{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:50:16Z","timestamp":1792648216165,"version":"4.5.0"},"update-to":[{"DOI":"10.1002\/14651858.cd007115.pub2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000}}],"reference-count":90,"publisher":"Wiley","issue":"10","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007115.pub3","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T11:32:35Z","timestamp":1388748755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":260,"title":["Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia"],"prefix":"10.1002","volume":"2015","author":[{"given":"Michael PT","family":"Lunn","sequence":"first","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery; Department of Neurology and MRC Centre for Neuromuscular Diseases; Queen Square London UK WC1N 3BG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard AC","family":"Hughes","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery; MRC Centre for Neuromuscular Diseases; PO Box 114 Queen Square London UK WC1N 3BG"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Wiffen","sequence":"additional","affiliation":[{"name":"University of Oxford; Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics); Pain Research Unit Churchill Hospital Oxford Oxfordshire UK OX3 7LE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,3]]},"reference":[{"issue":"9","key":"10.1002\/14651858.CD007115.pub3-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1002\/art.20485","article-title":"A double-blind multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder","volume":"50","author":"Arnold","year":"2004","journal-title":"Arthritis and Rheumatism"},{"issue":"1-3","key":"10.1002\/14651858.CD007115.pub3-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pain.2005.06.031","article-title":"A randomized double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder","volume":"119","author":"Arnold","year":"2005","journal-title":"Pain"},{"issue":"12","key":"10.1002\/14651858.CD007115.pub3-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.3899\/jrheum.100365","article-title":"Flexible dosed duloxetine in the treatment of fibromyalgia: a randomized double-blind placebo-controlled trial","volume":"37","author":"Arnold","year":"2010","journal-title":"Journal of Rheumatology"},{"issue":"9","key":"10.1002\/14651858.CD007115.pub3-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/AJP.0b013e3182510295","article-title":"Efficacy and safety of duloxetine 30 mg\/d in patients with fibromyalgia: a randomized, double-blind, placebo-controlled study","volume":"28","author":"Arnold","year":"2012","journal-title":"Clinical Journal of Pain"},{"issue":"11","key":"10.1002\/14651858.CD007115.pub3-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.4088\/JCP.v68n1110","article-title":"Efficacy and safety of duloxetine 60 mg once daily in the treatment of pain in patients with major depressive disorder and at least moderate pain of unknown etiology: a randomized controlled trial","volume":"68","author":"Brecht","year":"2007","journal-title":"Journal of Clinical Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0006|cit6","first-page":"91","article-title":"A six-month double-blind, placebo-controlled, randomized clinical trial of duloxetine for the treatment of fibromyalgia","volume":"30","author":"Chappell","year":"2009","journal-title":"International Journal of General Medicine"},{"issue":"22","key":"10.1002\/14651858.CD007115.pub3-BIB0007|cit7","first-page":"3184","article-title":"Duloxetine versus placebo in the treatment of patients with diabetic peripheral neuropathic pain in China","volume":"123","author":"Gao","year":"2010","journal-title":"Chinese Medical Journal"},{"issue":"10","key":"10.1002\/14651858.CD007115.pub3-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1185\/03007995.2011.609540","article-title":"Duloxetine versus placebo in the treatment of major depressive disorder and associated painful physical symptoms: a replication study","volume":"27","author":"Gaynor","year":"2011","journal-title":"Current Medical Research and Opinion"},{"issue":"10","key":"10.1002\/14651858.CD007115.pub3-BIB0009|cit9","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1185\/03007995.2011.609539","article-title":"A randomized placebo-controlled trial of duloxetine in patients with major depressive disorder and associated painful physical symptoms","volume":"27","author":"Gaynor","year":"2011","journal-title":"Current Medical Research and Opinion"},{"issue":"1-2","key":"10.1002\/14651858.CD007115.pub3-BIB0010|cit10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pain.2005.03.029","article-title":"Duloxetine vs. placebo in patients with painful diabetic neuropathy","volume":"116","author":"Goldstein","year":"2005","journal-title":"Pain"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2337\/dc10-1793","article-title":"A comparative evaluation of amitriptyline and duloxetine in painful diabetic neuropathy: a randomized, double-blind, cross-over clinical trial","volume":"34","author":"Kaur","year":"2011","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1002\/14651858.CD007115.pub3-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1526-4637.2005.00061.x","article-title":"A double-blind, randomized multicentre trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain","volume":"6","author":"Raskin","year":"2005","journal-title":"Pain Medicine"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.pain.2012.01.009","article-title":"Efficacy and safety of the \u03b14\u03b22 neuronal nicotinic receptor agonist ABT-894 in patients with diabetic peripheral neuropathic pain","volume":"153","author":"Rowbotham","year":"2012","journal-title":"Pain"},{"issue":"3","key":"10.1002\/14651858.CD007115.pub3-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.pain.2008.02.024","article-title":"Efficacy and safety of duloxetine for the treatment of fibromyalgia in patients with or without major depressive disorder: results from a 6-month randomized double-blind, placebo-controlled, fixed-dose trial","volume":"136","author":"Russell","year":"2008","journal-title":"Pain"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0015|cit15","article-title":"Duloxetine and pregabalin: high-dose monotherapy or their combination? The \u201cCOMBO-DN study\u201d \u2013 a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain","author":"Tesfaye","journal-title":"Pain"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0016|cit16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pain.2010.09.005","article-title":"Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial","volume":"152","author":"Vranken","year":"2011","journal-title":"Pain"},{"issue":"8","key":"10.1002\/14651858.CD007115.pub3-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1212\/01.wnl.0000240225.04000.1a","article-title":"A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain","volume":"67","author":"Wernicke","year":"2006","journal-title":"Neurology"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0018|cit18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.2040-1124.2010.00073.x","article-title":"Superiority of duloxetine to placebo in improving painful diabetic neuropathic pain: results of a randomized controlled trial in Japan","volume":"2","author":"Yasuda","year":"2011","journal-title":"Journal of Diabetes Investigation"},{"issue":"12","key":"10.1002\/14651858.CD007115.pub3-BIB0019|cit19","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.2337\/dc12-0656","article-title":"Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.","volume":"35","author":"Boyle","year":"2012","journal-title":"Diabetes Care."},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0020|cit20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpsychires.2004.04.011","article-title":"Duloxetine 60mg once daily in the treatment of painful physical symptoms in patients with major depressive disorder","volume":"39","author":"Brannan","year":"2005","journal-title":"Journal of Psychiatric Research"},{"issue":"8","key":"10.1002\/14651858.CD007115.pub3-BIB0021|cit21","first-page":"568","article-title":"Effects of duloxetin and amitriptilin in neuropathic pain: study in 180 patients","volume":"14","author":"C\u00e1novas","year":"2007","journal-title":"Revista de la Sociedad Espanola del Dolor"},{"issue":"3","key":"10.1002\/14651858.CD007115.pub3-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pain.2009.06.024","article-title":"Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial","volume":"146","author":"Chappell","year":"2009","journal-title":"Pain"},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1533-2500.2010.00401.x","article-title":"A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee","volume":"11","author":"Chappell","year":"2011","journal-title":"Pain Practice"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0024|cit24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.jcp.0000132448.65972.d9","article-title":"Duloxetine in the treatment of depression: a double-blind placebo-controlled comparison with paroxetine","volume":"24","author":"Goldstein","year":"2004","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"7","key":"10.1002\/14651858.CD007115.pub3-BIB0025|cit25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/pme.12084","article-title":"Experience and challenges presented by a multicenter crossover study of combination analgesic therapy for the treatment of painful HIV-associated polyneuropathies","volume":"14","author":"Harrison","year":"2013","journal-title":"Pain Medicine"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0026|cit26","first-page":"32676","article-title":"CALGB 170601: A phase III double blind trial of duloxetine to treat painful chemotherapy-induced peripheral neuropathy (CIPN)","volume":"Conference","author":"Lavoie Smith","year":"2012","journal-title":"Journal of clinical oncology"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0027|cit27","unstructured":"NCT00125892 A study of duloxetine in the treatment of fibromyalgia - clinicaltrials.gov\/show\/NCT00125892;"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0028|cit28","unstructured":"NCT00266643 Tolerability of switching to duloxetine for the management of diabetic nerve pain (NCT00266643) clinicaltrials.gov\/show\/NCT00266643; www.lillytrials.com\/results\/Cymbalta.pdf"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0029|cit29","unstructured":"NCT00385671 An open-label comparison of duloxetine to other alternatives for the management of diabetic peripheral neuropathic pain www.clinicaltrials.gov\/show\/NCT00385671"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0030|cit30","unstructured":"NCT00425230 Open label study of duloxetine for the treatment of phantom limb pain www.clinicaltrials.org\/show\/NCT00425230"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0031|cit31","unstructured":"NCT00552682 Pilot, opened, randomized clinical trial to assess the efficacy of duloxetine in the treatment of fibromyalgia in patients with infection by HIV 1+ www.clinicaltrials.gov\\show\\NCT00552682"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0032|cit32","unstructured":"NCT00641719 A long-term study for the treatment of painful diabetic neuropathy www.clinicaltrials.gov\/show\/NCT00641719"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0033|cit33","unstructured":"NCT01451606 Duloxetine for the treatment of chronic pelvic pain http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01451606"},{"issue":"s2","key":"10.1002\/14651858.CD007115.pub3-BIB0034|cit34","first-page":"221","article-title":"Duloxetine in the treatment of diabetic peripheral neuropathic pain - results from three clinical trials","volume":"12","author":"Raskin","year":"2005","journal-title":"European Journal of Neurology"},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/jpm.2006.9.29","article-title":"Duloxetine versus routine care in the long-term management of diabetic neuropathic pain","volume":"9","author":"Raskin","year":"2006","journal-title":"Journal of Palliative Medicine"},{"issue":"5","key":"10.1002\/14651858.CD007115.pub3-BIB0036|cit36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1526-4637.2006.00207.x","article-title":"Duloxetine for patients with diabetic peripheral neuropathic pain: a 6-month open-label safety study","volume":"7","author":"Raskin","year":"2006","journal-title":"Pain Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0037|cit37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ncpneuro0091","article-title":"Does duloxetine safely and effectively reduce the severity of diabetic peripheral neuropathic pain?","volume":"2","author":"Russell","year":"2006","journal-title":"Nature Clinical Practice Neurology"},{"issue":"Suppl 3","key":"10.1002\/14651858.CD007115.pub3-BIB0038|cit38","first-page":"320","article-title":"Efficacy of duloxetine in low back pain","volume":"15","author":"Skljarevski","year":"2008","journal-title":"European Journal of Neurology"},{"issue":"9","key":"10.1002\/14651858.CD007115.pub3-BIB0039|cit39","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1468-1331.2009.02648.x","article-title":"A double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain","volume":"16","author":"Skljarevski","year":"2009","journal-title":"European Journal of Neurology"},{"issue":"7","key":"10.1002\/14651858.CD007115.pub3-BIB0040|cit40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/dmrr.1000","article-title":"Evaluating the maintenance of effect of duloxetine in patients with diabetic peripheral neuropathic pain","volume":"25","author":"Skljarevski","year":"2009","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"issue":"13","key":"10.1002\/14651858.CD007115.pub3-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"E578","DOI":"10.1097\/BRS.0b013e3181d3cef6","article-title":"Efficacy and safety of duloxetine in patients with chronic low back pain","volume":"35","author":"Skljarevski","year":"2010","journal-title":"Spine"},{"issue":"12","key":"10.1002\/14651858.CD007115.pub3-BIB0042|cit42","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jpain.2010.03.002","article-title":"Duloxetine versus placebo in patients with chronic low back pain: a 12-week, fixed-dose, randomized, double-blind trial","volume":"11","author":"Skljarevski","year":"2010","journal-title":"Journal of Pain"},{"issue":"13","key":"10.1002\/14651858.CD007115.pub3-BIB0043|cit43","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jama.2013.2813","article-title":"Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial","volume":"309","author":"Smith","year":"2013","journal-title":"JAMA"},{"issue":"7","key":"10.1002\/14651858.CD007115.pub3-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4065\/mcp.2010.0681","article-title":"Duloxetine, pregabalin, and duloxetine plus gabapentin for diabetic peripheral neuropathic pain management in patients with inadequate pain response to gabapentin: an open-label, randomized, noninferiority comparison","volume":"86","author":"Tanenberg","year":"2011","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0045|cit45","first-page":"P1044","article-title":"A randomised, double-blind, placebo-controlled trial of duloxetine for the treatment of central neuropathic pain associated with multiple sclerosis","volume":"17 (10 suppl)","author":"Vollmer","year":"2011","journal-title":"Multiple Sclerosis Journal"},{"issue":"5","key":"10.1002\/14651858.CD007115.pub3-BIB0046|cit46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.curtheres.2006.10.001","article-title":"Duloxetine in the long-term management of diabetic neuropathic pain: an open-label, 52-week extension of a randomized controlled clinical trial","volume":"67","author":"Wernicke","year":"2006","journal-title":"Current Therapeutic Research"},{"issue":"6","key":"10.1002\/14651858.CD007115.pub3-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jpain.2006.01.443","article-title":"Cost-effectiveness of duloxetine versus routine treatment for U.S. patients with diabetic peripheral neuropathic pain","volume":"7","author":"Wu","year":"2006","journal-title":"The Journal of Pain"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0048|cit48","unstructured":"NCT00603265 A phase 2a, randomized, double-blind, placebo- and active-controlled, parallel-group, multicenter study to assess the safety and efficacy of ADL5859 100 mg BID in subjects with neuropathic pain associated with diabetic peripheral neuropathy www.clinicaltrials.gov\/show\/NCT00603265"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0049|cit49","unstructured":"NCT00457730 A randomized placebo controlled trial of duloxetine for central pain in multiple sclerosis http:\/\/clinicaltrials.gov\/show\/NCT00457730"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0050|cit50","unstructured":"NCT00619983 Three way interaction between gabapentin, duloxetine, and donepezil in patients with diabetic neuropathy http:\/\/clinicaltrials.gov\/show\/NCT00619983"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0051|cit51","unstructured":"NCT01179672 A study in patients with diabetic peripheral neuropathic pain in China http:\/\/clinicaltrials.gov\/show\/NCT01179672"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0052|cit52","unstructured":"NCT01237587 Effect of duloxetine 30\/60 mg once daily versus placebo in adolescents with juvenile primary fibromyalgia syndrome http:\/\/clinicaltrials.gov\/show\/NCT01237587"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0053|cit53","unstructured":"NCT01552057 A phase III clinical trial of duloxetine in participants with fibromyalgia http:\/\/clinicaltrials.gov\/show\/NCT01552057"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0054|cit54","first-page":"23","article-title":"Chapter 2 Antidepressant Drugs","volume-title":"Side Effects of Drugs","volume":"29","author":"Aronson","year":"2007"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0055|cit55","first-page":"19","article-title":"Chapter 2 Antidepressant Drugs","volume-title":"Side Effects of Drugs","volume":"30","author":"Aronson","year":"2008"},{"issue":"11","key":"10.1002\/14651858.CD007115.pub3-BIB0056|cit56","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1468-1331.2006.01511.x","article-title":"EFNS guidelines on pharmacological treatment of neuropathic pain","volume":"13","author":"Attal","year":"2006","journal-title":"European Journal of Neurology"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1185\/030079908X253852","article-title":"Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK","volume":"24","author":"Beard","year":"2008","journal-title":"Current Medical Research and Opinion"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"153\u201364","DOI":"10.3109\/15360288.2012.671240","article-title":"A cost-utility analysis of pregabalin versus duloxetine for the treatment of painful diabetic neuropathy","volume":"26","author":"Bellows","year":"2012","journal-title":"Journal of Pain & Palliative Care Pharmacotherapy"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0059|cit59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"European Journal of Pain"},{"issue":"5","key":"10.1002\/14651858.CD007115.pub3-BIB0060|cit60","first-page":"728","article-title":"The fibromyalgia impact questionnaire: development and validation","volume":"18","author":"Burckhardt","year":"1991","journal-title":"Journal of Rheumatology"},{"issue":"6","key":"10.1002\/14651858.CD007115.pub3-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0893-133X(01)00298-6","article-title":"Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors","volume":"25","author":"Bymaster","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1002\/14651858.CD007115.pub3-BIB0062|cit62","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1381612053764805","article-title":"The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression","volume":"11","author":"Bymaster","year":"2005","journal-title":"Current Pharmaceutical Design"},{"issue":"7","key":"10.1002\/14651858.CD007115.pub3-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/ncprheum0221","article-title":"Therapy Insight: fibromyalgia - a different type of pain needing a different type of treatment","volume":"2","author":"Dadabhoy","year":"2006","journal-title":"Nature Clinical Practice Rheumatology"},{"issue":"9","key":"10.1002\/14651858.CD007115.pub3-BIB0064|cit64","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1464-5491.2004.01271.x","article-title":"Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes","volume":"21","author":"Daousi","year":"2004","journal-title":"Diabetic Medicine"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpain.2007.09.005","article-title":"Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations","volume":"9","author":"Dworkin","year":"2008","journal-title":"Journal of Pain"},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0066|cit66","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ije\/31.1.140","article-title":"Meta-analyses involving cross-over trials: methodological issues","volume":"31","author":"Elbourne","year":"2002","journal-title":"International Journal of Epidemiology"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4088\/JCP.v65n0411","article-title":"The effect of duloxetine on painful physical symptoms in depressed patients: do improvements in these symptoms result in higher remission rates?","volume":"65","author":"Fava","year":"2004","journal-title":"Journal of Clinical Psychiatry"},{"issue":"1","key":"10.1002\/14651858.CD007115.pub3-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1185\/030079906X162719","article-title":"A retrospective polled analysis of duloxetine safety in 23,983 subjects","volume":"23","author":"Gahimer","year":"2007","journal-title":"Current Medical Research Opinion"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0069|cit69","unstructured":"Jan Brozek, Andrew Oxman, Holger Sch\u00fcnemann GRADEpro 2008"},{"issue":"1-2","key":"10.1002\/14651858.CD007115.pub3-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pain.2006.01.030","article-title":"Epidemiology and treatment of neuropathic pain: the UK primary care perspective","volume":"122","author":"Hall","year":"2006","journal-title":"Pain"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/9780470712184.ch8","article-title":"Chapter 8: Assessing risk of bias in included studies","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2008"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0072|cit72","unstructured":"Higgins JPT Green S (editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org"},{"issue":"Supplement","key":"10.1002\/14651858.CD007115.pub3-BIB0073|cit73","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1016\/j.clinthera.2007.12.002","article-title":"Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies","volume":"29","author":"Kajdasz","year":"2007","journal-title":"Clinical Therapeutics"},{"issue":"3","key":"10.1002\/14651858.CD007115.pub3-BIB0074|cit74","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004742.pub2","article-title":"Serotonin and noradrenaline reuptake inhibitors (SNRI) for stress urinary incontinence in adults","author":"Mariappan","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"10.1002\/14651858.CD007115.pub3-BIB0075|cit75","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/acr.20449","article-title":"Estimation of minimum clinically important difference for pain in fibromyalgia","volume":"63","author":"Mease","year":"2011","journal-title":"Arthritis Care & Research (Hoboken)."},{"issue":"3","key":"10.1002\/14651858.CD007115.pub3-BIB0076|cit76","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007076.pub2","article-title":"Pregabalin for acute and chronic pain in adults","author":"Moore","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD007115.pub3-BIB0077|cit77","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008242.pub2","article-title":"Amitriptyline for neuropathic pain and fibromyalgia in adults","author":"Moore","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0078|cit78","first-page":"51","article-title":"Definitions and Classification of Pain","volume-title":"Principles and practice of pain management","author":"Nagda","year":"2004"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0079|cit79","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005454.pub2","article-title":"Duloxetine versus other anti-depressive agents for depression","author":"Nose","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"12","key":"10.1002\/14651858.CD007115.pub3-BIB0080|cit80","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2165\/0019053-200826120-00007","article-title":"A cost-utility comparison of four first-line medications in painful diabetic neuropathy","volume":"26","author":"O'Connor","year":"2008","journal-title":"Pharmacoeconomics"},{"issue":"6","key":"10.1002\/14651858.CD007115.pub3-BIB0081|cit81","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/01.yic.0000224782.83287.3c","article-title":"Efficacy of duloxetine in painful symptoms: analgesic or antidepressant effect?","volume":"21","author":"Perahia","year":"2006","journal-title":"International Clinical Psychopharmacology"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0082|cit82","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005454","article-title":"Antidepressants for neuropathic pain","author":"Saarto","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0083|cit83","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ejpain.2003.09.004","article-title":"Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale","volume":"8","author":"Salaffi","year":"2004","journal-title":"European Journal of Pain"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0084|cit84","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1471-0528.2006.00877.x","article-title":"What do we know about duloxetine's mode of action? Evidence from animals to humans","volume":"113 Suppl 1","author":"Scheussler","year":"2006","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1002\/14651858.CD007115.pub3-BIB0085|cit85","unstructured":"Thorlund K Engstr\u00f8m J Wetterslev J Brok J Imberger G Gluud C Trial Sequential Analysis 2011"},{"issue":"18","key":"10.1002\/14651858.CD007115.pub3-BIB0086|cit86","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: Redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"issue":"5","key":"10.1002\/14651858.CD007115.pub3-BIB0087|cit87","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2165\/00002018-200730050-00007","article-title":"An evaluation of the cardiovascular safety profile of duloxetine","volume":"30","author":"Wernicke","year":"2007","journal-title":"Drug Safety"},{"issue":"3","key":"10.1002\/14651858.CD007115.pub3-BIB0088|cit88","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005452","article-title":"Gabapentin for acute and chronic pain","author":"Wiffen","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"2","key":"10.1002\/14651858.CD007115.pub3-BIB0089|cit89","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007115","article-title":"Duloxetine for treating painful neuropathy or chronic pain","author":"Lunn","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"10.1002\/14651858.CD007115.pub3-BIB0090|cit90","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007115.pub2","article-title":"Duloxetine for treating painful neuropathy or chronic pain","author":"Lunn","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/14651858.CD007115.pub3\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:06:40Z","timestamp":1738541200000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007115.pub3"}},"subtitle":[],"editor":[{"name":"Cochrane Neuromuscular Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,3]]},"references-count":90,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007115.pub3","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,3]]}}}