have a role in the management of patients with advanced head and neck cancer? Early results from the UK head and neck (UKHAN) trial (abstract) American Society of Clinical Oncology; 2001 2001 (abs no 888)"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0203|cit203","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1470-2045(09)70306-7","article-title":"Chemoradiotherapy for locally advanced head and neck cancer: 10-year follow-up of the UK Head and Neck (UKHAN1) trial","volume":"11","author":"Tobias","year":"2010","journal-title":"Lancet Oncology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0204|cit204","first-page":"20","article-title":"Early results from the UK head and neck (UKHAN) trial: the role of chemotherapy in primary management of advanced head and neck cancer","volume":"85","author":"Tobias","year":"2001","journal-title":"British Journal of Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0205|cit205","first-page":"S16","article-title":"UKHAN 1: a prospective multi-centre randomised trial investigating chemotherapy as part of initial management in advanced head and neck cancer","volume":"58","author":"Tobias","year":"2001","journal-title":"Radiotherapy and Oncology"},{"issue":"18S","key":"10.1002\/14651858.CD006386.pub4-BIB0206|cit206","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1200\/jco.2006.24.18_suppl.5522","article-title":"Impact on quality of life (QoL) of the addition of docetaxel (T) to neoadjuvant cisplatin plus 5-fluorouracil treatment in patients with locally advanced unresectable squamous cell carcinoma of the head and neck (SCCHN): EORTC study 24971","volume":"24","author":"Bernier","year":"2006","journal-title":"Journal of Clinical Oncology"},{"issue":"Suppl 4","key":"10.1002\/14651858.CD006386.pub4-BIB0207|cit207","first-page":"92","article-title":"Results of a randomized phase 2 trial of docetaxel (TXT) with cisplatin (CDDP) or TXT with 5-fluorouracil (5FU) in patients (pts) with unresectable locally advanced squamous cell carcinoma of the head and neck (SCCHN)","volume":"11","author":"Biakhov","year":"2000","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0208|cit208","unstructured":"Biakhov M Shah P Betka J Doval D Garin A A randomized phase II trial of taxotere (TXT) with cisplatin (CDDP) or TXT with 5-fluorouracil (5FU) in patients (PTS) with unresectable locally advanced squamous cell carcinoma of the head and neck (abstract) American Society of Clinical Oncology; 2000 2000 (abs no 1657)"},{"issue":"18S","key":"10.1002\/14651858.CD006386.pub4-BIB0209|cit209","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1200\/jco.2006.24.18_suppl.5516","article-title":"A randomized phase III multicenter trial of neoadjuvant docetaxel plus cisplatin and 5-fluorouracil (TPF) versus neoadjuvant PF in patients with locally advanced unresectable squamous cell carcinoma of the head and neck (SCCHN). Final analysis of EORTC 24971","volume":"24","author":"Remenar","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0210|cit210","doi-asserted-by":"crossref","first-page":"14S (abs no 550","DOI":"10.1200\/jco.2004.22.90140.5508","article-title":"Standard cisplatin\/infusional 5-fluorouracil (PF) vs docetaxel (T) plus PF (TPF) as neoadjuvant chemotherapy for nonresectable locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): a phase III trial of the EORTC Head and Neck Cancer Group (EORTC #24971)","volume":"22","author":"Vermorken","year":"2004","journal-title":"Journal of Clinical Oncology"},{"issue":"17","key":"10.1002\/14651858.CD006386.pub4-BIB0211|cit211","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"Vermorken","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0212|cit212","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/1097-0142(19900715)66:2<206::AID-CNCR2820660203>3.0.CO;2-X","article-title":"A randomized study comparing two regimens of neoadjuvant and adjuvant chemotherapy in multimodal therapy for locally advanced head and neck cancer","volume":"66","author":"Vokes","year":"1990","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0213|cit213","doi-asserted-by":"crossref","unstructured":"Schroder M Muller RP Knufermann H Volling P Improved survival after neoadjuvant carboplatin\/5 FU in resectable stage II and III squamous cell carcinomas of the oral cavity and tonsil European Journal of Cancer 1993 29Y S144","DOI":"10.1016\/0959-8049(93)91417-J"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0214|cit214","first-page":"45","article-title":"Results of a prospective randomized trial with induction chemotherapy for cancer of the oral cavity and tonsil","volume":"256","author":"Volling","year":"1999","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0215|cit215","first-page":"899","article-title":"Results of a prospective randomized trial with induction chemotherapy for cancer of the oral cavity and tonsils","volume":"47","author":"Volling","year":"1999","journal-title":"Deutsche Gesellschaft der Hals- Nasen- und Ohrena\u0308rzte"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0216|cit216","first-page":"909","article-title":"Induction chemotherapy in primary resectable head and neck tumors: a prospective randomized trial","volume":"4","author":"Volling","year":"1994","journal-title":"International Journal of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0217|cit217","first-page":"175","article-title":"Carboplatin\/5-FU + operation + radiotherapy versus operation + radiotherapy by primary operable head and neck carcinomas: 4-year results","volume":"Suppl II","author":"Volling","year":"1993","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0218|cit218","first-page":"58","article-title":"Preliminary results of a prospective randomized study of primary chemotherapy in carcinoma of the oral cavity and pharynx","volume":"43","author":"Volling","year":"1995","journal-title":"Deutsche Gesellschaft der Hals- Nasen- und Ohrena\u0308rzte"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0219|cit219","unstructured":"Keegan P Pillsbury H Weissler M Simultaneous cisplatinum -5FU and radiotherapy versus radiotherapy alone in advanced carcinoma of the head and neck American Society of Clinical Oncology; 1988 1988 157"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0220|cit220","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/archotol.1992.01880080028008","article-title":"Simultaneous chemoradiation in the treatment of advanced head and neck cancer","volume":"118","author":"Weissler","year":"1992","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0221|cit221","unstructured":"Wendt T Grabenbauer GG Thiel HJ Simultaneous radiation therapy and chemotherapy versus radiation therapy alone in stage III and IV carcinoma of the head and neck: results of a randomized trial 81st Scientific Assembly and Annual Meeting of the Radiological Society of North America; 1995 1995"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0222|cit222","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1200\/JCO.1998.16.4.1318","article-title":"Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study","volume":"16","author":"Wendt","year":"1998","journal-title":"Journal of Clinical Oncology"},{"issue":"9 Suppl 9","key":"10.1002\/14651858.CD006386.pub4-BIB0223|cit223","first-page":"179","article-title":"Radiotherapy versus concurrent chemotherapy followed by adjuvant chemotherapy in the treatment of locally advanced head and neck cancer","volume":"17","author":"Abdel Wahab","year":"2006","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0224|cit224","unstructured":"Abele R Honegger HP Grossenbacher R Kaplan E Randomized trial of methotrexate (M), bleomycin (B) hydroxyurea (HU) with versus without cisplatin in advanced squamous cell carcinoma of head and neck Proceedings of the American Society of Clinical Oncology 1984 186 (Abs No C724)"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0225|cit225","first-page":"S1","article-title":"Methotrexate (M), bleomycin (B), hydroxyurea (HU) versus M+B+HU and cisplatin (C) in stage III-IV squamous cell carcinoma of the head and neck: a randomized study","volume":"14","author":"Abele","year":"1985","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0226|cit226","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000492153","article-title":"Maintenance therapy with biweekly cetuximab: optimizing schedule can preserve activity and improves compliance in advanced head and neck cancer","volume":"95","author":"Addeo","year":"2018","journal-title":"Oncology"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0227|cit227","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<567::AID-HED2>3.0.CO;2-5","article-title":"A phase III randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer: preliminary results","volume":"19","author":"Adelstein","year":"1997","journal-title":"Head & Neck"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0228|cit228","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO;2-Y","article-title":"Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck","volume":"88","author":"Adelstein","year":"2000","journal-title":"Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0229|cit229","first-page":"21","article-title":"Definitive and adjuvant IMRT using simultaneous integrated boost in head and neck cancer","volume":"192","author":"Ahmad Khalil","year":"2016","journal-title":"Strahlentherapie und Onkologie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0230|cit230","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4103\/0019-509X.197740","article-title":"Comparison of two different radiation fractionation schedules with concurrent chemotherapy in head and neck malignancy","volume":"53","author":"Alam","year":"2016","journal-title":"Indian Journal of Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0231|cit231","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/1120009X.1989.11738867","article-title":"Comparative study of two neoadjuvant protocols (VBM and DDP-BLM) combined with radiation therapy in advanced head and neck cancer","volume":"1","author":"Amichetti","year":"1989","journal-title":"Journal of Chemotherapy"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0232|cit232","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1016\/S0959-8049(99)81077-6","article-title":"A phase III study of concurrent radiotherapy with carboplatin or weekly paclitaxel in patients with advanced squamous cell head and neck cancer (SCHNC)","volume":"35 Suppl 4","author":"Andreadis","year":"1999","journal-title":"European Journal of Cancer"},{"issue":"6003","key":"10.1002\/14651858.CD006386.pub4-BIB0233|cit233","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/bmj.1.6003.188","article-title":"Bleomycin in advanced squamous cell carcinoma: a random controlled trial. Report of Medical Research Council Working Party on Bleomycin","volume":"1","year":"1976","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0234|cit234","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/1097-0142(197001)25:1<78::AID-CNCR2820250112>3.0.CO;2-4","article-title":"Treatment of advanced cancer of the head and neck","volume":"25","author":"Ansfield","year":"1970","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0235|cit235","doi-asserted-by":"crossref","unstructured":"Antonadou D Pepelassi M Synodinou M Puglisi M Throuvalas N Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer International Journal of Radiation Oncology, Biology, Physics 2002 52 3 739 47","DOI":"10.1016\/S0360-3016(01)02683-9"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0236|cit236","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/annonc\/mdw204","article-title":"Phase II randomized trial of radiation therapy, cetuximab, and pemetrexed with or without bevacizumab in patients with locally advanced head and neck cancer","volume":"27","author":"Argiris","year":"2016","journal-title":"Annals of Oncology"},{"issue":"20","key":"10.1002\/14651858.CD006386.pub4-BIB0237|cit237","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMc060694","article-title":"Cetuximab plus radiotherapy for head and neck cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0238|cit238","doi-asserted-by":"crossref","unstructured":"Asif R Chandra K Chopra V Concurrent cisplatin and radiotherapy in advanced head and neck cancer Indian Journal of Otolaryngology and Head and Neck Surgery 2003 55 2 94 6","DOI":"10.1007\/BF02974612"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0239|cit239","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00285321","article-title":"Intravenous chemotherapy with syndronization in advanced cancer of oral cavity and oropharynx","volume":"90","author":"Auersperg","year":"1977","journal-title":"Zeitschrift fur Krebsforschung und Klinische Onkologie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0240|cit240","doi-asserted-by":"crossref","first-page":"S599","DOI":"10.1016\/S0167-8140(17)31527-X","article-title":"Low dose fractionated RT in association to TPF as induction therapy in advanced head and neck cancer","volume":"123","author":"Autorino","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0241|cit241","doi-asserted-by":"crossref","first-page":"Abstract 5530","DOI":"10.1200\/jco.2010.28.15_suppl.5530","article-title":"An open-label, randomized, study of h-R3mAb (nimotuzumab) in patients with advanced (stage III or IVa) squamous cell carcinoma of head and neck (SCCHN): four-year survival results from a phase IIb study","volume":"28","author":"Babu","year":"2010","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0242|cit242","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0360-3016(96)00430-0","article-title":"Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial","volume":"36","author":"Bachaud","year":"1996","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0243|cit243","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0360-3016(91)90098-O","article-title":"Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced squamous cell carcinoma of the head and neck: preliminary report of a randomized trial","volume":"20","author":"Bachaud","year":"1991","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1-2","key":"10.1002\/14651858.CD006386.pub4-BIB0244|cit244","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0360-3016(78)90125-6","article-title":"Double blind controlled clinical trial of radiation plus razoxane (ICRF 159) versus radiation plus placebo in the treatment of head and neck cancer","volume":"4","author":"Bakowski","year":"1978","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0245|cit245","article-title":"The impact of radiotherapy, in addition to chemotherapy, on overall survival in the initial management of patients with newly diagnosed metastatic head and neck squamous cell carcinoma","volume":"15 Supplement 1","author":"Baliga","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0246|cit246","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3329\/bmrcb.v44i2.38703","article-title":"Outcome of concurrent chemoradiotherapy and radiotherapy alone following induction chemotherapy in locally advanced squamous cell carcinoma of head and neck","volume":"44","author":"Bari","year":"2018","journal-title":"Bangladesh Medical Research Council Bulletin"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0247|cit247","doi-asserted-by":"crossref","unstructured":"Barney C Walston S Zamora P Nolan N Diavolitsis V Blakaj D Cetuximab versus platinum-based chemoradiation in locally advanced p16 positive oropharyngeal cancer Annual Conference of the European Society for Radiotherapy and Oncology, ESTRO 36, 2017; Austria 123 2017 S174 5","DOI":"10.1016\/S0167-8140(17)30773-9"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0248|cit248","doi-asserted-by":"crossref","unstructured":"Bell BR Leidner R Duhen R Koguchi Y Weinberg A A phase IB neoadjuvant trial of anti-OX-40 (medi6469) prior to definitive surgical resection in patients with head and neck squamous cell carcinoma 6th World Congress of the International Academy of Oral Oncology, IAOO, 2017; India. 39 2017 E46 7","DOI":"10.1158\/1557-3265.AACRAHNS17-37"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0249|cit249","first-page":"1044","article-title":"Concomitant radiochemotherapy with cisplatin (CDDP), 5-fluorouracil (5-FU) and mitomycin C (MMC) in locally advanced carcinoma of the oropharynx. Results of a phase II trial","volume":"82","author":"Berger","year":"1995","journal-title":"Bulletin du Cancer"},{"issue":"Suppl 10","key":"10.1002\/14651858.CD006386.pub4-BIB0250|cit250","doi-asserted-by":"crossref","first-page":"X102","DOI":"10.1093\/annonc\/mdx665.008","article-title":"Acute toxicity profile of concomitant chemoradiotherapy in head and neck cancers: a randomized controlled comparison of weekly versus triweekly cisplatin schedule","volume":"29","author":"Beryhy","year":"2017","journal-title":"Annals of Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0251|cit251","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/mpo.2950060412","article-title":"Treatment of advanced head and neck cancer by means of radiation therapy plus chemotherapy - a randomised trial","volume":"6","author":"Bezwoda","year":"1979","journal-title":"Medical & Pediatric Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0252|cit252","doi-asserted-by":"crossref","unstructured":"Bhattasali O Iganej S Cetuximab-based bioradiation therapy versus cisplatin-based chemoradiation therapy in the definitive treatment of locally advanced oropharyngeal squamous cell carcinoma International Journal of Radiation Oncology (58th Annual Meeting of the American Society for Radiation O, ASTRO) 2016 S82 3","DOI":"10.1016\/j.ijrobp.2016.06.209"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0253|cit253","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1007\/BF02580255","article-title":"Prospective randomized clinical trial for squamous cell carcinomas of the oral cavity: preoperative chemotherapy versus postoperative chemotherapy versus surgery alone","volume":"111","author":"Bier","year":"1986","journal-title":"Journal of Cancer Research & Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0254|cit254","first-page":"504","article-title":"Simultaneous treatment with c-DPP and radiation therapy for advanced head and neck tumors. A randomized study","volume":"82","author":"Boidi","year":"1991","journal-title":"Radiologia Medica"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0255|cit255","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0959-8049(94)90290-9","article-title":"Prevention of second primary tumours with etretinate in squamous cell carcinoma of the oral cavity and oropharynx. Results of a multicentric double-blind randomised study","volume":"30A","author":"Bolla","year":"1994","journal-title":"European Journal of Cancer"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0256|cit256","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck","volume":"354","author":"Bonner","year":"2006","journal-title":"New England Journal of Medicine"},{"issue":"18S","key":"10.1002\/14651858.CD006386.pub4-BIB0257|cit257","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1200\/jco.2007.25.18_suppl.6047","article-title":"A randomized phase II study of concomitant CT (docetaxel [plus or minus] cisplatin) and (RT) in first-line treatment of locally advanced head and neck cancer (LAHNC)","volume":"25","author":"Bouillet","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0258|cit258","first-page":"284","article-title":"Does the addition of chemotherapy to radiotherapy improve survival in advanced head and neck cancer","volume":"7","author":"Bradley","year":"1982","journal-title":"Clinical Otolaryngology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0259|cit259","unstructured":"Brigham BA Fisher RJ Stewart J Fong T Mead K Role of folinic acid in methotrexate treatment of head and neck squamous cancers Proceedings of the American Society of Clinical Oncology; 1998 1998 (Abs No 1518)"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0260|cit260","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1200\/JCO.1983.1.12.787","article-title":"Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer","volume":"1","author":"Browman","year":"1983","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0261|cit261","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/hed.2890080304","article-title":"Survival results from a phase III study of simultaneous versus 1-hour sequential methotrexate-5-fluorouracil chemotherapy in head and neck cancer","volume":"8","author":"Browman","year":"1986","journal-title":"Head & Neck Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0262|cit262","doi-asserted-by":"crossref","unstructured":"Browman GP Young JEM Archibald SD Kiehl K Prospective randomised trial of 1-hour sequential versus simultaneous methotrexate (MTX) + 5 fluorouracil (5FU) in squamous cell carcinoma of the head and neck (SCHN) Proceedings of the American Society of Clinical Oncology; 1983 1983 158 (Abs No C 616)","DOI":"10.1200\/JCO.1983.1.12.787"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0263|cit263","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1200\/JCO.1988.6.6.963","article-title":"Methotrexate\/fluorouracil scheduling influences normal tissue toxicity but not antitumor effects in patients with squamous cell head and neck cancer: results from a randomized trial","volume":"6","author":"Browman","year":"1988","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0264|cit264","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1200\/JCO.1990.8.2.203","article-title":"Modulation of the antitumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: a randomized placebo-controlled clinical trial","volume":"8","author":"Browman","year":"1990","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0265|cit265","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijrobp.2005.08.005","article-title":"Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study","volume":"64","author":"Buentzel","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0266|cit266","doi-asserted-by":"crossref","unstructured":"Buentzel J Monier A Ammon G Schmitt N Willich N Hammershaimb L Phase III randomized double blind placebo controlled trial of carboplatin and radiation therapy \u00b1 amifostine in patients with head and neck cancer Proceedings of the 43rd Annual Meeting of ASTRO; 2001 2001 85 (Abs No 151)","DOI":"10.1016\/S0360-3016(01)01980-0"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0267|cit267","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ijrobp.2016.10.011","article-title":"Subgroup analysis according to human papillomavirus status and tumor site of a randomized phase II trial comparing cetuximab and cisplatin combined with radiation therapy for locally advanced head and neck cancer","volume":"97","author":"Buglione","year":"2017","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"issue":"1 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0268|cit268","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/srao.2002.31356","article-title":"Amifostine in simultaneous radiochemotherapy of advanced head and neck cancer","volume":"12","author":"Buntzel","year":"2002","journal-title":"Seminars in Radiation Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0269|cit269","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s005200050150","article-title":"Radiochemotherapy with amifostine cytoprotection for head and neck cancer","volume":"6","author":"Buntzel","year":"1998","journal-title":"Supportive Care in Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0270|cit270","first-page":"R113","article-title":"Clinical experiences with amifostine in the radiochemotherapy of head neck cancer","volume":"124 Suppl 1","author":"Buntzel","year":"1998","journal-title":"Journal of Cancer Research & Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0271|cit271","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1023\/A:1008282412670","article-title":"Selective cytoprotection with amifostine in concurrent radiochemotherapy for head and neck cancer","volume":"9","author":"Buntzel","year":"1998","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0272|cit272","first-page":"S197","article-title":"Cytoprotection with amifostine (A) as the base for intensification of radiochemotherapy in head and neck cancer","volume":"77 Suppl 2","author":"Buntzel","year":"1998","journal-title":"Annals of Hematology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0273|cit273","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1200\/JCO.2017.35.15_suppl.6001","article-title":"LUX-head and neck 2: randomized, double-blind, placebo-controlled, phase III trial of afatinib as adjuvant therapy after chemoradiation (CRT) in primary unresected, high\/intermediate-risk, squamous cell cancer of the head and neck (HNSCC) patients (pts)","volume":"35","author":"Burtness","year":"2017","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0274|cit274","unstructured":"Campbell JB Dorman EB McCormick M Miles J Morton RP Rugman F A randomized phase III trial of cisplatinum, methotrexate, cisplatinum + methotrexate, and cisplatinum + 5-fluoro-uracil in end-stage head and neck cancer Acta Oto-Laryngologica 1987 103 5-6 519 28"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0275|cit275","first-page":"S105","article-title":"A phase 2 randomised study of cisplatin (CDDP) raltitrexed (TOM) levofolinic acid (LFA) and 5-fluoruracil (5-FU) or CDDP, methotrexate (MTX) LFA and 5-FU in locally advanced (LAD) or metastatic (M) head and neck cancer (HNC)","volume":"37","author":"Caponigro","year":"2001","journal-title":"Head and Neck Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0276|cit276","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000065470","article-title":"Cisplatin, raltitrexed, levofolinic acid and 5-fluorouracil in locally advanced or metastatic squamous cell carcinoma of the head and neck: a phase II randomized study","volume":"63","author":"Caponigro","year":"2002","journal-title":"Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0277|cit277","first-page":"422","article-title":"Randomized trial of vincristin-methotrexate-bleomycin and cis-platin or detorubicin for advanced head and neck cancer (author's transl)","volume":"68","author":"Cappelaere","year":"1981","journal-title":"Bulletin du Cancer"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0278|cit278","first-page":"1099","article-title":"Palliative chemotherapy of epidermoid carcinoma of the upper respiratory and digestive tracts with a combination of carboplatin and 5-fluorouracil","volume":"77","author":"Cappelaere","year":"1990","journal-title":"Bulletin du Cancer"},{"issue":"1068","key":"10.1002\/14651858.CD006386.pub4-BIB0279|cit279","doi-asserted-by":"crossref","first-page":"20160105","DOI":"10.1259\/bjr.20160105","article-title":"Cost analysis of cetuximab (Erbitux) plus radiotherapy (ERT) versus concomitant cisplatin plus radiotherapy (CRT) within an NHS oncology unit (single institution): a pilot study","volume":"89","author":"Caroline","year":"2016","journal-title":"British Journal of Radiology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0280|cit280","unstructured":"Carugati A Pradier R De la Torre A Combination chemotherapy preradical treatment for head and neck squamous cell carcinoma Proceedings of the American Society of Clinical Oncology 1988 152"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0281|cit281","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hed.24763","article-title":"High-dose or low-dose cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer","volume":"39","author":"Chang","year":"2017","journal-title":"Head and Neck"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0282|cit282","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1001\/jamaoncol.2017.0737","article-title":"Demonstrating noninferiority of accelerated radiotherapy with panitumumab vs standard radiotherapy with cisplatin in locoregionally advanced squamous cell head and neck carcinoma","volume":"3","author":"Cheng","year":"2017","journal-title":"JAMA Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0283|cit283","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/1097-0142(19870915)60:6<1173::AID-CNCR2820600603>3.0.CO;2-9","article-title":"Combination chemotherapy with methotrexate, bleomycin, and vincristine with or without cisplatin in advanced squamous cell carcinoma of the head and neck","volume":"60","author":"Clavel","year":"1987","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0284|cit284","first-page":"S14","article-title":"Randomized trial of cisplatin (C), methotrexate (A), bleomycin (B) and vincristine (O) vs ABO in advanced squamous cell cancer of the head and neck","volume":"14 Suppl 1","author":"Clavel","year":"1985","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0285|cit285","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1200\/JCO.1984.2.7.756","article-title":"Combination therapy with methotrexate and 5-fluorouracil: a prospective randomized clinical trial of order of administration","volume":"2","author":"Coates","year":"1984","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0286|cit286","doi-asserted-by":"crossref","first-page":"LBA37","DOI":"10.1093\/annonc\/mdw435.33","article-title":"Active8: a randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with motolimod immunotherapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck","volume":"27","author":"Cohen","year":"2016","journal-title":"Annals of Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0287|cit287","first-page":"85","article-title":"Sequential trials in initial chemotherapy of advanced tumors of the upper aero-digestive system. Cis-diamminedichloroplatinum (DDP) versus DDP-etoposide (VP16)","volume":"73","author":"Coninx","year":"1986","journal-title":"Bulletin du Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0288|cit288","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/1097-0142(19881101)62:9<1888::AID-CNCR2820620903>3.0.CO;2-M","article-title":"Sequential trial of initial chemotherapy for advanced cancer of the head and neck. DDP versus DDP + 5-fluorouracil","volume":"62","author":"Coninx","year":"1988","journal-title":"Cancer"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0289|cit289","first-page":"1993","article-title":"Chemoradiotherapy as an alternative to radiotherapy alone in fast proliferating head and neck squamous cell carcinomas","volume":"3","author":"Corvo","year":"1997","journal-title":"Clinical Cancer Research"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0290|cit290","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0959-8049(97)85531-1","article-title":"Randomized trial of cisplatin (P) plus 5-fluorouracil (F) with or without folinic acid in locally advanced head and neck cancer (LAHNC)","volume":"33","author":"Cruz","year":"1997","journal-title":"European Journal of Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0291|cit291","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.radonc.2007.09.010","article-title":"Five year results of a randomized trial comparing hyperfractionated to conventional radiotherapy over four weeks in locally advanced head and neck cancer","volume":"85","author":"Cummings","year":"2007","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0292|cit292","unstructured":"Dalley D Beller E Aroney R Dewar J Page J Philip R The value of chemotherapy (CT) prior to definitive local therapy (DLT) in patients with locally advanced squamous cell carcinoma (SCC) of the head and neck (HN) Proceedings of American Society of Clinical Oncology 1995 297"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0293|cit293","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/1097-0142(19810901)48:5<1061::AID-CNCR2820480502>3.0.CO;2-X","article-title":"A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin, and a methotrexate combination in head and neck cancer","volume":"48","author":"DeConti","year":"1981","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0294|cit294","first-page":"74","article-title":"Combination treatment in moderately advanced head & neck cancer","volume":"78 Suppl","author":"Deka","year":"1983","journal-title":"Indian Journal of Medical Research"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0295|cit295","first-page":"S143","article-title":"A randomized study of radiotherapy treatment of advanced head and neck cancer, with vs without tegafur","volume":"27 Suppl 2","author":"De la Torre","year":"1991","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0296|cit296","unstructured":"Di Blasio B Barbieri W Bozzetti A Iotti C Di Sarra S Cocconi G A prospective randomized trial in resectable head and neck carcinoma: loco-regional treatment with and without neoadjuvant chemotherapy Proceedings of the American Society of Clinical Oncology 1994 279"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0297|cit297","first-page":"S279","article-title":"Conventional vs accelerated fractionation in head and neck cancer","volume":"27","author":"Dobrowsky","year":"1996","journal-title":"British Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0298|cit298","unstructured":"Domenge C Marands P Douillard JY Peuvrel P Prevost B Lefebvre J Post surgical adjuvant chemotherapy in extracapsular spread invaded lymph node (N+ R+) of epidermoid carcinoma of the head and neck. A randomized multicentric trial Proceedings of the European Conference on Clinical Oncology; 1987 1987 242"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0299|cit299","unstructured":"Domenge C Marandas P Vignoud J Post-surgical adjuvant chemotherapy in extracapsular spread invaded lymph node (N+R+) of epidermoid carcinoma of the head and neck: a randomized multicentric trial 2nd International Conference on Head and Neck Cancer; 1988; Boston; American Society of Head & Neck Surgery 1988"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0300|cit300","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/1097-0142(19830801)52:3<399::AID-CNCR2820520303>3.0.CO;2-1","article-title":"A randomized trial of the combination of cis-platinum, oncovin and bleomycin (COB) versus methotrexate in patients with advanced squamous cell carcinoma of the head and neck","volume":"52","author":"Drelichman","year":"1983","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0301|cit301","doi-asserted-by":"crossref","first-page":"989P","DOI":"10.1093\/annonc\/mdw376.41","article-title":"Ototoxicity in locally advanced head and neck cancer (LAHNC) patients (pts) treated with induction chemotherapy (IC) followed by cisplatin-based chemoradiotherapy (CRT)","volume":"27","author":"Driessen","year":"2016","journal-title":"Annals of Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0302|cit302","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/2278-0513.113634","article-title":"Radical treatment of locally advanced head and neck cancer with concurrent chemo radiation-cisplatin versus carboplatin: a randomized comparative phase III trial","volume":"2","author":"Dutta","year":"2013","journal-title":"Clinical Cancer Investigation Journal"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0303|cit303","first-page":"629","article-title":"Cisplatin\/5FU versus carboplatin\/5FU. 5 year follow up","volume":"42","author":"Ebeling","year":"1994","journal-title":"Head and Neck Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0304|cit304","first-page":"S6","article-title":"DAHANCA 19: first results of a randomized phase III study of the importance of the EGFR-inhibitor zalutumumab for the outcome of primary curative radiotherapy for squamous cell carcinoma of the head and neck","volume":"49","author":"Eriksen","year":"2013","journal-title":"European Journal of Cancer (European Cancer Congress, ECC, 27 Sept-1 Oct 2013; Amsterdam Netherlands)"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0305|cit305","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijrobp.2013.11.021","article-title":"Evaluation of the EGFR-Inhibitor zalutumumab given with primary curative (CHEMO) radiation therapy to patients with squamous cell carcinoma of the head and neck: results of the DAHANCA 19 randomized phase 3 trial","volume":"88","author":"Eriksen","year":"2014","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0306|cit306","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0360-3016(92)90881-H","article-title":"First analysis of tumor regression for the European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas","volume":"22","author":"Chassagne","year":"1992","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0307|cit307","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0360-3016(97)00327-1","article-title":"Results of a European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas","volume":"39","author":"Eschwege","year":"1997","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0308|cit308","first-page":"85","article-title":"A randomized study of accelerated fractionation radiotherapy with and without mitomycin C in the treatment of locally advanced head and neck cancer","volume":"17","author":"Ezzat","year":"2005","journal-title":"Journal of the Egyptian National Cancer Institute"},{"issue":"OCT","key":"10.1002\/14651858.CD006386.pub4-BIB0309|cit309","first-page":"232","article-title":"Randomized phase II study of duligotuzumab (MEHD7945A) vs. cetuximab in squamous cell carcinoma of the head and neck (MEHGAN Study)","volume":"6","author":"Fayette","year":"2016","journal-title":"Frontiers in Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0310|cit310","first-page":"2475","article-title":"Efficacy and survival rate of intensity-modulated radiotherapy combined with chemotherapy for elderly patients with locally advanced oropharyngeal cancer","volume":"15","author":"Feng","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0311|cit311","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.ijrobp.2017.12.300","article-title":"Two-year update from CheckMate 141: outcomes with nivolumab (NIVO) vs investigator's choice (IC) in recurrent or metastatic (R\/M) squamous cell carcinoma of the head and neck (SCCHN) in the overall population and PD-l1 subgroups","volume":"100","author":"Ferris","year":"2018","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0312|cit312","doi-asserted-by":"crossref","unstructured":"Simpson S Cocks K Contente M DeRosa M Taylor F Shaw JW A quality-adjusted time without symptoms of disease and toxicity (Q-TWIST) analysis comparing nivolumab and therapy of investigator's choice (IC) in patients with recurrent or metastatic (R\/M) platinum-refractory squamous cell carcinoma of the head and neck (SCCHN) (checkmate 141) ISPOR 20th Annual European Congress; 2017; United Kingdom: 20 2017 A450","DOI":"10.1016\/j.jval.2017.08.292"},{"issue":"6A","key":"10.1002\/14651858.CD006386.pub4-BIB0313|cit313","first-page":"2347","article-title":"Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: preliminary results","volume":"14","author":"Fety","year":"1994","journal-title":"Anticancer Research"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0314|cit314","first-page":"2039","article-title":"Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas","volume":"4","author":"Fety","year":"1998","journal-title":"Clinical Cancer Research"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0315|cit315","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1023\/A:1008280206369","article-title":"Randomized trial of neoadjuvant chemotherapy with cisplatin plus 5-fluorouracil, with or without leucovorin, in locally advanced head and neck cancer","volume":"8","author":"Fonseca","year":"1997","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0316|cit316","unstructured":"Cruz JJ Fonseca E Gomez JG Rueda A Randomized phase II trial of induction chemotherapy in patients with locally advanced head and neck carcinoma (LA-HNC) Docetaxel plus cisplatin (DP) versus cisplatin plus 5-FU (PF): interim results Proceedings of the American Society of Clinical Oncology 2002 (Abs No 920)"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0317|cit317","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ejca.2005.02.019","article-title":"Induction chemotherapy with cisplatin\/docetaxel versus cisplatin\/5-fluorouracil for locally advanced squamous cell carcinoma of the head and neck: a randomised phase II study","volume":"41","author":"Fonseca","year":"2005","journal-title":"European Journal of Cancer"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0318|cit318","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1200\/JCO.2001.19.4.1088","article-title":"Phase III comparison of high-dose paclitaxel + cisplatin + granulocyte colony-stimulating factor versus low-dose paclitaxel + cisplatin in advanced head and neck cancer: Eastern Cooperative Oncology Group Study E1393","volume":"19","author":"Forastiere","year":"2001","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0319|cit319","unstructured":"Ciuleanu E Theophanopoulou M Kalogera-Fountzila A A randomised study of concomitant radiotherapy with cisplatin or carboplatin versus radiotherapy alone in patients with locally advanced non-nasopharyngeal head and neck cancer. A Hellenic Cooperative Oncology group phase III study Proceedings of the American Society of Clinical Oncology 2003 495 (Abs No 1991)"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0320|cit320","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1385\/MO:21:2:095","article-title":"Concomitant radiochemotherapy vs radiotherapy alone in patients with head and neck cancer","volume":"21","author":"Fountzilas","year":"2004","journal-title":"Medical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0321|cit321","unstructured":"Fu KK Phillips TL Silverberg IJ Friedman MA Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced head and neck cancer: interim report of NCOG randomized trial Proceedings of the American Society of Clinical Oncology 1983 159 (Abs No C 622)"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0322|cit322","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1200\/JCO.1987.5.9.1410","article-title":"Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial","volume":"5","author":"Fu","year":"1987","journal-title":"Journal of Clinical Oncology"},{"issue":"13","key":"10.1002\/14651858.CD006386.pub4-BIB0323|cit323","first-page":"1740","article-title":"Combination chemotherapy with 5-FU and CDDP or CDDP analog for head and neck cancer","volume":"23","author":"Fujii","year":"1996","journal-title":"Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0324|cit324","first-page":"1542","article-title":"Low-dose CDDP and 5-FU for head and neck cancer patients","volume":"26","author":"Fujii","year":"1999","journal-title":"Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0325|cit325","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0385-8146(12)80142-8","article-title":"Modified combination chemotherapy of cisplatin and 5-fluorouracil in squamous cell carcinomas of the head and neck","volume":"21","author":"Furukawa","year":"1994","journal-title":"Auris, Nasus, Larynx"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0326|cit326","first-page":"S93","article-title":"A cooperative AIRO\/PIEMONTE randomized clinical trial of carboplatin as an adjunct to radiotherapy in head and neck cancer","volume":"32 Suppl 1","author":"Gabriele","year":"1994","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0327|cit327","first-page":"18","article-title":"A phase III study of radiotherapy alone versus radiotherapy plus carboplatin in stage III-IV head and neck cancers. An analysis on oral cavity cancer","volume":"24 Suppl 1","author":"Gabriele","year":"1996","journal-title":"Journal of Cranio Maxillo Facial Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0328|cit328","doi-asserted-by":"crossref","first-page":"S519","DOI":"10.1016\/S0167-8140(16)32331-3","article-title":"Advanced head and neck ca-chemoradiotherapy with conventional fraction and accelerated fraction","volume":"119","author":"Gaffor","year":"2016","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0329|cit329","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00000421-199206000-00013","article-title":"Synchronous radiotherapy and chemotherapy with cisplatin in the management of locally advanced or recurrent head and neck cancer","volume":"15","author":"Gasparini","year":"1992","journal-title":"American Journal of Clinical Oncology: Cancer Clinical Trials"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0330|cit330","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0924-4212(96)85320-5","article-title":"Cancers of the base of the tongue and hypopharynx: results of a multicenter randomized trial of chemotherapy prior to locoregional treatment","volume":"83","author":"Gedouin","year":"1986","journal-title":"Bulletin du Cancer Radiotherapie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0331|cit331","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0924-4212(96)85320-5","article-title":"Cancers of the base of the tongue and hypopharynx: results of a multicenter randomized trial of chemotherapy prior to locoregional treatment","volume":"83","author":"Gedouin","year":"1996","journal-title":"Bulletin du Cancer Radiotherapie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0332|cit332","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/annonc\/3.suppl_3.S43","article-title":"Neoadjuvant combination of carboplatin and 5-FU in head and neck cancer: a randomized study","volume":"3 Suppl 3","author":"Gehanno","year":"1992","journal-title":"Annals of Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0333|cit333","doi-asserted-by":"crossref","first-page":"S510","DOI":"10.1016\/j.ijrobp.2014.05.1566","article-title":"Impact of weight loss on survival after chemoradiation for locally advanced head and neck cancer: secondary results of a randomized phase 3 trial (SAKK 10\/94)","volume":"90","author":"Ghadjar","year":"2014","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0334|cit334","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s00066-016-0999-3","article-title":"Haemoglobin and creatinine values as prognostic factors for outcome of concurrent radiochemotherapy in locally advanced head and neck cancers: secondary results of two European randomized phase III trials (ARO 95-06, SAKK 10\/94)","volume":"192","author":"Ghadjar","year":"2016","journal-title":"Strahlentherapie und Onkologie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0335|cit335","first-page":"13","article-title":"Induction docetaxel, cisplatin and 5 fluorouracil (TPF) followed by concomittant chemoradiotherapy versus concomittant chemoradiotherapy in unresectable locally advanced head and neck cancer: a phase III randomized study","volume":"79","author":"Ghali","year":"2011","journal-title":"Medical Journal of Cairo University"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0336|cit336","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1016\/j.ijrobp.2006.07.371","article-title":"Randomized trial of conventional fractionated RT (CFRT) vs. concomitant chemo radiotherapy (CTRT) and accelerated radiotherapy (ACRT) in patients with advanced, non nasopharyngeal, squamous cell cancers of the head and neck region","volume":"66","author":"Ghosh","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"15","key":"10.1002\/14651858.CD006386.pub4-BIB0337|cit337","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1200\/JCO.2005.01.057","article-title":"Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology Group","volume":"23","author":"Gibson","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"15 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0338|cit338","first-page":"S6097","article-title":"A randomized phase II study of chemoradiation (CRT) +\/- nivolumab (Nivo) with sequential safety evaluations of Nivo +\/- lirilumab (Liri) or ipilumumab (Ipi) concomitant with (C) RT in intermediate (IR) and high-risk (HR) head and neck squamous cell carcinoma (HNSCC)","volume":"35","author":"Gillison","year":"2017","journal-title":"Journal of Clinical Oncology (Annual Meeting of the American Society of Clinical Oncology, ASCO; 2017; United States)"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0339|cit339","first-page":"83","article-title":"Combined therapy in advanced head and neck cancer: a randomized study","volume":"114","author":"Gollin","year":"1972","journal-title":"American Journal of Roentgenology, Radium Therapy & Nuclear Medicine"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0340|cit340","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2214\/ajr.126.2.229","article-title":"Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study","volume":"126","author":"Lo","year":"1976","journal-title":"American Journal of Roentgenology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0341|cit341","first-page":"325","article-title":"Erlotinib (E) as adjuvant treatment for patients (pts) with resected head and neck squamous cell carcinoma (HNSCC) with evaluation of neoadjuvant biomarker modulation with E with or without sulindac (S): a feasibility report","volume":"26","author":"Grandis","year":"2008","journal-title":"Journal of Clinical Oncology (ASCO Annual Meeting Proceedings)"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0342|cit342","first-page":"577","article-title":"Comparison of methotrexate and cisplatin for patients with advanced squamous cell carcinoma of the head and neck region: a Southwest Oncology Group Study","volume":"69","author":"Grose","year":"1985","journal-title":"Cancer Treatment Reports"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0343|cit343","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/hed.24991","article-title":"Efficiency of electrochemotherapy with reduced bleomycin dose in the treatment of nonmelanoma head and neck skin cancer: preliminary results","volume":"40","author":"Groselj","year":"2017","journal-title":"Head and Neck"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0344|cit344","doi-asserted-by":"crossref","first-page":"x100","DOI":"10.1093\/annonc\/mdx665.002","article-title":"Oncological outcome following intensification of treatment by transoral robotic surgery (TORS) for HPV negative stage IV oropharyngeal cancer: a prospective trial","volume":"28","author":"Gupta","year":"2017","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0345|cit345","unstructured":"Haas C Byhardt R Cox J Duncovage J Grossman T Haas J Randomized study of 5-fluorouracil (F) and cis-platinum (P) as initial therapy of locally advanced squamous carcinoma of the head and neck (LASCHN): a preliminary analysis Proceedings of the American Society of Clinical Oncology 1985 143"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0346|cit346","unstructured":"Haas C Anderson T Byhardt R Cox J Duncavage J Grossman T Randomized neo-adjuvant study of 5-fluorouracil and cis-platinum for patients with advanced resectable head and neck squamous cancer Proceedings of the American Association for Cancer Research (AACR) 1986 185"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0347|cit347","unstructured":"Haas C Byhardt R Cox J Duncovage J Grossman T Haas J Randomized study of 5-fluorouracil (F) and cis-platinum (P) as initial therapy of locally advanced squamous carcinoma of the head and neck (LASCHN): a preliminary analysis Proceedings of the American Society of Clinical Oncology 1985 143"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0348|cit348","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0360-3016(93)90234-M","article-title":"Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials","volume":"27","author":"Haffty","year":"1993","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0349|cit349","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1200\/JCO.1997.15.1.268","article-title":"Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale mitomycin randomized trials","volume":"15","author":"Haffty","year":"1997","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0350|cit350","unstructured":"Hafty BG Son YH Papac R Sasaki CT Fischer D Rockwell S Chemotherapy as an adjunct to radiation therapy (RT) in the treatment of squamous cell carcinoma, a (SCC) of the head and neck (H and N): results of the Yale mitomycin C (MC) randomized trials Proceedings of the American Society of Clinical Oncology 1996 (Abs No 893)"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0351|cit351","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1520-6823(1997)5:5<235::AID-ROI4>3.0.CO;2-Z","article-title":"Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck","volume":"5","author":"Haffty","year":"1997","journal-title":"Radiation Oncology Investigations"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0352|cit352","doi-asserted-by":"crossref","first-page":"S246","DOI":"10.1016\/S0360-3016(03)01076-9","article-title":"Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial","volume":"57 Suppl 2","author":"Haffty","year":"2003","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0353|cit353","unstructured":"Haffty BG Son Y Papac R Wilson L The bioreductive alkylating agent mitomycin-C (MC) or porfiromycin (PORF) with radiation therapy (RT) in squamous cell carcinoma of the head and neck (SCCHN): results of a randomized clinical trial Proceedings of the American Society of Clinical Oncology 2001 (Abs No 901)"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0354|cit354","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijrobp.2004.07.730","article-title":"Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial","volume":"61","author":"Haffty","year":"2005","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0355|cit355","first-page":"626","article-title":"A radiotherapeutic clinical trial of twice per week vs. five times per week in oral cancer","volume":"156","author":"Handa","year":"1980","journal-title":"Strahlentherapie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0356|cit356","unstructured":"Hasegawa Y Matsuura H Fukushima M Kano M Shimozato K Potential suppression of distant and node metastasis by neoadjuvant chemotherapy in advanced head and neck cancer: result of a randomized trial Proceedings of the American Society of Clinical Oncology 1996 318"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0357|cit357","first-page":"279","volume-title":"Head and Neck Cancer","volume":"II","author":"Haselow","year":"1990"},{"issue":"679","key":"10.1002\/14651858.CD006386.pub4-BIB0358|cit358","first-page":"585","article-title":"A study of the effect of misonidazole in conjunction with radiotherapy for the treatment of head and neck cancer","volume":"57","author":"Henk","year":"1984","journal-title":"British Journal of Radiology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0359|cit359","doi-asserted-by":"crossref","first-page":"18S (Abs No 551","DOI":"10.1200\/jco.2006.24.18_suppl.5515","article-title":"Randomized phase II\/III clinical trial of induction chemotherapy (ICT) with either cisplatin\/5-fluorouracil (PF) or docetaxel\/cisplatin\/5-fluorouracil (TPF) followed by chemoradiotherapy (CRT) vs. CRT alone for patients (pts) with unresectable locally advanced head and neck cancer (LAHNC)","volume":"24","author":"Hitt","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0360|cit360","doi-asserted-by":"crossref","first-page":"519 (Abs No 557","DOI":"10.1200\/JCO.2004.00.1990","article-title":"Phase II\/III trial of induction chemotherapy (ICT) with cisplatin\/5-fluorouracil (PF) vs. docetaxel (T) plus PF (TPF) followed by chemoradiotherapy (CRT) vs. CRT for unresectable locally advanced head and neck cancer (LAHNC)","volume":"23","author":"Hitt","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"34","key":"10.1002\/14651858.CD006386.pub4-BIB0361|cit361","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1200\/JCO.2004.00.1990","article-title":"Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer","volume":"23","author":"Hitt","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0362|cit362","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/00130404-200409000-00010","article-title":"Randomized phase II trial of concomitant chemoradiotherapy using weekly carboplatin or daily low-dose cisplatin for squamous cell carcinoma of the head and neck","volume":"10","author":"Homma","year":"2004","journal-title":"Cancer Journal"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0363|cit363","first-page":"79","article-title":"Combined therapy in advanced head and neck cancer: hydroxyurea and radiotherapy","volume":"6","author":"Hussey","year":"1975","journal-title":"Progress in Clinical Cancer"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0364|cit364","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/annonc\/mdx202","article-title":"A two-arm multicenter phase II trial of one cycle chemoselection split-dose docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy before two cycles of split TPF followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)","volume":"28","author":"Inhestern","year":"2017","journal-title":"Annals of Oncology"},{"issue":"19","key":"10.1002\/14651858.CD006386.pub4-BIB0365|cit365","first-page":"3560","article-title":"Erratum: randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis","volume":"121","author":"Iyer","year":"2015","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0366|cit366","first-page":"3","article-title":"Methotrexate vs bleomycin experiences in advanced oral malignancies","volume":"16","author":"Jain","year":"1979","journal-title":"Indian Journal of Cancer"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0367|cit367","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2273.1992.tb01705.x","article-title":"A phase II study of cisplatinum versus cisplatinum + nifedipine in end-stage carcinoma of the head and neck","volume":"17","author":"Jones","year":"1992","journal-title":"Clinical Otolaryngology & Allied Sciences"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0368|cit368","first-page":"115","article-title":"A randomized EORTC study on the effect of preoperative polychemotherapy in pyriform sinus carcinoma treated by pharyngolaryngectomy and irradiation. Results from 5 to 10 years","volume":"90","author":"Jortay","year":"1990","journal-title":"Acta Chirurgica Belgica"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0369|cit369","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.oraloncology.2017.10.018","article-title":"Results of a phase II randomized controlled clinical trial comparing efficacy of cabazitaxel versus docetaxel as second line or above therapy in recurrent head and neck cancer","volume":"75","author":"Joshi","year":"2017","journal-title":"Oral Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0370|cit370","unstructured":"Kamioner D Haddad E Rocher MA Carboplatin-radiotherapy versus cisplatin-radiotherapy according to a concurrent schedule in advanced head and neck cancer: results of a randomized study Annals of Oncology 1994 5 Suppl 8 115"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0371|cit371","first-page":"1385","article-title":"Primary clinical effects of chemotherapy mainly with cisplatin, peplomycin (PP therapy) against head and neck cancer - the multi-institutional joint research in Tokai district","volume":"22","author":"Kaneda","year":"1987","journal-title":"Nippon Gan Chiryo Gakkai Shi [Journal of Japanese Society for Cancer Therapy]"},{"issue":"1-2","key":"10.1002\/14651858.CD006386.pub4-BIB0372|cit372","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0360-3016(78)90120-7","article-title":"Combined preoperative treatment with cobalt and bleomycin in patients with head and neck carcinoma - a controlled clinical study","volume":"4","author":"Kapstad","year":"1978","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0373|cit373","first-page":"171","article-title":"Cobalt and bleomycin against carcinomas of head and neck. A controlled clinical study","volume":"360","author":"Kapstad","year":"1979","journal-title":"Acta Oto Laryngologica"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0374|cit374","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00280-006-0370-y","article-title":"Comparison of hyperfractionation and conventional fractionation radiotherapy with concurrent docetaxel, cisplatin and 5-fluorouracil (TPF) chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)","volume":"60","author":"Katori","year":"2007","journal-title":"Cancer Chemotherapy & Pharmacology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0375|cit375","doi-asserted-by":"crossref","unstructured":"Katori K Tsukuda M Ishitoya J Kimura M Hirose S Takahashi M Comparison of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by radiation versus concurrent chemoradiotherapy with TPF in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) Journal of Clinical Oncology 2005 23 16S","DOI":"10.1200\/jco.2005.23.16_suppl.5580"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0376|cit376","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.oraloncology.2017.05.017","article-title":"Impact of combined modality treatment with radiotherapy and S-1 on T2N0 laryngeal cancer: possible improvement in survival through the prevention of second primary cancer and distant metastasis","volume":"71","author":"Kitani","year":"2017","journal-title":"Oral Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0377|cit377","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.oraloncology.2017.07.023","article-title":"A randomized, open-label, phase III clinical trial of nivolumab vs. therapy of investigator's choice in recurrent squamous cell carcinoma of the head and neck: a subanalysis of Asian patients versus the global population in checkmate 141","volume":"73","author":"Kiyota","year":"2017","journal-title":"Oral Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0378|cit378","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1017\/S0022215100119140","article-title":"Multimodality treatment in stage IV squamous cell carcinoma of the head and neck. A long-term follow-up","volume":"106","author":"Klima","year":"1992","journal-title":"Journal of Laryngology & Otology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0379|cit379","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1017\/S002221510010489X","article-title":"Adjuvant chemotherapy in stage III and IV squamous cell carcinoma of the head and neck","volume":"102","author":"Klima","year":"1988","journal-title":"Journal of Laryngology & Otology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0380|cit380","first-page":"297","article-title":"The effect of radio- and chemotherapy on survival in advanced head and neck tumors","volume":"163","author":"Klima","year":"1987","journal-title":"Strahlentherapie und Onkologie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0381|cit381","first-page":"78","article-title":"Chemotherapy or chemotherapy and radiotherapy in advanced head and neck tumors. A prospective, randomized study comparing the 2 therapeutic modalities","volume":"35","author":"Klima","year":"1987","journal-title":"Head & Neck Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0382|cit382","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-2007-998639","article-title":"Chemotherapy of advanced head and neck tumors. A prospective randomized study comparing the effectiveness of chemotherapy alone to a chemo-radiotherapy procedure","volume":"66","author":"Klima","year":"1987","journal-title":"Laryngologie, Rhinologie, Otologie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0383|cit383","first-page":"S45","article-title":"Conventional chemoradiation versus accelerated chemoradiation: a prospective study in oropharngeal cancer","volume":"12","author":"Korde","year":"2016","journal-title":"Journal of Cancer Research and Therapeutics (38th Annual Conference of the Association of Radiation Oncologists of India, AROICON 2016; India)"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0384|cit384","first-page":"987","article-title":"Multiple cooperative study of UFT-adjuvant chemotherapy for malignant tumor in the jaw and oral cavities. The Oral Surgery Malignant Tumor Research Association in Kanto Kohshinetsu District","volume":"21","author":"Kotani","year":"1994","journal-title":"Gan To Kagaku Ryoho"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0385|cit385","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.ijrobp.2019.11.352","article-title":"Concurrent chemoradiation (CCR) is better than accelerated radiation alone (ARA) in patients with moderate advanced head and neck squamous cell carcinoma (MAHNSCC). Mature results of HN08 Polish trial","volume":"106","author":"Ksiezniak-Baran","year":"2020","journal-title":"International Journal of Radiation Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0386|cit386","first-page":"269","article-title":"Comparative study of 2 chemotherapy induction protocols. Cisplatinum-methotrexate-bleomycin and oncovin-methotrexate-bleomycin","volume":"100","author":"Laccourreye","year":"1983","journal-title":"Annales d'Oto-Laryngologie et de Chirurgie Cervico-Faciale"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0387|cit387","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archotol.124.4.401","article-title":"Comparison of surgical complications after organ-preservation therapy in patients with stage III or IV squamous cell head and neck cancer","volume":"124","author":"Lavertu","year":"1998","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0388|cit388","unstructured":"Le QX Pinto HA Tate DJ Randomized phase II trial of tirpazamine in advanced squamous cell carcinoma of the head and neck: a preliminary report of radiation related toxicity 84th Annual Meeting of the Scientific Assembly of the Radiological Society of North America 1998"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0389|cit389","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0360-3016(89)90343-X","article-title":"A phase I\/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: a RTOG randomized study (#79-04)","volume":"16","author":"Lee","year":"1989","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0390|cit390","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1741-7015-12-16","article-title":"Selective intra-arterial infusion of rAd-p53 with chemotherapy for advanced oral cancer: a randomized clinical trial","volume":"12","author":"Li","year":"2014","journal-title":"BMC Medicine"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0391|cit391","first-page":"44","article-title":"Effect of administration time on toxicity induced by DCF in patients with oral squamous cell carcinoma","volume":"8","author":"Li","year":"2018","journal-title":"Anti-Tumor Pharmacy"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0392|cit392","doi-asserted-by":"crossref","first-page":"v385","DOI":"10.1093\/annonc\/mdx374.032","article-title":"Concurrent chemoradiotherapy (CCRT) versus induction docetaxel, cisplatin and 5-fluorouracil (TPF) followed by CCRT in locally advanced hypopharyngeal and base of tongue cancer: a randomized phase II study","volume":"28","author":"Lim","year":"2017","journal-title":"Annals of Oncology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0393|cit393","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.3904\/kjim.2019.161","article-title":"Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally advanced hypopharynx and base of tongue cancer","volume":"36","author":"Lim","year":"2020","journal-title":"Korean Journal of Internal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0394|cit394","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00170781","article-title":"Treatment of advanced squamous cell carcinoma of the head and neck with isotretinoin: a phase II randomized trial","volume":"6","author":"Lippman","year":"1988","journal-title":"Investigational New Drugs"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0395|cit395","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/bjc.1990.59","article-title":"A phase III randomised trial of cisplatinum, methotrextate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck. Liverpool Head and Neck Oncology Group","volume":"61","author":"Liverpool Head and Neck Oncology Group","year":"1990","journal-title":"British Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0396|cit396","first-page":"S147","article-title":"Induction chemotherapy in advanced head and neck cancer","volume":"27 Suppl 2","author":"Lopes","year":"1991","journal-title":"European Journal of Cancer"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0397|cit397","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1634\/theoncologist.2016-0296","article-title":"Randomized phase II study of cabazitaxel versus methotrexate in patients with recurrent and\/or metastatic squamous cell carcinoma of the head and neck previously treated with platinum-based therapy","volume":"21","author":"Machiels","year":"2016","journal-title":"Oncologist"},{"issue":"15 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0398|cit398","doi-asserted-by":"publisher","first-page":"abstract TPS609","DOI":"10.1200\/JCO.2017.35.15_suppl.TPS6090","article-title":"KEYNOTE-412: pembrolizumab (pembro) in combination with chemoradiation versus chemoradiation alone in locally advanced head and neck squamous cell carcinoma (LA-HNSCC)","volume":"35","author":"Machiels","year":"2017","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0399|cit399","doi-asserted-by":"crossref","unstructured":"Machiels JP Yen CJ Licitra L Rischin D Waldron J Burtness B Phase 3 KEYNOTE-412 trial: pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) Annals of Oncology 2017 xi28","DOI":"10.1093\/annonc\/mdx711.077"},{"issue":"1 Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0400|cit400","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1016\/j.ijrobp.2004.06.031","article-title":"Definitive radiotherapy +\/- erythropoietin for squamous cell carcinoma of the head and neck: preliminary report of RTOG 99-03","volume":"60","author":"Machtay","year":"2004","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"issue":"51","key":"10.1002\/14651858.CD006386.pub4-BIB0401|cit401","doi-asserted-by":"crossref","first-page":"e9151","DOI":"10.1097\/MD.0000000000009151","article-title":"The comparison of acute toxicity in 2 treatment courses: three-weekly and weekly cisplatin treatment administered with radiotherapy in patients with head and neck squamous cell carcinoma","volume":"96","author":"Mackiweicz","year":"2017","journal-title":"Medicine"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0402|cit402","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0360-3016(94)90225-9","article-title":"Double-blind randomized study of lonidamine and radiotherapy in head and neck cancer","volume":"29","author":"Magno","year":"1994","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0403|cit403","doi-asserted-by":"crossref","first-page":"e17456","DOI":"10.1200\/JCO.2017.35.15_suppl.e17546","article-title":"Phase II trial of valproic acid combined with cisplatin-based chemoradiation in locally advanced (LA) head and neck squamous cell carcinoma (HNSCC) patients (pts)","volume":"35","author":"Mak","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0404|cit404","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02907742","article-title":"Comparison of sequential chemoradiation with radiation alone in the treatment of advanced head and neck cancers","volume":"58","author":"Manocha","year":"2006","journal-title":"Indian Journal of Otolaryngology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0405|cit405","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s002620050515","article-title":"Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: a multicenter, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2","volume":"47","author":"Mantovani","year":"1998","journal-title":"Cancer Immunology & Immunotherapy"},{"issue":"17","key":"10.1002\/14651858.CD006386.pub4-BIB0406|cit406","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.ejca.2015.08.007","article-title":"Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: systematic review and meta-analysis","volume":"51","author":"Marta","year":"2015","journal-title":"European Journal of Cancer"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0407|cit407","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0360-3016(90)90021-B","article-title":"Randomized study of 5 fluorouracil and cisplatin as neoadjuvant therapy in head and neck cancer: a preliminary report","volume":"19","author":"Martin","year":"1990","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0408|cit408","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/978-2-8178-0765-2_41","volume-title":"Cancer Treatment: An Update","author":"Martin","year":"1994"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0409|cit409","doi-asserted-by":"crossref","first-page":"799","DOI":"10.31557\/APJCP.2020.21.3.799","article-title":"Cisplatin weekly versus every 3 weeks concurrently with radiotherapy in the treatment of locally advanced head and neck squamous cell carcinomas: what is the best dosing and schedule?","volume":"21","author":"Mashhour","year":"2020","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0410|cit410","first-page":"37","article-title":"Comparative evaluation of two administration schedules of cis-dichlorodiammineplatinum (DDP) in ovarian and head and neck cancers: a CMEA chemotherapy group study","volume":"34","author":"Mechl","year":"1987","journal-title":"Neoplasma"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0411|cit411","doi-asserted-by":"crossref","first-page":"TPS6091","DOI":"10.1200\/JCO.2017.35.15_suppl.TPS6091","article-title":"Phase III randomised controlled trial (RCT) comparing alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer (CompARE)","volume":"35","author":"Mehanna","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0412|cit412","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.ijrobp.2015.12.029","article-title":"Final results of a randomized phase 2 trial investigating the addition of cetuximab to induction chemotherapy and accelerated or hyperfractionated chemoradiation therapy for locoregionally advanced head and neck cancer: hPV-negative subset analysis","volume":"94","author":"Melotek","year":"2016","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0413|cit413","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijrobp.2016.04.030","article-title":"Final results of a randomized phase 2 trial investigating the addition of cetuximab to induction chemotherapy and accelerated or hyperfractionated chemoradiation for locoregionally advanced head and neck cancer","volume":"96","author":"Seiwert","year":"2016","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0414|cit414","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1016\/j.ijrobp.2016.06.544","article-title":"Updated results from a phase 1\/randomized phase 2 trial of response-adapted volume de-escalation (RAVD) for locally advanced head and neck cancer","volume":"96","author":"Melotek","year":"2016","journal-title":"International Journal of Radiation Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0415|cit415","doi-asserted-by":"crossref","first-page":"E351","DOI":"10.1016\/j.ijrobp.2016.06.1513","article-title":"Pooled analysis of late toxicity from 2 randomized phase 2 trials of induction chemotherapy (IC) and chemoradiation therapy (CRT) for locally advanced head and neck squamous cell cancer (LA-HNSCC)","volume":"96","author":"Melotek","year":"2016","journal-title":"International Journal of Radiation Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0416|cit416","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1159\/000507733","article-title":"Phase III randomized study of induction chemotherapy followed by definitive radiotherapy + cetuximab versus chemoradiotherapy in squamous cell carcinoma of head and neck: the INTERCEPTOR-GONO study (NCT00999700)","volume":"98","author":"Merlano","year":"2020","journal-title":"Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0417|cit417","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF03049595","article-title":"Chemoradiotherapy for advanced head and neck cancer - analysis of a prospective randomized trial","volume":"58","author":"Mitra","year":"2006","journal-title":"Indian Journal of Otolaryngology and Head and Neck Surgery"},{"issue":"Suppl 8","key":"10.1002\/14651858.CD006386.pub4-BIB0418|cit418","first-page":"116","article-title":"Concomitant carboplatin and radiotherapy versus standard irradiation in advanced head and neck cancer: preliminary results of a cooperative randomized trial","volume":"5","author":"Moro","year":"1994","journal-title":"Annals of Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0419|cit419","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF00263902","article-title":"Cisplatinum and bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck: a randomised factorial phase III controlled trial","volume":"15","author":"Morton","year":"1985","journal-title":"Cancer Chemotherapy & Pharmacology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0420|cit420","first-page":"141","article-title":"Cisplatin and bleomycin in the treatment of advanced or recurrent squamous cell carcinoma of the head and neck. A randomized facultative Phase III controlled study","volume":"81","author":"Morton","year":"1987","journal-title":"Sonderbande zur Strahlentherapie und Onkologie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0421|cit421","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/2278-330X.208840","article-title":"Phase IIb trial comparing two concurrent cisplatin schedules in locally advanced head and neck cancer","volume":"6","author":"Nair","year":"2017","journal-title":"South Asian Journal of Cancer"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0422|cit422","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.radonc.2016.08.009","article-title":"Reduction of the dose of radiotherapy to the elective neck in head and neck squamous cell carcinoma; a randomized clinical trial. Effect on late toxicity and tumor control","volume":"122","author":"Nevens","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0423|cit423","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1471-2407-13-133","article-title":"Early-stage squamous cell carcinoma of the oropharynx: radiotherapy vs. trans-oral robotic surgery (ORATOR) - study protocol for a randomized phase II trial","volume":"13","author":"Nichols","year":"2013","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0424|cit424","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/mpo.2950120312","article-title":"Treatment of advanced head and neck cancer: multiple daily dose fractionated radiation therapy and sequential multimodal treatment approach","volume":"12","author":"Nissenbaum","year":"1984","journal-title":"Medical & Pediatric Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0425|cit425","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2273.1979.tb01761.x","article-title":"Advanced head and neck cancer treated by combined radiotherapy and VBM cytotoxic regimen - four-year results","volume":"4","author":"O'Connor","year":"1979","journal-title":"Clinical Otolaryngology and Allied Sciences"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0426|cit426","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cdp.2003.11.007","article-title":"Results and failures with or without cisplatin containing induction chemotherapy in the treatment of squamous cell carcinoma of the head and neck","volume":"28","author":"Olasz","year":"2004","journal-title":"Cancer Detection & Prevention"},{"issue":"Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0427|cit427","first-page":"6007","article-title":"Randomized study of darbepoetin alfa as modifier of radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC): final outcome of the DAHANCA 10 trial","volume":"27","author":"Overgaard","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0428|cit428","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/0360-3016(84)90260-8","article-title":"Hyperfractionated radiotherapy with or without misonidazole: results of a prospective randomized study in stage III-IV squamous cell carcinoma of the head and neck","volume":"10","author":"Panis","year":"1984","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0429|cit429","first-page":"848","article-title":"Sequential treatment of advanced oral carcinoma by methotrexate and radiotherapy","volume":"61","author":"Pant","year":"1973","journal-title":"Indian Journal of Medical Research"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0430|cit430","first-page":"3150","article-title":"Controlled trial of methotrexate and Bacillus Calmette-Guerin therapy for advanced head and neck cancer","volume":"38","author":"Papac","year":"1978","journal-title":"Cancer Research"},{"issue":"2 Suppl 1","key":"10.1002\/14651858.CD006386.pub4-BIB0431|cit431","doi-asserted-by":"crossref","first-page":"E364","DOI":"10.1016\/j.ijrobp.2017.06.1472","article-title":"Survival and functional outcome after treatment for primary base of tongue cancer: a comparison of definitive radiotherapy versus surgery followed by adjuvant radiotherapy","volume":"99","author":"Park","year":"2017","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0432|cit432","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.4143\/crt.2017.498","article-title":"Survival and functional outcome after treatment for primary base of tongue cancer: a comparison of definitive chemoradiotherapy versus surgery followed by adjuvant radiotherapy","volume":"50","author":"Park","year":"2018","journal-title":"Cancer Research and Treatment"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0433|cit433","unstructured":"Patil DP Prabhash K Supta AS Gota V Pharmacokinetics study of oral metronomic chemotherapy in patients with head and neck squamous cell carcinoma 6th World Congress of the International Academy of Oral Oncology, IAOO 2017 India 2017 E91"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0434|cit434","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/00000421-198512000-00008","article-title":"A prospective study of preoperative chemotherapy and split-course irradiation for locally advanced or recurrent oral\/pharyngeal squamous carcinoma","volume":"8","author":"Pearlman","year":"1985","journal-title":"American Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0435|cit435","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/hed.2890050104","article-title":"Preoperative chemo-radiotherapy in advanced head and neck cancer","volume":"5","author":"Pearlman","year":"1982","journal-title":"Head & Neck Surgery"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0436|cit436","first-page":"779","article-title":"Clinical effect of nedaplatin in treatment of advanced head and neck cancer","volume":"14","author":"Peng","year":"2007","journal-title":"Chinese Journal of Cancer Prevention & Treatment"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0437|cit437","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/0360-3016(80)90570-2","article-title":"Interim report on a phase III study of bleomycin and methotrexate with radiotherapy in the treatment of inoperable head and neck cancer","volume":"6","author":"Phillips","year":"1980","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0438|cit438","first-page":"700","article-title":"Recombinant human granulocyte colony-stimulating factor in chemotherapy for advanced head and neck carcinoma","volume":"116","author":"Platzer","year":"1990","journal-title":"Journal of Cancer Research & Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0439|cit439","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/ijc.IJC_144_17","article-title":"Comparison of conventional fractionation (five fractions per week) and altered fractionation (six fractions per week) in stage I and II squamous cell carcinoma of oropharynx: an institutional study","volume":"54","author":"Poddar","year":"2017","journal-title":"Indian Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0440|cit440","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1200\/JCO.2017.35.15_suppl.6008","article-title":"Post-operative concurrent chemo-radiotherapy versus post-operative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck: a randomized phase III trial (Trans Tasman Radiation Oncology Group 05.01 Trial; POST study)","volume":"35","author":"Porceddu","year":"2017","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0441|cit441","doi-asserted-by":"crossref","first-page":"S566","DOI":"10.1016\/S0167-8140(17)31463-9","article-title":"Evaluation of induction chemotherapy followed by radiation therapy in advanced oropharyngeal cancers","volume":"123","author":"Pothamsetty","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0442|cit442","unstructured":"Pothamsetty RK Thaliath PB Ghosh RR Evaluate the responses and toxicities with conventional external beam radiotherapy versus intensity modulated radiotherapy after neoadjuvant chemotherapy in locally advanced oropharyngeal cancers: prospective study 6th World Congress of the International Academy of Oral Oncology, IAOO 2017 India 2017 E212 E214"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0443|cit443","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000225250","article-title":"Improved results in combination chemotherapy of head and neck cancer using a kinetically-based approach: a randomised study with and without adriamycin","volume":"35","author":"Price","year":"1978","journal-title":"Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0444|cit444","first-page":"165","article-title":"Combined modality therapy (chemoimmunotherapy + radiotherapy +\/- surgery) in advanced neoplasias of the head and neck","volume":"43","author":"Proto","year":"1993","journal-title":"Otorinolaringologia"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0445|cit445","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.radonc.2007.12.021","article-title":"Randomized clinical trial of post-operative radiotherapy versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvement","volume":"87","author":"Racadot","year":"2008","journal-title":"Radiotherapy and Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0446|cit446","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/s12885-016-2478-8","article-title":"Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg\/m(2) for definitive radiochemotherapy of locally advanced head-and-neck cancers","volume":"16","author":"Rades","year":"2016","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0447|cit447","first-page":"XC01","article-title":"A prospective randomised study of clinical outcome and toxicity patterns of head and neck squamous cell carcinoma treated with accelerated fractionated radiotherapy versus concurrent chemoradiotherapy","volume":"13","author":"Rastogi","year":"2019","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0448|cit448","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0001-6519(04)78546-5","article-title":"Efficacy of postoperative radiation therapy for squamous cell carcinoma of the head and neck: results of a prospective randomised clinical trial","volume":"55","author":"Rodrigo","year":"2004","journal-title":"Acta Otorrinolaringologica Espanola"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0449|cit449","first-page":"1689","article-title":"Multicenter randomized phase II study of paclitaxel (1-hour infusion), fluorouracil, hydroxyurea, and concomitant twice daily radiation with or without erythropoietin for advanced head and neck cancer","volume":"9","author":"Rosen","year":"2003","journal-title":"Clinical Cancer Research"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0450|cit450","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1200\/JCO.2015.62.5970","article-title":"Association of human papillomavirus and p16 status with outcomes in the IMCL-9815 phase III registration trial for patients with locoregionally advanced oropharyngeal squamous cell carcinoma of the head and neck treated with radiotherapy with or without cetuximab","volume":"34","author":"Rosenthal","year":"2016","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0451|cit451","first-page":"S49","article-title":"A prospective randomized study of locally advanced head and neck cancer comparing concomitant chemoradiotherapy versus pure accelarated radiotherapy","volume":"12","author":"Roy","year":"2016","journal-title":"Journal of Cancer Research and Therapeutics (38th Annual Conference of the Association of Radiation Oncologists of India, AROICON 2016)"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0452|cit452","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1200\/jco.2005.23.16_suppl.5543","article-title":"Use of chemotherapy in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients","volume":"23","author":"Saber","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0453|cit453","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/0360-3016(90)90342-H","article-title":"Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer","volume":"19","author":"Sanchiz","year":"1990","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0454|cit454","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0360-3016(98)00546-X","article-title":"Chemotherapy alternated with radiotherapy in the treatment of advanced head and neck carcinoma: predictive factors of outcome","volume":"44","author":"Sanguineti","year":"1999","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0455|cit455","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1017\/S0022215107007645","article-title":"Comparative study of efficacy and toxicities of cisplatin vs vinorelbine as radiosensitisers in locally advanced head and neck cancer","volume":"122","author":"Sarkar","year":"2008","journal-title":"Journal of Laryngology & Otology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0456|cit456","first-page":"48","article-title":"Liposomal formulated cisplatin (lipoplatin) in the treatment of squamous cell carcinoma of the head and neck (SCCHN): first safety results of a randomized phase III study","volume":"28 Suppl 3","author":"Schildhauer","year":"2005","journal-title":"Onkologie"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0457|cit457","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1016\/S1359-6349(05)81291-1","article-title":"Randomized phase III study in squamous cell carcinoma of the head & neck (SCCHN) using Lipoplatin: First safety results of a multicentre trial","volume":"3","author":"Schildhauer","year":"2005","journal-title":"European Journal of Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0458|cit458","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archotol.1989.01860270106023","article-title":"Combined therapy for resectable head and neck cancer. A phase 3 intergroup study","volume":"115","author":"Schuller","year":"1989","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0459|cit459","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10637-016-0364-5","article-title":"A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer","volume":"34","author":"Swiecicki","year":"2016","journal-title":"Investigational New Drugs"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0460|cit460","first-page":"314","article-title":"A preliminary clinical study in the use of misonidazole in cancer of the head and neck","volume":"37","author":"Sealy","year":"1978","journal-title":"British Journal of Cancer"},{"issue":"8300","key":"10.1002\/14651858.CD006386.pub4-BIB0461|cit461","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0140-6736(82)90726-7","article-title":"Combination treatment in advanced head and neck cancer","volume":"2","author":"Clifford","year":"1982","journal-title":"Lancet"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0462|cit462","first-page":"289","article-title":"A randomized trial of combined multidrug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. An interim report from the SECOG participants. South-East Co-operative Oncology Group","volume":"12","author":"South-East Co-operative Oncology Group","year":"1986","journal-title":"European Journal of Surgical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0463|cit463","first-page":"61","article-title":"Combined radiotherapy and chemotherapy in the treatment of squamous cell carcinoma of the oral cavity: results from two randomized trials","volume":"6","author":"Tobias","year":"1994","journal-title":"Clinical Oncology"},{"issue":"18S","key":"10.1002\/14651858.CD006386.pub4-BIB0464|cit464","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1200\/jco.2007.25.18_suppl.6030","article-title":"Concomitant chemoradiation versus radiotherapy in advanced squamous cell carcinoma of oropharynx and nasopharynx using weekly cisplatin: final result of a phase III trial","volume":"25","author":"Sharma","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0465|cit465","doi-asserted-by":"crossref","first-page":"V473","DOI":"10.1093\/annonc\/mdz252.064","article-title":"Concurrent chemotherapy and external radiation therapy: an open label non-inferiority phase III randomized controlled trial of weekly versus three weekly cisplatin and radical radiotherapy in locally advanced head and neck squamous cell carcinoma: CONCERT trial","volume":"30","author":"Sharma","year":"2019","journal-title":"Annals of Oncology"},{"issue":"6 Pt 1","key":"10.1002\/14651858.CD006386.pub4-BIB0466|cit466","first-page":"ORL","article-title":"A randomized combination chemotherapy trial, with and without adriamycin, in squamous cell carcinoma of the head and neck","volume":"86","author":"Shaw","year":"1978","journal-title":"Otolaryngology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0467|cit467","unstructured":"Shetty P Mehta A Shinde S Mazumdar A Hingorani C Controlled study in squamous cell carcinoma of base of tongue using conventional radiation, radiation with single drug, and radiation with multiple drug chemotherapy Proceedings of the Annual Meeting of the American Society of Clinical Oncology 1985 152"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0468|cit468","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2273.1989.tb00331.x","article-title":"Induction VBM plus radiotherapy, versus radiotherapy alone for advanced head and neck cancer: long-term results","volume":"14","author":"Siodlak","year":"1989","journal-title":"Clinical Otolaryngology & Allied Sciences"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0469|cit469","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/jamaoncol.2016.4510","article-title":"Effect of standard radiotherapy with cisplatin vs accelerated radiotherapy with panitumumab in locoregionally advanced squamous cell head and neck carcinoma: a randomized clinical trial","volume":"3","author":"Siu","year":"2017","journal-title":"JAMA Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0470|cit470","first-page":"253","article-title":"The role of adjuvant chemotherapy in surgically managed, p16-positive oropharyngeal squamous cell carcinoma","volume":"143","author":"Skillington","year":"2017","journal-title":"JAMA Otolaryngology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0471|cit471","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0360-3016(03)00207-4","article-title":"Postoperative concomitant irradiation and chemotherapy with mitomycin C and bleomycin for advanced head-and-neck carcinoma","volume":"56","author":"Smid","year":"2003","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"5-6","key":"10.1002\/14651858.CD006386.pub4-BIB0472|cit472","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/00016488109138548","article-title":"Comparison of preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck. Interim report","volume":"91","author":"Snow","year":"1981","journal-title":"Acta Oto-Laryngologica"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0473|cit473","unstructured":"Lim D Tai B Wee J Tan E Leong SS Randomised trial comparing surgery and adjuvant radiotherapy with concurrent chemoirradiation and salvage surgery in resectable stage III and IV squamous cell carcinoma of the head and neck ASCO 2003"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0474|cit474","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.bjc.6602696","article-title":"Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III\/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison","volume":"93","author":"Soo","year":"2005","journal-title":"British Journal of Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0475|cit475","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/annonc\/mdx300","article-title":"TPF plus cetuximab induction chemotherapy followed by biochemoradiation with weekly cetuximab plus weekly cisplatin or carboplatin: a randomized phase II EORTC trial","volume":"28","author":"Specenier","year":"2017","journal-title":"Annals of Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0476|cit476","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1148\/101.2.391","article-title":"Hydroxyurea and radiotherapy in head and neck cancer. Results of a prospective controlled study in 126 patients","volume":"101","author":"Stefani","year":"1971","journal-title":"Radiology"},{"issue":"10","key":"10.1002\/14651858.CD006386.pub4-BIB0477|cit477","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/0360-3016(80)90500-3","article-title":"Hydroxyurea and radiotherapy in head and neck cancer. Long term results of a double blind randomized prospective study","volume":"6","author":"Stefani","year":"1980","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0478|cit478","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0009-9260(83)80247-5","article-title":"Sequential chemotherapy and radiotherapy in advanced head and neck cancer","volume":"34","author":"Stell","year":"1983","journal-title":"Clinical Radiology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0479|cit479","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/bjc.1990.59","article-title":"A phase III randomised trial of cisplatinum, methotrexate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck","volume":"61","author":"Stell","year":"1990","journal-title":"British Journal of Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0480|cit480","first-page":"347","article-title":"Randomized neo-adjuvant chemotherapy trial for advanced head and neck cancer","volume":"28","author":"Stolwijk","year":"1985","journal-title":"Netherlands Journal of Medicine"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0481|cit481","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1016\/S0167-8140(17)30774-0","article-title":"Impact of HPV on effect of chemotherapy in SCCHN: results of the GORTEC 2007-01 randomized trial","volume":"123","author":"Sun","year":"2017","journal-title":"Radiotherapy and Oncology"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0482|cit482","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S1470-2045(20)30327-2","article-title":"Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study","volume":"21","author":"Sun","year":"2020","journal-title":"Lancet Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0483|cit483","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/odi.13252","article-title":"Neoadjuvant dose-modified docetaxel in squamous cell carcinoma of the head and neck: a phase 3 study","volume":"26","author":"Sun","year":"2020","journal-title":"Oral Diseases"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0484|cit484","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.radonc.2005.07.007","article-title":"Randomized clinical trial on continuous 7-days-a-week postoperative radiotherapy for high-risk squamous cell head-and-neck cancer: a report on acute normal tissue reactions","volume":"77","author":"Suwinski","year":"2005","journal-title":"Radiotherapy and Oncology"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0485|cit485","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s00405-015-3673-y","article-title":"Long-term remission of locally recurrent oropharyngeal cancer after docetaxel-based chemotherapy plus cetuximab","volume":"273","author":"Szturz","year":"2016","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0486|cit486","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.oraloncology.2017.06.002","article-title":"Very accelerated radiotherapy or concurrent chemoradiotherapy for N3 head and neck squamous cell carcinoma: pooled analysis of two GORTEC randomized trials","volume":"71","author":"Tao","year":"2017","journal-title":"Oral Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0487|cit487","first-page":"351","article-title":"A randomized trial of adjuvant immunotherapy in squamous-cell cancer of the head and neck","volume":"3","author":"Taylor","year":"1981","journal-title":"Head and Neck Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0488|cit488","unstructured":"Taylor SG Bytell DE Sisson GA Shetty RM Applebaum EA Dewys WD Randomized trial of adjuvant chemoimmunotherapy vs chemotherapy in head and neck cancer American Association for Cancer Research 1978 313"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0489|cit489","first-page":"A392","article-title":"Randomized trial of adjuvant immunotherapy in squamous cancer of the head and neck","volume":"2","author":"Taylor","year":"1979","journal-title":"Clinical Research"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0490|cit490","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/1097-0142(197909)44:3<824::AID-CNCR2820440306>3.0.CO;2-N","article-title":"A randomized comparison of two dosage schedules of methyl CCNU: three-week versus six-week treatments","volume":"44","author":"Taylor","year":"1979","journal-title":"Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0491|cit491","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1200\/JCO.1984.2.9.1006","article-title":"A randomized comparison of high-dose infusion methotrexate versus standard-dose weekly therapy in head and neck squamous cancer","volume":"2","author":"Taylor","year":"1984","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0492|cit492","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1001\/archotol.1986.03780040077016","article-title":"Surgical complications in patients with head and neck cancer receiving chemotherapy","volume":"112","author":"Corey","year":"1986","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0493|cit493","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1200\/JCO.1985.3.5.672","article-title":"A randomized trial of adjuvant chemotherapy in head and neck cancer","volume":"3","author":"Taylor","year":"1985","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006386.pub4-BIB0494|cit494","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1200\/JCO.1994.12.2.385","article-title":"Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer","volume":"12","author":"Taylor","year":"1994","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0495|cit495","doi-asserted-by":"crossref","unstructured":"Griem K Murthy A Vannetzel J Kies M Mittal BB Showel JL The five year results of an randomized trial of sequential versus concomitant cisplatin and fluorouracil and radiation in advanced head and neck cancer 37th Annual ASTRO Meeting 1995 (Abs No 105)","DOI":"10.1016\/0360-3016(95)97769-W"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0496|cit496","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/(SICI)1097-0347(199712)19:8<684::AID-HED6>3.0.CO;2-1","article-title":"Concomitant cisplatin\/5FU infusion and radiotherapy in advanced head and neck cancer: 8-year analysis of results","volume":"19","author":"Taylor","year":"1997","journal-title":"Head & Neck"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0497|cit497","first-page":"1680","article-title":"Interstitial brachytherapy of oral squamous cell carcinoma with ultrasound-guided iodine-125 radioactive seed implantation","volume":"22","author":"Tian","year":"2018","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0498|cit498","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1001\/archotol.1987.01860070072019","article-title":"Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. A preliminary report","volume":"113","author":"Toohill","year":"1987","journal-title":"Archives of Otolaryngology - Head & Neck Surgery"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0499|cit499","unstructured":"Toohill RJ Anderson T Byhardt RW Cisplatin\/5FU as neoadjuvant therapy in head and neck cancer: a preliminary report 5th Joint Meeting of the American Society for Head and Neck Surgery and Society of Head and Neck Surgeons Dorado, Puerto Rico 1985"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0500|cit500","first-page":"1169","article-title":"A prospective randomized trial of adjuvant chemotherapy with UFT for head and neck carcinoma. Head and Neck UFT Study Group","volume":"21","author":"Tsukuda","year":"1994","journal-title":"Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0501|cit501","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.bjc.6602804","article-title":"Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer","volume":"93","author":"Tsukuda","year":"2005","journal-title":"British Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0502|cit502","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00280-009-1217-0","article-title":"Randomized controlled phase II comparison study of concurrent chemoradiotherapy with docetaxel, cisplatin, 5-fluorouracil versus CCRT with cisplatin, 5-fluorouracil, methotrexate and leucovorin in patients with locally advanced squamous cell carcinoma of the head and neck","volume":"66","author":"Tsukuda","year":"2010","journal-title":"Cancer Chemotherapy Pharmacology"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0503|cit503","first-page":"700","article-title":"Polychemotherapy in advanced tumors of head and neck. A randomized study","volume":"32","author":"Vega","year":"1981","journal-title":"Acta Otorrinolaringologica Espanola"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0504|cit504","doi-asserted-by":"crossref","unstructured":"Venkatachalam VP Bhowmik KT Comparative evaluation of chemoimmunoradiotherapy and chemoradiotherapy in the management of advanced head and neck cancer Indian Journal of Otolaryngology 1998 50 4 345 8","DOI":"10.1007\/BF03000685"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0505|cit505","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/0360-3016(85)90267-6","article-title":"Bleomycin and radiation therapy in squamous cell carcinoma of the upper aero-digestive tract: a phase III clinical trial","volume":"11","author":"Vermund","year":"1985","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0506|cit506","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1200\/JCO.1985.3.8.1105","article-title":"High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: a randomized study","volume":"3","author":"Veronesi","year":"1985","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0507|cit507","first-page":"III45","article-title":"Randomized study to assess safety & efficacy of H-R3 monoclonal antibody against EGF receptor in combination with chemo-radiation therapy advanced (stage III or IVA) head and neck cancer","volume":"20","author":"Viswanath","year":"2009","journal-title":"Annals of Oncology"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0508|cit508","first-page":"454","article-title":"Preoperative chemotherapy results of 44 patients with advanced squamous cell carcinoma of the head and neck region","volume":"32","author":"Von Heyden","year":"1984","journal-title":"Head and Neck Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0509|cit509","first-page":"114","article-title":"2nd interim evaluation of a chemotherapy study on patients with squamous cell carcinomas of the head-neck area. A comparison of 2 therapy regimens: cis-diamminedichloroplatinum (II) and bleomycin versus methotrexate and vindesine","volume":"6","author":"Schroder","year":"1983","journal-title":"Onkologie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0510|cit510","unstructured":"Von Heyden H Schroder M Scherpe A Beyer J Chemotherapy (CT) of advanced squamous cell carcinoma of the head and neck, a randomized crossover trial between cis-dichlorodiamineplatinum (cis-DDP) and bleomycin (BLM) versus methotrexate (MTX) and vindesine (VDS) Proceedings of the American Society of Clinical Oncology 1984 178 (Abs No C 693)"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0511|cit511","first-page":"183","article-title":"Cytostatic therapy of advanced squamous cell carcinoma of the head and neck. A randomized study comparing cis-dichlorodiammineplatinum(II) and bleomycin with methotrexate and vindesine","volume":"7","author":"Von Heyden","year":"1984","journal-title":"Onkologie"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0512|cit512","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/978-3-642-82432-6_20","article-title":"Chemotherapy of squamous head and neck cancer: a prospective randomized trial comparing cis-platinum and bleomycin with methotrexate and vindesine","volume":"98","author":"Von Heyden","year":"1985","journal-title":"Recent Results in Cancer Research"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0513|cit513","first-page":"183","article-title":"Chemotherapy of advanced squamous carcinoma of the head and neck region. A randomized trial between cis-dichlorodiamineplatinum-(II) (cis-DDP) and bleomycin (BLM) against methotrexate (MTX) and vindesine (VDS)","volume":"7","author":"Von Heyden","year":"1984","journal-title":"Onkologie"},{"issue":"Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0514|cit514","first-page":"A16","article-title":"Multicentre crossover trial of cis-dichlorodiamine platinum (cDDP) and bleomycin (BL) versus methotrexate (MTX) and vindesine (VD) in advanced squamous cell carcinoma of the head and neck","volume":"103","author":"Von Heyden","year":"1982","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0515|cit515","first-page":"226","article-title":"Equivocal nodes in previously-negative nodal levels and other pitfalls of PET surveillance in patients with HPV-associated oropharynx cancer treated on a prospective de-intensification trial","volume":"6","author":"Wang","year":"2017","journal-title":"Journal of Radiation Oncology"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0516|cit516","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/0360-3016(81)90601-5","article-title":"Radiation therapy and mitomycin C in the treatment of head and neck cancer: prospective randomized trial","volume":"7","author":"Weissberg","year":"1981","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0517|cit517","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0360-3016(89)90362-3","article-title":"Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer","volume":"17","author":"Weissberg","year":"1989","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0518|cit518","unstructured":"Weissberg JB Son YH Papac RJ Sasaki DB Fischer DS Radiation therapy (RT) and mitomycin C (MC) in the treatment of head and neck cancer: prospective randomized trial American Association for Cancer Research proceedings 1985 170"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0519|cit519","unstructured":"Weissberg JB Son YH Papac RJ Radiation therapy (RT) and mitomycin C (MC) in the treatment of head and neck cancer: prospective randomized trial American Association for Cancer Research proceedings 1985 675"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0520|cit520","unstructured":"Weissberg JB Prospective randomized trial of radiation therapy (RT) versus RT plus mitomycin C (MC) in head and neck cancer American Society for Therapeutic Radiology and Oncology 27th Annual Meeting 1985"},{"issue":"Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0521|cit521","first-page":"abstract number","article-title":"The INSPIRE trial: a randomized trial of neoadjuvant and adjuvant therapy with the IRX-2 regimen in patients with newly diagnosed stage II, III, or IVa squamous cell carcinoma of the oral cavity","volume":"23","author":"Wolf","year":"2017","journal-title":"Clinical Cancer Research (AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA))"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0522|cit522","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0039-6109(16)41287-9","article-title":"A controlled study of combined methotrexate, BCG, and INH therapy for squamous cell carcinoma of the head and neck","volume":"57","author":"Woods","year":"1977","journal-title":"Surgical Clinics of North America"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0523|cit523","first-page":"155","article-title":"Methotrexate treatment of advanced head and neck cancers: a dose response evaluation","volume":"65 Suppl 1","author":"Woods","year":"1981","journal-title":"Cancer Treatment Reports"},{"issue":"6264","key":"10.1002\/14651858.CD006386.pub4-BIB0524|cit524","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/bmj.282.6264.600","article-title":"Methotrexate treatment of squamous-cell head and neck cancers: dose-response evaluation","volume":"282","author":"Woods","year":"1981","journal-title":"British Medical Journal Clinical Research Edition"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0525|cit525","unstructured":"Woods RL Gill PG Levi JA Chemotherapy (CT for advanced squamous cell carcinomas) (SCCs) of head and neck: a randomised comparison of high dose versus low dose cis platinum (CIS DDP) in combination with bleomycin and methotrexate American Association for Cancer Research 75th Annual Meeting 1984 (Abs No 764)"},{"issue":"27","key":"10.1002\/14651858.CD006386.pub4-BIB0526|cit526","doi-asserted-by":"crossref","first-page":"44842","DOI":"10.18632\/oncotarget.15107","article-title":"Phase III randomized trial of preoperative concurrent chemoradiotherapy versus preoperative radiotherapy for patients with locally advanced head and neck squamous cell carcinoma","volume":"8","author":"Yi","year":"2017","journal-title":"Oncotarget"},{"issue":"15","key":"10.1002\/14651858.CD006386.pub4-BIB0527|cit527","first-page":"2581","article-title":"A comparative clinical study of adjuvant chemotherapy of tumors in the head and neck areas by means of HCFU","volume":"18","author":"Yoshino","year":"1991","journal-title":"Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]"},{"issue":"6","key":"10.1002\/14651858.CD006386.pub4-BIB0528|cit528","first-page":"777","article-title":"A comparative clinical study on the treatment of head and neck tumors by adjuvant chemotherapy with HCFU - second study by Kinki Head and Neck Tumor Study Group","volume":"21","author":"Yoshino","year":"1994","journal-title":"Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0529|cit529","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.annonc.2020.08.1029","article-title":"Standard versus fractionated high dose cisplatin concomitant with radiotherapy in locally advanced head & neck squamous cell cancer (LA-HNSCC): results of the GORTEC 2015-02 CisFRad randomized trial","volume":"31","author":"Borel","year":"2020","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0530|cit530","doi-asserted-by":"crossref","unstructured":"Bourhis J Lapeyre M Tortochaux J Etassami A Wibault P Geoffrois L Preliminary results of the GORTEC 96-01 randomized trial, comparing very accelerated radiotherapy versus concomitant radio-chemotherapy for locally inoperable HNSCC Proceedings of the American Society of Clinical Oncology 2002 Abs No 905","DOI":"10.1016\/S0360-3016(01)01893-4"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0531|cit531","first-page":"S118","article-title":"Very accelerated RT versus CDDP-5FU in unresectable HNSCC: results of the GORTEC 96-01 randomized trial","volume":"64 Suppl 1","author":"Bourhis","year":"2002","journal-title":"Radiation Oncology"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0532|cit532","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1200\/JCO.2020.38.15_suppl.6518","article-title":"A prospective phase II open-label randomized controlled trial to compare mandibular preservation in upfront surgery to neoadjuvant chemotherapy followed by surgery in operable oral cavity cancer","volume":"38","author":"Chaukar","year":"2020","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0533|cit533","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1200\/JCO.2017.35.15_suppl.6016","article-title":"Randomised phase-II trial of concurrent chemoradiation (CRT) for locally advanced head and neck cancer (stage III-IVB): comparing dose reduced radiotherapy (63,6 Gy) with paclitaxel\/cisplatinum to standard radiotherapy (70,6 Gy) with fluorouracil\/cisplatinum","volume":"35","author":"Fietkau","year":"2017","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0534|cit534","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1093\/annonc\/mdx374.023","article-title":"Ralitrexed verus 5-fluorouracil with cisplatin and concurrent radiotherapy (CCRT) for locally advanced head and neck squamous cell carcinoma (LA-HNSCC): a randomized controlled multi-centered trial","volume":"28","author":"He","year":"2017","journal-title":"Annals of Oncology"},{"issue":"15S","key":"10.1002\/14651858.CD006386.pub4-BIB0535|cit535","doi-asserted-by":"publisher","first-page":"6009","DOI":"10.1200\/jco.2009.27.15_suppl.6009","article-title":"Final results of a randomized phase III trial comparing induction chemotherapy with cisplatin\/5-FU or docetaxel\/cisplatin\/5-FU follow by chemoradiotherapy (CRT) versus CRT alone as first-line treatment of unresectable locally advanced head and neck cancer (LAHNC)","volume":"27","author":"Hitt","year":"2009","journal-title":"Journal of Clinical Oncology"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0536|cit536","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1200\/JCO.2020.38.15_suppl.6502","article-title":"Phase II\/III trial of post-operative chemoradiotherapy comparing 3-weekly cisplatin with weekly cisplatin in high-risk patients with squamous cell carcinoma of head and neck (JCOG1008)","volume":"38","author":"Kiyota","year":"2020","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0537|cit537","article-title":"Prospective randomised study comparing concurrent chemo radiation with weekly and 3 weekly cisplatin in locally advanced oropharyngeal carcinoma","author":"Suneetha","year":"2016","journal-title":"Journal of Cancer Research and Therapeutics (38th Annual Conference of the Association of Radiation Oncologists of India, AROICON 2016. India)"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0538|cit538","first-page":"277","article-title":"Neo-adjuvant chemotherapy by using methotrexate prior to radiation therapy in the treatment of advanced oral cancers","volume":"41","author":"Tepmongkol","year":"1989","journal-title":"Siriraj Hospital Gazette"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0539|cit539","unstructured":"Safety and efficacy of nab-paclitaxel combined with cisplatin and 5-FU versus paclitaxel plus cisplatin and 5-FU for induction chemotherapy in locally advanced head and neck squamous cell carcinoma: a multicenter, open, randomized controlled clinical trial www.who.int\/trialsearch\/Trial2.aspx?TrialID=ChiCTR2100041869"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0540|cit540","unstructured":"A study to evaluate the role of chemotherapy (which administered therapeutic agents before a main treatment) in oral cavity cancer patients [sic] www.who.int\/trialsearch\/Trial2.aspx?TrialID=CTRI\/2021\/03\/032390"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0541|cit541","unstructured":"Radiation therapy with or without cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer clinicaltrials.gov\/ct2\/show\/NCT00956007"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0542|cit542","unstructured":"Study of post-op adjuvant concurrent chemo-RT with or without nimotuzumab for head & neck cancer clinicaltrials.gov\/ct2\/show\/NCT00957086"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0543|cit543","unstructured":"Induction chemotherapy followed by cetuximab plus definitive radiotherapy versus radiation plus cisplatin (INTERCEPTOR) clinicaltrials.gov\/ct2\/show\/NCT00999700"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0544|cit544","unstructured":"Testing docetaxel-cetuximab or the addition of an immunotherapy drug, atezolizumab, to the usual chemotherapy and radiation therapy in high-risk head and neck cancer clinicaltrials.gov\/ct2\/show\/NCT01810913"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0545|cit545","unstructured":"GDF15 based TPF induction chemotherapy for OSCC patients clinicaltrials.gov\/ct2\/show\/NCT02285530"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0546|cit546","unstructured":"Radiation therapy with or without cisplatin in treating patients with stage III-IVA squamous cell carcinoma of the head and neck who have undergone surgery clinicaltrials.gov\/ct2\/show\/NCT02734537"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0547|cit547","unstructured":"Study of pembrolizumab (MK-3475) or placebo with chemoradiation in participants with locally advanced head and neck squamous cell carcinoma (MK-3475-412\/KEYNOTE-412) clinicaltrials.gov\/ct2\/show\/NCT03040999"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0548|cit548","unstructured":"Docetaxel and loplatin induction chemotherapy followed by concurrent chemoradiotherapy for locally advanced SCCHN clinicaltrials.gov\/ct2\/show\/NCT03117257"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0549|cit549","unstructured":"Radiation therapy with durvalumab or cetuximab in treating patients with locoregionally advanced head and neck cancer who cannot take cisplatin clinicaltrials.gov\/ct2\/show\/NCT03258554"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0550|cit550","unstructured":"A study of atezolizumab (anti-Pd-L1 antibody) as adjuvant therapy after definitive local therapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck clinicaltrials.gov\/ct2\/show\/NCT03452137"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0551|cit551","unstructured":"A trial evaluating the addition of nivolumab to cisplatin-RT for treatment of cancers of the head and neck (NIVOPOSTOP) clinicaltrials.gov\/ct2\/show\/NCT03576417"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0552|cit552","unstructured":"Maintenance immune check-point inhibitor following post-operative chemo-radiation in subjects with HPV-negative HNSCC (ADHERE) clinicaltrials.gov\/ct2\/show\/NCT03673735"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0553|cit553","unstructured":"A prospective randomized trial of capecitabine treatment in patients with HNSCC clinicaltrials.gov\/ct2\/show\/NCT03678649"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0554|cit554","unstructured":"Concurent chemoradiotherapy in head and neck cancers clinicaltrials.gov\/ct2\/show\/NCT04780750"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0555|cit555","unstructured":"Randomized trial of avelumab-cetuximab-radiotherapy versus SOCs in LA SCCHN (REACH) (REACH) clinicaltrials.gov\/ct2\/show\/NCT02999087"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0556|cit556","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ejca.2020.09.008","article-title":"Avelumab-cetuximab-radiotherapy versus standards of care in locally advanced squamous-cell carcinoma of the head and neck: the safety phase of a randomised phase III trial GORTEC 2017-01 (REACH)","volume":"141","author":"Tao","year":"2020","journal-title":"European Journal of Cancer"},{"issue":"8","key":"10.1002\/14651858.CD006386.pub4-BIB0557|cit557","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.oraloncology.2011.05.004","article-title":"Population attributable risk of tobacco and alcohol or upper aerodigestive tract cancer","volume":"47","author":"Anantharaman","year":"2011","journal-title":"Oral Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0558|cit558","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/ijc.24994","article-title":"The role of human papillomavirus in the increased incidence of base of tongue cancer","volume":"126","author":"Attner","year":"2010","journal-title":"International Journal of Cancer"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0559|cit559","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/hed.1081","article-title":"Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer: A systematic review of the published literature with subgroup analysis","volume":"23","author":"Browman","year":"2001","journal-title":"Head & Neck"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0560|cit560","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006205.pub4","article-title":"Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment","author":"Bulsara","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0561|cit561","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010341.pub2","article-title":"Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy","author":"Chan","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0562|cit562","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/lary.27315","article-title":"Changing prognosis of oral cancer: an analysis of survival and treatment between 1973 and 2014","volume":"128","author":"Cheraghlou","year":"2018","journal-title":"Laryngoscope"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0563|cit563","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1002\/ijc.23430","article-title":"Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies","volume":"122","author":"Conway","year":"2008","journal-title":"International Journal of Cancer"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0564|cit564","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/ijc.29063","article-title":"Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries","volume":"136","author":"Conway","year":"2014","journal-title":"International Journal of Cancer"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0565|cit565","doi-asserted-by":"crossref","unstructured":"D'Souza G Kreimer AR Viscidi R Pawlita M Fakhry C Koch WM Case-control study of human papillomavirus and oropharyngeal cancer New England Journal of Medicine 2007 356 19 1944 56","DOI":"10.1056\/NEJMoa065497"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0566|cit566","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/1097-0142(19920701)70:1<14::AID-CNCR2820700103>3.0.CO;2-S","article-title":"Second primary tumors in patients with oral cancer","volume":"70","author":"Day","year":"1992","journal-title":"Cancer"},{"issue":"17","key":"10.1002\/14651858.CD006386.pub4-BIB0567|cit567","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1200\/JCO.2006.06.1291","article-title":"Clinical implications of human papillomavirus in head and neck cancers","volume":"24","author":"Fakhry","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0568|cit568","doi-asserted-by":"crossref","unstructured":"Fakhry C Westra WH Li S Cmelak A Ridge JA Pinto H Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial Journal of the National Cancer Institute 2008 100 4 261 9","DOI":"10.1093\/jnci\/djn011"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0569|cit569","doi-asserted-by":"crossref","unstructured":"Freedman ND Abnet CC Leitzmann MF Hollenbeck AR Schatzkin A Prospective investigation of the cigarette smoking-head and neck cancer association by sex Cancer 2007 110 7 1593 601","DOI":"10.1002\/cncr.22957"},{"issue":"12","key":"10.1002\/14651858.CD006386.pub4-BIB0570|cit570","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006387","article-title":"Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy","author":"Glenny","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD006386.pub4-BIB0571|cit571","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/jamaoncol.2018.2706","article-title":"Global, regional, and national cancer Incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: a systematic analysis for the Global Burden of Disease Study","volume":"4","author":"Global Burden of Disease Cancer Collaboration","year":"2018","journal-title":"JAMA Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0572|cit572","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A GRADE handbook for grading quality of evidence and strength of recommendations. Updated October 2013. The GRADE Working Group, 2013 Available from guidelinedevelopment.org\/handbook"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0573|cit573","unstructured":"GRADEpro Guideline Development Tool [Software] GRADEpro GDT McMaster University, 2020 (developed by Evidence Prime, Inc.) 2020"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0574|cit574","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3126\/nje.v6i4.17255","article-title":"Changing trends in oral cancer - a global scenario","volume":"6","author":"Gupta","year":"2016","journal-title":"Nepal Journal of Epidemiology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0575|cit575","doi-asserted-by":"crossref","unstructured":"Hammarstedt L Lindquist D Dahlstrand H Romanitan M Dahlgren LO Joneberg J Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer International Journal of Cancer 2006 119 11 2620 3","DOI":"10.1002\/ijc.22177"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0576|cit576","doi-asserted-by":"crossref","unstructured":"Higgins JPT Cochrane Handbook for Systematic Reviews of Interventions version 5.0.2 (updated September 2009). The Cochrane Collaboration, 2009 Available from www.cochrane-handbook.org","DOI":"10.1002\/9780470712184"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0577|cit577","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jjco\/hyv151","article-title":"Intra-arterial chemoradiotherapy for head and neck cancer","volume":"46","author":"Homma","year":"2016","journal-title":"Japanese Journal of Clinical Oncology"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0578|cit578","first-page":"e1","article-title":"Long-term surgical complications in the oral cancer patient: a comprehensive review. Part I","volume":"1","author":"Kolokythas","year":"2010","journal-title":"Journal of Oral & Maxillofacial Research"},{"issue":"5","key":"10.1002\/14651858.CD006386.pub4-BIB0579|cit579","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1368-8375(97)00029-8","article-title":"Epidemiology and prevention of oral cancer","volume":"33","author":"La Vecchia","year":"1997","journal-title":"Oral Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0580|cit580","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/srao.2003.50002","article-title":"The mechanism of action of radiosensitization of conventional chemotherapeutic agents","volume":"13","author":"Lawrence","year":"2003","journal-title":"Seminars in Radiation Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0581|cit581","unstructured":"Lefebvre C Glanville J Briscoe S Littlewood A Marshall C Technical Supplement to Chapter 4: Searching for and selecting studies. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.1 (updated September 2020). Cochrane, 2020 Available from www.training.cochrane.org\/handbook"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0582|cit582","doi-asserted-by":"crossref","unstructured":"Licitra L Perrone F Bossi P Suardi S Mariani L Artusi R High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma Journal of Clinical Oncology 2006 24 36 5630 6","DOI":"10.1200\/JCO.2005.04.6136"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0583|cit583","first-page":"181","article-title":"Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies","volume":"31B","author":"Macfarlane","year":"1995","journal-title":"Oral Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0584|cit584","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bjoms.2004.01.016","article-title":"Delay in diagnosis and its effect on outcome in head and neck cancer","volume":"43","author":"McGurk","year":"2005","journal-title":"British Journal of Oral and Maxillofacial Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0585|cit585","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1634\/theoncologist.2009-S105","article-title":"Recent advances in combined modality therapy","volume":"15","author":"Mierzwa","year":"2010","journal-title":"Oncologist"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0586|cit586","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(01)00486-7","article-title":"Global cancer statistics in the year 2000","volume":"2","author":"Parkin","year":"2001","journal-title":"Lancet Oncology"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0587|cit587","doi-asserted-by":"crossref","unstructured":"Parkin DM Bray F Ferlay J Pisani P Global cancer statistics, 2002 CA: a Cancer Journal for Clinicians 2005 55 2 74 108","DOI":"10.3322\/canjclin.55.2.74"},{"issue":"24","key":"10.1002\/14651858.CD006386.pub4-BIB0588|cit588","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8","article-title":"Extracting summary statistics to perform meta-analysis of the published literature for survival endpoints","volume":"17","author":"Parmar","year":"1998","journal-title":"Statistics in Medicine"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0589|cit589","first-page":"2718","article-title":"Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment","volume":"6","author":"Partridge","year":"2000","journal-title":"Clinical Cancer Research"},{"issue":"9208","key":"10.1002\/14651858.CD006386.pub4-BIB0590|cit590","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0591|cit591","doi-asserted-by":"crossref","unstructured":"Pignon JP le Maitre A Maillard E Bourhis J Group M-NC Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients Radiotherapy & Oncology 2009 92 1 4 14","DOI":"10.1016\/j.radonc.2009.04.014"},{"issue":"10 Suppl","key":"10.1002\/14651858.CD006386.pub4-BIB0592|cit592","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1002\/cncr.23745","article-title":"Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998-2003","volume":"113","author":"Ryerson","year":"2008","journal-title":"Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0593|cit593","first-page":"51","article-title":"The global incidence of lip, oral cavity and pharyngeal cancers by subsite in 2012","volume":"67","author":"Shield","year":"2017","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"7","key":"10.1002\/14651858.CD006386.pub4-BIB0594|cit594","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/cncr.22963","article-title":"Trends in head and neck cancer incidence in relation to smoking prevalence","volume":"110","author":"Sturgis","year":"2007","journal-title":"Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0595|cit595","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1634\/theoncologist.2017-0015","article-title":"Weekly low-dose versus three-weekly high-dose cisplatin for concurrent chemoradiation in locoregionally advanced non-nasopharyngeal head and neck cancer: a systematic review and meta-analysis of aggregate data","volume":"22","author":"Szturz","year":"2017","journal-title":"Oncologist"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0596|cit596","doi-asserted-by":"crossref","unstructured":"Warnakulasuriya S Global epidemiology of oral and oropharyngeal cancer Oral Oncology 2009 45 4-5 309 16","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"10.1002\/14651858.CD006386.pub4-BIB0597|cit597","volume-title":"ICD-O. International Statistical Classification of Diseases and Related Health Problems, 1989 Revision","year":"1992"},{"issue":"29","key":"10.1002\/14651858.CD006386.pub4-BIB0598|cit598","first-page":"doi.org\/10.1186","article-title":"Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review","volume":"46","author":"Winquist","year":"2017","journal-title":"Journal of Otolaryngology - Head & Neck Surgery"},{"issue":"3","key":"10.1002\/14651858.CD006386.pub4-BIB0599|cit599","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/sj.ebd.6401110","article-title":"Priority oral health research identification for clinical decision-making","volume":"16","author":"Worthington","year":"2015","journal-title":"Evidence-based Dentistry"},{"issue":"9","key":"10.1002\/14651858.CD006386.pub4-BIB0600|cit600","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006386.pub2","article-title":"Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy\u00a0","author":"Furness","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD006386.pub4-BIB0601|cit601","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006386.pub3","article-title":"Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy","author":"Furness","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD006386.pub4-BIB0602|cit602","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006386","article-title":"Interventions for the treatment of oral cancer: chemotherapy","author":"Oliver","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:38:09Z","timestamp":1744724289000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006386.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Oral Health Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,20]]},"references-count":602,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006386.pub4","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,20]]}}}