{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:48:36Z","timestamp":1767134916656,"version":"build-2238731810"},"update-to":[{"DOI":"10.1002\/14651858.cd007119","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000}}],"reference-count":71,"publisher":"Wiley","issue":"12","content-domain":{"domain":["wiley.com","cochranelibrary.com"],"crossmark-restriction":true},"short-container-title":[],"DOI":"10.1002\/14651858.cd007119.pub2","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T15:50:14Z","timestamp":1334245814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interventions for restoring patency of occluded central venous catheter lumens"],"prefix":"10.1002","volume":"2018","author":[{"given":"Clare","family":"van Miert","sequence":"first","affiliation":[{"name":"Alder Hey Children's NHS Foundation Trust; Children's Nursing Research Unit; Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Hill","sequence":"additional","affiliation":[{"name":"Alder Hey Children's NHS Foundation Trust; Department of Paediatric Cardiac Surgery; Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Jones","sequence":"additional","affiliation":[{"name":"The University of Liverpool; Cochrane Pregnancy and Childbirth, Department of Women's and Children's Health; First Floor, Liverpool Women's NHS Foundation Trust Crown Street Liverpool UK L8 7SS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"10.1002\/14651858.CD007119.pub2-BIB0001|cit1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.RVI.0000124950.24134.19","article-title":"Dose-ranging trial with a recombinant urokinase for occluded central venous catheters in oncology patients","volume":"15","author":"Deitcher","year":"2004","journal-title":"Journal of Vascular Interventional Radiology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0002|cit2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1345\/aph.1D004","article-title":"Alteplase for central catheter clearance: does 1mg\/ml versus 2mg\/2ml","volume":"38","author":"Fink","year":"2004","journal-title":"The Annals of Pharmacotherapy"},{"issue":"4","key":"10.1002\/14651858.CD007119.pub2-BIB0003|cit3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1055\/s-0038-1648911","article-title":"Urokinase versus recombinant tissue plasminogen activator in thrombosed central venous catheters:a double-blinded, randomized trial","volume":"72","author":"Haire","year":"1994","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0004|cit4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1160\/TH03-11-0686","article-title":"Recombinant urokinase for restoration of patency in occluded central venous access devices: A double-blind, placebo-controlled trial","volume":"92","author":"Haire","year":"2004","journal-title":"Thrombosis and Haemostasis"},{"issue":"7","key":"10.1002\/14651858.CD007119.pub2-BIB0005|cit5","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1200\/JCO.1997.15.7.2709","article-title":"Low-dose urokinase infusions to treat fibrinous obstruction of venous access devices in cancer patients","volume":"15","author":"Horne","journal-title":"Journal of Clinical Oncology"},{"issue":"19","key":"10.1002\/14651858.CD007119.pub2-BIB0006|cit6","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1200\/JCO.2006.05.8438","article-title":"Phase II trial of alfimeprase, a novel-acting fibrin degradation agent, for occluded central venous access devices","volume":"24","author":"Moll","year":"2006","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0007|cit7","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S1051-0443(07)61575-9","article-title":"Recombinant tissue plasminogen activator (alteplase) for restoration of flow in occluded central venous access devices: a double-blind placebo-controlled trial - the cardiovascular thrombolytic to open occluded lines (COOL) efficacy trial","volume":"12","author":"Ponec","year":"2001","journal-title":"Journal of Vascular Interventional Radiology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0008|cit8","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S1051-0443(07)61965-4","article-title":"Treatment of occluded central venous catheters with alteplase: results in 1,064","volume":"13","author":"Semba","year":"2002","journal-title":"Journal of Interventional Radiology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0009|cit9","first-page":"115","article-title":"Heparin versus saline flushing solutions in a small community hospital","volume":"25","author":"Barrett","year":"1990","journal-title":"Hospital Pharmacy"},{"issue":"9","key":"10.1002\/14651858.CD007119.pub2-BIB0010|cit10","first-page":"29","article-title":"The use of urokinase to restore the patency of occluded central venous catheters","volume":"9","author":"Lawson","year":"1982","journal-title":"The American Journal of Intravenous Therapy & Clinical Nutrition"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0011|cit11","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s00520-004-0616-3","article-title":"Urokinase for restoring patency of malfunctioning or blocked central venous catheters in children with hemato-oncological diseases","volume":"12","author":"Molinari","year":"2004","journal-title":"Supportive Cancer Care"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0012|cit12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.RVI.000099538.29957.F7","article-title":"Alteplase for treatment of occluded peripherally inserted central catheters: safety and efficacy in 240 patients","volume":"15","author":"Ng","year":"2004","journal-title":"Journal of Vascular and Interventional Radiology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0013|cit13","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/ajhp\/59.17.1638","article-title":"Reteplase for clearance of occluded venous catheters","volume":"59","author":"Owens","year":"2002","journal-title":"American Journal of Health System Pharmacy"},{"issue":"12","key":"10.1002\/14651858.CD007119.pub2-BIB0014|cit14","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1001\/jama.1974.03230500024021","article-title":"Urokinase-streptokinase embolism trial: phase 2 results. A cooperative study","volume":"229","author":"No authors","year":"1974","journal-title":"JAMA"},{"issue":"10","key":"10.1002\/14651858.CD007119.pub2-BIB0015|cit15","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1097\/01.CCM.0000142706.01717.EB","article-title":"Recombinant urokinase is safe and effective in restoring patency to occluded central venous access devices: A multiple-centre international trial","volume":"32","author":"Svoboda","year":"2004","journal-title":"Critical Care Medical"},{"issue":"28","key":"10.1002\/14651858.CD007119.pub2-BIB0016|cit16","first-page":"1377","article-title":"The action of various drugs in the prevention of re-occlusion following Dotter's catheter disobliteration","volume":"27","author":"Zeitler","year":"1976","journal-title":"Die Medizinische Welt"},{"issue":"12","key":"10.1002\/14651858.CD007119.pub2-BIB0017|cit17","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.jvir.2010.09.002","article-title":"TROPICS 1: a phase III, randomized, double-blind, placebo-controlled study of tenecteplase for restoration of function in dysfunctional catheters","volume":"21","author":"Gabrail","year":"December 2010","journal-title":"Journal of Vascular and Interventional Radiology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0018|cit18","unstructured":"Levine R A study of tenecteplase for restoration of function in dysfunctional central venous catheters ClinicalTrials.gov Nov 2006"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0019|cit19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0221-0363(10)70040-8","article-title":"Urokinase in the management of occluded PICC lines","volume":"3 C1","author":"Muller","year":"March 2010","journal-title":"Journal of Radiologie"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0020|cit20","unstructured":"Authors not reported Trial of a novel fibrinolytic (alfimeprase) to clear thrombosed vascular access devices ClinicalTrials.gov"},{"issue":"12","key":"10.1002\/14651858.CD007119.pub2-BIB0021|cit21","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1001\/jama.1974.03230500024021","article-title":"Urokinase Pulmonary Embolism Trial: Phase I Results","volume":"229","author":"[No authors listed]","year":"1974","journal-title":"JAMA"},{"issue":"3","key":"10.1002\/14651858.CD007119.pub2-BIB0022|cit22","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/0148607190014003310","article-title":"Investigational use of tissue plasminogen activator (t-PA) for occluded central venous catheters","volume":"14","author":"Atkinson","year":"1989","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD007119.pub2-BIB0023|cit23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00247-007-0610-2","article-title":"Malfunctioning central venous catheters in children: a diagnostic approach","volume":"38","author":"Barnacle","year":"2007","journal-title":"Pediatric Radiology"},{"issue":"3","key":"10.1002\/14651858.CD007119.pub2-BIB0024|cit24","first-page":"167","article-title":"Introduction: hypercoagulable states","volume":"34","author":"Bertina","year":"1997","journal-title":"Seminars in Hematology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0025|cit25","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1097\/01.RVI.0000241542.71063.83","article-title":"Alteplase for the treatment of central venous catheter occlusion in children: results of a prospective, open label, single arm study (the cathflo activase pediatric study)","volume":"17","author":"Blaney","year":"2006","journal-title":"Journal of Vascular Interventional Radiology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0026|cit26","volume-title":"The British Medical Dictionary","author":"British Medical Association","year":"2002"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0027|cit27","doi-asserted-by":"publisher","first-page":"2S1","DOI":"10.1111\/j.1469-0691.1999.tb00536.x","article-title":"Report of ESGNI-001 and ESGNI-002 studies. Bloodstream infections in Europe","volume":"5","author":"Bouza","year":"1999","journal-title":"Clinical Microbiology and Infection"},{"issue":"9","key":"10.1002\/14651858.CD007119.pub2-BIB0028|cit28","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/s0022-3468(87)80648-6","article-title":"Calcium phosphate crystal occlusion of central venous catheters used for total parenteral nutrition in infants and children prevention and treatment","volume":"22","author":"Breux","year":"1987","journal-title":"Journal of Pediatric Surgery"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0029|cit29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/875512250101700304","article-title":"Efficacy of urokinase and alteplase to reopen occluded central venous catheters in children","volume":"17","author":"Busseires","year":"2001","journal-title":"Journal of Pharmacology Technology"},{"issue":"11","key":"10.1002\/14651858.CD007119.pub2-BIB0030|cit30","doi-asserted-by":"crossref","first-page":"792","DOI":"10.7326\/0003-4819-136-11-200206040-00007","article-title":"Chlorhexidine compared with povidine-iodine solution for vascular catheter-site care: A meta-analysis","volume":"136","author":"Chaiyakunapruk","year":"2002","journal-title":"Annals of Internal Medicine"},{"issue":"8","key":"10.1002\/14651858.CD007119.pub2-BIB0031|cit31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/00043426-200211000-00010","article-title":"Use of tissue plasminogen activator (rt-PA) in young children with cancer and dysfunctional central venous catheters","volume":"24","author":"Chesler","year":"2002","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0032|cit32","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1067\/mpd.2001.115019","article-title":"The use of alteplase to restore patency of central venous lines in pediatric patients: a cohort study","volume":"139","author":"Choi","year":"2001","journal-title":"Journal of Pediatrics"},{"issue":"8","key":"10.1002\/14651858.CD007119.pub2-BIB0033|cit33","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1097\/00003246-199708000-00033","article-title":"Central venous catheter replacement strategies: A systematic review of the literature","volume":"25","author":"Cook","year":"1997","journal-title":"Critical Care Medical"},{"issue":"1","key":"10.1002\/14651858.CD007119.pub2-BIB0034|cit34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1200\/JCO.2002.20.1.317","article-title":"Safety and efficacy of alteplase for restoring function in occluded central venous catheters: results of the cardiovascular thrombolytic to open occluded lines trial","volume":"20","author":"Deitcher","year":"2002","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1002\/14651858.CD007119.pub2-BIB0035|cit35","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0022-3476(89)80449-4","article-title":"Treatment of central venous catheter occlusions with hydrochloric acid","volume":"114","author":"Duffy","year":"1989","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0036|cit36","first-page":"R91","article-title":"Line-associated bacteraemias","volume":"3","author":"Elliot","year":"1993","journal-title":"Communicable Disease Report. CDR review"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0037|cit37","first-page":"23","article-title":"Using sodium bicarbonate to clear a medication precipitate from a central venous catheter","volume":"1","author":"Goodwin","year":"1991","journal-title":"Journal of Vascular Access Networks"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0038|cit38","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.39490.551019.BE","article-title":"What is \"quality of evidence\" and why is it important to clinicians?","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"5","key":"10.1002\/14651858.CD007119.pub2-BIB0039|cit39","first-page":"s143","article-title":"Major thrombotic and nonthrombotic complications","volume":"21","author":"Hadaway","year":"1998","journal-title":"Journal of Intravenous Nursing"},{"issue":"6","key":"10.1002\/14651858.CD007119.pub2-BIB0040|cit40","first-page":"592","article-title":"Care improves whilst costs reduce. The clinical nurse specialist in total parenteral nutrition","volume":"8","author":"Hamilton","year":"1993","journal-title":"Professional Nurse"},{"issue":"3","key":"10.1002\/14651858.CD007119.pub2-BIB0041|cit41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/01.mco.0000165006.39449.1f","article-title":"Clogbusting: time for a concerted approach to catheter occlusions?","volume":"8","author":"Hardy","year":"2005","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"issue":"2","key":"10.1002\/14651858.CD007119.pub2-BIB0042|cit42","first-page":"64","article-title":"Avoiding catheter complications with lipid containing parenteral nutrition","volume":"16","author":"Hardy","year":"2006","journal-title":"British Journal of Intensive Care"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0043|cit43","first-page":"1","article-title":"Vascular access devices: managing related complications in home infusion","volume":"4 Suppl","author":"Herbst","year":"1998","journal-title":"Infusion"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0044|cit44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analysis","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0045|cit45","article-title":"Chapter 8: Assessing risk of bias in included studies","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]","author":"Higgins","year":"2011"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0046|cit46","article-title":"Chapter 16: Special topics in statistics","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Updated March 2011]","author":"Higgins","year":"2011"},{"issue":"12","key":"10.1002\/14651858.CD007119.pub2-BIB0047|cit47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta12120","article-title":"The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation","volume":"12","author":"Hockenhull","year":"2008","journal-title":"Health Technology Assessment"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0048|cit48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1067\/mpd.2001.118195","article-title":"Recombinant tissue plasminogen activator in the treatment of central venous catheter occlusion in children","volume":"139","author":"Jacobs","year":"2001","journal-title":"Journal of Pediatrics"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0049|cit49","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0749-0704(03)00002-2","article-title":"Central venous catheter occlusion and thrombosis","volume":"19","author":"Jacobs","year":"2003","journal-title":"Critical Care Clinical"},{"issue":"7303","key":"10.1002\/14651858.CD007119.pub2-BIB0050|cit50","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","article-title":"Systematic reviews in health care: Assessing the quality of controlled clinical trials","volume":"323","author":"Juni","year":"2001","journal-title":"BMJ"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0051|cit51","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/01.RVI.0000106385.63463.EC","article-title":"Efficacy and safety of reteplase for central venous catheter occlusion in patients with cancer","volume":"15","author":"Liu","year":"2004","journal-title":"Journal of Vascular Interventional Radiology"},{"issue":"6","key":"10.1002\/14651858.CD007119.pub2-BIB0052|cit52","doi-asserted-by":"crossref","first-page":"640s","DOI":"10.1378\/chest.102.6_Supplement.640S","article-title":"Pathogenisis of venous thrombosis","volume":"102","author":"Mammen","year":"1992","journal-title":"Chest"},{"issue":"3","key":"10.1002\/14651858.CD007119.pub2-BIB0053|cit53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/011542659601100259","article-title":"Techniques and Procedures FDA Safety Alert: Hazards of precipitation associated with parenteral nutrition","volume":"11","author":"McKinnon","year":"1996","journal-title":"Nutrition in Clinical Practice"},{"issue":"13","key":"10.1002\/14651858.CD007119.pub2-BIB0054|cit54","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S1051-0443(07)61865-X","article-title":"Central venous catheters in home infusion care: Outcomes analysis in 50,470 patients","volume":"10","author":"Moureau","year":"2002","journal-title":"Journal of Vascular and Interventional Radiology"},{"issue":"4","key":"10.1002\/14651858.CD007119.pub2-BIB0055|cit55","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00045415-200207000-00010","article-title":"Treatment of venous thromboembolism","volume":"10","author":"Nazario","year":"2002","journal-title":"Cardiology in Review"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0056|cit56","unstructured":"Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2011"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0057|cit57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0261-5614(97)80004-0","article-title":"Lock method using sodium hydroxide solution to clear occluded central venous access devices","volume":"16","author":"Sando","year":"1997","journal-title":"Clinical Nutrition"},{"issue":"1","key":"10.1002\/14651858.CD007119.pub2-BIB0058|cit58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/107602969900500106","article-title":"Regional thrombolysis with urokinase for central venous catheter-related thrombosis in patients undergoing high-dose chemotherapy with autologous blood stem cell rescue","volume":"5","author":"Schindler","year":"1999","journal-title":"Clinical and Applied Thrombosis\/Hemostasis"},{"issue":"11","key":"10.1002\/14651858.CD007119.pub2-BIB0059|cit59","first-page":"1","article-title":"CONSORT 2010 Statetment: updated guidelines for reporting parallel group randomized trials","volume":"152","author":"Schultz","year":"2010","journal-title":"Annals of Internal Medicine"},{"issue":"1","key":"10.1002\/14651858.CD007119.pub2-BIB0060|cit60","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00043426-200301000-00009","article-title":"Recombinant tissue plasminogen activator (alteplase) for restoration of function to occluded central venous catheters in pediatric patients","volume":"25","author":"Shen","year":"2003","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0061|cit61","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/0148607188012005509","article-title":"Use of hydrochloric acid to clear obstructed central venous catheters","volume":"12","author":"Shulman","year":"1988","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0062|cit62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ajic.2007.02.007","article-title":"Review and update of the use of urokinase in the prevention and management of CVAD-related complications in pediatric oncology patients","volume":"36","author":"Simon","year":"2008","journal-title":"American Journal of Infection Control"},{"issue":"1","key":"10.1002\/14651858.CD007119.pub2-BIB0063|cit63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/014860719501900175","article-title":"Are clinical signs accurate indicators of the cause of central venous catheter occlusion?","volume":"19","author":"Stephens","year":"1995","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"issue":"2","key":"10.1002\/14651858.CD007119.pub2-BIB0064|cit64","first-page":"100","article-title":"Urokinase administration in pediatric patients with occluded central venous catheters","volume":"13","author":"Wachs","year":"1990","journal-title":"Journal of Intravenous Nursing"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0065|cit65","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1200\/JCO.2002.11.135","article-title":"Complication rates amongst cancer patients with peripherally inserted central catheters","volume":"20","author":"Walshe","year":"2002","journal-title":"Journal of Clinical Oncology"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0066|cit66","volume-title":"Websters New World Medical Dictionary","author":"Authors","year":"2009"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0067|cit67","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/0148607195019005416","article-title":"Treatment of central venous catheter occlusions with ethanol and hydrochloric acid","volume":"5","author":"Werlin","year":"1995","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"issue":"4","key":"10.1002\/14651858.CD007119.pub2-BIB0068|cit68","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7326\/0003-4819-127-4-199708150-00001","article-title":"Prevention of central venous catheter related blood stream infection by use of an antiseptic-impregnated. A randomized controlled trial","volume":"127","author":"Wheeler","year":"1997","journal-title":"Annals of Internal Medicine"},{"key":"10.1002\/14651858.CD007119.pub2-BIB0069|cit69","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00270-002-2615-4","article-title":"Venous port salvage utilizing low dose tPA","volume":"25","author":"Whigham","year":"2002","journal-title":"Cardiovascular Interventional Radiology"},{"issue":"3","key":"10.1002\/14651858.CD007119.pub2-BIB0070|cit70","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1188\/03.CJON.345-348","article-title":"Vascular access device thrombosis","volume":"7","author":"Wingerter","year":"2003","journal-title":"Clinical Journal of Oncology Nursing"},{"issue":"4","key":"10.1002\/14651858.CD007119.pub2-BIB0071|cit71","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.NAN.0000326833.59655.9e","article-title":"Central venous catheter-related thrombosis: A systematic review","volume":"31","author":"Yacopetti","year":"2008","journal-title":"Journal of Infusion Nursing"}],"container-title":["Cochrane Database of Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/14651858.CD007119.pub2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T02:35:39Z","timestamp":1681871739000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/14651858.CD007119.pub2"}},"subtitle":[],"editor":[{"name":"Cochrane Emergency and Critical Care Group","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":71,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1002\/14651858.cd007119.pub2","relation":{},"ISSN":["1465-1858"],"issn-type":[{"value":"1465-1858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,18]]}}}