{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:03:53Z","timestamp":1793196233744,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006544","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000}}],"reference-count":72,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006544.pub2","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T18:33:20Z","timestamp":1263839600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prostanoids for critical limb ischaemia"],"prefix":"10.1002","author":[{"given":"Antonio J","family":"Ruffolo","sequence":"first","affiliation":[{"name":"Instituto de Efectividad Cl\u00ednica y Sanitaria; Viamonte 2146, 3er piso Buenos Aires Argentina C1056ABH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Romano","sequence":"additional","affiliation":[{"name":"Hospital Italiano Buenos Aires; Neurology Department; Gascon 450 CABA (Ciudad Autonoma de Buenos Aires) Buenos Aires Argentina 1181"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Ciapponi","sequence":"additional","affiliation":[{"name":"Institute for Clinical Effectiveness and Health Policy - Hospital Italiano de Buenos Aires; Argentine Cochrane Centre IECS - Family and Community Medicine Service; 2146 Viamonte 3rd Floor - Gasc\u00f3n 450 Buenos Aires Capital Federal Argentina C1056ABH - C1181ACH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0001|cit1","first-page":"229","article-title":"Reduction of ischaemic rest pain in advanced peripheral arterial occlusive disease. A double blind placebo controlled trial with iloprost","volume":"10","author":"Balzer","year":"1991","journal-title":"International Angiology\u00a0"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0002|cit2","first-page":"15","article-title":"Low-dose iloprost infusions compared to the standard dose in patients with peripheral arterial occlusive disease Fontaine stage IV. DAWID Study Group","volume":"27","author":"Beischer","year":"1998","journal-title":"Vasa Journal for vascular diseases"},{"issue":"8320","key":"10.1002\/14651858.CD006544.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0140-6736(83)91625-2","article-title":"Epoprostenol (prostacyclin) and severe arterial disease. A double-blind trial","volume":"1","author":"Belch","year":"1983","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jvs.2005.11.041","article-title":"Parenteral therapy with lipo-ecraprost, a lipid-based formulation of a PGE1 analog, does not alter six-month outcomes in patients with critical leg ischemia","volume":"43","author":"Brass","year":"2006","journal-title":"Journal of Vascular Surgery"},{"issue":"40","key":"10.1002\/14651858.CD006544.pub2-BIB0005|cit5","first-page":"1477","article-title":"Iloprost in the treatment of ischemic tissue lesions in diabetics: Results of a placebo-controlled multicenter study with a stable prostacyclin derivative","volume":"120","author":"Brock","year":"1990","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"51-52","key":"10.1002\/14651858.CD006544.pub2-BIB0006|cit6","first-page":"1501","article-title":"Peripheral arterial occlusive disease stage III and IV","volume":"40","author":"B\u00f6hme","year":"1989","journal-title":"Medizinische Welt"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0007|cit7","first-page":"52","article-title":"Clinical effects of intravenously administered prostaglandin E1 in patients with rest pain due to peripheral obliterative arterial disease (POAD) - a preliminary report on a placebo-controlled double-blind study","volume":"17","author":"Diehm","year":"1987","journal-title":"Vasa - Supplementum"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-642-73943-9_18","article-title":"Intravenous prostaglandin E1 therapy in patients with stage III peripheral arterial disease - a double-blind placebo controlled study","volume-title":"Prostaglandin E1 Wirkungen und therapeutische Wirksamkeit","author":"Diehm","year":"1988"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0009|cit9","first-page":"204","article-title":"Treatment of rest pain in peripheral arterial occlusive disease (PVVK) with intravenous prostaglandin infusion","volume":"20","author":"Diehm","year":"1987","journal-title":"Vasa Supplementum"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0950-821X(05)80337-8","article-title":"Treatment of limb threatening ischaemia with intravenous iloprost: A randomised double-blind placebo controlled study","volume":"5","author":"Dormandy JA. U.K. Severe Limb Ischaemia Study Group","year":"1991","journal-title":"European Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0011|cit11","first-page":"558","article-title":"Controlled randomized study of an oral prostacyclin analogue (iloprost) in patients with inoperable stage III and IV leg ischaemia","volume":"83","author":"Dormandy","year":"1996","journal-title":"British Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/ejvs.2000.1175","article-title":"Two randomised and placebo-controlled studies of an oral prostacyclin analogue (Iloprost) in severe leg ischaemia. Study A","volume":"20","author":"Dormandy","year":"2000","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/ejvs.2000.1175","article-title":"Two randomised and placebo-controlled studies of an oral prostacyclin analogue (Iloprost) in severe leg ischaemia. Study B","volume":"20","author":"Dormandy","year":"2000","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF03259752","article-title":"Treatment of lower limb ischaemia due to atherosclerosis in diabetic and nondiabetic patients with iloprost, a stable analogue of prostacyclin.\u00a0 Results of a French Multicentre Trial","volume":"3","author":"Guilmot","year":"1991","journal-title":"Drug Investigation"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0015|cit15","first-page":"540","article-title":"Long-term infusion of epoprostenol (prostacyclin) in patients with occlusive arteriopathy stage III-IV","volume":"89","author":"Hossmann","year":"1983","journal-title":"Verhandlungen der Deutschen Gesellschaft fur Innere Medizin"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/j.1552-4604.1991.tb01891.x","article-title":"The effect of ciprostene in patients with peripheral vascular disease (PVD) characterized by ischemic ulcers","volume":"31","author":"Linet","year":"Jan 1991","journal-title":"Journal of Clinical Pharmacology"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0017|cit17","first-page":"196","article-title":"Intra-arterial prostacyclin compared to Praxilene in the management of severe lower limb ischaemia: a double blind trial","volume":"28","author":"Negus","year":"1987","journal-title":"Journal of Cardiovascular Surgery (Torino)"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0950-821X(05)80784-4","article-title":"A stable prostacyclin analogue (Iloprost) in the treatment of ischaemic ulcers of the lower limb","volume":"4","author":"Norgren","year":"1990","journal-title":"European Journal of Vascular Surgery"},{"issue":"6","key":"10.1002\/14651858.CD006544.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.plefa.2003.10.006","article-title":"Microcirculation and tolerability following i.v. infusion of PGE1 and iloprost: a randomized cross-over study in patients with critical limb ischemia","volume":"70","author":"Schellong","year":"2004","journal-title":"Prostaglandins Leukotrienes & Essential Fatty Acids"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0020|cit20","first-page":"164","article-title":"Placebo controlled, double-blind study of the effectiveness of i.v. prostaglandin E1 in diabetic patients with stage IV arterial occlusive disease","volume":"35 (Suppl)","author":"Stiegler","year":"1992","journal-title":"VASA"},{"issue":"7","key":"10.1002\/14651858.CD006544.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/bjs.1800710710","article-title":"Prostaglandin E1 in severe lower limb ischaemia: a double-blind controlled trial","volume":"71","author":"Telles","year":"1984","journal-title":"British Journal of Surgery"},{"issue":"24","key":"10.1002\/14651858.CD006544.pub2-BIB0022|cit22","first-page":"955","article-title":"Prostaglandin E1 in stage III and IV arterial occlusive disease: results of a multi-center trial","volume":"112","author":"Trubestein","year":"1987","journal-title":"Deutsche Medizinische Wochenschrift"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0952-3278(93)90163-Q","article-title":"Treatment of patients with peripheral arterial occlusive disease Fontaine stage IV with intravenous iloprost and PGE1: a randomized open controlled study","volume":"49","author":"Altstaedt","year":"1993","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0024|cit24","first-page":"53","article-title":"Clinical and circulatory effects of Iloprost either administered for 1 week or 4 weeks in patients with peripheral obstructive arterial disease at Leriche-Fontaine stage III","volume":"2","author":"Arosio","year":"1998","journal-title":"European Review for Medical & Pharmacological Sciences"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0025|cit25","first-page":"249","article-title":"Analysis of side effects of prostanoid-based treatment in patients suffering from critical ischaemia of the lower limbs","volume":"5","author":"Bandiera","year":"1995","journal-title":"Chronica Dermatologica"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.7326\/0003-4819-130-5-199903020-00005","article-title":"Prostanoids for chronic critical leg ischemia. A randomized, controlled, open-label trial with prostaglandin E1","volume":"130","author":"Bertele","year":"1999","journal-title":"Annals of Internal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0027|cit27","first-page":"62","article-title":"Prostacyclin (iloprost) as an adjuvant in local surgical therapy of stage IV arterial occlusive disease - is quantification of the therapeutic effect possible with tcPO2 measurements?","volume":"24","author":"Breuer","year":"1995","journal-title":"VASA Journal for vascular diseases"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0028|cit28","first-page":"209","article-title":"Naftidrofuryl in comparison to alprostadil in peripheral arterial occlusive disease stage III and IV","volume":"45","author":"Bohme","year":"1994","journal-title":"Medizinische Welt"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/BF01616273","article-title":"Effects of iloprost, either administered for 1 week or 4 weeks, on systemic hemodynamics, peripheral blood flow, and exercise tolerance in patients with peripheral occlusive arterial disease at Leriche-Fontaine stage III","volume":"7","author":"Ceriello","year":"1998","journal-title":"International Journal of Angiology"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0030|cit30","first-page":"369","article-title":"Lindenauer SM, Graham LM, Stanley JC. Prostacyclin treatment of ischemic ulcers and rest pain in unreconstructable peripheral arterial occlusive disease","volume":"100","author":"Cronenwett","year":"1986","journal-title":"Surgery"},{"issue":"10","key":"10.1002\/14651858.CD006544.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1177\/039139880502801012","article-title":"Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease","volume":"28","author":"Paolo","year":"2005","journal-title":"International Journal of Artificial Organs"},{"issue":"20","key":"10.1002\/14651858.CD006544.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1055\/s-2008-1066673","article-title":"Iloprost, a stable prostacyclin derivative, in stage IV arterial disease. A placebo-controlled multicentre study","volume":"114","author":"Diehm","year":"1989","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0033|cit33","first-page":"522A","article-title":"Treatment of ischaemic ulceration or rest pain with intravenous Iloprost: A double-blind placebo controlled study","volume":"Suppl 1","author":"Fonseca","year":"1991","journal-title":"Diabetes 40"},{"issue":"7","key":"10.1002\/14651858.CD006544.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0011-393X(03)00125-5","article-title":"Comparison of beraprost and ticlopidine in Chinese patients with chronic peripheral arterial occlusion: a multicenter, single blind, randomized, controlled study","volume":"64","author":"Guan","year":"July\/ August 2003","journal-title":"Current Therapeutic Research"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0035|cit35","first-page":"13","article-title":"Controlled long-term blood pressure measurement with intravenous prostaglandin E1 infusion","volume":"20","author":"Heidrich","year":"1991","journal-title":"VASA"},{"issue":"12","key":"10.1002\/14651858.CD006544.pub2-BIB0036|cit36","first-page":"644","article-title":"A randomized study on patients with peripheral arterial occlusive disease (PAOD) stage III and IV","volume":"18","author":"Karnik","year":"1986","journal-title":"Herz Kreislauf"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006544.pub2-BIB0037|cit37","first-page":"104","article-title":"Alprostadil in the treatment of patients with severe peripheral arterial occlusive disease (PAOD) not amenable to surgery: results of a randomized, placebo-controlled multicenter study","volume":"14","author":"Menzoian","year":"1995","journal-title":"International Angiology"},{"issue":"6","key":"10.1002\/14651858.CD006544.pub2-BIB0038|cit38","first-page":"1243","article-title":"Medical Therapy in Diabetic Angiopathy With Inoperable Critical Limb Ischemia (Cli) - a Randomized, Between-Patients Study to Compare the Effects of Iloprost (I) Vs Pentoxyfilline (P).","volume":"69","author":"Mingardi","journal-title":"Thrombosis and Haemostasis"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0939-4753(04)80003-6","article-title":"Prostaglandin E1 versus lumbar sympathectomy in the treatment of\u00a0 peripheral arterial occlusive disease: randomised study of 86 patients","volume":"14","author":"Petronella","year":"Aug 2004","journal-title":"Nutrition Metabolism & Cardiovascular Diseases"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006544.pub2-BIB0040|cit40","first-page":"201","article-title":"Iloprost vs nitrates and aspirin in the treatment of geriatric patients suffering of peripheral arterial obliterative disease","volume":"14","author":"Schwarz","year":"1995","journal-title":"International Angiology"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0041|cit41","first-page":"44","article-title":"Intravenous prostaglandin E1 versus pentoxifylline therapy in chronic arterial occlusive disease - a controlled randomised multicenter study","volume":"Supplementum 28","author":"Trubestein","year":"1989","journal-title":"VASA"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0741-5214(92)90417-7","article-title":"Assessment of quality of life of patients with severe ischemia as a result of infrainguinal arterial occlusive disease","volume":"16","author":"Albers","year":"1992","journal-title":"Journal of Vascular Surgery"},{"issue":"4 Suppl","key":"10.1002\/14651858.CD006544.pub2-BIB0043|cit43","first-page":"1","article-title":"Second European Consensus Document on chronic critical leg ischemia","volume":"84","author":"Anonymous","year":"1991","journal-title":"Circulation"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0044|cit44","first-page":"229","article-title":"Reduction of ischaemic rest pain in advanced peripheral arterial occlusive disease. A double blind placebo controlled trial with iloprost","volume":"10","author":"Balzer","year":"1991","journal-title":"International Angiology"},{"issue":"12","key":"10.1002\/14651858.CD006544.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/01.CIR.97.12.1114","article-title":"Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia","volume":"97","author":"Baumgartner","year":"1998","journal-title":"Circulation"},{"issue":"40","key":"10.1002\/14651858.CD006544.pub2-BIB0046|cit46","first-page":"1447","article-title":"Iloprost in the treatment of ischemic tissue lessions in diabetics. Results of a placebo - controlled multicenter study with a stable prostacyclin derivative","volume":"120","author":"Brock","year":"1990","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"3","key":"10.1002\/14651858.CD006544.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1024\/0301-1526.33.3.137","article-title":"Meta-analysis of randomised controlled prostaglandin E1 studies in peripheral arterial occlusive disease stages III and IV","volume":"33","author":"Creutzig","year":"2004","journal-title":"Vasa"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/archsurg.1984.01390160060012","article-title":"Intermittent claudication. Current results of non operative management","volume":"119","author":"Cronenwett","year":"1984","journal-title":"Archives of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1358863X9600100212","article-title":"Prostanoid drug therapy for peripheral arterial occlusive disease - the European experience","volume":"1","author":"Dormandy","year":"1996","journal-title":"Vascular Medicine"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD006544.pub2-BIB0050|cit50","first-page":"S1","article-title":"Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC)","volume":"31","author":"Dormandy","year":"2000","journal-title":"Journal of Vascular Surgery"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1001\/jama.295.5.547","article-title":"Medical treatment of peripheral arterial disease","volume":"295","author":"Hankey","year":"2006","journal-title":"JAMA"},{"issue":"11","key":"10.1002\/14651858.CD006544.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/CIRCULATIONAHA.106.174526","article-title":"ACC\/AHA 2005 Practice guidelines for the management of patients with peripheral arterial disease.","volume":"113","author":"Hirsch","year":"2006","journal-title":"Circulation"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"412","DOI":"10.7326\/0003-4819-130-5-199903020-00005","article-title":"Prostanoids for chronic critical leg ischemia. A Randomized, Controlled, Open-Label trial with prostaglandin E1","volume":"130","author":"The ICAI Group","year":"1999","journal-title":"Annals of Internal Medicine"},{"issue":"11","key":"10.1002\/14651858.CD006544.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1161\/01.CIR.91.11.2687","article-title":"Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease","volume":"91","author":"Isner","year":"1995","journal-title":"Circulation"},{"issue":"9024","key":"10.1002\/14651858.CD006544.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0140-6736(96)03361-2","article-title":"Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb","volume":"348","author":"Isner","year":"1996","journal-title":"Lancet"},{"issue":"1-3","key":"10.1002\/14651858.CD006544.pub2-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0169-409X(97)00115-4","article-title":"Arterial gene transfer of naked DNA for therapeutic angiogenesis: Early clinical results","volume":"30","author":"Isner","year":"1998","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"1","key":"10.1002\/14651858.CD006544.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"issue":"6555","key":"10.1002\/14651858.CD006544.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/bmj.293.6555.1137","article-title":"Fate in intermittent claudication: outcome and risk factors","volume":"293","author":"Jelnes","year":"1986","journal-title":"British Medical Journal Clinical Research Ed"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.0954-6820.1986.tb02740.x","article-title":"Changes in peripheral blood pressures after 5 years of follow - up in non operated patients with intermittent claudication","volume":"220","author":"Jonason","year":"1986","journal-title":"Acta Medica Scandinavica"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/01.CIR.21.2.188","article-title":"Atherosclerosis obliterans. Review of 520 Cases with Special Reference to Pathogenic and Prognostic Factors","volume":"21","author":"Juerguens","year":"1960","journal-title":"Circulation"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00043798-199412000-00009","article-title":"Risk factors for atherosclerotic cardiovascular outcomes in different arterial territories","volume":"1","author":"Kannel","year":"1994","journal-title":"Journal of Cardiovascular Risk"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0062|cit62","first-page":"133","article-title":"A meta-analysis of randomized placebo control trials in Fontaine stages III and IV peripheral occlusive arterial disease","volume":"13","author":"Loosemore","year":"1994","journal-title":"International Angiology"},{"issue":"3","key":"10.1002\/14651858.CD006544.pub2-BIB0063|cit63","first-page":"147","article-title":"Skeletal Muscle Regeneration in Chronic Critical Limb Ischemia","volume":"10","author":"Mackiewicz","year":"2003","journal-title":"Acta Medica Lituanica"},{"issue":"3","key":"10.1002\/14651858.CD006544.pub2-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0890-5096(07)60040-5","article-title":"Basic data related to the natural history of intermittent claudication","volume":"3","author":"McDaniel","year":"1989","journal-title":"Annals of Vascular Surgery"},{"issue":"5","key":"10.1002\/14651858.CD006544.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0950-821X(05)80784-4","article-title":"A stable prostacyclin analogue (iloprost) in the treatment of ischaemic ulcers of the lower limb: A Scandinavian - Polish placebo controlled, randomised multicenter study","volume":"4","author":"Norgren","year":"1990","journal-title":"European Journal of Vascular Surgery"},{"issue":"3","key":"10.1002\/14651858.CD006544.pub2-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2174\/1568006043335989","article-title":"Critical limb ischemia: definition and natural history","volume":"4","author":"Novo","year":"2004","journal-title":"Current Drug Targets Cardiovascular & Haematological Disorders"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0067|cit67","doi-asserted-by":"crossref","unstructured":"Liberati A Altman DG Tezlaff J The PRISMA Statement for Reporting Systematic Reviews and Meta - Analyses of Studies that Evaluate Health Care Interventions: Explanation and Elaboration PLoS Med July 2009","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"issue":"4","key":"10.1002\/14651858.CD006544.pub2-BIB0068|cit68","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000986.pub2","article-title":"Prostanoids for intermittent claudication (Cochrane review)","author":"Reiter","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0069|cit69","unstructured":"Tact-Nagoya Therapeutic Angiogenesis Using Cell Transplantation (TACT( Study http:\/\/clinicaltrials.gov\/ct\/gui\/show\/NCT00145262"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0070|cit70","unstructured":"Nikol S. The Talisman 2001 Clinical Trial Investigators Therapeutic angiogenesis with intramuscular NV1FGF improves amputatiuon-free survival in patients with critical limb ischaemia http:\/\/acc06online.acc.org\/Lectures.aspx?sessionId=1&date=12"},{"key":"10.1002\/14651858.CD006544.pub2-BIB0071|cit71","first-page":"44","article-title":"Intravenous prostaglandin E1 versus pentoxifylline therapy in chronic arterial occlusive disease - a controlled randomised multicenter study","volume":"28","author":"Trubestein","year":"1989","journal-title":"Vasa - Supplementum"},{"issue":"2","key":"10.1002\/14651858.CD006544.pub2-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/1358863X9400500201","article-title":"prostaglandins in critical limb ischemia","volume":"5","author":"Verstraete","year":"1994","journal-title":"Vascular Medicine Review"}],"updated-by":[{"DOI":"10.1002\/14651858.cd006544.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD006544.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:00:54Z","timestamp":1628546454000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD006544.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Vascular Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,1,20]]},"references-count":72,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006544.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD006544.pub3","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,20]]}}}