{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:52:45Z","timestamp":1790790765963,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006681.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T00:00:00Z","timestamp":1501977600000}}],"reference-count":103,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T00:00:00Z","timestamp":1501977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T00:00:00Z","timestamp":1501977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006681.pub4","type":"journal-article","created":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T17:21:17Z","timestamp":1502040077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization"],"prefix":"10.1002","volume":"2017","author":[{"given":"Aniek AG","family":"Zee","sequence":"first","affiliation":[{"name":"VieCuri Medical Centre of Northern Limburg; Department of Surgery; Venlo Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"van Lieshout","sequence":"additional","affiliation":[{"name":"Deventer Ziekenhuis; Emergency Department; Deventer Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"van der Heide","sequence":"additional","affiliation":[{"name":"VieCuri Medical Centre of Northern Limburg; Venlo Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loes","family":"Janssen","sequence":"additional","affiliation":[{"name":"VieCuri Medical Centre of Northern Limburg; Department of Clinical Epidemiology; Tegelseweg 210 Venlo Netherlands 5912 BL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich MJ","family":"Janzing","sequence":"additional","affiliation":[{"name":"VieCuri Medical Centre of Northern Limburg; Department of Surgery; Venlo Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,6]]},"reference":[{"key":"10.1002\/14651858.CD006681.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.injury.2017.02.018","article-title":"Nadroparin or fondaparinux versus no thromboprophylaxis in patients immobilised in a below-knee plaster cast (PROTECT): a randomised controlled trial","volume":"376","author":"Bruntink","year":"2017","journal-title":"Injury"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006681.pub4-BIB0002|cit2","first-page":"S141","article-title":"Trial setup and preliminary results of PROTECT: prophylaxis of thromboembolic complications trial","volume":"37","author":"Derksen","year":"2011","journal-title":"European Journal of Trauma and Emergency Surgery"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0003|cit3","unstructured":"NTR1733 Prevention of thrombosis in patients who are treated with a plaster cast for a fracture of the ankle or foot www.trialregister.nl\/trialreg\/admin\/rctview.asp?TC=1733"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0004|cit4","unstructured":"Jorgensen PS Warming Hansen K Paltred C Berg H Jensen R Low molecular weight heparin (Innohep) thromboprophylaxis in outpatients with plaster casts. A phlebografic controlled study Danish Orthopaedic Society Autumn Meeting Copenhagen, Denmark"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0049-3848(02)00059-2","article-title":"Low molecular weight heparin (Innohep) as thromboprophylaxis in outpatients with a plaster cast; a venography controlled study","volume":"105","author":"Jorgensen","year":"2002","journal-title":"Thrombosis Research"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0006|cit6","first-page":"105","article-title":"Ambulatory prevention of thrombosis with low molecular weight heparin in plaster immobilization of the lower extremity","volume":"35","author":"Kock","year":"1992","journal-title":"Vasa Supplementum"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0008|cit7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-3-642-78271-8_134","article-title":"Ambulant thrombosis prophylaxis with low-molecular heparin in plaster immobilisation of the lower extremities","volume":"232","author":"Kock","year":"1993","journal-title":"Hefte zur der Unfallchirurg"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0007|cit8","first-page":"483","article-title":"Ambulatory prevention of thrombosis with low molecular weight heparin in plaster immobilization of the lower extremity","volume":"64","author":"Kock","year":"1993","journal-title":"Der Chirurg"},{"issue":"8973","key":"10.1002\/14651858.CD006681.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0140-6736(95)91320-3","article-title":"Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg","volume":"346","author":"Kock","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF02588744","article-title":"Patient compliance during low molecular weight heparin thromboprophylaxis in outpatients with plaster cast immobilisation of the leg","volume":"20","author":"Kock","year":"1994","journal-title":"Unfallchirurgie"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0011|cit11","first-page":"S36","article-title":"Prophylaxis of venous thromboembolism with low molecular weight heparin in surgical outpatients with immobilization of the lower limb by plaster cast","volume":"13 (suppl)","author":"Kock","year":"1993","journal-title":"Haemostaseologie"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0012|cit12","first-page":"222","article-title":"Prevention of thrombosis with low molecular weight heparin in ambulatory patients with injury of the lower extremity: an ultrasound study","volume":"33","author":"Habscheid","year":"1991","journal-title":"Vasa Supplementum"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0013|cit13","first-page":"372","article-title":"Thromboembolism prophylaxis in ambulatory surgery","volume":"30","author":"Kujath","year":"1995","journal-title":"Aktuelle Chirurgie"},{"issue":"suppl 1","key":"10.1002\/14651858.CD006681.pub4-BIB0015|cit14","first-page":"20","article-title":"Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb","volume":"23","author":"Kujath","year":"1993","journal-title":"Haemostasis"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0014|cit15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2008-1062272","article-title":"Thrombosis prevention in outpatients with lower limb injuries","volume":"117","author":"Kujath","year":"1992","journal-title":"Deutsche Medizinische Wochenschrift"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006681.pub4-BIB0016|cit16","first-page":"165","article-title":"Prolonged thromboprophylaxis with dalteparin after surgical treatment of Achilles tendon rupture - a randomized, placebo-controlled study","volume":"91-B","author":"Lapidus","year":"2009","journal-title":"Journal of Bone and Joint Surgery - British Volume"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.bot.0000250741.65003.14","article-title":"Prolonged thromboprophylaxis with Dalteparin after surgical treatment of achilles tendon rupture: a randomized, placebo-controlled study","volume":"21","author":"Lapidus","year":"2007","journal-title":"Journal of Orthopaedic Trauma"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/17453670710014185","article-title":"Prolonged thromboprophylaxis with Dalteparin during immobilization after ankle fracture surgery: a randomized, placebo-controlled, double-blind study","volume":"78","author":"Lapidus","year":"2007","journal-title":"Acta Orthopaedica"},{"issue":"5","key":"10.1002\/14651858.CD006681.pub4-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.5858\/2003-127-0584-IOTIST","article-title":"Investigations of the immunoglobulin subtype transformation of anti-heparin-platelet factor 4 antibodies during treatment with a low-molecular-weight heparin (clivarin) in orthopaedic patients","volume":"127","author":"Ahmad","year":"2003","journal-title":"Archives of Pathology and Laboratory Medicine"},{"issue":"10","key":"10.1002\/14651858.CD006681.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1056\/NEJMoa011327","article-title":"Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization","volume":"347","author":"Lassen","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0021|cit21","unstructured":"NCT01542762 Pot-Cast: thrombosis prophylaxis during plaster cast lower leg immobilisation clinicaltrials.gov\/ct2\/show\/NCT01542762?term=nct01542762&rank=1"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1056\/NEJMoa1613303","article-title":"Thromboprophylaxis after knee arthroscopy and lower-leg casting","volume":"376","author":"Adrichem","year":"2017","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00005131-199605000-00002","article-title":"Incidence of deep-vein thrombosis in patients with fractures of the lower extremity distal to the hip","volume":"10","author":"Abelseth","year":"1996","journal-title":"Journal of Orthopaedic Trauma"},{"issue":"5","key":"10.1002\/14651858.CD006681.pub4-BIB0024|cit24","first-page":"1166","article-title":"A survey of thrombosis prophylaxis use in patients with lower limb fractures","volume":"92","author":"Ageno","year":"2004","journal-title":"Thrombosis and Haemostasis"},{"issue":"43","key":"10.1002\/14651858.CD006681.pub4-BIB0025|cit25","first-page":"2774","article-title":"Low molecular weight heparin in the prevention of thrombosis during plaster cast immobilization","volume":"41","author":"Anonymous","year":"1991","journal-title":"Therapiewoche"},{"issue":"9","key":"10.1002\/14651858.CD006681.pub4-BIB0026|cit26","first-page":"641","article-title":"Plaster cast immobilization and deep vein thrombosis","volume":"7","author":"Anonymous","year":"1995","journal-title":"Sang Thrombose Vaisseaux"},{"issue":"11","key":"10.1002\/14651858.CD006681.pub4-BIB0027|cit27","first-page":"926","article-title":"Plaster-free, early functional after-care of surgically managed Achilles tendon rupture","volume":"64","author":"Armbrecht","year":"1993","journal-title":"Der Chirurg; Zeitschrift f\u00fcr alle Gebiete der operativen Medizen"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0028|cit28","first-page":"64","article-title":"Comparison of three different protocols in the prevention of postoperative deep vein thrombosis in patients at high-risk: randomized clinical study","volume":"50","author":"Ayhan","year":"2013","journal-title":"European Surgical Research"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0029|cit29","first-page":"229","article-title":"Thrombosis following leg injuries","volume":"90","author":"Bauer","year":"1944","journal-title":"Acta Chirurgica Scandinavica"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0030|cit30","first-page":"423","article-title":"The risk of thromboembolism due to plaster cast immobilisation and operation of the lower extremity","volume":"164","author":"Breyer","year":"1984","journal-title":"Hefte zur Unfallheilkunde"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.TA.0000044351.01324.C5","article-title":"Expedited discharge in trauma patients requiring anticoagulation for deep venous thrombosis prophylaxis: the LEAP Program","volume":"54","author":"Bridges","year":"2003","journal-title":"Journal of Trauma: Injury Infection and Critical Care"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.jcrc.2011.02.010","article-title":"PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan","volume":"26","author":"Cook","year":"2011","journal-title":"Journal of Critical Care"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/eci.12383","article-title":"Bed rest does not induce hypercoagulability","volume":"45","author":"Cvirn","year":"2015 Jan","journal-title":"European Journal of Clinical Investigation"},{"issue":"18","key":"10.1002\/14651858.CD006681.pub4-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1056\/NEJMoa011100","article-title":"Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. Steering Committee of the Pentasaccharide in Hip-Fracture Surgery Study","volume":"345","author":"Eriksson","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/archsurg.1967.01330160037005","article-title":"Posttraumatic venous thrombosis","volume":"95","author":"Freeark","year":"1967","journal-title":"Archives of Surgery"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0036|cit36","first-page":"JC1","article-title":"ACP Journal Club. Dalteparin did not differ from unfractionated heparin for reducing proximal DVT in critically ill patients","volume":"155","author":"Garcia","year":"2011","journal-title":"New England Journal of Medicine"},{"issue":"24","key":"10.1002\/14651858.CD006681.pub4-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1056\/NEJM199412153312401","article-title":"A prospective study of venous thromboembolism after major trauma","volume":"331","author":"Geerts","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"10","key":"10.1002\/14651858.CD006681.pub4-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199609053351003","article-title":"A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma","volume":"335","author":"Geerts","year":"1996","journal-title":"New England Journal of Medicine"},{"issue":"7","key":"10.1002\/14651858.CD006681.pub4-BIB0039|cit39","first-page":"362","article-title":"Is prevention of thromboembolism in ambulatory and conservative therapy of rupture of the fibular ligament of the upper ankle joint necessary?","volume":"97","author":"Gehling","year":"1994","journal-title":"Unfallchirurg"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s001130050231","article-title":"A comparison of acetylsalicylic acid with low-molecular-weight heparin for prophylaxis of deep-vein thrombosis in outpatients with injuries and immobilizing bandages of the lower limb","volume":"101","author":"Gehling","year":"1998","journal-title":"Unfallchirurg"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s001130050568","article-title":"Is a general pharmacologic thromboembolism prophylaxis necessary in ambulatory treatment by plaster cast immobilization in lower limb injuries?","volume":"103","author":"Giannadakis","year":"2000","journal-title":"Unfallchirurg"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1302\/0301-620X.91B3.20820","article-title":"Prophylaxis of deep-vein thrombosis in fractures below the knee: a prospective randomised controlled trial","volume":"91-B","author":"Goel","year":"2009","journal-title":"Journal of Bone and Joint Surgery - British Volume"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/00005373-199701000-00017","article-title":"Posttrauma thromboembolism prophylaxis","volume":"42","author":"Greenfield","year":"1997","journal-title":"Journal of Trauma: Injury Infection and Critical Care"},{"issue":"5","key":"10.1002\/14651858.CD006681.pub4-BIB0044|cit44","first-page":"237","article-title":"Prevention of thromboembolism with low molecular weight heparin","volume":"9","author":"Haas","year":"1989","journal-title":"Hamostaseologie"},{"issue":"11","key":"10.1002\/14651858.CD006681.pub4-BIB0045|cit45","first-page":"1284","article-title":"Prevention of thromboembolism with low-molecular-weight heparin in ambulatory surgery and unoperated surgical and orthopedic patients","volume":"123","author":"Harenberg","year":"1998","journal-title":"Zentralblatt Chirurgie"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0046|cit46","first-page":"209","article-title":"Incidence of thrombosis in patients with tibial fractures","volume":"134","author":"Hjelmstedt","year":"1968","journal-title":"Acta Chirurgica Scandinavica"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1378\/chest.14-0235","article-title":"The anticoagulation of calf thrombosis (ACT) project: results from the randomized controlled external pilot trial","volume":"146","author":"Horner","year":"2014 Dec","journal-title":"Chest"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2106\/00004623-199173020-00021","article-title":"Treatment for acute tears of the lateral ligaments of the ankle","volume":"73-A","author":"Kannus","year":"1991","journal-title":"Journal of Bone and Joint Surgery - American Volume"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/00005373-199609000-00010","article-title":"Use of low molecular weight heparin in preventing thromboembolism in trauma patients","volume":"41","author":"Knudson","year":"1996","journal-title":"Journal of Trauma: Injury Infection and Critical Care"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"490-6, discussi","DOI":"10.1097\/01.sla.0000137138.40116.6c","article-title":"Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank","volume":"240","author":"Knudson","year":"2004","journal-title":"Annals of Surgery"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0002-9610(89)90182-7","article-title":"Silent deep vein thrombosis in immobilized multiple trauma patients","volume":"158","author":"Kudsk","year":"1989","journal-title":"American Journal of Surgery"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0052|cit52","first-page":"491A","article-title":"Efficacy and safety of low molecular weight heparin (Elivarine) in the prophylaxis of venous thromboembolism in patients with brace immobilization after injury of the lower extremity","volume":"96","author":"Lassen","year":"2000","journal-title":"Blood"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/CCM.0000000000000713","article-title":"Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients","volume":"43","author":"Lim","year":"2015","journal-title":"Critical Care Medicine"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-0038-1655306","article-title":"Prevention of venous thromboembolism beyond the period of hospitalisation and during out-of-hospital surgery","volume":"15","author":"Lippert","year":"1995","journal-title":"Hamostaseologie"},{"issue":"11","key":"10.1002\/14651858.CD006681.pub4-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1182\/blood.V104.11.1764.1764","article-title":"A prospective, randomized, placebo-controlled study of extended-duration post-discharge thromboprophylaxis with enoxaparin following arthroscopic reconstruction of the anterior cruciate ligament","volume":"104","author":"Marlovits","year":"2004","journal-title":"Blood"},{"issue":"7","key":"10.1002\/14651858.CD006681.pub4-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.arthro.2007.02.001","article-title":"Extended-duration thromboprophylaxis with enoxaparin after arthroscopic surgery of the anterior cruciate ligament: a prospective, randomized, placebo-controlled study","volume":"23","author":"Marlovits","year":"2007","journal-title":"Arthroscopy"},{"issue":"66","key":"10.1002\/14651858.CD006681.pub4-BIB0057|cit57","first-page":"159","article-title":"Heparin prophylaxis for a leg cast?","volume":"12","author":"Martinole","year":"2003","journal-title":"Prescrire International"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00003086-197505000-00031","article-title":"Thromboembolic complications of cast immobilization for injuries of the lower extremities","volume":"108","author":"Micheli","year":"1975","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0059|cit59","unstructured":"NCT00843492 A study to evaluate the efficacy and safety of fondaparinux for the prevention of venous blood clots in patients with a plaster cast or other type of immobilization for a below-knee injury not needing surgery (FONDACAST) clinicaltrials.gov\/ct2\/show\/NCT00843492"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S1067-2516(96)80135-9","article-title":"Deep venous thrombosis and pulmonary embolism following cast immobilization of the lower extremity","volume":"35","author":"Nesheiwat","year":"1996","journal-title":"Journal of Foot and Ankle Surgery"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0061|cit61","first-page":"110","article-title":"Prevention of thromboembolism in surgery","volume":"17","author":"Reilmann","year":"1988","journal-title":"Orthopade"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0062|cit62","first-page":"117","article-title":"Prevention of thrombosis in ambulatory patients","volume":"22","author":"Reilmann","year":"1993","journal-title":"Orthopade"},{"issue":"10","key":"10.1002\/14651858.CD006681.pub4-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1111\/jth.12395","article-title":"Comparison of fondaparinux with low molecular weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid immobilization for isolated non-surgical below-knee injury","volume":"11","author":"Samama","year":"2013","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0064|cit64","first-page":"153","article-title":"Comparison of fondaparinux with low-molecular-weight heparin for venous thromboembolism prevention in patients requiring rigid or semi-rigid Immobilization for isolated non-surgical below-knee injury","volume":"4","author":"Samama","year":"2014","journal-title":"Annales Francaises de Medecine d'Urgence"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fas.2013.11.002","article-title":"The impact of risk assessment on the implementation of venous thromboembolism prophylaxis in foot and ankle surgery","volume":"20","author":"Saragas","year":"2014 Jun","journal-title":"Foot and Ankle Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/01.TA.0000119687.23542.EC","article-title":"Incidence of asymptomatic pulmonary embolus in moderately to severely injured trauma patients","volume":"56","author":"Schultz","year":"2004","journal-title":"Journal of Trauma: Injury Infection and Critical Care"},{"issue":"5","key":"10.1002\/14651858.CD006681.pub4-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/BOT.0000000000000250","article-title":"A double-blind, randomized controlled trial of the prevention of clinically important venous thromboembolism after isolated lower leg fractures","volume":"29","author":"Selby","year":"2015","journal-title":"Journal of Orthopaedic Trauma"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD006681.pub4-BIB0068|cit68","first-page":"7","article-title":"Clinically important venous thromboembolism (CIVTE) following isolated leg fractures distal to the knee: epidemiology & prevention: the D-KAF (dalteparin in knee-to-ankle fracture) trial","volume":"92-B","author":"Selby","year":"2010","journal-title":"Journal of Bone and Joint Surgery - British Volume"},{"issue":"43","key":"10.1002\/14651858.CD006681.pub4-BIB0069|cit69","first-page":"1535","article-title":"Traumatic thromboses of the deep venous system in recent tibial fractures","volume":"102","author":"Spieler","year":"1972","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5604\/12321966.1120610","article-title":"Can deep vein thrombosis be predicted after varicose vein operation in women in rural areas?","volume":"21","author":"Warot","year":"2014","journal-title":"Annals of Agricultural and Environmental Medicine"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0071|cit71","first-page":"109","article-title":"Ambulatory prevention of thrombosis in a traumatologic patient sample","volume":"35","author":"Wolf","year":"1992","journal-title":"Vasa Supplementum"},{"issue":"7","key":"10.1002\/14651858.CD006681.pub4-BIB0072|cit72","first-page":"331","article-title":"Ambulatory thromboembolism prevention in traumatology using self-injection of heparin","volume":"93","author":"Zagrodnick","year":"1990","journal-title":"Unfallchirurg"},{"issue":"23 suppl 1","key":"10.1002\/14651858.CD006681.pub4-BIB0073|cit73","first-page":"I","article-title":"Risk factors for venous thromboembolism","volume":"107","author":"Anderson","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1001\/jama.1986.03380060070028","article-title":"Consensus conference: prevention of venous thrombosis and pulmonary embolism","volume":"256","author":"Anonymous","year":"1986","journal-title":"JAMA"},{"issue":"7454","key":"10.1002\/14651858.CD006681.pub4-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/bmj.328.7454.1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"Atkins","year":"2004","journal-title":"BMJ"},{"issue":"9","key":"10.1002\/14651858.CD006681.pub4-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"813-7","DOI":"10.1016\/j.injury.2006.03.016","article-title":"Thromboprophylaxis following cast immobilisation for lower limb injuries-survey of current practice in United Kingdom","volume":"37","author":"Batra","year":"2006","journal-title":"Injury"},{"issue":"19","key":"10.1002\/14651858.CD006681.pub4-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1001\/archinte.162.19.2173","article-title":"Venous thromboembolism in patients undergoing laparoscopic and arthroscopic surgery and in leg casts","volume":"162","author":"Bergqvist","year":"2002","journal-title":"Archives of Internal Medicine"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.injury.2011.05.007","article-title":"Incidence and diagnosis of heparin-induced thrombocytopenia (HIT) in patients with traumatic injuries treated with unfractioned or low-molecular-weight heparin: a literature review","volume":"43","author":"Bloemen","year":"2012","journal-title":"Injury"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0079|cit79","unstructured":"CBO (Centraal Begeleidingsorgaan voor de intercollegiale toetsing) Concept directive diagnostics, prevention and treatment of venous thromboembolism and secondary prevention of arterial thrombosis Quality Institute for Health Care (Kwaliteitsinstituut voor de Gezondheidszorg), the Netherlands (http:\/\/www.cvgk.nl\/legacy\/bestanden\/CBO-richtlijn-Stolling-2009.pdf) 2008"},{"issue":"4 Suppl","key":"10.1002\/14651858.CD006681.pub4-BIB0080|cit80","first-page":"312S-34S","article-title":"Prevention of venous thromboembolism","volume":"108","author":"Clagett","year":"1995","journal-title":"Chest"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0081|cit81","unstructured":"Deeks JJ Higgins JPT Altman DG Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.handbook.cochrane.org"},{"issue":"7","key":"10.1002\/14651858.CD006681.pub4-BIB0082|cit82","first-page":"778","article-title":"II Italian intersociety consensus statement on antithrombotic prophylaxis in orthopedics and traumatology","volume":"79","author":"Della Rocca","year":"2013","journal-title":"Minerva Anestesiologica"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1067\/msy.2000.108224","article-title":"The risk assessment profile score identifies trauma patients at risk for deep vein thrombosis","volume":"128","author":"Gearhart","year":"2000","journal-title":"Surgery"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"338S","DOI":"10.1378\/chest.126.3_suppl.338S","article-title":"Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126 (3 Suppl)","author":"Geerts","year":"2004","journal-title":"Chest"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0085|cit85","unstructured":"McMaster University (developed by Evidence Prime, Inc) GRADEpro Guideline Development Tool (GRADEpro GDT)"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1148\/radiol.2343031009","article-title":"Ventilaton-perfusion scanning and helical CT in suspected pulmonary embolism: Meta-analysis of diagnostic performance","volume":"234","author":"Hayashino","year":"2005","journal-title":"Radiology"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0087|cit87","unstructured":"Higgins JP Green S editor(s) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.handbook.cochrane.org"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0088|cit88","first-page":"282-7","article-title":"Heparin prophylaxis for deep venous thrombosis in a patient with multiple injuries: an evidence-based approach to a clinical problem","volume":"45","author":"Hill","year":"2002","journal-title":"Canadian Journal of Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"357-65","DOI":"10.1111\/j.1365-2141.2006.06200.x","article-title":"The post-thrombotic syndrome: progress and pitfalls","volume":"134","author":"Kahn","year":"2006","journal-title":"British Journal of Haematology"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0090|cit90","first-page":"1361","article-title":"Prevention of venous thromboembolism","volume-title":"Haemostasis and thrombosis","author":"Kakkar","year":"1994"},{"issue":"suppl 1","key":"10.1002\/14651858.CD006681.pub4-BIB0091|cit91","first-page":"20-6","article-title":"Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb","volume":"23","author":"Kujath","year":"1991","journal-title":"Haemostasis"},{"issue":"6","key":"10.1002\/14651858.CD006681.pub4-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1056\/NEJM198902093200602","article-title":"Detection of deep-vein thrombosis by real-time B-mode ultrasonography","volume":"320","author":"Lensing","year":"1989","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD006681.pub4-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1148\/radiology.177.2.2217792","article-title":"Lower extremity venography with iohexol: results and complications","volume":"177","author":"Lensing","year":"1990","journal-title":"Radiology"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0094|cit94","doi-asserted-by":"crossref","first-page":"50-6","DOI":"10.1016\/S0741-5214(98)70291-5","article-title":"Late clinical and hemodynamic sequelae of isolated calf vein thrombosis","volume":"27","author":"McLafferty","year":"1998","journal-title":"Journal of Vascular Surgery"},{"key":"10.1002\/14651858.CD006681.pub4-BIB0095|cit95","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"11","key":"10.1002\/14651858.CD006681.pub4-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/emermed-2013-203134","article-title":"Guidelines in Emergency Medicine Network (GEMNet): guideline for the use of thromboprophylaxis in ambulatory trauma patients requiring temporary limb immobilisation","volume":"30","author":"Roberts","year":"2013","journal-title":"Emergency Medicine Journal"},{"issue":"Suppl.1","key":"10.1002\/14651858.CD006681.pub4-BIB0097|cit97","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1538-7836.2007.02490.x","article-title":"Distal DVT: worth diagnosing? Yes","volume":"5","author":"Schellong","year":"2007","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"349-57","DOI":"10.1111\/j.0954-6820.1986.tb03323.x","article-title":"Long-term sequelae of calf vein thrombosis treated with heparin or low-dose streptokinase","volume":"219","author":"Schulman","year":"1986","journal-title":"Acta Medica Scandinavica"},{"issue":"3","key":"10.1002\/14651858.CD006681.pub4-BIB0099|cit99","first-page":"131","article-title":"Thromboprophylaxis in immobilized medical patients","volume":"9","author":"Vaitkus","year":"2004","journal-title":"European Journal of Medical Research"},{"issue":"1","key":"10.1002\/14651858.CD006681.pub4-BIB0100|cit100","first-page":"23","article-title":"Thromboprophylaxis for lower leg cast immobilisation and knee arthroscopy: a survey study","volume":"73","author":"Adrichem","year":"2015","journal-title":"Netherlands Journal of Medicine"},{"issue":"10","key":"10.1002\/14651858.CD006681.pub4-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1056\/NEJM199709043371007","article-title":"Low-molecular-weight heparins","volume":"Volume 337","author":"Weitz","year":"September 1997","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0102|cit102","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006681.pub2","article-title":"Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization","author":"Testroote","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD006681.pub4-BIB0103|cit103","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006681.pub3","article-title":"Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization","author":"Testroote","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD006681.pub4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T20:58:01Z","timestamp":1719349081000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006681.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Vascular Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,6]]},"references-count":103,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006681.pub4","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,6]]}}}