{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:01:03Z","timestamp":1785243663299,"version":"3.55.0"},"update-to":[{"DOI":"10.1002\/14651858.cd006991","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000}}],"reference-count":60,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd006991.pub2","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T17:34:17Z","timestamp":1417455257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"2014","author":[{"given":"Joanne","family":"Rimmer","sequence":"first","affiliation":[{"name":"Guy's Hospital; ENT Department; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wytske","family":"Fokkens","sequence":"additional","affiliation":[{"name":"Academic Medical Centre; Department of Otorhinolaryngology; Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Yee","family":"Chong","sequence":"additional","affiliation":[{"name":"UK Cochrane Centre; Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Guy's Hospital; ENT Department; London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD006991.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1398-9995.2005.00725.x","article-title":"Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments","volume":"60","author":"Alobid","year":"2005","journal-title":"Allergy"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/00016488809119457","article-title":"Surgical versus medical treatment of nasal polyps","volume":"105","author":"Lildholdt","year":"1988","journal-title":"Acta Otolaryngologica"},{"issue":"6","key":"10.1002\/14651858.CD006991.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/archotol.1997.01900060037006","article-title":"Glucocorticoid treatment for nasal polyps","volume":"123","author":"Lildholdt","year":"1997","journal-title":"Archives of Otolaryngology, Head and Neck Surgery"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2273.1995.tb00007.x","article-title":"Efficacy of topical corticosteroid powder for nasal polyps: a double-blind, placebo-controlled study of budesonide","volume":"20","author":"Lildholdt","year":"1995","journal-title":"Clinical Otolaryngology and Allied Sciences"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1183\/09031936.06.00043305","article-title":"Treatment of chronic rhinosinusitis and its effects on asthma","volume":"28","author":"Ragab","year":"2006","journal-title":"European Respiratory Journal"},{"issue":"6","key":"10.1002\/14651858.CD006991.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1398-9995.2006.01044.x","article-title":"Nasal nitric oxide in objective evaluation of chronic rhinosinusitis therapy","volume":"61","author":"Ragab","year":"2006","journal-title":"Allergy"},{"issue":"5","key":"10.1002\/14651858.CD006991.pub2-BIB0008|cit7","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00005537-200405000-00027","article-title":"Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial","volume":"114","author":"Ragab","year":"2004","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0007|cit8","first-page":"305","article-title":"Impact of chronic rhinosinusitis therapy on quality of life: a prospective randomized controlled trial","volume":"48","author":"Ragab","year":"2010","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0009|cit9","unstructured":"Fokkens WJ FES: FESS Effectiveness Study: a multi-centre randomised controlled trial studying the effectiveness of functional endoscopic sinus surgery (FESS) in adult patients with chronic rhinosinusitis\/nasal polyps unresponsive to medical therapy http:\/\/www.controlled-trials.com"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0010|cit10","first-page":"184","article-title":"Comparison of conservative versus surgical treatment of ethmoidal nasal polyps","volume":"4","author":"Rohail","year":"2010","journal-title":"Pakistan Journal of Medical and Health Sciences"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1017\/S0022215111001149","article-title":"Effect of antioxidants on the clinical outcome of patients with nasal polyposis","volume":"125","author":"Sagit","year":"2011","journal-title":"Journal of Laryngology & Otology"},{"issue":"200","key":"10.1002\/14651858.CD006991.pub2-BIB0012|cit12","first-page":"1","article-title":"Current estimates from the National Health Interview Survey, 1996","volume":"10","author":"Adams","year":"1999","journal-title":"Vital and Health Statistics. Series 10, Data from the National Health Survey"},{"issue":"5","key":"10.1002\/14651858.CD006991.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2500\/105065800781329573","article-title":"Nasal polyposis: from cytokines to growth","volume":"14","author":"Bachert","year":"2000","journal-title":"American Journal of Rhinology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/002221503321046577","article-title":"Nasal polyps: still more questions than answers","volume":"117","author":"Bateman","year":"2003","journal-title":"Journal of Laryngology and Otology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1001\/archotol.1993.01880200030004","article-title":"Bacterial allergy in nasal polyposis","volume":"119","author":"Calenoff","year":"1993","journal-title":"Archives of Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0017|cit17","first-page":"631","article-title":"Are nasal polyps an allergic phenomenon?","volume":"29","author":"Caplin","year":"1971","journal-title":"Annals of Allergy"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11882-013-0416-2","article-title":"Efficacy and safety of long-term antibiotics (macrolides) for the treatment of chronic rhinosinusitis","volume":"14","author":"Cervin","year":"2014","journal-title":"Current Allergy & Asthma Reports"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MOO.0b013e32835bc3f9","article-title":"Nasal polyposis: an inflammatory condition requiring effective anti-inflammatory treatment","volume":"21","author":"Chin","year":"2013","journal-title":"Current Opinion in Otolaryngology Head & Neck Surgery"},{"issue":"4","key":"10.1002\/14651858.CD006991.pub2-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/alr.21297","article-title":"The fungal microbiome in chronic rhinosinusitis: richness, diversity, postoperative changes and patient outcomes","volume":"4","author":"Cleland","year":"2014","journal-title":"International Forum of Allergy and Rhinology"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0021|cit21","first-page":"169","article-title":"Consensus report on acoustic rhinometry and rhinomanometry","volume":"43","author":"Clement","year":"2005","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0022|cit22","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0194-59989570152-4","article-title":"The health impact of chronic sinusitis in patients seeking otolaryngologic care","volume":"113","author":"Glicklich","year":"1995","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2500\/108854196778662192","article-title":"Hereditary factor for nasal polyps","volume":"17","author":"Greisner","year":"1996","journal-title":"Allergy and Asthma Proceedings"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0025|cit25","unstructured":"Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 Available from www.cochrane-handbook.org"},{"issue":"8","key":"10.1002\/14651858.CD006991.pub2-BIB0026|cit26","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1097\/01.mlg.0000230399.24306.50","article-title":"Complications of sinonasal surgery","volume":"116","author":"Hopkins","year":"2006","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1002\/14651858.CD006991.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clinical Otolaryngology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1017\/S002221510010177X","article-title":"Atopy and nasal polyposis","volume":"101","author":"Jamal","year":"1987","journal-title":"Journal of Laryngology and Otology"},{"issue":"7","key":"10.1002\/14651858.CD006991.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/000348940311200709","article-title":"Prevalence of nasal polyps in adults: the Skovde population based study","volume":"112","author":"Johansson","year":"2003","journal-title":"Annals of Otology, Rhinology, and Laryngology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2273.1997.00862.x","article-title":"A study of CT findings in 100 patients with rhinosinusitis and 100 controls","volume":"22","author":"Jones","year":"1997","journal-title":"Clinical Otolaryngology and Allied Sciences"},{"issue":"12","key":"10.1002\/14651858.CD006991.pub2-BIB0031|cit31","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006549.pub2","article-title":"Topical steroids for nasal polyps","author":"Kalish","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0032|cit32","first-page":"S1","article-title":"Prognostic factors, outcomes and staging in ethmoids sinus surgery","volume":"102","author":"Kennedy","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0033|cit33","unstructured":"Lange B Holst R Thilsing T Baelum J Kjeldsen A Quality of life and associated factors in persons with chronic rhinosinusitis in the general population Clinical Otolaryngology 10.1111\/coa.12189"},{"issue":"12","key":"10.1002\/14651858.CD006991.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1288\/00005537-198912000-00012","article-title":"Nasal polyps: epithelium and goblet cell density","volume":"99","author":"Larsen","year":"1989","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1002\/14651858.CD006991.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/00005537-200404000-00022","article-title":"Origin of nasal polyps: an endoscopic autopsy study","volume":"114","author":"Larsen","year":"2004","journal-title":"Laryngoscope"},{"issue":"S8","key":"10.1002\/14651858.CD006991.pub2-BIB0036|cit36","first-page":"31","article-title":"Surgical versus medical treatment of nasal polyps","volume":"27","author":"Lildholdt","year":"1989","journal-title":"Rhinology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/000348949510410s02","article-title":"Quantification for staging sinusitis","volume":"167","author":"Lund","year":"1995","journal-title":"Annals of Otology, Rhinology & Laryngology Supplement"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis","volume":"117","author":"Lund","year":"1997","journal-title":"Otolaryngology - Head and Neck Surgery"},{"issue":"7","key":"10.1002\/14651858.CD006991.pub2-BIB0039|cit39","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005232.pub3","article-title":"Oral steroids for nasal polyps","author":"Martinez-Devesa","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1002\/14651858.CD006991.pub2-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/BF00168498","article-title":"Prevalence and risk factors of chronic sinusitis in Korea: results of a nationwide survey","volume":"253","author":"Min","year":"1996","journal-title":"European Archives of Oto-rhino-laryngology"},{"issue":"3 Pt 1","key":"10.1002\/14651858.CD006991.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00005537-200003000-00017","article-title":"HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis","volume":"110","author":"Molnar-Gabor","year":"2000","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1002\/14651858.CD006991.pub2-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF03257167","article-title":"Targeting cysteinyl leukotrienes in patients with rhinitis, sinusitis and paranasal polyps","volume":"1","author":"Parnes","year":"2002","journal-title":"American Journal of Respiratory Medicine"},{"issue":"6","key":"10.1002\/14651858.CD006991.pub2-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11882-005-0027-7","article-title":"Pathogenesis of nasal polyps: an update","volume":"5","author":"Pawliczak","year":"2005","journal-title":"Current Allergy and Asthma Reports"},{"issue":"6","key":"10.1002\/14651858.CD006991.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2500\/105065895781808711","article-title":"Psychometric and Clinimetric Validity of the 31-Item Rhinosinusitis Outcome Measure (RSOM-31)","volume":"9","author":"Piccirillo","year":"1995","journal-title":"American Journal of Rhinology"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mhn.2002.121022","article-title":"Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20)","volume":"126","author":"Piccirillo","year":"2002","journal-title":"Otolaryngology - Head and Neck Surgery"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4065\/74.9.877","article-title":"The diagnosis and incidence of allergic fungal sinusitis","volume":"74","author":"Ponikau","year":"1999","journal-title":"Mayo Clinic Proceedings"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0091-6749(99)70117-X","article-title":"Quality of life in nasal polyposis","volume":"104","author":"Radenne","year":"1999","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0048|cit48","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014"},{"issue":"2","key":"10.1002\/14651858.CD006991.pub2-BIB0049|cit49","first-page":"75","article-title":"Epidemiological and clinical aspects of nasal polyps in France: the ORLI group experience","volume":"40","author":"Rugina","year":"2002","journal-title":"Rhinology"},{"issue":"5","key":"10.1002\/14651858.CD006991.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"975","DOI":"10.7326\/0003-4819-68-5-975","article-title":"Intolerance to aspirin. Clinical studies and consideration of its pathogenesis","volume":"68","author":"Samter","year":"1968","journal-title":"Annals of Internal Medicine"},{"issue":"11","key":"10.1002\/14651858.CD006991.pub2-BIB0051|cit51","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006990.pub2","article-title":"Surgical interventions for chronic rhinosinusitis with nasal polyps","author":"Sharma","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"22","key":"10.1002\/14651858.CD006991.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/jama.1997.03550220055009","article-title":"Nasal polyps and sinusitis","volume":"278","author":"Slavin","year":"1997","journal-title":"JAMA"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0053|cit53","volume-title":"Functional Endoscopic Sinus Surgery. The Messerklinger Technique","author":"Stammberger","year":"1991"},{"issue":"2","key":"10.1002\/14651858.CD006991.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0091-6749(93)90267-J","article-title":"Eosinophils in nasal polyps and nasal mucosa: an immunohistochemical study","volume":"91","author":"Stoop","year":"1993","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1002\/14651858.CD006991.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-4486.2011.02420.x","article-title":"The importance of side difference in nasal obstruction and rhinomanometry: a retrospective correlation of symptoms and rhinomanometry in 1000 patients","volume":"37","author":"Thulesius","year":"2012","journal-title":"Clinical Otolaryngology"},{"issue":"1","key":"10.1002\/14651858.CD006991.pub2-BIB0056|cit56","first-page":"5","article-title":"Results of oral steroid treatment in nasal polyposis","volume":"32","author":"Camp","year":"1994","journal-title":"Rhinology"},{"issue":"4","key":"10.1002\/14651858.CD006991.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jaci.2004.07.013","article-title":"Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis","volume":"114","author":"Zele","year":"2004","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1081-1206(10)62468-4","article-title":"Nasal polyposis: clinical course during 20 years","volume":"85","author":"Vento","year":"2000","journal-title":"Annals of Allergy, Asthma and Immunology"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2500\/105065800782102717","article-title":"Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage","volume":"14","author":"Yamada","year":"2000","journal-title":"American Journal of Rhinology"},{"issue":"3","key":"10.1002\/14651858.CD006991.pub2-BIB0060|cit60","first-page":"162","article-title":"An update on the impact of staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis","volume":"43","author":"Zhang","year":"2005","journal-title":"Rhinology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD006991.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T07:07:21Z","timestamp":1719040041000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD006991.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane ENT Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":60,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd006991.pub2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725255847.793522787","asserted-by":"object"}]},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}