{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:10:08Z","timestamp":1775553008952,"version":"3.50.1"},"update-to":[{"DOI":"10.1002\/14651858.cd006752","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000}}],"reference-count":52,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006752.pub2","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T15:05:54Z","timestamp":1239807954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sertindole versus other atypical antipsychotics for schizophrenia"],"prefix":"10.1002","volume":"2012","author":[{"given":"Katja","family":"Komossa","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychosomatische und Medizin und Psychotherapie; Moehlstrasse 26 M\u00fcnchen Germany 81675"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Rummel-Kluge","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie der Universit\u00e4t Leipzig; Semmelweisstr. 10 04103 Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Hunger","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Schmid","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lewis","sequence":"additional","affiliation":[{"name":"Cardiff University; Department of Primary Care and Public Health; Centre for Health Sciences \/ North Wales Clinical School School of Medicine, Gwenfro Building Wrexham UK LL13 7YP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Kissling","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Leucht","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen Klinikum rechts der Isar; Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie; M\u00f6hlstr. 26 M\u00fcnchen Germany 81675"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"issue":"1","key":"10.1002\/14651858.CD006752.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.yic.0000177020.26311.a7","article-title":"A double-blind, controlled study of sertindole versus risperidone in the treatment of moderate-to-severe schizophrenia","volume":"21","author":"Azorin","year":"2006","journal-title":"International Clinical Psychopharmacology"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0002|cit2","first-page":"490","article-title":"Safety and efficacy of sertindole and risperidone in treatment resistant patients with schizophrenia","volume":"31","author":"Kane","year":"2005","journal-title":"Schizophrenia Bulletin"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0003|cit3","unstructured":"Nielsen J Munk-Jorgensen P Augmenting clozapine with sertindole - a double blinded randomized placebo study http:\/\/www.clinicaltrials.gov\/ 2006"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0004|cit4","doi-asserted-by":"crossref","unstructured":"Perro C Naber D Lambert M Moritz S Krause M A prospective clinical comparative-study of four atypical antipsychotic agents in the treatment of schizophrenia Proceedings of the 11th World Congress of Psychiatry; 1999 Aug 6-11; Hamburg, Germany Hamburg 1999 13","DOI":"10.2165\/00128413-199912110-00012"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0005|cit5","unstructured":"Potkin SG Zhobrowsky JN Wu JC Mack JC Sebree TB Wallin BC Brain imaging to determine the effects of sertindole in schizophrenic patients. Proceeding of the 149th Annual Meeting of the American Psychiatric Association;1996 May 4-9; New York, USA New York American Psychiatric Association 1996"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0006|cit6","unstructured":"University of Zurich The effect of sertindole on sensory gating and cognition in schizophrenic patients http:\/\/www.clinicaltrials.gov\/ 2008"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0007|cit7","unstructured":"Cheung HK Sertindole versus risperidone safety outcome study: A randomised, partially-blinded, parallel-group, active-controlled, post-marketing study http:\/\/www.ekg.org.hk\/HAREC-CTR\/index.jsp 2005"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0008|cit8","unstructured":"Cheung HK Sertindole versus risperidone safety outcome study: a randomised, partially-blinded, parallel-group, active-controlled, post-marketing study http:\/\/www.clinicaltrials.gov\/ 2007"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0009|cit9","unstructured":"Lundbeck H A prospective randomised partially-blinded parallel-group active-controlled study of sertindole in schizophrenia http:\/\/www.lundbecktrials.com\/ 2002"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0010|cit10","unstructured":"Lundbeck H A prospective randomised double-blind parallel-group active-referenced trial of sertindole in schizophrenia http:\/\/www.lundbecktrials.com\/ 2006"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0011|cit11","unstructured":"Lundbeck H Exploratory cognition study of sertindole in patients with schizophrenia http:\/\/www.clinicaltrials.gov\/ 2006"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0012|cit12","unstructured":"Lundbeck H Study on metabolic parameters of sertindole in patients' with schizophrenia http:\/\/www.clinicaltrials.gov 2007"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0013|cit13","unstructured":"Lundbeck H Efficacy study exploring the effects on cognition of sertindole versus comparator in patients with schizophrenia http:\/\/www.clinicaltrials.gov\/ 2008"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0014|cit14","unstructured":"Sireling 2003 Study a) Sertindole versus risperidone safety outcome study: a randomised, partially blinded, parallel-group, active-controlled, post marketing study. Study b) Sertindole post-marketing surveillance study National Research Register 2003"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0015|cit15","unstructured":"Prague Psychiatric Center Eli Lilly Study with information technology (IT) - aided preventive program in schizophrenia http:\/\/www.clinicaltrials.gov\/ 2008"},{"issue":"1-3","key":"10.1002\/14651858.CD006752.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.schres.2007.09.005","article-title":"ITAREPS: information technology aided relapse prevention programme in schizophrenia","volume":"98","author":"Spaniel","year":"2008","journal-title":"Schizophrenia Research"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0017|cit17","unstructured":"Weiser M Abramovitz Y Teitelbaum A Comparison of cognitive functions of schizophrenic patients treated with sertindole versus risperidone http:\/\/www.clinicaltrials.gov\/ 2007"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/bmj.313.7066.1200","article-title":"Detecing skewness from summary information","volume":"313","author":"Altman","year":"1996","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0019|cit19","first-page":"1","volume-title":"Practice guidelines for the treatment of patients with schizophrenia","author":"American Psychiatric Association","year":"2004"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0893-133X(97)00112-7","article-title":"Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence","volume":"18","author":"Arnt","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1192\/bjp.154.5.672","article-title":"A rating scale for drug-induced akathisia","volume":"154","author":"Barnes","year":"1989","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/bmj.315.7108.600","article-title":"Statistics notes. Trials randomised in clusters","volume":"315","author":"Bland","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1002\/14651858.CD006752.pub2-BIB0023|cit23","first-page":"405","article-title":"The problem of therapeutic efficacy indices. 3. Comparison of the indices and their use","volume":"54","author":"Boissel","year":"1999","journal-title":"Therapie"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM199403103301006","article-title":"Schizophrenia","volume":"330","author":"Carpenter","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0025|cit25","unstructured":"Deeks J Issues in the selection for meta-analyses of binary data Proceedings of the 8th International Cochrane Colloquium; 2000 Oct 25-28th; Cape Town, South Africa Cape Town Cochrane Collabor 2000"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF02599201","article-title":"The unit of analysis error in studies about physicians' patient care behavior","volume":"7","author":"Divine","year":"1992","journal-title":"Journal of General Internal Medicine"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1002\/sim.1301","article-title":"Issues in the meta-analysis of cluster randomized trials","volume":"21","author":"Donner","year":"2002","journal-title":"Statistics in Medicine"},{"issue":"2","key":"10.1002\/14651858.CD006752.pub2-BIB0028|cit28","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001359.pub2","article-title":"Olanzapine for schizophrenia","author":"Duggan","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD006752.pub2-BIB0029|cit29","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004578.pub3","article-title":"Aripiprazole for schizophrenia","author":"El-Sayeh","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jclinepi.2005.06.006","article-title":"Imputing missing standard deviations in meta-analyses can provide accurate results","volume":"59","author":"Furukawa","year":"2006","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0031|cit31","unstructured":"Gaebel W Falkai P Weinmann S Wobrock T Treatment guidelines for schizophrenia Steinkopf 2006"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/oxfordjournals.aje.a009904","article-title":"Components of variance and intraclass correlations for the design of community-based surveys and intervention studies: data from the Health Survey for England 1994","volume":"149","author":"Gulliford","year":"1999","journal-title":"American Journal of Epidemiology"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0033|cit33","doi-asserted-by":"crossref","unstructured":"Guy U ECDEU assessment manual for psychopharmacology National Institute of Mental Health 1976","DOI":"10.1037\/e591322011-001"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1176\/appi.ajp.163.2.185","article-title":"Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine","volume":"163","author":"Heres","year":"2006","journal-title":"American Journal of Psychiatry"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0036|cit36","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 5.0.1 [updated September 2008] The Cochrane Colllaboration 2008","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archpsyc.63.10.1079","article-title":"Randomized controlled trial of the effect on quality of life","volume":"63","author":"Jones","year":"2006","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/archpsyc.1988.01800330013001","article-title":"Clozapine for the treatment of treatment-resistant schizophrenia: a double-blind comparison with chlorpromazine","volume":"45","author":"Kane","year":"1988","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0039|cit39","first-page":"585","article-title":"Treatment programme and long term outcome in chronic schizophrenia","volume":"46","author":"Kane","year":"1993","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0040|cit40","volume-title":"Positive and negative syndrome scale (PANSS) manual","author":"Kay","year":"1986"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.schres.2005.04.008","article-title":"What does the PANSS mean?","volume":"79","author":"Leucht","year":"2005","journal-title":"Schizophrenia Research"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1192\/bjp.187.4.366","article-title":"Clinical implications of Brief Psychiatric Rating Scale Scores","volume":"187","author":"Leucht","year":"2005","journal-title":"British Journal of Psychiatry"},{"issue":"Issue 3","key":"10.1002\/14651858.CD006752.pub2-BIB0043|cit43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001715.pub2","article-title":"Sertindole for schizophrenia","author":"Lewis","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"Lieberman","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0045|cit45","unstructured":"Lundbeck Sertindole product information Lundbeck Ltd 2006"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1192\/bjp.176.3.249","article-title":"Unpublished rating scales - a major source of bias in randomised controlled trials of treatments for schizophrenia?","volume":"176","author":"Marshall","year":"2000","journal-title":"British Journal of Psychiatry"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1001\/jama.285.15.1987","article-title":"The CONSORT Statement: Revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"285","author":"Moher","year":"2001","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0048|cit48","first-page":"329","article-title":"New assessment of atypical antipsychotics","volume":"71","author":"M\u00f6ller","year":"2000","journal-title":"Nervenarzt"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2466\/pr0.1962.10.3.799","article-title":"The Brief Psychiatric Rating Scale","volume":"10","author":"Overall","year":"1962","journal-title":"Psychological Reports"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0447.1970.tb02066.x","article-title":"A rating scale for extrapyramidal side-effects","volume":"212","author":"Simpson","year":"1970","journal-title":"Acta Psychiatrica Scandinavica Supplementum"},{"issue":"5","key":"10.1002\/14651858.CD006752.pub2-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.3310\/hta3050","article-title":"Methods for evaluating area-wide and organisation-based interventions in health and health care: a systematic review","volume":"3","author":"Ukoumunne","year":"1999","journal-title":"Health Technology Assessment"},{"key":"10.1002\/14651858.CD006752.pub2-BIB0052|cit52","doi-asserted-by":"crossref","unstructured":"Leucht S Komossa K Rummel-Kluge C Corves C Hunger H Schmid F Asenjo Lobos C Schwarz S Davis JM A meta-analysis of head-to-head comparisons of second-generation antipsychotics of schizophrenia American Journal of Psychiatry 2008 epub 10.1176\/appi.ajp.2008.08030368","DOI":"10.1176\/appi.ajp.2008.08030368"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD006752.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:32:49Z","timestamp":1775550769000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006752.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Schizophrenia Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,4,15]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006752.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,15]]}}}