{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:55:25Z","timestamp":1789052125279,"version":"build-2803163510"},"update-to":[{"DOI":"10.1002\/14651858.cd006606.pub4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000}}],"reference-count":103,"publisher":"Wiley","issue":"2","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006606.pub5","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T06:44:28Z","timestamp":1738824268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction"],"prefix":"10.1002","volume":"2025","author":[{"given":"Charalampos S","family":"Siristatidis","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Second Department of Obstetrics and Gynaecology; Medical School, National and Kapodistrian University of Athens; Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Papapanou","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Second Department of Obstetrics and Gynaecology; Medical School, National and Kapodistrian University of Athens; Athens Greece"},{"name":"Obstetrics, Gynecology, and Reproductive Medicine Working Group; Society of Junior Doctors; Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Aberdeen Fertility Centre; NHS Grampian; Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Vaidakis","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health; Medical School, University of Nicosia; Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"Suppl 1","key":"10.1002\/14651858.CD006606.pub5-BIB0001|cit1","first-page":"i311","article-title":"GnRH agonist for triggering final oocyte maturation versus IVM in patients at risk of OHSS","volume":"28","author":"Gidoni","year":"2013","journal-title":"Human Reproduction"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD006606.pub5-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.fertnstert.2014.07.909","article-title":"Comparison between IVF antagonist protocol versus IVM protocol to treat infertile PCOS patients. A prospective randomized study. Preliminary results","volume":"102","author":"Shavit","year":"2014","journal-title":"Fertility and Sterility"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"e435","DOI":"10.1016\/j.fertnstert.2019.08.015","article-title":"In vitro maturation (IVM) versus in vitro fertilization (IVF) in women with high antral follicle count (AFC): a randomized controlled trial (NCT03405701)","volume":"112","author":"Vuong","year":"2019","journal-title":"Fertility and Sterility"},{"issue":"11","key":"10.1002\/14651858.CD006606.pub5-BIB0004|cit4","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1093\/humrep\/deaa240","article-title":"In-vitro maturation of oocytes versus conventional IVF in women with infertility and a high antral follicle count: a randomized non-inferiority controlled trial","volume":"35","author":"Vuong","year":"2020","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0005|cit5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1093\/humrep\/deab243","article-title":"In vitro maturation without gonadotropins versus in vitro fertilization with hyperstimulation in women with polycystic ovary syndrome: a non-inferiority randomized controlled trial","volume":"37","author":"Zheng","year":"2022","journal-title":"Human Reproduction (Oxford, England)"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/humrep\/15.1.165","article-title":"Prospective randomized study of human chorionic gonadotrophin priming before immature oocyte retrieval from unstimulated women with polycystic ovarian syndrome","volume":"15","author":"Chian","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0015-0282(00)00812-8","article-title":"Applicability of a hCG priming of unstimulated PCOS patients for improving IVM\/IVF-ET outcome","volume":"74 Suppl 3","author":"Chung","year":"2000","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.fertnstert.2007.02.021","article-title":"Exposure to human chorionic gonadotropin during in vitro maturation does not improve the maturation rate and developmental potential of immature oocytes from patients with polycystic ovary syndrome","volume":"89","author":"Ge","year":"2008","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.rbmo.2012.10.007","article-title":"Does supplementation of in-vitro culture medium with melatonin improve IVF outcome in PCOS?","volume":"26","author":"Kim","year":"2013","journal-title":"Reproductive Biomedicine Online"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/rep.0.1220587","article-title":"Benefit of FSH priming of women with PCOS to the in vitro maturation procedure and the outcome: a randomized prospective study","volume":"122","author":"Mikkelsen","year":"2001","journal-title":"Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0011|cit11","first-page":"14","article-title":"Clinical application of in vitro maturation of human immature oocytes for infertile women with polycystic ovary syndrome","volume":"47","author":"Xu","year":"2012","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1477-7827-10-40","article-title":"Effect of hCG priming on embryonic development of immature oocytes collected from unstimulated women with polycystic ovarian syndrome","volume":"10","author":"Zheng","year":"2012","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0013|cit13","unstructured":"A multicentre randomised controlled trial comparing in vitro maturation of oocytes with in vitro fertilisation in women with an increased risk of ovarian hyperstimulation syndrome http:\/\/www.isrctn.com\/ISRCTN61229302 10.1186\/ISRCTN61229302"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0014|cit14","unstructured":"In vitro maturation with in vitro fertilization (IVF) compared to mild in vitro fertilization (IVM vs IVF) clinicaltrials.gov\/show\/NCT00867763"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0015|cit15","unstructured":"Comparison between two fertility protocols in obese polycystic ovary syndrome patients clinicaltrials.gov\/show\/NCT01473459"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0016|cit16","unstructured":"Comparison of clinical outcomes between IVM and minimal stimulation IVF in patients with PCOS ClinicalTrials.gov\/show\/NCT03134482 https:\/\/www.clinicaltrials.gov\/ct2https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT03134482"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0017|cit17","unstructured":"A randomised controlled trial comparing in vitro maturation of oocytes with in vitro fertilisation in women with an increased risk of ovarian hyperstimulation syndrome trialsearch.who.int\/Trial2.aspx?TrialID=NL-OMON24086 2010"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bpobgyn.2004.05.007","article-title":"Hirsutism and acne in polycystic ovary syndrome","volume":"18","author":"Archer","year":"2004","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nature Reviews Disease Primers"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0015-0282(16)58330-7","article-title":"Production of embryos from in vitro-matured primary human oocytes","volume":"65","author":"Barnes","year":"1996","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1022516806423","article-title":"Retrieval, maturation, and fertilization of immature oocytes obtained from unstimulated patients with polycystic ovary syndrome","volume":"16","author":"Beckers","year":"1999","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1472-6483(10)60421-X","article-title":"Natural cycle IVF and oocyte in-vitro maturation in polycystic ovary syndrome: a collaborative prospective study","volume":"18","author":"Benkhalifa","year":"2009","journal-title":"Reproductive Biomedicine Online"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.fertnstert.2005.07.195","article-title":"Congenital abnormalities and perinatal outcome in pregnancies following IVM, IVF, and ICSI delivered in a single center","volume":"84 Suppl","author":"Buckett","year":"2005","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/01.AOG.0000284627.38540.80","article-title":"Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection","volume":"110","author":"Buckett","year":"2007","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.fertnstert.2007.06.107","article-title":"Pregnancy loss in pregnancies conceived after in vitro oocyte maturation, conventional in vitro fertilization, and intracytoplasmic sperm injection","volume":"90","author":"Buckett","year":"2008","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/humupd\/4.2.103","article-title":"Maturation in vitro of immature human oocytes for clinical use","volume":"4","author":"Cha","year":"1998","journal-title":"Human Reproduction Update"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0015-0282(00)00422-2","article-title":"Pregnancies and deliveries after in vitro maturation culture followed by in vitro fertilization and embryo transfer without stimulation in women with polycystic ovary syndrome","volume":"73","author":"Cha","year":"2000","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.fertnstert.2004.11.044","article-title":"Obstetric outcome of patients with polycystic ovary syndrome treated by in vitro maturation and in vitro fertilization-embryo transfer","volume":"83","author":"Cha","year":"2005","journal-title":"Fertility and Sterility"},{"issue":"21","key":"10.1002\/14651858.CD006606.pub5-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1056\/NEJM199911183412118","article-title":"Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome","volume":"341","author":"Chian","year":"1999","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0015-0282(01)02853-9","article-title":"In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome","volume":"76","author":"Child","year":"2001","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0031|cit31","first-page":"665","article-title":"A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries","volume":"100","author":"Child","year":"2002","journal-title":"Obstetrics and Gynecology"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0032|cit32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1093\/molehr\/gav071","article-title":"Ultrastructure of human oocytes after in vitro maturation","volume":"22","author":"Coticchio","year":"2016","journal-title":"Molecular Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0033|cit33","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1093\/humrep\/deac069","article-title":"Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response","volume":"37","author":"Cozzolino","year":"2022","journal-title":"Human Reproduction"},{"issue":"7","key":"10.1002\/14651858.CD006606.pub5-BIB0034|cit34","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/humrep\/dew109","article-title":"Clinical definition paper on in vitro maturation of human oocytes","volume":"31","author":"Dahan","year":"2016","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0035|cit35","doi-asserted-by":"publisher","first-page":"100812","DOI":"10.1016\/j.repbio.2023.100812","article-title":"Oocyte quality is impaired in a hyperandrogenic PCOS mouse model by increased Foxo1 expression","volume":"23","author":"Danfeng","year":"2023","journal-title":"Reproductive Biology"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.fertnstert.2012.06.043","article-title":"Retrieving oocytes from small non-stimulated follicles in polycystic ovary syndrome (PCOS): in vitro maturation (IVM) is not indicated in the new GnRH antagonist era","volume":"98","author":"Ziegler","year":"2012","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0037|cit37","doi-asserted-by":"publisher","first-page":"i460","DOI":"10.1093\/humrep\/33.Supplement_1.1","article-title":"Oocyte quality in patients with polycystic ovary syndrome (PCOS): impact on the extended culture and live birth rates","volume":"33","author":"Delaroche","year":"2018","journal-title":"Human Reproduction"},{"issue":"11","key":"10.1002\/14651858.CD006606.pub5-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/humrep\/der297","article-title":"Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries","volume":"26","author":"Dewailly","year":"2011","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/208349a0","article-title":"Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes","volume":"208","author":"Edwards","year":"1965","journal-title":"Nature"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0040|cit40","first-page":"77","article-title":"IVM results are comparable and may have advantages over standard IVF","volume":"6","author":"Ellenbogen","year":"2014","journal-title":"Facts, Views and Vision in Obstetrics and Gynaecology"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0041|cit41","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12958-020-00622-y","article-title":"Association between mild stimulated IVF\/M\u2009cycle and early embryo arrest in sub fertile women with\/without PCOS","volume":"18","author":"Elshewy","year":"2020","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0042|cit42","first-page":"19","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2003","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1472-6483(10)60263-5","article-title":"Predictive factors in in-vitro maturation in unstimulated women with normal ovaries","volume":"18","author":"Fadini","year":"2009","journal-title":"Reproductive Biomedicine Online"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.fertnstert.2013.01.138","article-title":"Oocyte in vitro maturation in normo-ovulatory women","volume":"99","author":"Fadini","year":"2013","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0045|cit45","doi-asserted-by":"publisher","first-page":"e89713","DOI":"10.1371\/journal.pone.0089713","article-title":"Growth development of French children born after in vitro maturation","volume":"9","author":"Foix-L'H\u00e9lias","year":"2014","journal-title":"PLOS One"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0046|cit46","first-page":"129","article-title":"In vitro maturation, in vitro fertilisation and embryo transfer (IVM-IVF) combined with low dose FSH over metformin pretreatment and frozen-thawed cycles should be a routine ART option for polycystic ovarian syndrome (PCOS) patients","volume":"86 Suppl","author":"Fukuda","year":"2006","journal-title":"Fertility and Sterility"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0047|cit47","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.fertnstert.2023.02.010","article-title":"Oocyte in vitro maturation: physiological basis and application to clinical practice","volume":"119","author":"Gilchrist","year":"2023","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0048|cit48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/humupd\/dmad023","article-title":"A fresh start for IVM: capacitating the oocyte for development using pre-IVM","volume":"30","author":"Gilchrist","year":"2024","journal-title":"Human Reproduction Update"},{"issue":"8","key":"10.1002\/14651858.CD006606.pub5-BIB0049|cit49","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1007\/s43032-021-00613-3","article-title":"The improvement and clinical application of human oocyte in vitro maturation (IVM)","volume":"29","author":"Gong","year":"2022","journal-title":"Reproductive Sciences"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0050|cit50","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime) 2018"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.fertnstert.2013.01.090","article-title":"In vitro maturation of oocytes: uncommon indications","volume":"99","author":"Grynberg","year":"2013","journal-title":"Fertility and Sterility"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.fertnstert.2004.04.043","article-title":"Randomized, controlled trial of priming with 10,000 IU versus 20,000 IU of human chorionic gonadotropin in women with polycystic ovary syndrome who are undergoing in vitro maturation","volume":"82","author":"Gulekli","year":"2004","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/humupd\/dmi036","article-title":"A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome","volume":"12","author":"Heijnen","year":"2006","journal-title":"Human Reproduction Update"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0054|cit54","unstructured":"Higgins JP Thomas J Chandler J Cumpston M Li T Page MJ Welch VA Cochrane Handbook for Systematic Reviews of Interventions Version 6.4 (updated August 2023). Cochrane, 2023 Available from training.cochrane.org\/handbook\/archive\/v6.4"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006606.pub5-BIB0055|cit55","doi-asserted-by":"publisher","first-page":"deac106.001","DOI":"10.1093\/humrep\/deac106.001","article-title":"Latest development of IVM in assisted reproduction","volume":"37","author":"Ho","year":"2022","journal-title":"Human Reproduction"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fertnstert.2006.11.087","article-title":"In vitro maturation of oocytes collected from unstimulated ovaries for oocyte donation","volume":"88","author":"Holzer","year":"2007","journal-title":"Fertility and Sterility"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/humrep\/deh603","article-title":"In vitro maturation for the treatment of infertility associated with polycystic ovarian syndrome: the French experience","volume":"20","author":"Le Du","year":"2005","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.fertnstert.2005.06.064","article-title":"Confocal microscopic analysis of the spindle and chromosome configurations of human oocytes matured in vitro","volume":"85","author":"Li","year":"2006","journal-title":"Fertility and Sterility"},{"issue":"8","key":"10.1002\/14651858.CD006606.pub5-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/humrep\/deg335","article-title":"Combination of FSH priming and hCG priming for in-vitro maturation of human oocytes","volume":"18","author":"Lin","year":"2003","journal-title":"Human Reproduction"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0060|cit60","first-page":"230","article-title":"In vitro maturation, fertilization and embryo transfer of human immature oocyte","volume":"38","author":"Liu","year":"2003","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/oxfordjournals.humrep.a138029","article-title":"A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization","volume":"8","author":"MacDougall","year":"1993","journal-title":"Human Reproduction"},{"issue":"12","key":"10.1002\/14651858.CD006606.pub5-BIB0062|cit62","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1093\/humrep\/deaa200","article-title":"Early pregnancy loss in patients with polycystic ovary syndrome after IVM versus standard ovarian stimulation for IVF\/ICSI","volume":"35","author":"Mackens","year":"2020","journal-title":"Human Reproduction"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1472-6483(10)61666-5","article-title":"Strategies in human in-vitro maturation and their clinical outcome","volume":"10","author":"Mikkelsen","year":"2005","journal-title":"Reproductive Biomedicine Online"},{"issue":"5","key":"10.1002\/14651858.CD006606.pub5-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0015-0282(16)58285-5","article-title":"Pregnancy and birth after intracytoplasmic sperm injection of in vitro matured germinal-vesicle stage oocytes: case report","volume":"65","author":"Nagy","year":"1996","journal-title":"Fertility and Sterility"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0065|cit65","unstructured":"National Institute for Health and Care Excellence Fertility: assessment and treatment for people with fertility problems National Institute for Health and Care Excellence: Clinical Guidelines. London: National Institute for Health and Care Excellence (UK); 2003 https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK11822\/"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0066|cit66","doi-asserted-by":"publisher","first-page":"i243","DOI":"10.1093\/humrep\/deab130.238","article-title":"In vitro maturation of human oocytes: a systematic review and data analysis","volume":"36","author":"Nikiforov","year":"2021","journal-title":"Human Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0067|cit67","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.repbio.2019.06.004","article-title":"Aberrant endometrial steroid receptor expression in in-vitro maturation cycles despite hormonal luteal support: a pilot study","volume":"19","author":"Ortega-Hrepich","year":"2019","journal-title":"Reproductive Biology"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0068|cit68","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s10815-023-02752-9","article-title":"Cumulative live birth rate after oocyte in vitro maturation with a pre-maturation step in women with polycystic ovary syndrome or high antral follicle count","volume":"40","author":"Pham","year":"2023","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1084\/jem.62.5.665","article-title":"The comparative behaviour of mammalian eggs in vivo and in vitro","volume":"62","author":"Pincus","year":"1935","journal-title":"Journal of Experimental Medicine"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0070|cit70","unstructured":"Practice Committee of the ASRM Definition of infertility: a committee opinion https:\/\/www.asrm.org\/globalassets\/_asrm\/practice-guidance\/practice-guidelines\/pdf\/definition-of-infertility.pdf"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/humupd\/dmq032","article-title":"Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence","volume":"17","author":"Qiao","year":"2011","journal-title":"Human Reproduction Update"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0072|cit72","unstructured":"Royal College of Obstetricians and Gynaecologists The management of ovarian hyperstimulation syndrome https:\/\/www.rcog.org.uk\/media\/or1jqxbf\/gtg_5_ohss.pdf https:\/\/www.rcog.org.uk\/media\/or1jqxbf\/gtg_5_ohss.pdf"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-2007-992932","article-title":"In vitro maturation for patients with polycystic ovary syndrome","volume":"26","author":"Reinblatt","year":"2008","journal-title":"Seminars in Reproductive Medicine"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0074|cit74","unstructured":"Review Manager (RevMan) The Cochrane Collaboration 2020"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0075|cit75","doi-asserted-by":"publisher","first-page":"e600","DOI":"10.1002\/wsbm.1600","article-title":"In vitro maturation of oocytes as a laboratory approach to polycystic ovarian syndrome (PCOS): from oocyte to embryo","volume":"15","author":"Rodrigues","year":"2023","journal-title":"WIREs Mechanisms of Disease"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0412.2011.01299.x","article-title":"In vitro maturation: a five-year experience","volume":"91","author":"Roesner","year":"2012","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0077|cit77","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1093\/humrep\/dex068","article-title":"Two-year development of children conceived by IVM: a prospective controlled single-blinded study","volume":"32","author":"Roesner","year":"2017","journal-title":"Human Reproduction"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0078|cit78","first-page":"128","article-title":"IVM is a promising alternative to conventional IVF treatment for women with polycystic ovarian syndrome (PCOS)","volume":"86 Suppl","author":"Sandraa","year":"2006","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0079|cit79","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/OGX.0000000000000150","article-title":"In vitro maturation and its role in clinical assisted reproductive technology","volume":"70","author":"Sauerbrun-Cutler","year":"2015","journal-title":"Obstetrical and Gynecological Survey"},{"issue":"10","key":"10.1002\/14651858.CD006606.pub5-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.earlhumdev.2006.01.012","article-title":"Growth and development of children conceived by in-vitro maturation of human oocytes","volume":"82","author":"Shu-Chi","year":"2006","journal-title":"Early Human Development"},{"issue":"8","key":"10.1002\/14651858.CD006606.pub5-BIB0081|cit81","doi-asserted-by":"publisher","first-page":"e0134696","DOI":"10.1371\/journal.pone.0134696","article-title":"In vitro maturation in women with vs. without polycystic ovarian syndrome: a systematic review and meta-analysis","volume":"10","author":"Siristatidis","year":"2015","journal-title":"PLOS One"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/humrep\/deh768","article-title":"Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients","volume":"20","author":"Soderstrom-Anttila","year":"2005","journal-title":"Human Reproduction"},{"issue":"11","key":"10.1002\/14651858.CD006606.pub5-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/humrep\/dei195","article-title":"Fertilization, cleavage and blastocyst development according to the maturation timing of oocytes in in vitro maturation cycles","volume":"20","author":"Son","year":"2005","journal-title":"Human Reproduction"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.fertnstert.2006.11.027","article-title":"Pregnancies and deliveries after transfer of human blastocysts derived from in vitro matured oocytes in in vitro maturation cycles","volume":"87","author":"Son","year":"2007","journal-title":"Fertility and Sterility"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/humupd\/dmq014","article-title":"Laboratory and embryological aspects of hCG-primed in vitro maturation cycles for patients with polycystic ovaries","volume":"16","author":"Son","year":"2010","journal-title":"Human Reproduction Update"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0086|cit86","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0087|cit87","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/humupd\/dmaa056","article-title":"Maternal and neonatal outcome and children\u2019s development after medically assisted reproduction with in-vitro matured oocytes \u2013 a systematic review and meta-analysis","volume":"27","author":"Strowitzki","year":"2021","journal-title":"Human Reproduction Update"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/GCO.0b013e3282f88e33","article-title":"In-vitro maturation: its role in fertility treatment","volume":"20","author":"Suikkari","year":"2008","journal-title":"Current Opinion in Gynecology and Obstetrics"},{"issue":"10","key":"10.1002\/14651858.CD006606.pub5-BIB0089|cit89","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1210\/clinem\/dgad463","article-title":"Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome","volume":"108","author":"Teede","year":"2023","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0015-0282(16)56891-5","article-title":"In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients","volume":"62","author":"Trounson","year":"1994","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1530\/rep.0.1210051","article-title":"Maturation of human oocytes in vitro and their developmental competence","volume":"121","author":"Trounson","year":"2001","journal-title":"Reproduction"},{"issue":"2","key":"10.1002\/14651858.CD006606.pub5-BIB0092|cit92","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10815-019-01677-6","article-title":"Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome","volume":"37","author":"Vuong","year":"2020","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"23","key":"10.1002\/14651858.CD006606.pub5-BIB0093|cit93","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.fertnstert.2023.01.046","article-title":"Outcomes of clinical IVM programs for treating infertility in hyperresponders: a systematic review","volume":"S0015-0282","author":"Vuong","year":"2023","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0094|cit94","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/humrep\/deu248","article-title":"In vitro maturation as an alternative to standard in vitro fertilization for patients diagnosed with polycystic ovaries: a comparative analysis of fresh, frozen and cumulative cycle outcomes","volume":"30","author":"Walls","year":"2015","journal-title":"Human Reproduction"},{"key":"10.1002\/14651858.CD006606.pub5-BIB0095|cit95","unstructured":"World Health Organization Infertility https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/infertility"},{"issue":"15","key":"10.1002\/14651858.CD006606.pub5-BIB0096|cit96","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.21037\/atm-21-3037","article-title":"Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis","volume":"9","author":"Xu","year":"2021","journal-title":"Annals of Translational Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006606.pub5-BIB0097|cit97","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.fertnstert.2017.08.020","article-title":"Development of in vitro maturation techniques for clinical applications","volume":"108","author":"Yang","year":"2017","journal-title":"Fertility and Sterility"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1023\/A:1016632621452","article-title":"Pregnancies resulting from in vitro matured oocytes collected from women with regular menstrual cycle","volume":"18","author":"Yoon","year":"2001","journal-title":"Journal of Assisted Reproduction and Genetics"},{"issue":"3","key":"10.1002\/14651858.CD006606.pub5-BIB0099|cit99","first-page":"173","article-title":"In vitro maturation and fertilization of unstimulated immature oocyte for the treatment of infertile women","volume":"41","author":"Zhao","year":"2006","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"6","key":"10.1002\/14651858.CD006606.pub5-BIB0100|cit100","first-page":"409","article-title":"Outcome of pregnancy in women with polycystic ovary syndrome treated by in vitro maturation of immature oocytes","volume":"44","author":"Zhao","year":"2009","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"1","key":"10.1002\/14651858.CD006606.pub5-BIB0101|cit101","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006606.pub2","article-title":"In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction","author":"Siristatidis","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"10","key":"10.1002\/14651858.CD006606.pub5-BIB0102|cit102","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006606.pub3","article-title":"In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction","author":"Siristatidis","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"11","key":"10.1002\/14651858.CD006606.pub5-BIB0103|cit103","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006606.pub4","article-title":"In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction","author":"Siristatidis","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:17:39Z","timestamp":1774934259000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006606.pub5"}},"subtitle":[],"editor":[{"name":"Cochrane Central Editorial Service","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":103,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006606.pub5","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}