{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:47:06Z","timestamp":1767134826867,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd007065","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T00:00:00Z","timestamp":1223424000000}}],"reference-count":48,"publisher":"Wiley","issue":"11","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007065.pub2","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T21:07:07Z","timestamp":1223500027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interventions for heartburn in pregnancy"],"prefix":"10.1002","volume":"2015","author":[{"given":"James P","family":"Neilson","sequence":"first","affiliation":[{"name":"The University of Liverpool; Department of Women's and Children's Health; First Floor, Liverpool Women's NHS Foundation Trust Crown Street Liverpool UK L8 7SS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,8]]},"reference":[{"key":"10.1002\/14651858.CD007065.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1471-0528.1961.tb02824.x","article-title":"The use of prostigmine in the heartburn of pregnancy","volume":"63","author":"Bower","year":"1961","journal-title":"Journal of Obstetrics and Gynaecology of the British Commonwealth"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0020-7292(99)00020-X","article-title":"Antacids vs antacids plus non-prescription ranitidine for heartburn during pregnancy","volume":"66","author":"Rayburn","year":"1999","journal-title":"International Journal of Gynecology & Obstetrics"},{"issue":"11","key":"10.1002\/14651858.CD007065.pub2-BIB0003|cit3","first-page":"680","article-title":"Pyrosis and pregnancy","volume":"13","author":"Reisfield","year":"1971","journal-title":"Current Therapeutic Research, Clinical & Experimental"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0004|cit4","doi-asserted-by":"crossref","unstructured":"Atlay RD Weekes ARL Entwistle GD Parkinson DJ Treating heartburn in pregnancy: comparison of acid and alkali mixtures BMJ 1978 919 20","DOI":"10.1136\/bmj.2.6142.919"},{"issue":"4","key":"10.1002\/14651858.CD007065.pub2-BIB0005|cit5","first-page":"167","article-title":"Heartburn in pregnancy - a continuation study","volume":"26","author":"Briggs","year":"1972","journal-title":"British Journal of Clinical Practice"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0006|cit6","unstructured":"Brunclik V Privrel T Double-blind comparison of an oxetacain-antacid combination against the antacid alone in the treatment of heartburn in pregnancy Schweizerische Rundschau fur Medizin Praxis 1988 587 91"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0007|cit7","first-page":"135","article-title":"Double-blind trial of mucaine in heartburn of pregnancy","volume":"8","author":"Carne","year":"1964","journal-title":"Journal of the College of General Practitioners"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0008|cit8","doi-asserted-by":"crossref","unstructured":"Hey VMF Ostick DG Metoclopramide and the gastro-oesophageal sphincter - a study in pregnant women with heartburn Anaesthesia 1978 462 5","DOI":"10.1111\/j.1365-2044.1978.tb12465.x"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1447-0756.1990.tb00361.x","article-title":"Is mucaine an appropriate medication for the relief of heartburn during pregnancy?","volume":"16","author":"Kovacs","year":"1990","journal-title":"Asia-Oceania Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0010|cit10","first-page":"48","article-title":"Comparative study of algicon suspension and magnesium trisilicate mixture in the treatment of reflux dyspepsia of pregnancy","volume":"66","author":"Lang","year":"1989","journal-title":"British Journal of Clinical Practice"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD007065.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S0002-9378(97)80122-6","article-title":"Double-blind, placebo controlled study of ranitidine (zantac(r)) for gastroesophageal reflux symptoms during pregnancy","volume":"176","author":"Larson","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0029-7844(97)00126-9","article-title":"Double-blind, placebo-controlled study of ranitidine for gastroesophageal reflux symptoms during pregnancy","volume":"90","author":"Larson","year":"1997","journal-title":"Obstetrics & Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0013|cit13","first-page":"91","article-title":"Sucralfate in the treatment of pregnancy pyrosis","volume":"12","author":"Ranchet","year":"1990","journal-title":"Giornale Italiano di Ostetricia e Ginecologia"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/030006057800600215","article-title":"Randomized controlled trial of Syn-Ergel and an active placebo in the treatment of heartburn of pregnancy","volume":"6","author":"Shaw","year":"1978","journal-title":"Journal of International Medical Research"},{"issue":"2","key":"10.1002\/14651858.CD007065.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/aim.2009.000497","article-title":"Acupuncture for dyspepsia in pregnancy: a prospective, randomised, controlled study","volume":"27","author":"Silva","year":"2009","journal-title":"Acupuncture in Medicine"},{"issue":"1 Pt 2","key":"10.1002\/14651858.CD007065.pub2-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1016\/S0002-9378(97)80718-1","article-title":"Does chewing gum reduce pregnancy associated heartburn?","volume":"176","author":"Marks","year":"1997","journal-title":"American Journal of Obstetrics and Gynecology"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0017|cit17","first-page":"1","article-title":"Prevalence of gastrointestinal symptoms in pregnancy","volume":"9","author":"Audu","year":"2006","journal-title":"Nigerian Journal of Clinical Practice"},{"issue":"4","key":"10.1002\/14651858.CD007065.pub2-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0889-8553(21)00600-2","article-title":"Gastroesophageal reflux disease in pregnancy","volume":"21","author":"Baron","year":"1992","journal-title":"Gastroenterology Clinics of North America"},{"issue":"6","key":"10.1002\/14651858.CD007065.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1471-0528.1977.tb12619.x","article-title":"Pregnancy heartburn in Nigerians and Caucasians with theories about aetiology based on manometric recordings from the oesophagus and stomach","volume":"84","author":"Bassey","year":"1977","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0020|cit20","first-page":"501","article-title":"Symptoms in pregnancy:nausea and vomiting, heartburn, constipation and leg cramps","volume-title":"Effective care in pregnancy and childbirth","volume":"1","author":"Bracken","year":"1990"},{"issue":"6334","key":"10.1002\/14651858.CD007065.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/bmj.285.6334.61-b","article-title":"Heartburn in pregnancy","volume":"285","author":"Brock-Utne","year":"1982","journal-title":"British Medical Journal Clinical Research Ed."},{"issue":"2","key":"10.1002\/14651858.CD007065.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0091-2182(88)90162-0","article-title":"Management of common minor discomforts in pregnancy. Part III: Managing gastrointestinal problems in pregnancy","volume":"33","author":"Brucker","year":"1988","journal-title":"Journal of Nurse-Midwifery"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1041-2972.2005.00003.x","article-title":"The role of proton pump inhibitors in the treatment of heartburn during pregnancy","volume":"17","author":"Christopher","year":"2005","journal-title":"Journal of the American Academy of Nurse Practitioners"},{"issue":"6328","key":"10.1002\/14651858.CD007065.pub2-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1136\/bmj.284.6328.1560-b","article-title":"Heartburn in pregnancy","volume":"284","author":"Cochrane","year":"1982","journal-title":"British Medical Journal Clinical Research Ed."},{"key":"10.1002\/14651858.CD007065.pub2-BIB0025|cit25","doi-asserted-by":"crossref","DOI":"10.1002\/9780470693926.ch15","article-title":"Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis","volume-title":"Systematic reviews in health care: meta-analysis in context","author":"Deeks","year":"2001"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0026|cit26","doi-asserted-by":"crossref","unstructured":"Diav-Citrin O Arnon J Shechtman S Schaefer C van Tonningen MR Clementi M The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled study Alimentary Pharmacology & Therapeutics 2005 269 75","DOI":"10.1111\/j.1365-2036.2005.02306.x"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0027|cit27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"6323","key":"10.1002\/14651858.CD007065.pub2-BIB0028|cit28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/bmj.284.6323.1138","article-title":"Heartburn in pregnancy","volume":"284","author":"Feeney","year":"1982","journal-title":"British Medical Journal Clinical Research Ed."},{"issue":"6","key":"10.1002\/14651858.CD007065.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0016-5085(78)90698-4","article-title":"Altered lower esophageal sphincter function during early pregnancy","volume":"74","author":"Fisher","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0030|cit30","doi-asserted-by":"crossref","unstructured":"Garbis H Elefant E Diav-Citrin O Mastroiacovo P Schaefer C Vial T Pregnancy outcome after exposure to ranitidine and other H2-blockers. A collaborative study of the European Network of Teratology Information Services Reproductive Toxicology 2005 453 8","DOI":"10.1016\/j.reprotox.2004.09.002"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0031|cit31","unstructured":"Gates S Methodological Guidelines In: the Editorial Team. Pregnancy and Childbirth Group. About the Cochrane Collaboration (Collaborative Review Groups (CRGs) 2005, Issue 2"},{"issue":"7","key":"10.1002\/14651858.CD007065.pub2-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.5694\/j.1326-5377.2005.tb06735.x","article-title":"Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy.[see comment]","volume":"182","author":"Gordon","year":"2005","journal-title":"Medical Journal of Australia"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0033|cit33","first-page":"1","article-title":"Heartburn in pregnancy","volume":"6 Suppl 1","author":"Hart","year":"1978","journal-title":"Journal of International Medical Research"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0034|cit34","doi-asserted-by":"crossref","unstructured":"Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 5.0.0 [updated February 2008] Available from www.cochrane-handbook.org 2008","DOI":"10.1002\/9780470712184"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0035|cit35","doi-asserted-by":"crossref","unstructured":"Kallen BA Use of omeprazole during pregnancy--no hazard demonstrated in 955 infants exposed during pregnancy European Journal of Obstetrics, Gynecology, & Reproductive Biology 2001 63 8","DOI":"10.1016\/S0301-2115(00)00388-2"},{"issue":"1","key":"10.1002\/14651858.CD007065.pub2-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0028-2243(95)02069-1","article-title":"Upper gastrointestinal symptoms in the third trimester of the normal pregnancy","volume":"60","author":"Knudsen","year":"1995","journal-title":"European Journal of Obstetrics and Gynecology & Reproductive Biology"},{"issue":"9","key":"10.1002\/14651858.CD007065.pub2-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1471-0528.1992.tb13873.x","article-title":"Determinants of pregnancy heartburn","volume":"99","author":"Marrero","year":"1992","journal-title":"British Journal of Obstetrics and Gynaecology"},{"issue":"11","key":"10.1002\/14651858.CD007065.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/BF01071906","article-title":"Symptomatic gastroesophageal reflux: incidence and precipitating factors","volume":"21","author":"Nebel","year":"1976","journal-title":"American Journal of Digestive Diseases"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0039|cit39","doi-asserted-by":"crossref","unstructured":"Nelson MM Forfar JO Associations between drugs administered during pregnancy and congenital abnormalities of the fetus British Medical Journal 1971 523 7","DOI":"10.1136\/bmj.1.5748.523"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0040|cit40","doi-asserted-by":"crossref","unstructured":"Nielsen GL Sorensen HT Thulstrup AM Tage-Jensen U Olesen C Ekbom A The safety of proton pump inhibitors in pregnancy Alimentary Pharmacology & Therapeutics 1999 1085 9","DOI":"10.1046\/j.1365-2036.1999.00578.x"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0041|cit41","doi-asserted-by":"crossref","unstructured":"Nikfar S Abdollahi M Moretti ME Magee LA Koren G Nikfar S Use of proton pump inhibitors during pregnancy and rates of major malformations: a meta-analysis Digestive Diseases & Sciences 2002 1526 9","DOI":"10.1023\/A:1015863018105"},{"issue":"9","key":"10.1002\/14651858.CD007065.pub2-BIB0042|cit42","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011379.pub2","article-title":"Interventions for heartburn in pregnancy","author":"Phupong","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0043|cit43","unstructured":"The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2008"},{"issue":"9","key":"10.1002\/14651858.CD007065.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1365-2036.2005.02654.x","article-title":"Review article: the management of heartburn in pregnancy","volume":"22","author":"Richter","year":"2005","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0045|cit45","doi-asserted-by":"crossref","unstructured":"Ruigomez A Garcia Rodriguez LA Cattaruzzi C Troncon MG Agostinis L Wallander MA Use of cimetidine, omeprazole, and ranitidine in pregnant women and pregnancy outcomes American Journal of Epidemiology 1999 476 81","DOI":"10.1093\/oxfordjournals.aje.a010036"},{"issue":"4 Pt 1","key":"10.1002\/14651858.CD007065.pub2-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0016-5085(77)80151-0","article-title":"Heartburn of pregnancy","volume":"72","author":"Thiel","year":"1977","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1002\/14651858.CD007065.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0002-9378(81)90037-5","article-title":"Evidence refuting a role for increased abdominal pressure in the pathogenesis of the heartburn associated with pregnancy","volume":"140","author":"Thiel","year":"1981","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1002\/14651858.CD007065.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1067\/S0002-9378(03)00486-1","article-title":"Helicobacter pylori infection and the occurrence and severity of gastrointestinal symptoms during pregnancy","volume":"189","author":"Weyermann","year":"2003","journal-title":"American Journal of Obstetrics and Gynecology"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD007065.pub2\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:32:09Z","timestamp":1705293129000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007065.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Pregnancy and Childbirth Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2008,10,8]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007065.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,8]]}}}