{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:33:39Z","timestamp":1790681619829,"version":"4.1.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007077.pub3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000}}],"reference-count":231,"publisher":"Wiley","issue":"8","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007077.pub4","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T10:15:03Z","timestamp":1630318503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Partial breast irradiation versus whole breast radiotherapy for early breast cancer"],"prefix":"10.1002","volume":"2021","author":[{"given":"Brigid E","family":"Hickey","sequence":"additional","affiliation":[{"name":"Radiation Oncology Raymond Terrace; Princess Alexandra Hospital; Brisbane Australia"},{"name":"School of Medicine; The University of Queensland; Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Lehman","sequence":"additional","affiliation":[{"name":"School of Medicine; The University of Queensland; Brisbane Australia"},{"name":"Division of Cancer Services; Princess Alexandra Hospital; Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00066-014-0556-x","article-title":"Partial breast irradiation with intraoperative electrons versus conventional external whole breast irradiation for early breast cancer. Results of the ELIOT trial","volume":"190","author":"Fastner","year":"2014","journal-title":"Strahlentherpie und Onkologie"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0002|cit2","unstructured":"Randomized clinical trial: comparison between quadrantectomy followed by external fractionated radiotherapy and quadrantectomy associated with intraoperative radiotherapy in women >= 48 years of age affected by early-stage breast carcinoma clinicaltrials.gov\/ct2\/show\/NCT01849133"},{"issue":"13","key":"10.1002\/14651858.CD007077.pub4-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S1470-2045(13)70497-2","article-title":"Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised equivalence trial","volume":"14","author":"Veronesi","year":"2013","journal-title":"Lancet Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0004|cit4","unstructured":"European Brachytherapy Breast Cancer GEC-ESTRO Working Group Interstitial brachytherapy alone versus external beam radiation therapy after breast conserving surgery for low risk invasive carcinoma and low risk duct carcinoma in-situ (DCIS) of the female breast (Study protocol) clinicaltrials.gov"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0005|cit5","unstructured":"APBI versus EBRT therapy after breast conserving surgery for low-risk breast cancer clinicaltrials.gov\/ct2\/show\/NCT00402519"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0006|cit6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.radonc.2016.06.019","article-title":"GEC-ESTRO multicenter phase 3-trial: accelerated partial breast irradiation with interstitial multicatheter brachytherapy versus external beam whole breast irradiation: early toxicity and patient compliance","volume":"120","author":"Ott","year":"2016","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0007|cit7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S1470-2045(17)30011-6","article-title":"Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial","volume":"18","author":"Polg\u00e1r","year":"2017","journal-title":"Lancet Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0008|cit8","first-page":"S47","article-title":"Incidences of late toxicities and cosmetic results after accelerated partial breast irradiation with multi-catheter brachytherapy or whole breast irradiation: 5-year results of the GEC-ESTRO Phase III APBI trial brachytherapy","volume":"15","author":"Polg\u00e1r","year":"2016","journal-title":"World Congress of Brachytherapy Conference Publication"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"S230","DOI":"10.1016\/S0167-8140(16)31730-3","article-title":"Late toxicity and cosmesis after APBI with brachytherapy vs WBI: 5-year results of a phase III trial","volume":"2016","author":"Polg\u00e1r","year":"2016","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1470-2045(18)30195-5","article-title":"Quality-of-life results for accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation in early breast cancer after breast-conserving surgery (GEC-ESTRO): 5-year results of a randomised, phase 3 trial","volume":"19","author":"Sch\u00e4fer","year":"2018","journal-title":"Lancet Oncology"},{"issue":"S1","key":"10.1002\/14651858.CD007077.pub4-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0167-8140(18)30636-4","article-title":"QOL after APBI (multicatheter brachytherapy) versus WBI: 5-year results, phase 3 GEC-ESTRO Trial","volume":"127","author":"Schafer","year":"2018","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0012|cit12","first-page":"153","article-title":"5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial","volume":"27","author":"Strnad","year":"2016","journal-title":"Breast Diseases"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(15)00471-7","article-title":"5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial","volume":"387","author":"Strnad","year":"2016","journal-title":"Lancet"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD007077.pub4-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0167-8140(12)72055-8","article-title":"First clinical results of the GEC-ESTRO breast WG phase III multicentric PBI\/APBI trial","volume":"103","author":"Strnad","year":"2012","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.brachy.2016.04.013","article-title":"Accelerated partial breast irradiation (APBI) using sole interstitial multicatheter brachytherapy-GECESTRO phase III non-inferiority trial: subanalysis of 5-year results reflecting current GEC-ESTRO and ASTRO recommendations for patient selection","volume":"15","author":"Strnad","year":"2016","journal-title":"Brachytherapy"},{"issue":"11","key":"10.1002\/14651858.CD007077.pub4-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.ejca.2015.04.008","article-title":"In regard to Livi et al. \"Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5 year survival analysis of a phase 3 randomised controlled trial\"","volume":"51","author":"Bhattacharjee","year":"2015","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.radonc.2019.01.036","article-title":"Can patient-reported outcomes be used instead of clinician-reported outcomes and photographs as primary endpoints of late normal tissue effects in breast radiotherapy trials? Results from the IMPORT LOW trial","volume":"134","author":"Bhattacharya","year":"2019","journal-title":"Radiotherapy and Oncology"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0018|cit18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1200\/JCO.18.00982","article-title":"Patient-reported outcomes over 5 years after whole- or partial-breast radiotherapy: longitudinal analysis of the IMPORT LOW (CRUK\/06\/003) phase III randomized controlled trial","volume":"37","author":"Bhattacharya","year":"2019","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/S0167-8140(18)30466-3","article-title":"Concordance of patient reported outcomes with clinician and photographic assessments in IMPORT LOW","volume":"3","author":"Bhattacharya","year":"2018","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0959-8049(18)30265-X","article-title":"A longitudinal analysis of patient reported outcomes over 5 years in the IMPORT LOW (partial breast radiotherapy after breast conservation surgery) phase III randomised controlled trial","volume":"92","author":"Bhattacharya","year":"2018","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0021|cit21","first-page":"S4","article-title":"Partial breast radiotherapy for women with early breast cancer: first results of local recurrence data for IMPORT LOW (CRUK\/06\/003)","volume":"2","author":"Coles","year":"2016","journal-title":"European Journal of Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0022|cit22","first-page":"S80","article-title":"Randomised trial testing intensity modulated radiotherapy and partial organ radiotherapy in early breast cancer (import trial)","volume":"91","author":"Coles","year":"2004","journal-title":"British Journal of Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1016\/S0167-8140(17)30756-9","article-title":"Partial breast irradiation after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK\/06\/003) phase III trial","volume":"123","author":"Coles","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0024|cit24","first-page":"0454","article-title":"Partial breast radiotherapy for women with early breast cancer: first analysis of late cosmesis adverse events from IMPORT LOW (CRUK\/06\/003)","volume":"50","author":"Coles","year":"2014","journal-title":"European Journal of Cancer"},{"issue":"8","key":"10.1002\/14651858.CD007077.pub4-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.clon.2006.07.010","article-title":"The IMPORT trials are launched (September 2006)","volume":"18","author":"Coles","year":"2006","journal-title":"Clinical Oncology"},{"issue":"10099","key":"10.1002\/14651858.CD007077.pub4-BIB0026|cit26","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","article-title":"Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial","volume":"390","author":"Coles","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"10.1002\/14651858.CD007077.pub4-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.ejso.2008.09.005","article-title":"Titanium clip placement to allow accurate tumour bed localisation following breast conserving surgery: audit on behalf of the IMPORT Trial Management Group","volume":"35","author":"Coles","year":"2009","journal-title":"European Journal of Surgical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0028|cit28","unstructured":"Radiation therapy in treating women with early-stage breast cancer who have undergone breast conservation therapy clinicaltrials.gov\/ct2\/show\/NCT00983684"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ijrobp.2009.04.070","article-title":"Accelerated partial breast irradiation with IMRT: new technical approach and interim analysis of acute toxicity in a phase III randomized controlled trial","volume":"77","author":"Livi","year":"2010","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0030|cit30","first-page":"S5","article-title":"Accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation: 5-year survival results of a phase 3 randomized trial","volume":"75","author":"Livi","year":"2015","journal-title":"Cancer Research"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0031|cit31","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ejca.2014.","article-title":"Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year analysis of a phase 3 randomised controlled trial","volume":"51","author":"Livi","year":"2015","journal-title":"European Journal of Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0032|cit32","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0167-8140(12)70470-X","article-title":"Accelerated partial breast irradiation with IMRT: 3-years interim analysis of a phase III randomised clinical trial","volume":"103","author":"Livi","year":"2012","journal-title":"Radiotherapy and Oncology"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1016\/S0959-8049(12)70532-4","article-title":"Accelerated partial breast irradiation with intensity-modulated radiotherapy (IMRT): the Florence phase III randomized clinical trial at 3 years median follow-up","volume":"48","author":"Livi","year":"2012","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/S0167-8140(15)40042-8","article-title":"APBI versus whole breast irradiation in women age 70 years or older: a subgroup analysis of a phase 3 randomised trial","volume":"115","author":"Meattini","year":"2015","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10549-015-3565-2","article-title":"Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomised phase 3 trial","volume":"153","author":"Meattini","year":"2015","journal-title":"Breast Cancer Research and Treatment"},{"issue":"35","key":"10.1002\/14651858.CD007077.pub4-BIB0036|cit36","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1200\/JCO.20.00650","article-title":"Accelerated partial-breast irradiation compared with whole-breast irradiation for early breast cancer: long-term results of the randomized phase III APBI-IMRT-Florence trial","volume":"38","author":"Meattini","year":"2020","journal-title":"Journal of Clinical Oncology"},{"issue":"11","key":"10.1002\/14651858.CD007077.pub4-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s11547-015-0541-1","article-title":"Four-dimensional computed tomography in accelerated partial breast irradiation planning: single series from a phase III trial","volume":"120","author":"Meattini","year":"2015","journal-title":"Radiologica Medicina"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0038|cit38","first-page":"S1","article-title":"Accelerated partial breast irradiation versus whole breast irradiation: short term quality of life results from a phase 3 trial","volume":"76","author":"Meattini","year":"2016","journal-title":"Cancer Research"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0039|cit39","first-page":"S1","article-title":"Accelerated partial breast irradiation versus whole breast irradiation: short term quality of life results from a phase 3 trial","volume":"76","author":"Meattini","year":"2016","journal-title":"Cancer Research"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0040|cit40","first-page":"S47","article-title":"Accelerated partial breast irradiation versus whole breast radiotherapy: quality of life results from a phase 3 randomized trial and focus on patients aged 70 years or older","volume":"2","author":"Meattini","year":"2016","journal-title":"European Journal of Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1016\/S0167-8140(16)31762-5","article-title":"Accelerated partial breast irradiation for luminal-a breast cancer: analysis from a phase 3 trial","volume":"119","author":"Meattini","year":"2016","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0042|cit42","first-page":"4","article-title":"Accelerated partial breast or whole breast irradiation after breast conservation surgery for patients with early breast cancer: 10-year follow up results of the APBI IMRT Florence randomized phase 3 trial","volume":"80","author":"Meattini","year":"2019","journal-title":"Cancer Research"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10549-015-3565-2","article-title":"Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial","volume":"153","author":"Meattini","year":"2015","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejca.2017.01.023","article-title":"Accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation: health-related quality of life final analysis from the Florence phase 3 trial","volume":"76","author":"Meattini","year":"2017","journal-title":"European Journal of Cancer"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0045|cit45","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0959-8049(17)30106-5","article-title":"Health-related quality of life analysis from the accelerated partial breast irradiation IMRT-Florence phase 3 trial: impact of age and scores trend over time","volume":"72","author":"Meattini","year":"2017","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0046|cit46","unstructured":"Randomised phase II trial of accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation clinicaltrials.gov\/ct2\/show\/NCT02104895"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/j.ijrobp.2006.07.351","article-title":"Magnetic resonance imaging (MRI) identifies multifocal and multicentric disease in breast cancer patients eligible for the NSABP B-39\/RTOG 0413 partial breast irradiation (PBI) trial","volume":"66","author":"Al-Hallaq","year":"2006","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"10","key":"10.1002\/14651858.CD007077.pub4-BIB0048|cit48","first-page":"719","article-title":"NSABP B-39, RTOG 0413: a randomized phase III study of conventional whole breast irradiation versus partial breast irradiation for women with stage 0, I, or II breast cancer","volume":"4","year":"2006","journal-title":"Clinical Advances in Hematology & Oncology"},{"issue":"3 Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"S735","DOI":"10.1016\/j.ijrobp.2007.07.2287","article-title":"The effect of tumor bed location on heart dosimetry for 3-D conformal partial breast irradiation and whole breast irradiation","volume":"69","author":"Gale","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0050|cit50","first-page":"508","article-title":"Patient-reported outcomes (PROs) in NRG oncology\/NSABP B-39\/RTOG 0413: a randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) in stage 0, I, or II breast cancer","volume":"37","author":"Ganz","year":"2019","journal-title":"Journal of Oncology"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0051|cit51","doi-asserted-by":"crossref","first-page":"S622","DOI":"10.1016\/j.ijrobp.2007.07.1949","article-title":"Analysis of biologically equivalent lung tissue dose for 3-D conformal partial breast irradiation and whole breast irradiation","volume":"69","author":"Jain","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijrobp.2008.10.041","article-title":"Does three-dimensional external beam partial breast irradiation spare lung tissue compared with standard whole breast irradiation?","volume":"75","author":"Jain","year":"2009","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0053|cit53","doi-asserted-by":"crossref","unstructured":"Julian TB A randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, or II breast cancer. NSABP B-39\/RTOG 0413 Cancer Research 2014 71 S24 3","DOI":"10.1158\/0008-5472.SABCS11-OT2-06-02"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1200\/jco.2011.29.15_suppl.1011","article-title":"Early toxicity results with 3D conformal external beam therapy (CEBT) from the NSABP B-39\/RTOG 0413 accelerated partial breast irradiation (APBI) trial","volume":"29","author":"Julian","year":"2011","journal-title":"Journal of Clinical Oncology"},{"issue":"12","key":"10.1002\/14651858.CD007077.pub4-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1118\/1.2799579","article-title":"Dosimetric comparison of partial and whole breast external beam irradiation in the treatment of early stage breast cancer","volume":"34","author":"Kim","year":"2007","journal-title":"Medical Physics"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"301","DOI":"10.6004\/jnccn.2005.0017","article-title":"Partial-breast irradiation for early staged breast cancers: hypothesis, existing data, and a planned phase III trial","volume":"3","author":"McCormick","year":"2005","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0057|cit57","unstructured":"Radiation therapy (WBI versus PBI) in treating women who have undergone surgery for ductal carcinoma in situ or stage I or stage II breast cancer clinicaltrials.gov\/ct2\/show\/NCT00103181"},{"issue":"8","key":"10.1002\/14651858.CD007077.pub4-BIB0058|cit58","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1002\/cncr.24172","article-title":"Preoperative breast magnetic resonance imaging in early breast cancer: implications for partial breast irradiation","volume":"115","author":"Tendulkar","year":"2009","journal-title":"Cancer"},{"issue":"10215","key":"10.1002\/14651858.CD007077.pub4-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/S0140-6736(19)32514-0","article-title":"Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial","volume":"394","author":"Vicini","year":"2019","journal-title":"Lancet"},{"issue":"4 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0060|cit60","first-page":"GS4","article-title":"Primary results of NSABP B-39\/RTOG 0413 (NRG Oncology): a randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, or II breast cancer","volume":"79","author":"Vicini","year":"2019","journal-title":"Cancer Research"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2019.06.384","article-title":"Cosmetic outcome from post lumpectomy whole breast irradiation (WBI) versus partial breast irradiation (PBI) on the NRG Oncology\/NSABP B39-RTOG 0413 phase III clinical trial","volume":"105","author":"White","year":"2019","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0062|cit62","first-page":"S3, no. 5","article-title":"Cosmetic outcome from post lumpectomy whole breast irradiation (WBI) versus partial breast irradiation (PBI) on the NRG Oncology\/NSABP B39-RTOG 0413 phase III clinical trial","volume":"105","author":"White","year":"2019","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ijrobp.2007.03.055","article-title":"Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy - 4 year results of a randomized trial","volume":"69","author":"L\u00f6vey","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0167-8140(05)80007-6","article-title":"Incidence of fat necrosis following whole breast radiotherapy versus partial breast irradiation: results of the Budapest partial breast irradiation trial","volume":"75","author":"Lovey","year":"2005","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ijrobp.2007.04.022","article-title":"Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast cancer - 5-year results of a randomized trial","volume":"69","author":"Polg\u00e1r","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.radonc.2013.05.008","article-title":"Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial","volume":"108","author":"Polg\u00e1r","year":"2013","journal-title":"Radiotherapy and Oncology"},{"issue":"Suppl 2","key":"10.1002\/14651858.CD007077.pub4-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0167-8140(12)72054-6","article-title":"Breast-conserving therapy with partial or whole breast radiation: 10-year results of the Budapest randomized trial","volume":"103","author":"Polg\u00e1r","year":"2012","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S0167-8140(15)30265-6","article-title":"Toxicity and cosmetic results of partial vs whole breast irradiation: 10-year results of a randomized trial","volume":"111","author":"Polg\u00e1r","year":"2014","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0069|cit69","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jso.10110","article-title":"Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a phase I-II study and initial findings of a randomized phase III trial","volume":"80","author":"Polg\u00e1r","year":"2002","journal-title":"Journal of Surgical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ijrobp.2004.05.012","article-title":"High-dose-rate brachytherapy alone versus whole breast radiotherapy with or without tumour bed boost after breast-conserving surgery: seven-year results of a comparative study","volume":"60","author":"Polgar\u0301","year":"2004","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"6","key":"10.1002\/14651858.CD007077.pub4-BIB0071|cit71","first-page":"867","article-title":"Aesthetic outcome after breast conserving surgery and either intraoperative radiotherapy or whole breast external beam radiotherapy for early breast cancer: objective assessment of patients in a randomized controlled trial in Lublin, Poland","volume":"38","author":"Williams","year":"2017","journal-title":"European Journal of Gynaecological Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0072|cit72","unstructured":"3D conformal Radiation therapy for Accelerated Partial breast IrraDiation (RAPID) trial www.isrctn.com\/ISRCTN62704822"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0073|cit73","unstructured":"RAPID: randomized trial of accelerated partial breast irradiation clinicaltrials.gov\/ct2\/show\/NCT00282035"},{"issue":"32","key":"10.1002\/14651858.CD007077.pub4-BIB0074|cit74","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1200\/JCO.2013.50.5511","article-title":"Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy","volume":"31","author":"Olivotto","year":"2013","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.ijrobp.2014.12.040","article-title":"Predictors of adverse cosmetic outcome in the RAPID trial: an exploratory analysis","volume":"91","author":"Peterson","year":"2015","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"6","key":"10.1002\/14651858.CD007077.pub4-BIB0076|cit76","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00066-020-01609-9","article-title":"Reducing the risk of ipsilateral breast tumor relapse: external beam accelerated partial breast irradiation following breast-conserving surgery in patients with ductal carcinoma in situ and cancer: the multicentric randomised RAPID trial","volume":"196","author":"Souchon","year":"2020","journal-title":"Strahelentherapie und Onkologie"},{"issue":"4 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0077|cit77","first-page":"GS4","article-title":"RAPID: a randomized trial of accelerated partial breast irradiation using 3-dimensional conformal radiotherapy (3D-CRT)","volume":"79","author":"Whelan","year":"2019","journal-title":"Cancer Research"},{"issue":"10215","key":"10.1002\/14651858.CD007077.pub4-BIB0078|cit78","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0140-6736(19)32515-2","article-title":"External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial","volume":"394","author":"Whelan","year":"2019","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0079|cit79","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.ijrobp.2013.08.046","article-title":"Five-year outcomes, cosmesis, and toxicity with 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation","volume":"87","author":"Rodr\u00edguez","year":"2013","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"Suppl 1","key":"10.1002\/14651858.CD007077.pub4-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"S400","DOI":"10.1016\/S0167-8140(12)71351-8","article-title":"Phase III study comparing accelerated partial breast irradiation vs whole breast radiation therapy using 3D-CRT","volume":"103","author":"Rodr\u00edguez","year":"2012","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0081|cit81","first-page":"S201","article-title":"Phase III study comparing accelerated partial breast irradiation vs whole breast irradiation using 3D-CRT. Interim analysis","volume":"88","author":"Rodr\u00edguez","year":"2008","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0082|cit82","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/j.ijrobp.2012.07.230","article-title":"Interim cosmetic results and toxicity using 3D conformal external beam radiation therapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer","volume":"84","author":"Rodriguez de Dios","year":"2012","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1016\/j.ijrobp.2016.06.635","article-title":"Intraoperative (IORT) versus whole-breast radiation therapy (WBRT) for early breast cancer: single-center results from the randomized phase 3 TARGIT-A trial A","volume":"96","author":"Abo-Madyan","year":"2016","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.breast.2011.07.011","article-title":"Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: a randomized trial","volume":"21","author":"Andersen","year":"2012","journal-title":"Breast"},{"issue":"9976","key":"10.1002\/14651858.CD007077.pub4-BIB0085|cit85","first-page":"1396","article-title":"Erratum: radiotherapy for breast cancer, the TARGIT-A trial (The Lancet (2014) 383(9930) (1716)","volume":"385","year":"2015","journal-title":"Lancet"},{"issue":"9735","key":"10.1002\/14651858.CD007077.pub4-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0140-6736(10)60837-9","article-title":"Erratum: targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial","volume":"376","year":"2010","journal-title":"Lancet"},{"issue":"18 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"Abstract LBA517","DOI":"10.1200\/jco.2010.28.18_suppl.lba517","article-title":"Safety and efficacy of targeted intraoperative radiotherapy (TARGIT) for early breast cancer: first report of a randomized controlled trial at 10-years maximum follow-up","volume":"28","author":"Baum","year":"2010","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0088|cit88","first-page":"S95","article-title":"TARGIT-A trial (targeted intraoperative radiotherapy): updated analysis of local recurrence","volume":"22","author":"Baum","year":"2013","journal-title":"Breast"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0089|cit89","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijrobp.2016.04.024","article-title":"Cosmesis and breast-related quality of life outcomes after intraoperative radiation therapy for early breast cancer: a substudy of the TARGIT-A trial","volume":"96","author":"Corica","year":"2016","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0090|cit90","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13014-018-0998-x","article-title":"Cosmetic outcome as rated by patients, doctors, nurses and BCCT core software assessed over 5 years in a subset of patients in the TARGIT-A Trial","volume":"13","author":"Corica","year":"2018","journal-title":"Radiation Oncology"},{"issue":"S5","key":"10.1002\/14651858.CD007077.pub4-BIB0091|cit91","first-page":"106","article-title":"Patient preferences for adjuvant radiotherapy - outcomes from the TARGIT - a study in Western Australia","volume":"12","author":"Corica","year":"2016","journal-title":"Asia-Pacific Journal of Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0092|cit92","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.amjsurg.2007.06.018","article-title":"The TARGIT trial: targeted intraoperative radiation therapy versus conventional postoperative whole-breast radiotherapy after breast-conserving surgery for the management of early-stage invasive breast cancer (a trial update)","volume":"194","author":"Holmes","year":"2007","journal-title":"American Journal of Surgery"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0093|cit93","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/S0167-8140(12)71977-1","article-title":"TARGIT","volume":"103 Suppl 2","author":"Joseph","year":"2012","journal-title":"Radiotherapy and Oncology"},{"issue":"15","key":"10.1002\/14651858.CD007077.pub4-BIB0094|cit94","first-page":"S1","article-title":"Cosmetic outcome after intraoperative radiotherapy or external beam radiotherapy for early breast cancer: an objective assessment of patients from a randomized controlled trial","volume":"31","author":"Keshtgar","year":"2013","journal-title":"Journal of Clinical Oncology"},{"issue":"24S","key":"10.1002\/14651858.CD007077.pub4-BIB0095|cit95","first-page":"5","article-title":"Cosmetic outcome is better after intraoperative radiotherapy compared with external beam radiotherapy: an objective assessment of patients from a randomized controlled trial","volume":"73","author":"Keshtgar","year":"2013","journal-title":"Cancer Research"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0096|cit96","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1007\/s10549-013-2641-8","article-title":"Objective assessment of cosmetic outcome after targeted intraoperative radiotherapy in breast cancer: results from a randomised controlled trial","volume":"140","author":"Keshtgar","year":"2013","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0097|cit97","first-page":"S225","article-title":"Cosmetic outcome 1, 2, 3, and 4 years after intraoperative radiotherapy compared with external beam radiotherapy for treatment of early breast cancer: an objective assessment of patients from a randomized controlled trial","volume":"80","author":"Keshtgar","year":"2011","journal-title":"Proceedings of ASTRO"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0098|cit98","doi-asserted-by":"crossref","first-page":"Abstract 570","DOI":"10.1200\/jco.2010.28.15_suppl.570","article-title":"Cosmetic outcome two and three years after intraoperative radiotherapy compared with external beam radiotherapy for early breast cancer: an objective assessment of patients from a randomized controlled trial","volume":"28","author":"Keshtgar","year":"2010","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0099|cit99","unstructured":"Comparison of intra-operative radiotherapy with post-operative radiotherapy for women with early breast cancer (TARGIT) clinicaltrials.gov\/ct2\/show\/NCT00983684"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0100|cit100","first-page":"S46","article-title":"Targeted intraoperative radiotherapy in elderly patients (TARGIT-E) with early breast cancer; first safety analysis after 80 treated patients","volume":"191(1S1)","author":"Neumaier","year":"2015","journal-title":"Strahlentherapie und Onkologie"},{"issue":"8","key":"10.1002\/14651858.CD007077.pub4-BIB0101|cit101","doi-asserted-by":"crossref","first-page":"e014944","DOI":"10.1136\/bmjopen-2016-014944","article-title":"Health economics of targeted intraoperative radiotherapy (TARGIT-IORT) for early breast cancer: a cost-effectiveness analysis in the United Kingdom","volume":"7","author":"Vaidya","year":"2017","journal-title":"BMJ Open"},{"issue":"9","key":"10.1002\/14651858.CD007077.pub4-BIB0102|cit102","doi-asserted-by":"crossref","first-page":"A584","DOI":"10.1016\/j.jval.2017.08.2440","article-title":"Cost-utility analysis (CUA) of targeted intraoperative radiotherapy alone (TARGIT-A) in the Brazilian early breast cancer patients","volume":"20","author":"Vaidya","year":"2017","journal-title":"Value in Health"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0103|cit103","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijrobp.2015.03.022","article-title":"Pride, prejudice, or science: attitudes towards the results of the TARGIT - a trial of targeted intraoperative radiation therapy for breast cancer","volume":"92","author":"Vaidya","year":"2015","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0104|cit104","first-page":"S97","article-title":"Fewer non-breast cancer deaths in TARGIT-A trial: systemic benefit of TARGIT or lack of EBRT toxicity","volume":"22","author":"Vaidya","year":"2013","journal-title":"Breast"},{"issue":"S1","key":"10.1002\/14651858.CD007077.pub4-BIB0105|cit105","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0167-8140(15)40467-0","article-title":"Whole breast radiotherapy does not affect growth of cancer foci in other quadrants: results from the TARGIT A trial","volume":"115","author":"Vaidya","year":"2015","journal-title":"Radiotherapy and Oncology"},{"issue":"73","key":"10.1002\/14651858.CD007077.pub4-BIB0106|cit106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta20730","article-title":"An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)","volume":"20","author":"Vaidya","year":"2016","journal-title":"Health Technology Assessment"},{"issue":"2836","key":"10.1002\/14651858.CD007077.pub4-BIB0107|cit107","first-page":"1","article-title":"Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial","volume":"370","author":"Vaidya","year":"2020","journal-title":"BMJ"},{"issue":"2 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0108|cit108","doi-asserted-by":"crossref","first-page":"S240","DOI":"10.1016\/j.ijrobp.2013.06.623","article-title":"The lower non-breast cancer mortality with TARGIT in the TARGIT - a trial could be a systemic effect of TARGIT on tumor microenvironment","volume":"87","author":"Vaidya","year":"2013","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"S1","key":"10.1002\/14651858.CD007077.pub4-BIB0109|cit109","first-page":"S136","article-title":"Targeted intraoperative radiotherapy for breast cancer (TARGIT): an international trial","volume":"64","author":"Vaidya","year":"2002","journal-title":"Radiotherapy and Oncology"},{"issue":"9735","key":"10.1002\/14651858.CD007077.pub4-BIB0110|cit110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0140-6736(10)60837-9","article-title":"Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial","volume":"376","author":"Vaidya","year":"2010","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0111|cit111","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.semradonc.2004.10.007","article-title":"TARGeted Intraoperative radiotherapy (TARGIT): an innovative approach to partial-breast irradiation","volume":"15","author":"Vaidya","year":"2005","journal-title":"Seminars in Radiation Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0112|cit112","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1016\/j.ijrobp.2013.06.025","article-title":"Omitting whole breast radiation therapy did not increase axillary recurrence in the TARGIT-A trial","volume":"87","author":"Vaidya","year":"2013","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9917","key":"10.1002\/14651858.CD007077.pub4-BIB0113|cit113","first-page":"602","article-title":"Erratum","volume":"383","author":"Vaidya","year":"2014","journal-title":"Lancet"},{"issue":"9917","key":"10.1002\/14651858.CD007077.pub4-BIB0114|cit114","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(13)61950-9","article-title":"Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT - a randomised trial","volume":"383","author":"Vaidya","year":"2014","journal-title":"Lancet"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0115|cit115","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.breast.2006.06.001","article-title":"In favour of partial breast irradiation in selected patients and a well-directed intraoperative boost","volume":"15","author":"Vaidya","year":"2006","journal-title":"Breast"},{"issue":"7","key":"10.1002\/14651858.CD007077.pub4-BIB0116|cit116","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ncponc0850","article-title":"Partial breast irradiation using targeted intraoperative radiotherapy (TARGIT)","volume":"4","author":"Vaidya","year":"2007","journal-title":"Nature Clinical Practice Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0117|cit117","first-page":"S206","article-title":"Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A","volume":"81","author":"Welzel","year":"2011","journal-title":"Proceedings of ASTRO"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0118|cit118","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1748-717X-8-9","article-title":"Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A","volume":"8","author":"Welzel","year":"2013","journal-title":"Radiation Oncology"},{"issue":"2 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0119|cit119","doi-asserted-by":"crossref","first-page":"S241","DOI":"10.1016\/j.ijrobp.2013.06.625","article-title":"Local recurrence and survival for the German centers in the TARGIT-A (TARGeted Intraoperative Radiation Therapy - Alone) trial","volume":"87","author":"Wenz","year":"2013","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"8","key":"10.1002\/14651858.CD007077.pub4-BIB0120|cit120","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.clon.2005.07.018","article-title":"A randomised study of whole-breast vs tumour-bed irradiation after local excision and axillary dissection for early breast cancer","volume":"17","author":"Dodwell","year":"2005","journal-title":"Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0121|cit121","unstructured":"Intensity modulated radiotherapy (IMRT) vs. 3D-conformal accelerated partial breast irradiation (APBI) for early stage breast cancer after lumpectomy clinicaltrials.gov\/show\/NCT01185132"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0122|cit122","unstructured":"Partial breast irradiation with concurrent chemotherapy for women with breast cancer clinicaltrials.gov\/show\/NCT01928589"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0123|cit123","unstructured":"Accelerated partial breast irradiation with 3D-CRT and IMRT (APERT) clinicaltrials.gov\/ct2\/show\/NCT02003560"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0124|cit124","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0167-8140(96)01747-1","article-title":"Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial","volume":"39","author":"Magee","year":"1996","journal-title":"Radiotherapy and Oncology"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0125|cit125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0936-6555(05)80215-8","article-title":"Conservation of the breast using two different radiotherapy techniques: interim report of a clinical trial","volume":"2","author":"Ribeiro","year":"1990","journal-title":"Clinical Oncology"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0126|cit126","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0936-6555(05)80900-8","article-title":"The Christie Hospital breast conservation trial: an update at 8 years from inception","volume":"5","author":"Ribeiro","year":"1993","journal-title":"Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0127|cit127","unstructured":"TARGIT-B: an international randomised controlled trial to compare targeted intra-operative radiotherapy boost with conventional external beam radiotherapy boost after lumpectomy for breast cancer in women with a high risk of local recurrence apps.who.int\/trialsearch\/Trial.aspx?TrialID=ISRCTN43138042"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0128|cit128","unstructured":"Accelerated partial breast irradiation for early breast cancer clinicaltrials.gov\/ct2\/show\/NCT00418210"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0129|cit129","unstructured":"Randomized study on postmenopausal women with early stage breast cancer: WBI versus APBI clinicaltrials.gov\/ct2\/show\/NCT02375048"},{"issue":"S1","key":"10.1002\/14651858.CD007077.pub4-BIB0130|cit130","doi-asserted-by":"crossref","first-page":"S700","DOI":"10.1016\/S0167-8140(18)31580-9","article-title":"Randomized phase II study of hypofractionated WBI versus APBI using VMAT: early toxicity results","volume":"127","author":"Rose","year":"2018","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0131|cit131","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.adro.2019.09.005","article-title":"Comparison of toxicity and cosmetic outcomes after accelerated partial breast irradiation or whole breast irradiation using 3-dimensional conformal external beam radiation therapy","volume":"5","author":"Yadav","year":"2020","journal-title":"Advances in Radiation Oncology"},{"issue":"4 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0132|cit132","first-page":"P3","article-title":"Comparison of accelerated partial breast irradiation (APBI) with whole breast irradiation (WBI) using 3D conformal external beam radiation therapy (3D CRT)","volume":"79","author":"Yadav","year":"2019","journal-title":"Cancer Research"},{"issue":"S1","key":"10.1002\/14651858.CD007077.pub4-BIB0133|cit133","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.1016\/S0167-8140(17)31008-3","article-title":"OC-0568: accelerated PBI vs standard radiotherapy (IRMA trial): interim cosmetic and toxicity results","volume":"123","author":"Meduri","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0134|cit134","unstructured":"Breast cancer with low risk of local recurrence: partial and accelerated radiation with three-dimensional conformal radiotherapy (3DCRT) vs. standard radiotherapy after conserving surgery (phase III study) clinicaltrials.gov\/ct2\/show\/NCT01803958"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0135|cit135","unstructured":"Partial breast versus whole breast irradiation in elderly women operated on for early breast cancer clinicaltrials.gov\/ct2\/show\/NCT00892814"},{"issue":"S1","key":"10.1002\/14651858.CD007077.pub4-BIB0136|cit136","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0167-8140(17)30757-0","article-title":"Partial breast radiotherapy after breast conservation for breast cancer: early results from the randomised DBCG PBI trial","volume":"123","author":"Offersen","year":"2017","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0137|cit137","unstructured":"A phase 3 trial of accelerated whole breast irradiation with hypofractionation plus sequential boost for early stage breast cancer clinicaltrials.gov\/ct2\/show\/NCT03553797"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0138|cit138","unstructured":"A phase II randomized clinical trial of accelerated partial breast irradiation compared with whole breast irradiation with IMRT in early breast cancer clinicaltrials.gov\/ct2\/show\/NCT03583619"},{"issue":"15 Suppl","key":"10.1002\/14651858.CD007077.pub4-BIB0139|cit139","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1200\/JCO.2019.37.15_suppl.508","article-title":"Patient-reported outcomes (PROs) in NRG oncology\/NSABP B-39\/RTOG 0413: a randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) in stage 0, I, or II breast cancer","volume":"37","author":"Ganz","year":"2019","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0140|cit140","unstructured":"Phase III randomized study of adjuvant whole breast versus partial breast irradiation using once daily or twice daily fractionation scheme in women with stage I or II breast cancer clinicaltrials.gov\/ct2\/show\/NCT03616626"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0141|cit141","unstructured":"Medico economic study, comparing Intrabeam\u00ae on surgical resection bed to conventional surgery + EBRT, in breast cancer (RIOP-SEIN) clinicaltrials.gov\/ct2\/show\/NCT03637738"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0142|cit142","first-page":"76","article-title":"SHARE: a French multicenter phase III trial comparing accelerated partial irradiation versus standard or hypofractionated whole breast irradiation in breast cancer patients at low risk of local recurrence","volume":"11","author":"Belkacemi","year":"2013","journal-title":"Clinical Advances in Haematology and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0143|cit143","doi-asserted-by":"crossref","first-page":"24S","DOI":"10.1158\/0008-5472.SABCS12-OT1-2-02","article-title":"SHARE. A French multicenter phase III trial comparing accelerated partial irradiation (APBI) versus standard or hypofractionated whole breast irradiation in low risk of local recurrence breast cancer","volume":"72","author":"Belkacemi","year":"2012","journal-title":"Cancer Research"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0144|cit144","unstructured":"Standard or hypofractionated radiotherapy versus accelerated partial breast irradiation (PBI\/APBI) for breast cancer (SHARE) clinicaltrials.gov\/ct2\/show\/NCT01247233"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0145|cit145","first-page":"133","article-title":"Evaluation of breast conserving therapy: clinical, methodological and psychological perspectives","volume":"14","author":"Aaronson","year":"1998","journal-title":"European Journal of Surgery"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0146|cit146","volume-title":"Practical Statistics for Medical Research","author":"Altman","year":"1992"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0147|cit147","doi-asserted-by":"publisher","first-page":"2873-80","DOI":"10.1245\/s10434-013-2997-3","article-title":"Cost-effectiveness analysis of intraoperative radiation therapy for early-stage breast cancer","volume":"20","author":"Alvarado","year":"2013","journal-title":"Annals of Surg Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0148|cit148","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0167-8140(95)90055-1","article-title":"LENT SOMA tables","volume":"35","year":"1995","journal-title":"Radiotherapy and Oncology"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0149|cit149","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1524-4741.2011.01132.x","article-title":"ACR Appropriateness Criteria\u00ae conservative surgery and radiation - stage I and II breast carcinoma: expert panel on radiation oncology: breast","volume":"17","author":"Bellon","year":"2011","journal-title":"Breast Journal"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0150|cit150","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.ejca.2013.02.031","article-title":"Radiotherapy and\/or tamoxifen after breast conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial","volume":"49","author":"Blamey","year":"2013","journal-title":"European Journal of Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0151|cit151","unstructured":"BlueCross BlueShield Association Accelerated partial breast irradiation as sole radiotherapy after breast-conserving surgery for early stage breast cancer - executive summary Technology Assessment Central Assessment Program 2007 22 4 1 4"},{"issue":"10","key":"10.1002\/14651858.CD007077.pub4-BIB0152|cit152","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/annonc\/mdz235","article-title":"Estimating the benefits of therapy for early-stage breast cancer: the St. Gallen International Consensus Guidelines for the primary therapy of early breast cancer 2019","volume":"30","author":"Burskin","year":"2019","journal-title":"Annals of Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0153|cit153","unstructured":"Cancer Council Australia Breast cancer www.cancer.org.au\/about-cancer\/types-of-cancer\/breast-cancer\/#:~:text=In%202015%2C%2016%2C852%20women%20and,year%20survival%20rate%20is%2091%25"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0154|cit154","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity Criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organisation for Research and Treatment of Cancer","volume":"31","author":"Cox","year":"1995","journal-title":"International Journal of Radiation Therapy Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0155|cit155","unstructured":"National Institute of Health and Human Services National Cancer Institute Common Terminology Criteria for Adverse Effects Version 3.0 ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/ctcaev3.pdf"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0156|cit156","unstructured":"National Institute of Health and Human Services National Cancer Institute Common Toxicity Criteria for Adverse Effects, Version 4.0 evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03\/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0157|cit157","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0158|cit158","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.radonc.2006.12.008","article-title":"Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy","volume":"82","author":"Donovan","year":"2007","journal-title":"Radiotherapy and Oncology"},{"issue":"22","key":"10.1002\/14651858.CD007077.pub4-BIB0159|cit159","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJM199511303332202","article-title":"Effects of radiotherapy and surgery in early breast cancer. An overview of the randomised trial","volume":"333","author":"Early Breast Cancer Trialists' Collaborative Group","year":"1995","journal-title":"New England Journal of Medicine"},{"issue":"9804","key":"10.1002\/14651858.CD007077.pub4-BIB0160|cit160","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials","volume":"378","author":"Early Breast Cancer Trialists' Collaborative Group (EBCTCG)","year":"2011","journal-title":"Lancet"},{"issue":"22","key":"10.1002\/14651858.CD007077.pub4-BIB0161|cit161","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJM199511303332203","article-title":"Re-analysis and results after 12 years of follow-up in a randomised clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer","volume":"333","author":"Fisher","year":"1995","journal-title":"New England Journal of Medicine"},{"issue":"16","key":"10.1002\/14651858.CD007077.pub4-BIB0162|cit162","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year follow-up of a randomised trial comparing total mastectomy, lumpectomy and lumpectomy plus irradiation for the treatment of invasive breast cancer","volume":"347","author":"Fisher","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0163|cit163","volume-title":"AJCC Cancer Staging Manual","author":"Fleming","year":"1997"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0164|cit164","first-page":"125","article-title":"Limited surgery with or without radiotherapy for early breast carcinoma","volume":"32","author":"Freeman","year":"1981","journal-title":"Journal Canadian Association of Radiology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0165|cit165","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1056\/NEJMoa040595","article-title":"Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer","volume":"351","author":"Fyles","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0166|cit166","unstructured":"Sch\u00fcnemann H Bro\u017cek J Guyatt G Oxman A Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. Updated October 2013. GRADE Working Group, 2013 Available from gdt.gradepro.org\/app\/handbook\/handbook.html"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0167|cit167","unstructured":"GRADEpro GDT McMaster University (developed by Evidence Prime)"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0168|cit168","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2307\/2530643","article-title":"Estimation of a common effect parameter from sparse follow-up data","volume":"41","author":"Greenland","year":"1985","journal-title":"Biometrics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0169|cit169","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0360-3016(79)90729-6","article-title":"Analysis of cosmetic results following primary radiation therapy for Stage I and II carcinoma of the breast","volume":"5","author":"Harris","year":"1979","journal-title":"International Journal of Radiation Oncology Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0170|cit170","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clon.2008.03.017","article-title":"Evaluation of a method for grading late photographic change in breast appearance after radiotherapy for early breast cancer","volume":"20","author":"Haviland","year":"2008","journal-title":"Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0171|cit171","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet Oncology"},{"issue":"11","key":"10.1002\/14651858.CD007077.pub4-BIB0172|cit172","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"issue":"7414","key":"10.1002\/14651858.CD007077.pub4-BIB0173|cit173","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0174|cit174","volume-title":"Cochrane Reviewers' Handbook 6.2","author":"Higgins","year":"2021"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0175|cit175","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/1097-0142(19850901)56:5<979::AID-CNCR2820560502>3.0.CO;2-N","article-title":"Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery","volume":"56","author":"Holland","year":"1985","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0176|cit176","unstructured":"Howlader N Noone AM Krapcho M Neyman N Aminou R Waldron W SEER cancer statistics review, 1975-2009 (vintage 2009 populations) seer.cancer.gov\/csr\/1975_2009_pops09\/"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0177|cit177","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1056\/NEJMoa040587","article-title":"Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer","volume":"351","author":"Hughes","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"14","key":"10.1002\/14651858.CD007077.pub4-BIB0178|cit178","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM199504063321402","article-title":"Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer","volume":"332","author":"Jacobson","year":"1995","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0179|cit179","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/tbj.12226","article-title":"Efficacy and safety of accelerated partial breast irradiation after breast-conserving surgery: a meta-analysis of published comparative studies","volume":"20","author":"Kong","year":"2014","journal-title":"Breast Journal"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0180|cit180","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10549-019-05209-9","article-title":"Toxicity and clinical outcomes of partial breast irradiation compared to whole breast irradiation for early-stage breast cancer: a systematic review and meta-analysis","volume":"175","author":"Korzets","year":"2019","journal-title":"Breast Cancer Research and Treatment"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0181|cit181","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ijrobp.2004.04.010","article-title":"Changes in temporal patterns of local failure after breast-conserving therapy and their prognostic implications","volume":"60","author":"Krauss","year":"2004","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0182|cit182","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1470-2045(14)71221-5","article-title":"Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial","volume":"16","author":"Kunkler","year":"2015","journal-title":"Lancet Oncology"},{"issue":"11","key":"10.1002\/14651858.CD007077.pub4-BIB0183|cit183","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/1097-0142(19831201)52:11<2173::AID-CNCR2820521133>3.0.CO;2-0","article-title":"Segmental mastectomy without radiotherapy. Short-term follow-up","volume":"52","author":"Lagios","year":"1983","journal-title":"Cancer"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0184|cit184","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1200\/JCO.1988.6.12.1798","article-title":"Quality of life in stage II breast cancer an instrument for clinical trials","volume":"6","author":"Levine","year":"1998","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0185|cit185","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ijrobp.2007.03.055","article-title":"Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy - 4-year results of a randomized trial","volume":"69","author":"L\u00f6vey","year":"2007","journal-title":"International Journal of Radiation Oncology Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0186|cit186","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0167-8140(86)80061-5","article-title":"Alpha\/beta value and the importance of size of dose per fraction for late complications of the supraglottic larynx","volume":"7","author":"Maciejewski","year":"1986","journal-title":"Radiotherapy and Oncology"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0187|cit187","first-page":"719","article-title":"Statistical aspects of the analysis of data for retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0188|cit188","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.radonc.2014.11.014","article-title":"Accelerated partial irradiation for breast cancer: systematic review and meta-analysis of 8653 women in eight randomized trials","volume":"114","author":"Marta","year":"2015","journal-title":"Radiotherapy and Oncology"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0189|cit189","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/014107687807100506","article-title":"Clinical study of recurrence rate and survival time of patients with carcinoma of the breast treated by biopsy excision without any other therapy","volume":"71","author":"Montgomery","year":"1978","journal-title":"Journal of the Royal Society of Medicine"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0190|cit190","unstructured":"National Comprehensive Cancer Network NCCN guidelines version 2.2015 invasive breast cancer www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0191|cit191","unstructured":"Cancer Therapy Evaluation Program Common terminology criteria for adverse events, version 3.0, DCTD, NCI, NIH, DHHS evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03_2010-06-14_QuickReference_8.5x11.pdf"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0192|cit192","unstructured":"National Health Institute for Health and Care Excellence (NICE) Early and locally advanced breast cancer: diagnosis and management (NG101), July 2018 nice.org.uk\/guidance\/ng101"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0193|cit193","unstructured":"Office of National Statistics Breast cancer in England, 2010 release www.ons.gov.uk\/ons\/rel\/cancer-unit\/breast-cancer-in-england\/2010\/sum-1.html"},{"issue":"6","key":"10.1002\/14651858.CD007077.pub4-BIB0194|cit194","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1470-2045(06)70699-4","article-title":"Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial","volume":"7","author":"Owen","year":"2006","journal-title":"Lancet Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0195|cit195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0167-8140(95)97448-M","article-title":"Later Effects Working Group. Late effects toxicity scoring: the SOMA scale","volume":"35","author":"Pavy","year":"1995","journal-title":"Radiotherapy and Oncology"},{"issue":"18","key":"10.1002\/14651858.CD007077.pub4-BIB0196|cit196","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1200\/JCO.2009.27.4498","article-title":"Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer; results from TROG 02.02","volume":"28","author":"Peters","year":"2010","journal-title":"Journal of Clinical Oncology"},{"issue":"13","key":"10.1002\/14651858.CD007077.pub4-BIB0197|cit197","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","article-title":"A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis","volume":"26","author":"Pignol","year":"2008","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0198|cit198","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/cncr.11580","article-title":"Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomised Trial","volume":"98","author":"Poggi","year":"2003","journal-title":"Cancer"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0199|cit199","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.radonc.2010.01.014","article-title":"Patient selection for accelerated partial-breast irradiation (PBI\/APBI) after breast-conserving surgery: recommendations of the Groupe Europ\u00e9en de Curieth\u00e9rapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009)","volume":"94","author":"Polg\u00e1r","year":"2010","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0200|cit200","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ijrobp.2006.12.045","article-title":"Lumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer","volume":"68","author":"Potter","year":"2007","journal-title":"International Journal of radiation Oncology, Biology, Physics"},{"issue":"i-x","key":"10.1002\/14651858.CD007077.pub4-BIB0201|cit201","first-page":"1","article-title":"A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial","volume":"11","author":"Prescott","year":"2007","journal-title":"Health Technology Assessment"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0202|cit202","unstructured":"Review Manager Web (RevMan Web) The Cochrane Collaboration 2019"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0203|cit203","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0167-8140(95)01548-U","article-title":"Late effects consensus conference: RTOG\/EORTC","volume":"35","year":"1995","journal-title":"Radiotherapy and Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0204|cit204","unstructured":"Saris-Baglama RN Dewey CJ Chisholm GB Plumb E King J Kosinski M Quality Metric health outcomes\u2122 scoring software 4.0 Lincoln, RI: Quality Metric Incorporated 2010 138"},{"issue":"28","key":"10.1002\/14651858.CD007077.pub4-BIB0205|cit205","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1200\/JCO.2005.06.032","article-title":"Impact of patient distance to radiation therapy on mastectomy use in early-stage breast cancer patients","volume":"23","author":"Schroen","year":"2005","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0206|cit206","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.clbc.2013.10.005","article-title":"Evaluating radiotherapy options in breast cancer: does intraoperative radiotherapy represent the most cost-efficacious option?","volume":"14","author":"Shah","year":"2014","journal-title":"Clinical Breast Cancer"},{"issue":"5","key":"10.1002\/14651858.CD007077.pub4-BIB0207|cit207","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0360-3016(00)01378-X","article-title":"True recurrence vs new primary ipsilateral breast tumour relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses and therapeutic management","volume":"48","author":"Smith","year":"2000","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0208|cit208","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.ijrobp.2009.02.031","article-title":"Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO)","volume":"74","author":"Smith","year":"2009","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0209|cit209","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1200\/JCO.1996.14.10.2756","article-title":"The European Organisation for Research and Treatment of Cancer cancer-specific quality-of-life questionnaire module: first results from a three-country field study","volume":"14","author":"Sprangers","year":"1996","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0210|cit210","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/1097-0142(20010615)91:12<2273::AID-CNCR1258>3.0.CO;2-1","article-title":"Form or function? Part I. Subjective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy","volume":"91","author":"Stanton","year":"2001","journal-title":"Cancer"},{"issue":"4","key":"10.1002\/14651858.CD007077.pub4-BIB0211|cit211","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1470-2045(08)70077-9","article-title":"The UK standardisation of breast radiotherapy (START) trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial","volume":"9","author":"Bentzen","year":"2008","journal-title":"Lancet Oncology"},{"issue":"9618","key":"10.1002\/14651858.CD007077.pub4-BIB0212|cit212","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(08)60348-7","article-title":"The UK standardisation of breast radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial","volume":"371","author":"Bentzen","year":"2008","journal-title":"Lancet"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0213|cit213","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0360-3016(92)90690-J","article-title":"High dose rate intracavitary brachytherapy for carcinoma of the cervix: the Madison System 1: clinical and radiobiological considerations","volume":"24","author":"Stitt","year":"1992","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0214|cit214","doi-asserted-by":"crossref","unstructured":"Tierney JF Stewart LA Ghersi D Burdett S Sydes MR Practical methods for incorporating summary time-to-event data into meta-analysis Trials 2007 8 16 1 16","DOI":"10.1186\/1745-6215-8-16"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0215|cit215","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1053-4296(03)00031-6","article-title":"CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"Trotti","year":"2003","journal-title":"Seminars in Radiation Oncology"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0216|cit216","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ijrobp.2016.05.008","article-title":"Reduced mortality with partial-breast irradiation for early breast cancer: a meta-analysis of randomized trials","volume":"96","author":"Vaidya","year":"2016","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0217|cit217","doi-asserted-by":"crossref","unstructured":"Vaidya JS Wenz F Bulsara M Health Technology Assessment, No. 20.73. 2016, Chapter 6 ncbi.nlm.nih.gov\/books\/NBK390266 2016","DOI":"10.3310\/hta20730"},{"issue":"3","key":"10.1002\/14651858.CD007077.pub4-BIB0218|cit218","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1524-4741.2010.00905.x","article-title":"Partial breast irradiation or whole breast radiotherapy for early breast cancer: a meta-analysis of randomized controlled trials","volume":"16","author":"Valachis","year":"2010","journal-title":"Breast Journal"},{"issue":"14","key":"10.1002\/14651858.CD007077.pub4-BIB0219|cit219","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/92.14.1143","article-title":"Long-term results of a randomised trial comparing breast-conserving therapy with mastectomy: European Organisation for Research and Treatment of Cancer 10801 trial","volume":"92","author":"Dongen","year":"2000","journal-title":"Journal of the National Cancer Institute"},{"issue":"10","key":"10.1002\/14651858.CD007077.pub4-BIB0220|cit220","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/0959-8049(95)00271-J","article-title":"Breast conservation is a safe method in patients with a small cancer of the breast. Long-term results of three randomised trial on 1973 patients","volume":"31","author":"Veronesi","year":"1995","journal-title":"European Journal of Cancer"},{"issue":"16","key":"10.1002\/14651858.CD007077.pub4-BIB0221|cit221","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa020989","article-title":"Twenty-year follow-up of a randomised study comparing breast-conserving surgery with radical mastectomy for early breast cancer","volume":"347","author":"Veronesi","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0222|cit222","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.brachy.2020.03.003","article-title":"Partial-breast irradiation versus whole-breast radiotherapy for early breast cancer: a systematic review and update meta-analysis","volume":"19","author":"Viani","year":"2020","journal-title":"Brachytherapy"},{"issue":"8","key":"10.1002\/14651858.CD007077.pub4-BIB0223|cit223","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2105\/AJPH.78.8.961","article-title":"Odd man out: a graphical approach to meta-analysis","volume":"78","author":"Walker","year":"1988","journal-title":"American Journal of Public Health"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0224|cit224","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jnci\/djh023","article-title":"Workshop on partial breast irradiation: state of the art and the science. Bethesda MD December 8th-10th 2002","volume":"96","author":"Wallner","year":"2004","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1002\/14651858.CD007077.pub4-BIB0225|cit225","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1200\/JCO.1992.10.3.356","article-title":"Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast carcinoma","volume":"10","author":"Wazer","year":"1992","journal-title":"Journal of Clinical Oncology"},{"issue":"10","key":"10.1002\/14651858.CD007077.pub4-BIB0226|cit226","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2260::AID-CNCR9>3.0.CO;2-M","article-title":"The effects of radiation therapy on quality of life of women with breast carcinoma: results of a randomised trial. Ontario Clinical Oncology Group","volume":"88","author":"Whelan","year":"2000","journal-title":"Cancer"},{"issue":"15","key":"10.1002\/14651858.CD007077.pub4-BIB0227|cit227","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/94.15.1143","article-title":"Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer","volume":"94","author":"Whelan","year":"2002","journal-title":"Journal of the National Cancer Institute"},{"issue":"1","key":"10.1002\/14651858.CD007077.pub4-BIB0228|cit228","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejca.2009.10.007","article-title":"Radiation therapy and tamoxifen after breast-conserving surgery: updated results of a 2x2 randomised clinical trial in patients with low risk of recurrence","volume":"46","author":"Winzer","year":"2010","journal-title":"European Journal of Cancer"},{"issue":"2","key":"10.1002\/14651858.CD007077.pub4-BIB0229|cit229","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-8140(83)80021-8","article-title":"A new isoeffect curve for change in dose per fraction","volume":"1","author":"Withers","year":"1983","journal-title":"Radiotherapy and Oncology"},{"issue":"6","key":"10.1002\/14651858.CD007077.pub4-BIB0230|cit230","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1593\/tlo.13580","article-title":"Accelerated partial breast irradiation for breast cancer: a meta-analysis","volume":"6","author":"Ye","year":"2013","journal-title":"Translational Oncology"},{"issue":"7","key":"10.1002\/14651858.CD007077.pub4-BIB0231|cit231","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007077.pub3","article-title":"Partial breast irradiation for early breast cancer","author":"Hickey","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:21:19Z","timestamp":1698747679000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007077.pub4"}},"subtitle":[],"editor":[{"name":"Cochrane Breast Cancer Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":231,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007077.pub4","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]}}}