{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:42:03Z","timestamp":1783471323719,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006716.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000}}],"reference-count":92,"publisher":"Wiley","issue":"7","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006716.pub3","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T03:45:10Z","timestamp":1441338310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Interventions for the treatment of metastatic extradural spinal cord compression in adults"],"prefix":"10.1002","volume":"2018","author":[{"given":"Reena","family":"George","sequence":"first","affiliation":[{"name":"Christian Medical College; Palliative Care Unit; Vellore Tamil Nadu India 632004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer Jeba","family":"Sundararaj","sequence":"additional","affiliation":[{"name":"Christian Medical College; Palliative Care Unit; Vellore Tamil Nadu India 632004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkumar","family":"Govindaraj","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital; Department of Radiation Oncology; North Terrace Adelaide SA Australia 5000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari G","family":"Chacko","sequence":"additional","affiliation":[{"name":"Christian Medical College; Neurosciences; Vellore Tamil Nadu India 632002"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathap","family":"Tharyan","sequence":"additional","affiliation":[{"name":"Christian Medical College; Cochrane South Asia, Prof. BV Moses Centre for Evidence-Informed Healthcare and Health Policy; Carman Block II Floor CMC Campus, Bagayam Vellore Tamil Nadu India 632002"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.clon.2005.08.015","article-title":"A pilot randomised comparison of dexamethasone 96 mg vs 16 mg per day for malignant spinal-cord compression treated by radiotherapy: TROG 01.05 Superdex study","volume":"18","author":"Graham","year":"2006","journal-title":"Clinical Oncology (R Coll Radiol)"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0002|cit2","doi-asserted-by":"crossref","unstructured":"Kwok Y Patchell RA Regine WF Journal of Clinical Oncology 2005 8272 4","DOI":"10.1200\/JCO.2005.03.4959"},{"issue":"15","key":"10.1002\/14651858.CD006716.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1200\/JCO.2005.11.940","article-title":"Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo [comment on: Journal of Clinical Oncology 2005;23(15),3358-65]","volume":"23","author":"Kwok","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"32","key":"10.1002\/14651858.CD006716.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"8270","DOI":"10.1200\/JCO.2005.03.4694","article-title":"Radiation dose in spinal cord compression. Comment on: Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo. [J Clin Oncol. 2005 20;23(15):3308-10]","volume":"23","author":"Macbeth","year":"2005","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0006|cit5","doi-asserted-by":"crossref","unstructured":"Maranzano E Bellavita R Rossi R Radiotherapy alone or surgery in spinal cord compression? The choice depends on accurate patient selection Journal of Clinical Oncology 2005 8270 2","DOI":"10.1200\/JCO.2005.03.3522"},{"issue":"15","key":"10.1002\/14651858.CD006716.pub3-BIB0005|cit6","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1200\/JCO.2005.08.193","article-title":"Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial","volume":"23","author":"Maranzano","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.radonc.2010.12.011","article-title":"Reirradiation of metastatic spinal cord compression: definitive results of two randomized trials","volume":"98","author":"Maranzano","year":"2011","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.radonc.2010.12.011","article-title":"Reirradiation of metastatic spinal cord compression: definitive results of two randomized trials","volume":"98","author":"Maranzano","year":"2011","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.radonc.2009.05.012","article-title":"8Gy single-dose radiotherapy is effective in metastatic spinal cord compression: results of a phase III randomized multicentre Italian trial","volume":"93","author":"Maranzano","year":"2009","journal-title":"Radiotherapy and Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/BRS.0b013e318193a25b","article-title":"Selecting treatment for patients with malignant epidural spinal cord compression-does age matter?:results from a randomized clinical trial","volume":"34","author":"Chi","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/neuonc\/nos062","article-title":"The combined use of surgery and radiotherapy to treat patients with epidural cord compression due to metastatic disease: a cost-utility analysis","volume":"14","author":"Furlan","year":"2012","journal-title":"Neuro-oncology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0012|cit12","unstructured":"Furlan JC Chan KKW Sandoval G Lam KC Klinger CA Patchell RA An Ontario-based cost-utility analysis comparing the standard of care with direct decompressive surgical resection followed by radiotherapy in the palliative care of patients with metastatic spinal cord cancer Canadian Journal of Neurological Sciences. [Conference Abstract] 2011 1) S12"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0013|cit13","doi-asserted-by":"crossref","unstructured":"Koch M De Keyser J Surgical resection in metastatic spinal cord compression Lancet 2006 109","DOI":"10.1016\/S0140-6736(06)67954-3"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0014|cit14","doi-asserted-by":"crossref","unstructured":"Kunkler I Surgical resection in metastatic spinal cord compression Lancet 2006 109","DOI":"10.1016\/S0140-6736(06)67955-5"},{"issue":"32","key":"10.1002\/14651858.CD006716.pub3-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"8270-2; author","DOI":"10.1200\/JCO.2005.03.3522","article-title":"Radiotherapy alone or surgery in spinal cord compression? The choice depends on accurate patient selection. Comment on Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo. [J Clin Oncol. 2005]","volume":"23","author":"Maranzano","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"314; author rep","DOI":"10.1016\/j.ijrobp.2006.12.040","article-title":"Be careful in getting cost-effectiveness conclusions from a debatable trial! Comment on Cost-effectiveness of surgery plus radiotherapy versus radiotherapy alone for metastatic epidural spinal cord compression. [International Journal of Radiation Oncology, Biology, Physics, 2006]","volume":"68","author":"Maranzano","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0017|cit17","first-page":"237S","article-title":"A randomized trial of direct decompressive surgical resection in the treatment of spinal cord compression caused by metastasis","volume":"21","author":"Patchell","year":"2003","journal-title":"Journal of Clinical Oncology"},{"issue":"9486","key":"10.1002\/14651858.CD006716.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","article-title":"Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial","volume":"366","author":"Patchell","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"10.1002\/14651858.CD006716.pub3-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.ijrobp.2006.06.021","article-title":"Cost-effectiveness of surgery plus radiotherapy versus radiotherapy alone for metastatic epidural spinal cord compression","volume":"66","author":"Thomas","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9486","key":"10.1002\/14651858.CD006716.pub3-BIB0020|cit20","first-page":"609","article-title":"Surgical resection improves outcome in metastatic epidural spinal cord compression [comment on: Lancet 2005;366(9486):643-8]","volume":"366","author":"Bent","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0959-8049(05)80011-5","article-title":"Effect of high-dose dexamethasone in carcinomatous metastatic spinal cord compression treated with radiotherapy: a randomised trial","volume":"30A","author":"Sorensen","year":"1994","journal-title":"European Journal of Cancer"},{"issue":"9","key":"10.1002\/14651858.CD006716.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1212\/WNL.39.9.1255","article-title":"Initial bolus of conventional versus high-dose dexamethasone in metastatic spinal cord compression","volume":"39","author":"Vecht","year":"1989","journal-title":"Neurology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3171\/jns.1980.53.6.0741","article-title":"Treatment of spinal epidural metastases: randomized prospective comparison of laminectomy and radiotherapy","volume":"53","author":"Young","year":"1980","journal-title":"Journal of Neurosurgery"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/10428190290006152","article-title":"Spinal cord compression as a primary manifestation of aggressive malignant lymphomas: long-term analysis of treatments with radiotherapy, chemotherapy or combined therapy","volume":"43","author":"Aviles","year":"2002","journal-title":"Leukemia & Lymphoma"},{"issue":"3","key":"10.1002\/14651858.CD006716.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1227\/01.neu.0000317317.33365.15","article-title":"Predictors of ambulatory function after decompressive surgery for metastatic epidural spinal cord compression","volume":"62","author":"Chaichana","year":"2008","journal-title":"Neurosurgery."},{"issue":"3","key":"10.1002\/14651858.CD006716.pub3-BIB0026|cit26","first-page":"155","article-title":"Recombinant human erythropoietin (r-HuEPO) in the prevention of neurologic sequelae from malignant spinal cord compression (MSCC): A multicenter, placebo-controlled, phase 2 randomized study","volume":"42","author":"Holden","year":"2011","journal-title":"Journal of Medical Imaging and Radiation Sciences. [Conference Abstract]"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0027|cit27","first-page":"13","article-title":"Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomized trial","volume":"22","author":"Hunter","year":"2008","journal-title":"British Journal of Neurosurgery"},{"issue":"6","key":"10.1002\/14651858.CD006716.pub3-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/02688690701593579","article-title":"The surgical management of metastatic spinal disease: prospective assessment and long-term follow-up","volume":"21","author":"Mannion","year":"2007","journal-title":"British Journal of Neurosurgery."},{"issue":"15","key":"10.1002\/14651858.CD006716.pub3-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1002\/cncr.25223","article-title":"Validation and simplification of a score predicting survival in patients irradiated for metastatic spinal cord compression","volume":"116","author":"Rades","year":"2010","journal-title":"Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijrobp.2008.04.044","article-title":"Preliminary results of spinal cord compression recurrence evaluation (score-1) study comparing short-course versus long-course radiotherapy for local control of malignant epidural spinal cord compression","volume":"73","author":"Rades","year":"2009","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9","key":"10.1002\/14651858.CD006716.pub3-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1002\/cncr.24993","article-title":"Radiosurgical decompression of metastatic epidural compression","volume":"116","author":"Ryu","year":"2010","journal-title":"Cancer"},{"issue":"11","key":"10.1002\/14651858.CD006716.pub3-BIB0032|cit32","first-page":"2395","article-title":"Prospective clinical trial of minimal-invasive instrumentation of the spine in spinal metastasis-benefit or dead end","volume":"21","author":"Schaefer","year":"2012","journal-title":"European Spine Journal. [Conference Abstract]."},{"key":"10.1002\/14651858.CD006716.pub3-BIB0033|cit33","unstructured":"Hegazy M Wahba H Single- versus multi-fraction radiation treatment for metastatic spinal cord compression: Functional outcome study Neurology. Conference 64th American Academy of Neurology Annual Meeting New Orleans, LA United States. Conference Start. 20120421 Conference End: 20120428. Conference Publication: (var.pagings)"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0034|cit34","unstructured":"A randomised feasibility study of single fraction radiotherapy compared to multi-fraction radiotherapy in patients with metastatic spinal cord compression http:\/\/controlled-trials.com, UK Clinical Trials Gateway"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0035|cit35","unstructured":"A randomised phase III trial of two fractionation schemes in the treatment of malignant spinal cord compression (Spinal Cord Compression. ICORG 05-03, V6) http:\/\/clinicaltrials.gov\/show\/NCT00968643"},{"issue":"4","key":"10.1002\/14651858.CD006716.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE\u00a0guidelines: 3. Rating the\u00a0quality\u00a0of evidence","volume":"64","author":"Balshem","year":"2011","journal-title":"Journal of Clinical Epidemiology"},{"issue":"12","key":"10.1002\/14651858.CD006716.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1001\/jama.2010.310","article-title":"Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis","volume":"303","author":"Bassler","year":"2010","journal-title":"JAMA"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/BRS.0b013e318193a25b","article-title":"Selecting treatment for patients with malignant epidural spinal cord compression-does age matter?: results from a randomized clinical trial","volume":"34","author":"Chi","year":"2009","journal-title":"Spine (Phila Pa 1976)."},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00586-009-1252-x","article-title":"Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group","volume":"19","author":"Choi","year":"2010","journal-title":"European Spine Journal"},{"issue":"3","key":"10.1002\/14651858.CD006716.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"e1000251","DOI":"10.1371\/journal.pmed.1000251","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"7","author":"Schulz","year":"2010","journal-title":"PLoS Medicine"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0041|cit41","article-title":"Chapter 9: Analysing data and undertaking meta-analyses","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Deeks","year":"2011. Available from www.cochrane-handbook.org"},{"issue":"6","key":"10.1002\/14651858.CD006716.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3171\/jns.1989.70.6.0920","article-title":"A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor","volume":"70","author":"Delattre","year":"1989","journal-title":"Journal of Neurosurgery"},{"issue":"5\/6","key":"10.1002\/14651858.CD006716.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/02841860310014895","article-title":"A systematic overview of radiation therapy effects in skeletal metastases","volume":"42","author":"Falkmer","year":"2003","journal-title":"Acta Oncologica"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/neuonc\/nos062","article-title":"The combined use of surgery and radiotherapy to treat patients with epidural cord compression due to metastatic disease: a cost-utility analysis","volume":"14","author":"Furlan","year":"2012","journal-title":"Neuro-oncology 2012"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0045|cit45","unstructured":"GRADE Working Group GRADE Profiler; version 3.6 2004"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0046|cit46","unstructured":"Jan Brozek Andrew Oxman Holger Sch\u00fcnemann GRADEpro. Version 3.2 for Windows 2008"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"e3863","DOI":"10.1136\/bmj.e3863","article-title":"Problems of stopping trials early","volume":"344","author":"Guyatt","year":"2012","journal-title":"BMJ"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0048|cit48","first-page":"141","article-title":"High incidence of serious side effects of high-dose dexamethasone treatment in patients with epidural spinal cord compression","volume":"12","author":"Heimdal","year":"1992","journal-title":"Journal of Neuroncology"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0360-3016(99)00333-8","article-title":"Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables including survival and gait function in 153 patients","volume":"46","author":"Helweg-Larsen","year":"2000","journal-title":"International Journal of Radiation Oncology, Biology and Physics"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0051|cit51","unstructured":"Higgins JPT Altman DG Sterne JAC (editors) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0052|cit52","article-title":"Chapter 16: Special topics in statistics","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Higgins","year":"2011. Available from www.cochrane-handbook.org"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/SPC.0b013e32834de701","article-title":"Malignant epidural spinal cord compression: the role of external beam radiotherapy","volume":"6","author":"Holt","year":"2012","journal-title":"Current Opinion in Supportive and Palliative Care"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/BRS.0b013e318223b9b6","article-title":"Clinical outcome of metastatic spinal cord compression treated with surgical excision \u00b1 radiation versus radiation therapy alone: a systematic review of literature","volume":"37","author":"Kim","year":"2012","journal-title":"Spine (Philadelphia, Pa.: 1976)"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1634\/theoncologist.9-2-188","article-title":"Surgical management of spinal metastases","volume":"9","author":"Klimo","year":"2004","journal-title":"Oncologist"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1215\/S1152851704000262","article-title":"A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease","volume":"7","author":"Klimo","year":"2005","journal-title":"Neuro-oncology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0057|cit57","unstructured":"Laperriere NJ The management of spinal cord compression Toronto, Ontario, Canada, Princess Margaret Hospital 1996"},{"issue":"4","key":"10.1002\/14651858.CD006716.pub3-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1200\/JCO.1998.16.4.1613","article-title":"Emergency treatment of malignant spinal cord compression: an evidence based guideline","volume":"16","author":"Loblaw","year":"1998","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD006716.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0936-6555(02)00400-4","article-title":"A population-based study of malignant spinal cord compression in Ontario","volume":"15","author":"Loblaw","year":"2003","journal-title":"Clinical Oncology (R Coll Radiol)"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1200\/JCO.2005.00.067","article-title":"Systematic review of the diagnosis and management of malignant extradural spinal cord compression: The Cancer Care Ontario Practice Guidelines Initiative's Neuro-oncology Disease Site Group","volume":"23","author":"Loblaw","year":"2005","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ijrobp.2012.01.014","article-title":"A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression","volume":"84","author":"Loblaw","year":"2012","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"6","key":"10.1002\/14651858.CD006716.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.3747\/co.19.1128","article-title":"Treatment of metastatic spinal cord compression: cepo review and clinical recommendations.","volume":"19","author":"L'esp\u00e9rance","year":"2012","journal-title":"Current Oncology"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/1097-0142(19910301)67:5<1311::AID-CNCR2820670507>3.0.CO;2-R","article-title":"Radiation therapy in metastatic spinal cord compression. A prospective analysis of 105 consecutive patients","volume":"67","author":"Maranzano","year":"1991","journal-title":"Cancer"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijrobp.2006.12.040","article-title":"Be careful in getting cost effectiveness conclusions from a debatable trial","volume":"68","author":"Maranzano","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0065|cit65","unstructured":"Chandler J Churchill R Higgins J Lasserson T Tovey D Methodological Expectations of Cochrane Intervention Reviews (MECIR) Methodological standards for the conduct of new Cochrane Intervention Reviews. Version 2.1, 8 December 2011. Available at: http:\/\/www.editorial-unit.cochrane.org\/sites\/editorial-unit.cochrane.org\/files\/uploads\/MECIR_conduct_standards%202.1.pdf"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0066|cit66","doi-asserted-by":"publisher","first-page":"598148","DOI":"10.1155\/2011\/598148","article-title":"A systematic review of the current role of minimally invasive spine surgery in the management of metastatic spine disease","volume":"2011","author":"Molina","year":"2011","journal-title":"International Journal of Surgical Oncology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0067|cit67","unstructured":"National Institute for Clinical Excellence (NICE) CG 75 Metastatic spinal cord compression Available at: http:\/\/guidance.nice.org.uk\/CG75\/NICEGuidance\/pdf"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0360-3016(00)01408-5","article-title":"Prognostic significance of the time of developing motor deficits before radiation therapy in metastatic spinal cord compression: one-year results of a prospective trial","volume":"48","author":"Rades","year":"2000","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"issue":"11","key":"10.1002\/14651858.CD006716.pub3-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1002\/cncr.20633","article-title":"A prospective evaluation of two radiotherapy schedules with 10 versus 20 fractions for the treatment of metastatic spinal cord compression: final results of a multicenter study","volume":"101","author":"Rades","year":"2004","journal-title":"Cancer"},{"issue":"24","key":"10.1002\/14651858.CD006716.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1200\/JCO.2005.05.0542","article-title":"Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression","volume":"20","author":"Rades","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/cncr.23702","article-title":"Prognostic factors for functional outcome and survival after re-irradiation for in-\ufb01eld recurrences of metastatic spinal cord compression","volume":"113","author":"Rades","year":"2008","journal-title":"Cancer"},{"issue":"15","key":"10.1002\/14651858.CD006716.pub3-BIB0072|cit72","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1002\/cncr.25223","article-title":"Validation and simplification of a score predicting survival in patients irradiated for metastatic spinal cord compression","volume":"116","author":"Rades","year":"2010","journal-title":"Cancer"},{"issue":"22","key":"10.1002\/14651858.CD006716.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1200\/JCO.2010.28.5635","article-title":"Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression","volume":"28","author":"Rades","year":"2010","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ijrobp.2009.10.073","article-title":"Final results of a prospective study comparing the local control of short-course and long-course radiotherapy for metastatic spinal cord compression","volume":"79","author":"Rades","year":"2011","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"e861","DOI":"10.1016\/j.ijrobp.2010.11.056","article-title":"Surgery followed by radiotherapy versus radiotherapy alone for metastatic spinal cord compression from unfavorable tumors","volume":"81","author":"Rades","year":"2011","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"5","key":"10.1002\/14651858.CD006716.pub3-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00066-011-0058-z","article-title":"Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?","volume":"188","author":"Rades","year":"2012","journal-title":"Strahlentherapie und Onkologie"},{"issue":"6","key":"10.1002\/14651858.CD006716.pub3-BIB0077|cit77","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00066-013-0342-1","article-title":"A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression","volume":"189","author":"Rades","year":"2013","journal-title":"Strahlentherapie und Onkologie"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0078|cit78","unstructured":"The Nordic Cochrane Centre Review Manager (RevMan) 2014"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00007632-198501000-00003","article-title":"A profile of metastatic carcinoma of the spine","volume":"10","author":"Schaberg","year":"1985","journal-title":"Spine"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0080|cit80","article-title":"Chapter 12: Interpreting results drawing conclusions","volume-title":"Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Available from www.cochrane-handbook.org","author":"Sch\u00fcnemann","year":"2011"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3171\/2010.3.SPINE09202","article-title":"Diagnosis and management of metastatic spine disease. A review","volume":"13","author":"Sciubba","year":"2010","journal-title":"Journal of Neurosurgery. Spine"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.ijrobp.2006.06.021","article-title":"Cost-effectiveness of surgery plus radiotherapy vs. radiotherapy alone for treatment of metastatic epidural spinal cord compression","volume":"66","author":"Thomas","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9","key":"10.1002\/14651858.CD006716.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1097\/01.brs.0000180401.06919.a5","article-title":"A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis","volume":"30","author":"Tokuhashi","year":"2005","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"10.1002\/14651858.CD006716.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/BRS.0b013e3181913f19","article-title":"Outcome of treatment for spinal metastases using scoring system for preoperative evaluation of prognosis","volume":"34","author":"Tokuhashi","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"10.1002\/14651858.CD006716.pub3-BIB0085|cit85","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00007632-200102010-00016","article-title":"Surgical strategy for spinal metastases","volume":"26","author":"Tomita","year":"2001","journal-title":"Spine"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0086|cit86","doi-asserted-by":"crossref","unstructured":"Ushio Y Posner R Posner JB Shapiro WR Experimental spinal cord compression by epidural neoplasms Neurology 1977 422 9","DOI":"10.1212\/WNL.27.5.422"},{"issue":"2","key":"10.1002\/14651858.CD006716.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/cncr.20756","article-title":"Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy","volume":"103","author":"Linden","year":"2005","journal-title":"Cancer"},{"issue":"3","key":"10.1002\/14651858.CD006716.pub3-BIB0088|cit88","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3171\/spi.2004.1.3.0287","article-title":"Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: results in 140 patients","volume":"1","author":"Wang","year":"2004","journal-title":"Journal of Neurosurgery. Spine"},{"issue":"18","key":"10.1002\/14651858.CD006716.pub3-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1097\/00007632-199909150-00014","article-title":"Complication, survival rates, and risk factors of surgery for metastatic disease of the spine","volume":"24","author":"Wise","year":"1999","journal-title":"Spine"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ncpneuro0116","article-title":"Surgery insight: current management of epidural spinal cord compression from metastatic spine disease","volume":"2","author":"Witham","year":"2006","journal-title":"Nature Clinical Practice Neurology"},{"key":"10.1002\/14651858.CD006716.pub3-BIB0091|cit91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007632-199001000-00001","article-title":"Spinal metastases: the obvious, the occult, and the impostors","volume":"15","author":"Wong","year":"1990","journal-title":"Spine"},{"issue":"4","key":"10.1002\/14651858.CD006716.pub3-BIB0092|cit92","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006716","article-title":"Interventions for the treatment of metastatic extradural spinal cord compression in adults","author":"George","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD006716.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T22:41:56Z","timestamp":1718059316000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006716.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Pain, Palliative and Supportive Care Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,4]]},"references-count":92,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006716.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,4]]}}}