{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:18:27Z","timestamp":1792513107615,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006560.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000}}],"reference-count":178,"publisher":"Wiley","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006560.pub3","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:59:01Z","timestamp":1458032341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":247,"title":["Interventions for improving outcomes in patients with multimorbidity in primary care and community settings"],"prefix":"10.1002","author":[{"given":"Susan M","family":"Smith","sequence":"first","affiliation":[{"name":"RCSI Medical School; HRB Centre for Primary Care Research, Department of General Practice; 123 St Stephens Green Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Wallace","sequence":"additional","affiliation":[{"name":"RCSI Medical School; HRB Centre for Primary Care Research, Department of General Practice; 123 St Stephens Green Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"O'Dowd","sequence":"additional","affiliation":[{"name":"Trinity College Centre for Health Sciences; Department of Public Health and Primary Care; Adelaide and Meath Hosptials, Incorporating the National Children's Hospital Tallaght Dublin Ireland 24"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fortin","sequence":"additional","affiliation":[{"name":"University of Sherbrooke; Department of Family Medicine; Unite de Medicine de famille de Chicoutimi 305, St-Vallier Chicoutimi Quebec QC Canada G7H 5H6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"issue":"6","key":"10.1002\/14651858.CD006560.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"e98704","DOI":"10.1371\/journal.pone.0098704","article-title":"The UPBEAT nurse-delivered personalized care intervention for people with coronary heart disease who report current chest pain and depression: A randomised controlled pilot study","volume":"9","author":"Barley","year":"June 2014","journal-title":"PLOS One"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1370\/afm.843","article-title":"Integration of depression and hypertension treatment: a pilot, randomized controlled trial","volume":"6","author":"Bogner","year":"2008","journal-title":"Annals of Family Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/gerona\/63.3.321","article-title":"Early effects of \"Guided Care\" on the quality of healthcare for multimorbid older persons: A cluster randomized controlled trial","volume":"63","author":"Boult","year":"2008","journal-title":"The Journals of Gerontology"},{"issue":"8","key":"10.1002\/14651858.CD006560.pub3-BIB0004|cit4","first-page":"555","article-title":"Guided Care and the cost of complex healthcare: A preliminary report","volume":"15","author":"Leff","year":"2009","journal-title":"American Journal of Managed Care"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"h368","DOI":"10.1136\/bmj.h638","article-title":"Integrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial for patients with depression comorbid with diabetes or cardiovascular disease","volume":"350","author":"Coventry","year":"2015","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1037\/0278-6133.26.4.392","article-title":"Resources for Health: A Primary-Care-Based Diet and Physical Activity Intervention Targeting Urban Latinos With Multiple Chronic Conditions","volume":"26","author":"Eakin","year":"2007","journal-title":"Health Psychology"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12875-015-0267-0","article-title":"OPTIMAL, an occupational therapy led self-management support programme for people with multimorbidity in primary care: a randomized controlled trial","volume":"16","author":"Garvey","year":"2015","journal-title":"BMC Family Practice"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1532-5415.2008.02147.x","article-title":"Long-term effect on mortality of a home intervention that reduces functional difficulties in older adults: Results from a randomized trial","volume":"57","author":"Giltin","year":"2009","journal-title":"Journal of the American Geriatrics Society"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1532-5415.2006.00703.x","article-title":"A randomized trial of a multicomponent home intervention to reduce functional difficulties in older adults","volume":"54","author":"Gitlin","year":"2006","journal-title":"Journal of the American Geriatrics Society"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pec.2010.01.018","article-title":"Making the Most of Your Healthcare intervention for older adults with multiple chronic illnesses","volume":"81","author":"Hochhalter","year":"2010","journal-title":"Patient Education and Counselling"},{"issue":"12","key":"10.1002\/14651858.CD006560.pub3-BIB0011|cit11","first-page":"e76","article-title":"Randomized controlled trial of Anticipatory and Preventive multidisciplinary Team Care","volume":"55","author":"Hogg","year":"December 2009","journal-title":"Canadian Family Physician"},{"issue":"27","key":"10.1002\/14651858.CD006560.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1056\/NEJMoa1003955","article-title":"Collaborative care for patients with depression and chronic illnesses","volume":"363","author":"Katon","year":"2010","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archgenpsychiatry.2011.1548","article-title":"Cost-effectiveness of a multicondition collaborative care intervention: a randomized controlled trial","volume":"69","author":"Katon","year":"2012","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"f2882","DOI":"10.1136\/bmj.f2882","article-title":"Implementation of self management support for long term conditions in routine primary care settings: cluster randomised controlled trial","volume":"346","author":"Kennedy","year":"2013","journal-title":"BMJ"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ageing\/30.3.205","article-title":"Pharmacist-led medication review in patients over 65: a randomized controlled trial in primary care","volume":"30","author":"Krska","year":"2001","journal-title":"Age and Ageing"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00005650-199901000-00003","article-title":"Evidence suggesting that a chronic disease self-management programme can improve health status and reduce hospitalisation","volume":"37","author":"Lorig","year":"1999","journal-title":"Medical Care"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.5888\/pcd11.130349","article-title":"A self-management intervention for African Americans with comorbid diabetes and hypertension: a pilot randomized controlled trial","volume":"11","author":"Lynch","year":"2014","journal-title":"Preventing Chronic Disease"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0018|cit18","unstructured":"Martin PR Aiello R Gilson K Meadows G Milgrom J Reece J Co-morbid recurrent headaches and major depressive disorder: An RCT of cognitive behavior therapy Cephalalgia : an international journal of headache. Conference: 2013 International Headache Congress of the International Headache Society and American Headache Society Boston, MA United States 2013 33"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"e002171","DOI":"10.1136\/bmjopen-2012-002171","article-title":"The TrueBlue model of collaborative care using practice nurses as case managers for depression alongside diabetes or heart disease: a randomised trial","volume":"3","author":"Morgan","year":"2013","journal-title":"BMJ Open"},{"issue":"12","key":"10.1002\/14651858.CD006560.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1001\/archinte.160.12.1825","article-title":"Physician, nurse and social worker collaboration in primary care for chronically ill seniors","volume":"160","author":"Sommers","year":"2000","journal-title":"Archives Internal Medicine"},{"issue":"8","key":"10.1002\/14651858.CD006560.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/tmj.2011.0237","article-title":"Outcomes of a home telehealth intervention for patients with diabetes and hypertension","volume":"18","author":"Wakefield","year":"2012","journal-title":"Telemedicine Journal and e-Health"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2036.2004.02193.x","article-title":"Psychological support counselling improves gluten-free diet compliance in coeliac patients with affective disorders","volume":"20","author":"Addolorato","year":"2004","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"6","key":"10.1002\/14651858.CD006560.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"e008110","DOI":"10.1136\/bmjopen-2015-008110","article-title":"Rationale and methods of a multicentre randomised controlled trial of the effectiveness of a Community Health Assessment Programme with Emergency Medical Services (CHAP-EMS) implemented on residents aged 55 years and older in subsidised seniors' housing buildings in Ontario, Canada","volume":"5","author":"Agarwal","year":"2015","journal-title":"BMJ Open"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s11606-015-3185-x","article-title":"A Patient Navigator Intervention to Reduce Hospital Readmissions among High-Risk Safety-Net Patients: A Randomized Controlled Trial","volume":"30","author":"Balaban","year":"2015","journal-title":"Journal of General Internal Medicine"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1532-5415.1997.tb03085.x","article-title":"A randomized trial of group outpatient visits for chronically ill older HMO members: The Cooperative Health Care Clinic","volume":"45","author":"Beck","year":"1997","journal-title":"Journal of the American Geriatrics Society"},{"issue":"8","key":"10.1002\/14651858.CD006560.pub3-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/jnnp-2013-306553","article-title":"Comprehensive educational plan for patients with epilepsy and comorbidity (EDU-COM): a pragmatic randomised trial","volume":"85","author":"Beretta","year":"2014","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"e008031","DOI":"10.1136\/bmjopen-2015-008031","article-title":"Efficacy of a minimal home-based psychoeducative intervention versus usual care for managing anxiety and dyspnoea in patients with severe chronic obstructive pulmonary disease: a randomised controlled trial protocol","volume":"5","author":"Bove","year":"2015","journal-title":"BMJ Open"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1071\/AH040275","article-title":"A transitional care service for elderly chronic disease patients at risk of readmission","volume":"28","author":"Brand","year":"2004","journal-title":"Australian Health Review"},{"issue":"10","key":"10.1002\/14651858.CD006560.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1111\/jan.12375","article-title":"A randomized controlled trial of a nurse led case management programme for hospital-discharged older adults with co-morbidities","volume":"70","author":"Chow","year":"2014","journal-title":"Journal of Advanced Nursing"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0030|cit30","first-page":"e1001265","article-title":"Effect of a community-based nursing intervention on mortality in chronically ill older patients: a randomized controlled trial","volume":"9","author":"Coburn","year":"2012","journal-title":"PLoS Medicine\/Public Library of Science"},{"issue":"12","key":"10.1002\/14651858.CD006560.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1111\/j.1532-5415.2008.02005.x","article-title":"The effect of technology-supported, multidisease care management on the mortality and hospitalisation of seniors","volume":"56","author":"Dorr","year":"2008","journal-title":"Journal of the American Geriatrics Society"},{"issue":"9","key":"10.1002\/14651858.CD006560.pub3-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1136\/annrheumdis-2013-204733","article-title":"Impact of a nurse-led programme on comorbidity management and impact of a patient self-assessment of disease activity on the management of rheumatoid arthritis: results of a prospective, multicentre, randomised, controlled trial (COMEDRA)","volume":"74","author":"Dougados","year":"2015","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1037\/h0080330","article-title":"Assertive community treatment for patients with co-occurring severe mental illness and substance use disorder: a clinical trial","volume":"68","author":"Drake","year":"1998","journal-title":"American Journal of Orthopsychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/1745-6215-14-337","article-title":"Telephone-based health coaching for chronically ill patients: study protocol for a randomized controlled trial","volume":"14","author":"Dwinger","year":"2013","journal-title":"Trials"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2318-13-76","article-title":"One-year outcome of frailty indicators and activities of daily living following the randomised controlled trial; \"Continuum of care for frail older people\"","volume":"13","author":"Eklund","year":"2013","journal-title":"BMC Geriatrics"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1176\/appi.ps.57.2.185","article-title":"Comparison of ACT and standard case management for delivering integrated treatment for co-occuring disorders","volume":"57","author":"Essock","year":"2006","journal-title":"Psychiatric Services"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S2215-0366(14)00049-2","article-title":"An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial","volume":"2","author":"Fischer","year":"2015","journal-title":"The Lancet Psychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1745-6215-12-163","article-title":"Primary care practice-based care management for chronically ill patients (PraCMan): study protocol for a cluster randomized controlled trial [ISRCTN56104508]","volume":"12","author":"Freund","year":"2011","journal-title":"Trials"},{"issue":"Supplement s1","key":"10.1002\/14651858.CD006560.pub3-BIB0039|cit39","first-page":"Pages iii-vi, 1","article-title":"The effect of nurse practitioner co-management on quality of care of patients with chronic conditions in an academic geriatric practice","volume":"58","author":"Ganz","year":"2010","journal-title":"Journal of the American Geriatrics Society"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.genhosppsych.2004.09.004","article-title":"Improving depression outcomes in older adults with comorbid medical illness","volume":"27","author":"Harpole","year":"2005","journal-title":"General Hospital Psychiatry"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2337\/dc14-1416","article-title":"The effect of a Diabetes-Specific Cognitive Behavioral Treatment Program (DIAMOS) for patients with diabetes and subclinical depression: results of a randomized controlled trial","volume":"38","author":"Hermanns","year":"2015","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1002\/14651858.CD006560.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1176\/appi.ajp.161.8.1426","article-title":"Promising treatments for women with comorbid PTSD and substance use disorders","volume":"161","author":"Hien","year":"2004","journal-title":"American Journal of Psychiatry"},{"issue":"9, Supplement","key":"10.1002\/14651858.CD006560.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1016\/j.pmrj.2013.08.309","article-title":"Recruitment of Chronically Ill and Mobility-Restricted Older Adults for an Exercise Intervention Study Supported by the General Practitioner's Practice","volume":"5","author":"Hinrichs","year":"2013","journal-title":"PM&R"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/1745-6215-14-301","article-title":"Predictive risk stratification model: a progressive cluster-randomised trial in chronic conditions management (PRISMATIC) research protocol","volume":"14","author":"Hutchings","year":"2013","journal-title":"Trials"},{"issue":"10","key":"10.1002\/14651858.CD006560.pub3-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archpsyc.61.10.1042","article-title":"The Pathways Study: A randomized trial of collaborative care in patients with diabetes and depression","volume":"61","author":"Katon","year":"2004","journal-title":"Archives of General Psychiatry"},{"issue":"10","key":"10.1002\/14651858.CD006560.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1532-5415.1998.tb04533.x","article-title":"Preventing disability and managing chronic illness in frail older adults: a randomized trial of a community-based partnership with primary care","volume":"46","author":"Leveille","year":"1998","journal-title":"Journal of the American Geriatrics Society"},{"issue":"18","key":"10.1002\/14651858.CD006560.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1001\/jama.290.18.2428","article-title":"Effect of improving depression care on pain and functional outcomes among older adults with arthritis","volume":"290","author":"Lin","year":"2003","journal-title":"Journal of the American Medical Association"},{"issue":"10","key":"10.1002\/14651858.CD006560.pub3-BIB0048|cit48","first-page":"e348","article-title":"Outcomes among chronically ill adults in a medical home prototype","volume":"19","author":"Liss","year":"2013","journal-title":"The American Journal of Managed Care"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0163-8343(02)00288-8","article-title":"Using nurse practitioners to implement an intervention in primary care for high-utilizing patients with medically unexplained symptoms","volume":"25","author":"Lyles","year":"2003","journal-title":"General Hospital Psychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1096\/fasebj.27.1_supplement.1055.8","article-title":"A cardiovascular risk reduction intervention in patients with hypertension and\/or type 2 diabetes in San Jos\u00e9, Costa Rica and Chiapas, Mexico","volume":"27","author":"Martinez","year":"2013","journal-title":"FASEB Journal"},{"issue":"18","key":"10.1002\/14651858.CD006560.pub3-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1056\/NEJMsa1011785","article-title":"Results of the Medicare Health Support disease-management pilot program","volume":"365","author":"McCall","year":"2013","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.genhosppsych.2015.03.007","article-title":"A randomized trial of a depression self-care toolkit with or without lay telephone coaching for primary care patients with chronic physical conditions","volume":"37","author":"McCusker","year":"2015","journal-title":"General Hospital Psychiatry"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/edn.177","article-title":"Screening and guided self-help intervention for anxiety and depression in patients with type 2 diabetes","volume":"8","author":"Meeuwissen","year":"2011","journal-title":"European Diabetes Nursing"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1123\/japa.14.3.324","article-title":"Project LIFE: a partnership to increase physical activity in elders with multiple chronic illnesses","volume":"14","author":"Morey","year":"2006","journal-title":"Journal of Aging & Physical Activity"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1370\/afm.1316","article-title":"Depression treatment in patients with general medical conditions: results from the CO-MED trial","volume":"10","author":"Morris","year":"2012","journal-title":"Annals of Family Medicine"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0056|cit56","first-page":"959","article-title":"Effect of a health coaching self-management program for older adults with multimorbidity in nursing homes","volume":"8","author":"Park","year":"2014","journal-title":"Patient Preference and Adherence"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jad.2014.02.013","article-title":"A group-based counselling intervention for depression comorbid with HIV\/AIDS using a task shifting approach in South Africa: a randomized controlled pilot study","volume":"158","author":"Petersen","year":"2014","journal-title":"Journal of Affective Disorders"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1472-6963-13-164","article-title":"Implementation and effectiveness of 'care navigation', coordinated management for people with complex chronic illness: rationale and methods of a randomised controlled trial","volume":"13","author":"Plant","year":"2013","journal-title":"BMC Health Serv Res"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0059|cit59","unstructured":"Reuben DB Team care to manage chronic illnesses in older persons Journal of the American Geriatrics Society Conference 2012 Annual Scientific Metting of the American Geriatrics Society Seattle, WA United States 2012"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0060|cit60","doi-asserted-by":"crossref","unstructured":"Rodriguez-Pascual C Paredes-Galan E Ferrero-Martinez AL Gonzalez-Guerrero JL Hornillos M Abizanda P A disease management program intervention in elderly patients with high comorbidity: Results of a randomized-controlled trial European Geriatric Medicine 2013 Conference: 9th Congress of the European Union Geriatric Medicine Society, EUGMS Venice Italy 2013 S15","DOI":"10.1016\/j.eurger.2013.07.034"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1468-0009.2006.00441.x","article-title":"The Indiana Chronic Disease Management Program","volume":"84","author":"Rosenman","year":"2006","journal-title":"Milbank Quarterly"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2296-13-115","article-title":"The CareWell-primary care program: design of a cluster controlled trial and process evaluation of a complex intervention targeting community-dwelling frail elderly","volume":"13","author":"Ruikes","year":"2012","journal-title":"BMC Family Practice"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00004479-200507000-00003","article-title":"Managing elders with comorbidities","volume":"28","author":"Schraeder","year":"2005","journal-title":"Journal of Ambulatory Care Management"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-244X-12-207","article-title":"Problem-solving versus cognitive restructuring of medically ill seniors with depression (PROMISE-D trial): study protocol and design","volume":"12","author":"Sharpe","year":"2012","journal-title":"BMC Psychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1186\/1471-2458-14-515","article-title":"Manage at work: a randomized, controlled trial of a self-management group intervention to overcome workplace challenges associated with chronic physical health conditions","volume":"14","author":"Shaw","year":"2014","journal-title":"BMC Public Health"},{"issue":"3 SUPPL. 1","key":"10.1002\/14651858.CD006560.pub3-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1016\/j.jagp.2013.12.158","article-title":"Adjunctive tai chi in geriatric depression with comorbid arthritis: A randomized, controlled trial","volume":"22","author":"Srinivasan","year":"2014","journal-title":"American Journal of Geriatric Psychiatry"},{"issue":"10","key":"10.1002\/14651858.CD006560.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archinternmed.2012.256","article-title":"A randomized controlled trial of telemonitoring in older adults with multiple health issues to prevent hospitalizations and emergency department visits","volume":"172","author":"Takahashi","year":"2012","journal-title":"Archives of Internal Medicine"},{"issue":"11","key":"10.1002\/14651858.CD006560.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1345\/aph.1Q212","article-title":"Pharmacist-led group medical appointments for the management of type 2 diabetes with comorbid depression in older adults","volume":"45","author":"Taveira","year":"2011","journal-title":"The Annals of Pharmacotherapy"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.2196\/mhealth.2526","article-title":"The development of a mobile monitoring and feedback tool to stimulate physical activity of people with a chronic disease in primary care: a user-centered design","volume":"1","author":"Weegen","year":"2013","journal-title":"JMIR Mhealth Uhealth"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/1471-2458-12-385","article-title":"Triage of frail elderly with reduced exercise tolerance in primary care (TREE). A clustered randomized diagnostic study","volume":"12","author":"Mourik","year":"2012","journal-title":"BMC Public Health"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1258\/jtt.2012.SFT112","article-title":"Results of a telehealth-enabled chronic care management service to support people with long-term conditions at home","volume":"18","author":"Venter","year":"2012","journal-title":"Journal of Telemedicine & Telecare"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2296-14-96","article-title":"Effectiveness of a drug dosing service provided by community pharmacists in polymedicated elderly patients with renal impairment--a comparative study","volume":"14","author":"Via-Sosa","year":"2013","journal-title":"BMC Family Practice"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cct.2012.03.010","article-title":"Group interventions for co-morbid insomnia and osteoarthritis pain in primary care: The lifestyles cluster randomized trial design","volume":"33","author":"Korff","year":"2012","journal-title":"Contemporary Clinical Trials"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0074|cit74","first-page":"104","article-title":"Towards rational approaches of health care utilization in complex patients: an exploratory randomized trial comparing a novel combined clinic to multiple specialty clinics in patients with renal disease-cardiovascular disease-diabetes","volume":"iii","author":"Weber","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"11","key":"10.1002\/14651858.CD006560.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2318-11-24","article-title":"Design of a randomized controlled study of a multi-professional and multidimensional intervention targeting frail elderly people","volume":"14","author":"Wilhelmson","year":"2011","journal-title":"BMC Geriatriatrics"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2296-14-27","article-title":"The effectiveness of medical assistant health coaching for low-income patients with uncontrolled diabetes, hypertension, and hyperlipidemia: protocol for a randomized controlled trial and baseline characteristics of the study population","volume":"14","author":"Willard-Grace","year":"2013","journal-title":"BMC Family Practice"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0077|cit77","first-page":"62","article-title":"Working with CALD groups: testing the feasibility of an intervention to improve medication self-management in people with kidney disease, diabetes, and cardiovascular disease","volume":"8","author":"Williams","year":"2012","journal-title":"Renal Society of Australasia Journal"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1472-6963-13-90","article-title":"Effectiveness of Moving On: an Australian designed generic self-management program for people with a chronic illness","volume":"13","author":"Williams","year":"2013","journal-title":"BMC Health Services Research"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pec.2012.07.015","article-title":"Complex health care decisions with older patients in general practice: patient-centeredness and prioritization in consultations following a geriatric assessment","volume":"90","author":"Wrede","year":"2013","journal-title":"Patient Education & Counseling"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1472-6963-13-402","article-title":"Protocol for a randomised blocked design study using telephone and text-messaging to support cardiac patients with diabetes: a cross cultural international collaborative project","volume":"13","author":"Wu","year":"2013","journal-title":"BMC Health Services Research"},{"issue":"11","key":"10.1002\/14651858.CD006560.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jagp.2013.05.006","article-title":"Untangling therapeutic ingredients of a personalized intervention for patients with depression and severe COPD","volume":"22","author":"Alexopoulos","year":"2014","journal-title":"American Journal of Geriatric Psychiatry"},{"issue":"6","key":"10.1002\/14651858.CD006560.pub3-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/AJP.0000000000000176","article-title":"Individualized guided internet-delivered cognitive-behavior therapy for chronic pain patients with comorbid depression and anxiety: A randomized controlled trial","volume":"31","author":"Buhrman","year":"2015","journal-title":"Clinical Journal of Pain"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD006560.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/S1878-7649(14)70131-7","article-title":"Caring for elderly with multimorbidity: Evaluation of ambulatory geriatric unit (AGU) (the AGe-FIT-study) - A randomized controlled trial","volume":"5","author":"Ekdahl","year":"2014","journal-title":"European Geriatric Medicine"},{"issue":"Supplement 1","key":"10.1002\/14651858.CD006560.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"A192","DOI":"10.2337\/db18-192-OR","article-title":"Enhancing diabetes and hypertension self-management: A randomized trial of a mhealth strategy in a community clinic setting","volume":"64","author":"Katz","year":"2015","journal-title":"Diabetes"},{"issue":"6","key":"10.1002\/14651858.CD006560.pub3-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.cct.2011.08.001","article-title":"Protocol for a randomised controlled trial of chronic disease self-management support for older Australians with multiple chronic diseases","volume":"32","author":"Trial Registration number ACTRN12609000726257","year":"2011","journal-title":"Contemporary Clinical Trials"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cct.2013.07.010","article-title":"Tailored Case Management for Diabetes and Hypertension (TEACH-DM) in a community population: study design and baseline sample characteristics","volume":"36","author":"Crowley","year":"2013","journal-title":"Contemporary Clinical Trials"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-244X-8-9","article-title":"Web-based cognitive behavioural therapy (W-CBT) for diabetes patients with co-morbid depression: design of a randomised controlled trial","volume":"8","author":"Trial Registration number ISRCTN24874457","year":"2008","journal-title":"BMC Psychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/1745-6215-15-243","article-title":"Practice network-based care management for patients with type 2 diabetes and multiple comorbidities (GEDIMAplus): study protocol for a randomized controlled trial","volume":"15","author":"Current Controlled Trials ISRCTN 83908315","year":"2014","journal-title":"Trials"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13063-015-0760-8","article-title":"Improving quality of care and long-term health outcomes through continuity of care with the use of an electronic or paper patient-held portable health file (COMMUNICATE): study protocol for a randomized controlled trial","volume":"16","author":"Lassere","year":"2015","journal-title":"Trials"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0090|cit90","unstructured":"Mercer S Care Plus Study Annual Scientific meeting Society for Academic Primary Care, UK July 2014"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1472-6963-12-258","article-title":"Controlled trial of a collaborative primary care team model for patients with diabetes and depression: rationale and design for a comprehensive evaluation","volume":"12","author":"Trial registration number NCT01328639","year":"2012","journal-title":"BMC Health Services Research"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1472-6963-14-191","article-title":"Behavioral health coaching for rural veterans with diabetes and depression: a patient randomized effectiveness implementation trial","volume":"14","author":"Trial registration number NCT01572389","year":"2014","journal-title":"BMC Health Services Research"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1472-6963-13-49","article-title":"Case management and self-management support for frequent users with chronic disease in primary care: a pragmatic randomized controlled trial","volume":"13","author":"Trial Registration number NCT01719991","year":"2013","journal-title":"BMC Health Services Research"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-2296-12-68","article-title":"The effectiveness of case management for comorbid diabetes type 2 patients; the CasCo study. Design of a randomized controlled trial","volume":"12","author":"Trial Registration number NTR1847","year":"2011","journal-title":"BMC Family Practice"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0095|cit95","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1745-6215-13-6","article-title":"Managing co-morbid depression and anxiety in primary care patients with asthma and\/or chronic obstructive pulmonary disease: study protocol for a randomized controlled trial","volume":"13","author":"NTR2626","year":"2012","journal-title":"Trials"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-244X-13-128","article-title":"Cost-effectiveness of a stepped-care intervention to prevent major depression in patients with type 2 diabetes mellitus and\/or coronary heart disease and subthreshold depression: design of a cluster-randomized controlled trial","volume":"13","author":"Trial Registration number NTR3715","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0097|cit97","unstructured":"Pr1MaC Ongoing study 2011"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0098|cit98","unstructured":"Salisbury C The 3D Study Annual Scientific meeting of the Society for Academic Primary Care, UK July 2014"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0099|cit99","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mhpa.2011.04.001","article-title":"Design and methods for a pilot randomized clinical trial involving exercise and behavioral activation to treat comorbid type 2 diabetes and major depressive disorder","volume":"4","author":"Schneider","year":"2011","journal-title":"Mental Health Phys Act"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0100|cit100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","article-title":"Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study","volume":"380","author":"Barnett\u00a0K","year":"2012","journal-title":"The Lancet"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1477-7525-2-47","article-title":"Predicting declines in physical function in persons with multiple chronic medical conditions: what we can learn from the medical problem list","volume":"2","author":"Bayliss","year":"2004","journal-title":"Health and Quality of Life Outcomes"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0102|cit102","unstructured":"BMJ Multimorbidity Collection www.bmj.com\/specialties\/multimorbidity"},{"issue":"6","key":"10.1002\/14651858.CD006560.pub3-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"e66742","DOI":"10.1371\/journal.pone.0066742","article-title":"Relative impact of multimorbid chronic conditions on health-related quality of life - results from the MultiCare Cohort Study","volume":"8","author":"Brettschneider","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0104|cit104","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12913-015-0698-2","article-title":"Multimorbidity, health care utilization and costs in an elderly community-dwelling population: a claims data based observational study","volume":"15","author":"B\u00e4hler","year":"2015","journal-title":"BMC Health Services Research"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0105|cit105","unstructured":"Challis D Hughes J Intensive care\/case management, Expert Briefing Paper 1 Manchester: Personal Social Services Research Unit. http:\/\/sites.nursing.manchester.ac.uk\/pssru\/research\/nihrsscr\/productsandtoolkits\/IntensiveCaseManagement.pdf"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0106|cit106","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0107|cit107","volume-title":"Statistical power analysis for the behavioural sciences","author":"Cohen","year":"1988"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.archger.2007.02.005","article-title":"Hospital admissions among people 65+ related to multimorbidity, municipal and outpatient care","volume":"46","author":"Condelius","year":"2008","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0109|cit109","volume-title":"A handbook of research synthesis","author":"Cooper","year":"1994"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1440-1584.2002.00426.x","article-title":"Goal Attainment Scaling: an effective outcome measure for rural and remote health services","volume":"10","author":"Cox","year":"2002","journal-title":"Australian Journal of Rural Health"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jclinepi.2003.09.002","article-title":"How to measure comorbidity: a critical review of available methods","volume":"57","author":"Groot","year":"2004","journal-title":"Journal of Clinical Epidemiology"},{"issue":"1-2","key":"10.1002\/14651858.CD006560.pub3-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1300\/J074v14n01_03","article-title":"Health profiles and profile-specific health expectancies of older women and men","volume":"14","author":"Deeg","year":"2002","journal-title":"Journal of Women & Aging"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0113|cit113","unstructured":"Duerden M Avery T Payne R Polypharmacy and medicines optimisation http:\/\/www.kingsfund.org.uk\/sites\/files\/kf\/field\/field_publication_file\/polypharmacy-and-medicines-optimisation-kingsfund-nov13.pdf (accessed September 2015)"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"h949","DOI":"10.1136\/bmj.h949","article-title":"Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines","volume":"350","author":"Dumbreck","year":"2015","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0115|cit115","unstructured":"Thomson Reuters EndNote 2013"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0116|cit116","unstructured":"Effective Practice Organisation of Care (EPOC) EPOC Taxonomy Oslo: Norwegian Knowledge Centre for the Health Services; 2002. Available at: https:\/\/epoc.cochrane.org\/epoc-taxonomy"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0117|cit117","unstructured":"Effective Practice and Organisation of Care (EPOC). What study designs should be included in an EPOC review? EPOC Resources for review authors. Oslo: Norwegian Knowledge Centre for the Health Services. http:\/\/epoc.cochrane.org\/epoc-specific-resources-review-authors"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0118|cit118","unstructured":"Effective Practice Organisation of Care (EPOC) Data collection form. EPOC Resources for review authors. Oslo: Norwegian Knowledge Centre for the Health Services; 2013 Available at http:\/\/epoc.cochrane.org\/epoc-specific-resources-review-authors"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0119|cit119","unstructured":"Effective Practice Organisation of Care (EPOC) Suggested risk of bias criteria for EPOC reviews. EPOC Resources for review authors. Oslo: Norwegian Knowledge Centre for the Health Services; 2015. Available at: http:\/\/epoc.cochrane.org\/epoc-specific-resources-review-authors"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1477-7525-2-51","article-title":"Multimorbidity and quality of life in primary care: a systematic review","volume":"2","author":"Fortin","year":"2004","journal-title":"Health and Quality of Life Outcomes."},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0121|cit121","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1370\/afm.272","article-title":"Prevalence of multimorbidity among adults seen in Family Practice","volume":"3","author":"Fortin","year":"2005","journal-title":"Annals of Family Medicine"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0122|cit122","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1370\/afm.528","article-title":"Psychological distress and multimorbidity in primary care","volume":"4","author":"Fortin","year":"2006","journal-title":"Annals of Family Medicine"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0123|cit123","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11136-005-8661-z","article-title":"Relationship between multimorbidity and health-related quality of life of patients in primary care","volume":"15","author":"Fortin","year":"2006","journal-title":"Quality of Life Research"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1370\/afm.516","article-title":"Randomized clinical trials: do they have external validity for patients with multiple comorbidities?","volume":"4","author":"Fortin","year":"2006","journal-title":"Annals of Family Medicine"},{"issue":"7602","key":"10.1002\/14651858.CD006560.pub3-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1136\/bmj.39201.463819.2C","article-title":"Multimorbidity's many challenges","volume":"334","author":"Fortin","year":"2007","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0126|cit126","first-page":"30-5","article-title":"External Validity of Clinical Trials in Multiple Chronic Conditions","volume":"3","author":"Fortin","year":"2013","journal-title":"Journal of Comorbidity"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0127|cit127","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005108.pub2","article-title":"Self-management education programmes by lay leaders for people with chronic conditions","author":"Foster","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0128|cit128","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1370\/afm.1249","article-title":"Understanding patients\u2019 experiences of treatment burden in chronic heart failure using normalization process theory","volume":"9","author":"Gallacher","year":"2011","journal-title":"Annals of Family Medicine"},{"issue":"16","key":"10.1002\/14651858.CD006560.pub3-BIB0129|cit129","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1056\/NEJMsa020703","article-title":"Adverse drug events in ambulatory care","volume":"348","author":"Gandhi","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1532-5415.2006.00703.x","article-title":"A randomized trial of a multicomponent home intervention to reduce functional difficulties in older adults","volume":"54","author":"Gitlin","year":"2006","journal-title":"Journal of the American Geriatrics Society"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/ageing\/28.3.275","article-title":"Goal attainment scaling as a measure of clinically important change in nursing-home patients","volume":"28","author":"Gordon","year":"1999","journal-title":"Age & Aging"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0132|cit132","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00127-010-0330-z","article-title":"The association between chronic illness, multimorbidity and depressive symptoms in an Australian primary care cohort","volume":"47","author":"Gunn","year":"2012","journal-title":"Social Psychiatry and Psychiatric Epidemiology"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"d3514","DOI":"10.1136\/bmj.d3514","article-title":"High risk prescribing in primary care patients particularly vulnerable to adverse drug events: cross sectional population database analysis in Scottish general practice","volume":"342","author":"Guthrie","year":"2011","journal-title":"BMJ"},{"issue":"7651","key":"10.1002\/14651858.CD006560.pub3-BIB0134|cit134","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.39490.551019.BE","article-title":"GRADE Working Group. Rating quality of evidence and strength of recommendations: What is \"quality of evidence\" and why is it important to clinicians?","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0135|cit135","doi-asserted-by":"crossref","first-page":"e004694","DOI":"10.1136\/bmjopen-2013-004694","article-title":"Examining different measures of multimorbidity, using a large prospective cross-sectional study in Australian general practice","volume":"4","author":"Harrison","year":"2014","journal-title":"BMJ Open"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0136|cit136","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000011.pub3","article-title":"Interventions for enhancing medication adherence","author":"Haynes","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"18","key":"10.1002\/14651858.CD006560.pub3-BIB0137|cit137","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1001\/jama.1996.03540180029029","article-title":"Persons with chronic conditions. Their prevalence and costs","volume":"276","author":"Hoffman","year":"1996","journal-title":"Journal of the American Medical Association"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0138|cit138","unstructured":"International Research Community on Multimorbidity http:\/\/crmcspl-blog.recherche.usherbrooke.ca.ca\/?page_id=248"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archgenpsychiatry.2011.1548","article-title":"Cost-effectiveness of a multicondition collaborative care intervention: a randomized controlled trial","volume":"69","author":"Katon","year":"2012","journal-title":"Archives of General Psychiatry"},{"issue":"6","key":"10.1002\/14651858.CD006560.pub3-BIB0140|cit140","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF01530764","article-title":"Goal attainment scaling: a general method for evaluating comprehensive community health programs","volume":"4","author":"Kiresuk","year":"1968","journal-title":"Community Mental Health Journal"},{"issue":"8","key":"10.1002\/14651858.CD006560.pub3-BIB0141|cit141","first-page":"555","article-title":"Guided Care and the cost of complex healthcare: A preliminary report","volume":"15","author":"Leff","year":"2009","journal-title":"American Journal of Managed Care"},{"issue":"7433","key":"10.1002\/14651858.CD006560.pub3-BIB0142|cit142","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/bmj.328.7433.220","article-title":"Rethinking management of chronic diseases","volume":"328","author":"Lewis","year":"2004","journal-title":"BMJ"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0895-4356(98)00160-7","article-title":"Chronic comorbidity and outcomes of hospital care: length of stay, mortality, and readmission at 30 and 365 days","volume":"52","author":"Librero","year":"1999","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0144|cit144","unstructured":"Department of Health London Supporting people with long term conditions Department of Health 2005"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0145|cit145","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.arr.2011.03.003","article-title":"Aging with multimorbidity: a systematic review of the literature","volume":"10","author":"Marengoni","year":"2011","journal-title":"Ageing Research Reviews"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0146|cit146","doi-asserted-by":"crossref","first-page":"b2803","DOI":"10.1136\/bmj.b2803","article-title":"We need minimally disruptive medicine","volume":"339","author":"May","year":"2009","journal-title":"BMJ"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0147|cit147","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0895-4356(00)00368-1","article-title":"Prevalence of morbidity and multimorbidity in elderly male populations and their impact on 10-year all-cause mortality: The FINE study (Finland, Italy, Netherlands, Elderly)","volume":"54","author":"Menotti","year":"2001","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0148|cit148","unstructured":"Craig P Dieppe P Macintyre S Michie S Nazareth I Petticrew M the Medical Research Council Developing and evaluating complex interventions: new guidance www.mrc.ac.uk\/complexinterventionsguidance"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0149|cit149","unstructured":"Minist\u00e8re de la Sant\u00e9 et des Services sociaux Emerging solutions - Report and Recommendations (of the Commission d'etude sur les services de sante et les services sociaux) http:\/\/tools.hhr-rhs.ca\/index.php?option=com_mtree&task=visit&link_id=5093&Itemid=109&lang=en 2001"},{"issue":"7477","key":"10.1002\/14651858.CD006560.pub3-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1136\/bmj.329.7477.1251","article-title":"Case management and community matrons for long term conditions","volume":"329","author":"Murphy","year":"2004","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0151|cit151","unstructured":"National Institute for Health and Care Excellence Depression in adults with a chronic physical health problem: treatment and management (Clinical guideline 91) www.nice.org.uk\/guidance\/cg91. 2009"},{"issue":"2","key":"10.1002\/14651858.CD006560.pub3-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1532-5415.1995.tb06377.x","article-title":"Validation of the Cumulative Illness Rating Scale in a geriatric residential population","volume":"43","author":"Parmelee","year":"1995","journal-title":"Journal of American Geriatrics Society"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0153|cit153","doi-asserted-by":"crossref","first-page":"E221","DOI":"10.1503\/cmaj.121349","article-title":"The effect of physical multimorbidity, mental health conditions and socioeconomic deprivation on unplanned admissions to hospital: a retrospective cohort study","volume":"185","author":"Payne","year":"2013","journal-title":"Canandian Medical Association Journal"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0154|cit154","volume-title":"Metaanalysis, decision analysis, and cost effectiveness analysis","author":"Petitti","year":"1994"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0155|cit155","unstructured":"PROMIS http:\/\/nihpromis.org\/"},{"issue":"11","key":"10.1002\/14651858.CD006560.pub3-BIB0156|cit156","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/00005650-199611000-00004","article-title":"Comorbid illness is associated with survival and length of hospital stay in patients with chronic disability. A prospective comparison of three comorbidity indices","volume":"34","author":"Rochon","year":"1996","journal-title":"Medical Care"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0157|cit157","volume-title":"Keeping People Out of Hospital: The Challenge of Reducing Emergency Admissions","author":"Hilary","year":"2006"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"18","DOI":"10.15256\/joc.2013.3.28","article-title":"Improving the evidence base on multimorbidities through better research: a commentary on the US HHS initiative, Multiple Chronic Conditions: A Strategic Framework","volume":"3","author":"Satariano","year":"2013","journal-title":"Journal of Comorbidity"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/ewjm.175.5.292","article-title":"Treating depression in patients with chronic disease","volume":"175","author":"Simon","year":"2001","journal-title":"Western Journal of Medicine"},{"issue":"537","key":"10.1002\/14651858.CD006560.pub3-BIB0160|cit160","first-page":"268","article-title":"Chronic diseases: what happens when they come in multiples?","volume":"57","author":"Smith","year":"2007","journal-title":"British Journal of General Practice"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2296-9-6","article-title":"Multimorbidity in younger deprived patients: an exploratory study of research and service implications in general practice","volume":"9","author":"Smith","year":"2008","journal-title":"BMC Family Practice"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"10","DOI":"10.15256\/joc.2013.3.21","article-title":"How to design and evaluate interventions to improve outcomes for patients with multimorbidity","volume":"3","author":"Smith","year":"2013","journal-title":"Journal of Comorbidity"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0163|cit163","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1370\/afm.387","article-title":"Radical ideas","volume":"3","author":"Stange","year":"2005","journal-title":"Annals of Family Medicine"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0164|cit164","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195125429.001.0001","volume-title":"Primary care: balancing health needs, services and technology","author":"Starfield","year":"1998"},{"issue":"465","key":"10.1002\/14651858.CD006560.pub3-BIB0165|cit165","first-page":"303","article-title":"New paradigms for quality in primary care","volume":"51","author":"Starfield","year":"2001","journal-title":"British Journal of General Practice"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0166|cit166","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1370\/afm.307","article-title":"Comorbidity and the use of primary care and specialist care in the elderly","volume":"3","author":"Starfield","year":"2005","journal-title":"Annals of Family Medicine"},{"issue":"7419","key":"10.1002\/14651858.CD006560.pub3-BIB0167|cit167","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/bmj.327.7419.837","article-title":"Managing multiple morbidity in mid-life: a qualitative study of attitudes to drug use","volume":"327","author":"Townsend","year":"2006","journal-title":"BMJ"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0168|cit168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15256\/joc.2011.1.11","article-title":"Research on patients with multiple health conditions: different constructs, different views, one voice","volume":"1","author":"Valderas","year":"2011","journal-title":"Journal of Comorbidity"},{"issue":"5","key":"10.1002\/14651858.CD006560.pub3-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0895-4356(97)00306-5","article-title":"Multimorbidity in general practice: prevalence, incidence and determinants of co-occurring chronic and recurrent diseases","volume":"51","author":"Akker","year":"1998","journal-title":"Journal of Clinical Epidemiology"},{"issue":"3","key":"10.1002\/14651858.CD006560.pub3-BIB0170|cit170","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/jama.1995.03520270026023","article-title":"A new definition of primary care","volume":"272","author":"Vaneslow","year":"1995","journal-title":"Journal of Americal Medical Association"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0171|cit171","doi-asserted-by":"crossref","first-page":"h176","DOI":"10.1136\/bmj.h176","article-title":"Managing patients with multimorbidity in primary care","volume":"350","author":"Wallace","year":"2015","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0172|cit172","unstructured":"World Health Organization Innovative care for chronic conditions: building blocks for action: global report Global Report, Geneva 2002"},{"issue":"20","key":"10.1002\/14651858.CD006560.pub3-BIB0173|cit173","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1001\/archinte.162.20.2269","article-title":"Prevalence, expenditures, and complications of multiple chronic conditions in the elderly","volume":"162","author":"Wolff","year":"2002","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD006560.pub3-BIB0174|cit174","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1097\/MLR.0b013e3182a51b3d","article-title":"Out of context: clinical practice guidelines and patients with multiple chronic conditions: a systematic review","volume":"52 (Suppl 3)","author":"Wyatt","year":"2014","journal-title":"Medical Care"},{"issue":"7","key":"10.1002\/14651858.CD006560.pub3-BIB0175|cit175","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s11606-010-1629-x","article-title":"Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials","volume":"26","author":"Zulman","year":"2011","journal-title":"Journal of General Internal Medicine"},{"issue":"4. Art. No.: CD","key":"10.1002\/14651858.CD006560.pub3-BIB0176|cit176","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002797","article-title":"Case management: effects on professional practice and health care outcomes (Protocol)","author":"Zwarenstein","year":"2000","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"10.1002\/14651858.CD006560.pub3-BIB0177|cit177","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006560","article-title":"Interventions for improving outcomes in patients with multimorbidity in primary care and community settings","author":"Smith","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD006560.pub3-BIB0178|cit178","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006560","article-title":"Interventions for improving outcomes in patients with multimorbidity in primary care and community settings","author":"Smith","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd006560.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD006560.pub3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:51:41Z","timestamp":1718412701000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD006560.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Effective Practice and Organisation of Care Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,15]]},"references-count":178,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006560.pub3","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD006560.pub4","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,15]]}}}