{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:34:58Z","timestamp":1791167698411,"version":"4.1.0"},"publisher-location":"Chichester, UK","reference-count":21,"publisher":"John Wiley & Sons, Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/14651858.cd006884.pub2","type":"reference-entry","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T18:41:59Z","timestamp":1256150519000},"source":"Crossref","is-referenced-by-count":28,"title":["Methotrexate for maintenance of remission in Crohn's disease"],"prefix":"10.1002","author":[{"given":"Vishal","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John WD","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Chande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"issue":"22","key":"10.1002\/14651858.CD006884.pub2-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJM200006013422202","article-title":"A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators","volume":"342","author":"Feagan","year":"2000","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1002\/14651858.CD006884.pub2-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1097\/00042737-200012110-00010","article-title":"6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease","volume":"12","author":"Mat\u00e9-Jim\u00e9nez","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1002\/14651858.CD006884.pub2-BIB3|cit3","first-page":"2203","article-title":"Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial","volume":"92","author":"Oren","year":"1997","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1002\/14651858.CD006884.pub2-BIB4|cit4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1590-8658(03)00372-4","article-title":"Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: a randomised, investigator-blind study","volume":"35","author":"Ardizzone","year":"2003","journal-title":"Dig Liver Dis"},{"issue":"27","key":"10.1002\/14651858.CD006884.pub2-BIB5|cit5","first-page":"1724","article-title":"Methotrexate in Crohn's disease: results of a randomized, double-blind, placebo-controlled trial","volume":"46","author":"Arora","year":"1999","journal-title":"Hepatogastroenterology"},{"issue":"12","key":"10.1002\/14651858.CD006884.pub2-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1046\/j.1365-2036.1999.00667.x","article-title":"A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis","volume":"13","author":"Egan","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1002\/14651858.CD006884.pub2-BIB7|cit7","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003459.pub2","article-title":"Methotrexate for induction of remission in refractory Crohn's disease","author":"Alfadhli","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD006884.pub2-BIB8|cit8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1365-2702.2002.00573.x","article-title":"A study of parenteral use of methotrexate in rheumatic conditions","volume":"11","author":"Arthur","year":"2002","journal-title":"J Clin Nurs"},{"issue":"7","key":"10.1002\/14651858.CD006884.pub2-BIB9|cit9","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMoa020888","article-title":"Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease","volume":"348","author":"Baert","year":"2003","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1002\/14651858.CD006884.pub2-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1200\/JCO.1988.6.12.1882","article-title":"Pharmacokinetics of subcutaneous methotrexate","volume":"6","author":"Balis","year":"1988","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1002\/14651858.CD006884.pub2-BIB11|cit11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1440-1746.2006.04393.x","article-title":"Long-term results with azathioprine therapy in patients with corticosteroid-dependent Crohn's disease: open-label prospective study","volume":"22","author":"Chebli","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1002\/14651858.CD006884.pub2-BIB12|cit12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0009-9236(99)70119-0","article-title":"Systemic and intestinal pharmacokinetics of methotrexate in patients with inflammatory bowel disease","volume":"65","author":"Egan","year":"1999","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"10.1002\/14651858.CD006884.pub2-BIB13|cit13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199502023320503","article-title":"Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators","volume":"332","author":"Feagan","year":"1995","journal-title":"N Engl J Med"},{"issue":"9317","key":"10.1002\/14651858.CD006884.pub2-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","article-title":"Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"issue":"7414","key":"10.1002\/14651858.CD006884.pub2-BIB15|cit15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD006884.pub2-BIB16|cit16","unstructured":"Higgins JPT Altman DG (editors) Chapter 8: Assessing risk of bias in included studies Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008] The Cochrane Collaboration"},{"issue":"1","key":"10.1002\/14651858.CD006884.pub2-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"issue":"3","key":"10.1002\/14651858.CD006884.pub2-BIB18|cit18","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/j.gastro.2006.01.047","article-title":"American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease","volume":"130","author":"Lichtenstein","year":"2006","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1002\/14651858.CD006884.pub2-BIB19|cit19","article-title":"Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease","author":"Prefontaine","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1002\/14651858.CD006884.pub2-BIB20|cit20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1136\/gut.48.6.790","article-title":"Methotrexate in Crohn's disease","volume":"48","author":"Rampton","year":"2001","journal-title":"Gut"},{"issue":"4","key":"10.1002\/14651858.CD006884.pub2-BIB21|cit21","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000301","article-title":"Corticosteroids for maintenance of remission in Crohn's disease","author":"Steinhart","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"}],"updated-by":[{"DOI":"10.1002\/14651858.cd006884.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000}}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD006884.pub2\/epdf\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T22:04:48Z","timestamp":1628546688000},"score":1,"resource":{"primary":{"URL":"https:\/\/doi.wiley.com\/10.1002\/14651858.CD006884.pub2"}},"subtitle":[],"editor":[{"given":"Nilesh","family":"Chande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2009,10,7]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006884.pub2","relation":{"new_version":[{"id-type":"doi","id":"10.1002\/14651858.CD006884.pub3","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[2009,10,7]]}}}